Effectiveness of Aqueous Versus Alcoholic Extracts of Melia azedarach in Amelioration of Lipid Profile, Liver Enzymes and Innate Inflammatory Indices for White New Zealand Rabbits
Effectiveness of Aqueous Versus Alcoholic Extracts of Melia azedarach in Amelioration of Lipid Profile, Liver Enzymes and Innate Inflammatory Indices for White New Zealand Rabbits
Marah Salim Hameed1, Raad Mahmood Hussein Al Zubaidi2, Ali Ibrahim Ali Al-Ezzy3*
ABSTRACT
M. azedarach is widespread over most tropical and subtropical areas and is popular to tropical Asia. To determine the physiological effectiveness of aqueous versus alcoholic extracts of Melia azedarach in amelioration of lipid profile, liver enzymes and innate Inflammatory indices for white New Zealand rabbits. Thirty adult white New Zealand male rabbits were classified equally in to 3 groups, G1 were administrated 28mg/day of aqueous extract of Melia azedarach for 14 days, G2, were administrated 28mg/day of ethanolic extract of Melia azedarach for 14 day, G3 administrated pellets and green food for 14 days. Blood samples were taken at (0, 7, 14) days for separation of serum. Serum cholesterol, triglyceride, total serum protein, albumin and globulin, total serum cortisol, total serum bilirubin, liver enzymes (ALT, AST, and ALP) were determined. Significant variation was reported in serum cholesterol between ethanolic extract vs control. Significant variation in total Serum albumin was reported between aqueous extract vs ethanolic group. Significant variation was reported in total Serum bilirubin between groups (aqueous extract vs control). No significant variation was reported in total serum bilirubin between groups (ethanolic extract vs control, aqueous extract vs ethanolic group; aqueous extract, ethanolic vs control. No significant variation in serum ALT, AST, ALP were reported between groups. Ethanolic extract of Melia azedarach at 28mg/day dose has significant effects on serum cholesterol level and total serum albumin. Aqueous extract of Melia azedarach at 28mg/day dose has significant effects on total serum bilirubin. Ethanolic and aqueous extracts of Melia azedarach have equal effects on ALT, AST, ALP enzymes and innate inflammatory indices for white New Zealand rabbits.
Keywords | Inflammatory indices, Lipid profile, Liver enzymes, Melia azedarach, New Zealand rabbits, Physiological effect
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July 2024
Vol. 12, Iss. 7, pp. 1206-1409
