Systematic and Integrated Analysis Approach to Prioritize Mastitis Resistant Genes
Systematic and Integrated Analysis Approach to Prioritize Mastitis Resistant Genes
Iqra Mahmood1, Asif Nadeem1*, Masroor Ellahi Babar2, Muhammad Muddassir Ali1, Maryam Javed1, Aisha Siddiqa1, Tanveer Hussain2 and Muhammad Tariq Pervez2
ABSTRACT
Mastitis (mammary gland inflammation) is one of the most important diseases causing economic losses to dairy farm owners. In order to develop new strategies to prevent mastitis, a detailed understanding of the molecular mechanisms underlying the host immune response to the infectious agents is necessary. Identification of the genes, and their variants, involved in innate immune responses is essential for the understanding of this inflammatory disease and to identify potential genetic markers for resistance to mastitis. This article presents a systematic integration of complex biological interactions of 226 mammary gland genes to uncover underlying regulatory networks. Data were collected from various databases after having an exhaustive literature study. Network, functional and pathway analysis of the mammary gland genes were performed to find mastitis resistant genes, which helped us to identify prime genes of mammary gland that are more resistant to mastitis, and analysis of those resistant genes helped to find the solution of mastitis and immunity related diseases.
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