Role of Soluble Vascular Endothelial Growth Factor Receptor-1 and -2 in Regulating Branch Retinal Vein Occlusion with Macular Edema
Role of Soluble Vascular Endothelial Growth Factor Receptor-1 and -2 in Regulating Branch Retinal Vein Occlusion with Macular Edema
Pengliang Xie1, Lufang Zheng2*, Mingxia Dong3, Huaiqiang Zhang1 and Fang Chen1
ABSTRACT
The objective of this study was to investigate the mechanism of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and sVEGFR-2 in regulating branch retinal vein occlusion with macular edema. A total of 45 patients with branch retinal vein occlusion and macular edema who were treated at Tangshan Eye Hospital from November 2018 to June 2020 were enrolled in the study, including 19 cases of localized macular edema, 12 cases of diffuse macular edema, and 14 cases of cystoid macular edema. Forty-five healthy people in physical examination were recruited as control. We found that the diseased group had higher proportion of hypertension (P<0.05) compared with the control group, and there was no difference in other general information (gender, age, BMI) (P>0.05). Compared with the control group, the diseased group had higher expression of sVEGFR-1 and sVEGFR-2 mRNA (P<0.05), and higher content of VEGF, PlGF, sICAM-1, MCP-1 and PDGF than the control group (P<0.05). The diseased group had higher protein expression of IL-6, IL-8, IL-12 and IL-13 than the control group (P<0.05). In detection of protein expression levels of sVEGFR-1 and sVEGFR-2 in patients with different severity levels, diffuse macular edema group had higher protein expression levels of sVEGFR-1 and sVEGFR-2 than the localized macular edema group (P<0.05), and cystoid macular edema group had higher protein expression levels of sVEGFR-1 and sVEGFR-2 than diffuse macular edema group (P<0.05). In the case of more severe macular edema, the sVEGFR-1 and sVEGFR-2 protein expression levels are higher. It is concluded that the aqueous humor levels of factors associated with branch retinal vein occlusion with macular edema, such as growth factors, sVEGFR-1, sVEGFR-2 and inflammatory factors, are increased, indicating that there is a very important relationship between cytokine networks, which can help us better understand the disease mechanism and develop new treatment methods.
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