Hepato-Nephrotoxic Effects of Induced Fluorosis in Rabbits and Broilers
Hepato-Nephrotoxic Effects of Induced Fluorosis in Rabbits and Broilers
Barirah Rehman Talpur1, Zaheer Ahmed Nizamani1*, Imdad Hussain Leghari2, Mansoor Tariq1, Aisha Rehman3, Shahnawaz Kumbhar1
ABSTRACT
Fluorosis in humans, animals and birds is often caused by drinking of fluoride contaminated groundwater. The study was designed to evaluate nephro-hepatotoxic effects of fluorosis on liver and kidneys in rabbits and broilers. Sixteen rabbits and sixteen broilers of four weeks age were divided into four subgroups each were given 0mg (control),50 mg, 100 mg and 200 mg Sodium Fluoride /liter in water daily for 18 days. The clinical signs and mortality were noted. Blood was collected at days 0, 5, 10, 15 and 18 of experiment, for evaluation of liver and kidney functions. Dose and time dependent significant (p<0.05) increase in serum Alanine aminotransferase (GPT), Alkaline phosphatase (ALP), Gamma glutamyl transferase (γGT), uric acid and creatinine levels and significant (p<0.05) decrease of serum calcium levels were noted in all treatment groups of both species as compared to control. In rabbits and broilers, necropsy findings included mild inflammation and discoloration of liver along with nephritis. While in broilers, toxic lesions were observed on mucus membranes of duodenum and proventriculus along with nephritis. Histological lesions observed in livers of both rabbits and broilers included dilation of central vein and sinusoids and fatty degeneration of hepatocytes. Kidney tissues of both rabbits and broilers revealed marked shrinkage of glomeruli with widened bowman’s spaces along with inflammatory cellular infiltration. It is concluded that high dose (200mg/l) of Sodium Fluoride causes liver and kidney dysfunction in both species along with lesions in digestive system of broilers.
Keywords | Fluorosis, Rabbits, Broilers, Liver, Kidney
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