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Intervention Effect of Total Glucoside of Paeony on Mesangial Proliferative Glomerulonephritis in Rats

Intervention Effect of Total Glucoside of Paeony on Mesangial Proliferative Glomerulonephritis in Rats

Xiujun Yao1, Haofeng Wang 2, Ligong Zhang3, Jingzhang Wu4 and Lijun Wang1*

1Departments of Paediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Province 250021, China.
2Departments of Combine Tracitional Chinese and Western Medicine, The Fifth Hospital of Jinan, 250000, China.
3Departments of Anesthesia, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Province 250021, China.
4Urology Departmengt, Hengshui Peoples Hospital, Hebei Province 053000, China.

*      Corresponding author: nv1h58@163.com

ABSTRACT

Ten out of 30 rats were randomly selected as normal group. Remaining 20 rats were used to establish rat model of mesangial proliferative glomerulonephritis (MsPGN), and were equally divided into model group and total glucoside of paeony (TGP) group. TGP group was given 150 mg/kg TGP by gavage, normal group and model group were given the same amount of saline by gavage. After 12 weeks of intervention, 24-h urine protein quantity, serum levels of IL-6, IFN-γ, and TNF-α ,kidney ROS and MDA levels, relative content of TGF-β1 and CTGF in TGP group were lower than that in model group (P <0.05); serum levels of IL-2 and CTLA-4,SOD levels in TGP group were higher than that in model group (P <0.05).These results indicated that TGP could reduce urinary protein quantity, inhibit inflammatory response, and reduce expression of TGF-β1 and CTGF in kidney tissue of MsPGN rats.
 

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Pakistan Journal of Zoology

August

Vol. 53, Iss. 4, Pages 1201-1601

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