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Effect of Isoliquiritin on Wound Healing in Scalded Rats

Effect of Isoliquiritin on Wound Healing in Scalded Rats

Qiang Tang1 and Qianli Tang2*

1Department of Burn Plastic and Wound Repair Surgery, Jinan University , Guangzhou, Guangdong Province, 510000, China.
2Department of General Surgery, Youjiang Medical College for Nationalities, Baise Guangxi Province, 533000, China

*      Corresponding author: oanppx23@163.com

ABSTRACT

The aim of study was to investigate effect and possible mechanism of isoliquiritin on wound healing in scalded rats. The results show that at 24 h after the last administration, wound healing rate of isoliquiritin group was higher than that of model group (p=0.024). Compared with control group, thickness of epidermis and dermis in model group was thinner (p<0.001), and width of subdermal collagen fibers also decreased (p<0.001), inflammatory factors TNF-α, IL-6 and IL-1β in skin tissue increased (all p<0.001), and expression levels of Ang-1 and Tie-2 proteins in skin tissue decreased (both p<0.001). Compared with model group, thickness of epidermis, dermis and collagen fibers, and expression levels of Ang-1 and Tie-2 proteins in skin tissue in isoliquiritin group increased (all p<0.001), and inflammatory factors TNF-α, IL-6 and IL-1β contents and expression level of Ang-2 protein in skin tissue decreased (all p<0.001). Hence, this can be concluded thatisoliquiritin can promote the healing of acute wounds in rats. The mechanism may be related to increasing skin thickness, inhibiting the release of inflammatory factors, up-regulating the expression of Ang-1 and Tie-2 proteins and down-regulating the expression of Ang-2 protein.
 

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Pakistan Journal of Zoology

June

Vol. 53, Iss. 3, Pages 801-1200

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