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Clinical Overview of Hepatitis C Patients with Terminal Renal Disease

Clinical Overview of Hepatitis C Patients with Terminal Renal Disease

Nayle Maria Oliveira da Silva1*, Ricardo do Carmo Zanella2


1Federal University of Rio Grande, General Osório S/N, Rio Grande; 2Pompeia Hospital, Av. Julio de Castilhos 2163, Caxias do Sul, Rio Grande do Sul, Brazil.

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Hepatitis C virus (HCV) is a serious public health issue, and it is estimated that 3% of the world’s population is infected with the virus. Patients in hemodialysis units have an increased risk for contracting HCV, and high prevalence rates have been found in hemodialysis units around the world. HCV induces chronic liver disease, which is characterized by a persistent hepatic parenchyma inflammatory process that may progress to cirrhosis and hepatocarcinoma. Viral clearance occurs in a minority of patients with viral hepatitis C, whereas chronic infection is established in 60 to 80% of all cases, 20 to 40% of which may evolve to cirrhosis and hepatocarcinoma. Genetic differences among infected hosts can determine the progression and outcome of the virus infection, causing different individuals to respond in different ways to the viral infection.




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Hosts and Viruses


Vol. 8, Iss. 1, Pages 1-22


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