Protective Effect of Caffeic Acid on Streptozotocin Induced Gestational Diabetes Mellitus in Rats: Possible Mechanism
Protective Effect of Caffeic Acid on Streptozotocin Induced Gestational Diabetes Mellitus in Rats: Possible Mechanism
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
ABSTRACT
Gestational diabetes mellitus (GDM) is an atypical condition of pregnancy outcome that affect the maternity and infant. Pregnant women are a high risk to develop the GDM suffering from the diabetes, it showed the effect on the development and growth of the fetus. During the GDM increase the incidence of oxidative stress. Caffeic acid is a powerful free radical scavenger and possesses antioxidant effect against the various diseases. Previous study suggests that the caffeic acid have potent anti-inflammatory activity. The aim of the current study was to scrutinize the protective effect of caffeic acid against the streptozotocin induced GDM in rats and explores the possible mechanism of action. A total 36 female rats were caged into the male rats for the pregnancy, and 33 female pregnant rats were collected and weight. The female rats were group into following groups and each group contains 6 rats. Once the pregnancy was verified, the streptozotocin (STZ) single intraperitoneal injection was used for the induction of diabetes. The rats were received the various dose of caffeic acid. After the pregnancy (19 day) the blood sample was collected via puncturing the retro arbital and collecting the fetus from all the groups. The rats, fetus weight and placental weight were calculated. The blood glucose level, serum, lipids, antioxidant, cytokines and C-peptide was recorded. GDM group rats showed the lower weight of pregnant rats, fetal and placental weight as compared to other group rats. Caffeic acid treated group rats exhibited the modulated level of blood glucose level, lipid profile and antioxidant parameters at dose dependent manner. Caffeic acid significantly (P<0.001) enhanced the level of insulin, hepatic glycogen as compared to GDM control group rats. Caffeic acid significantly (P<0.001) increased the level of antioxidant enzymes in the liver and pancreas tissue at dose dependent manner. Our finding clearly supported the beneficial effect of caffeic acid on not only the diabetes mellitus, but also alleviating Gestational diabetes mellitus.
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June 2021
Vol. 53, Iss. 3, Pages 801-1200
