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Cardioprotective Effect of Naringenin against Myocardial Ischemia-Reperfusion Injury via Alteration of Apoptotic Signaling Pathway

Cardioprotective Effect of Naringenin against Myocardial Ischemia-Reperfusion Injury via Alteration of Apoptotic Signaling Pathway

Tao Ren1, Guiqiu Cao2, Xiao Han3, Feng Tan1, Qiaoli Chen4, Shicheng Yang5 and Haiyan Zhang6*

1Department of Third Cardiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, 832008, China
2Department of Cardiology, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China
3Department of Cardiology,General Hospital of Fuming of Liaoning Health Industry Group, Fushun, Liaoning, 113000, China
4Department of Cardiology, First People’s Hospital of Wuyi County, Jinhua, Zhejiang, 321200, China
5Department of Cardiology, Tianjin Chest Hospital, Tianjin, 300222, China
6Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, China
Tao Ren and Guiqiu Cao are co-first authors and contributed equally to this work.
* Corresponding author:


Ischemic heart disease (IHD) is a common multiple cardiovascular disease (CVD) in clinical settings. It is a major contributor to mortality and morbidity worldwide and causes a serious threat to human life and health. Naringenin, a flavonoid possesses the potent antioxidant potential and it is proposed to be useful in the treatment of CVD. In this experimental study, we aimed to scrutinize the cardio-protective effect of naringenin against the I/R induced myocardial injury and elucidate the possible mechanism of action. In vitro studies, the H9c2 cardiomyocytes cells were treated with naringenin or without naringenin and then subjected to I/R, respectively. At end of the experimental study, the rats were anesthetized and blood samples were collected to scrutinize the various parameters such as creatine kinase myocardial band (CK-MB), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), creatine, troponin-T (TRT), cholesterol, C - reactive protein (CRP), and concentration of mitochondrial enzymes viz., Ca2+, Na+ and K+ ions were estimated in blood. Heart tissue was also isolated for caspase-3 activity. Our result showed that naringenin pretreatment significantly increased cardiac dysfunction via scavenged free radicals and a reduction of inflammatory reaction. Dose-dependent treatment of naringenin significantly altered the CK-MB, HDL, LDL, creatinine, cholesterol, CRP, Ca2+, Na+ and K+, respectively. A significant alleviating change in these biochemical parameters along with caspase-3 activity was noticed. Thus, in our study, we determined that I/R induced cardiac remodeling can be successfully mitigated by naringenin.

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Pakistan Journal of Zoology


Pakistan J. Zool., Vol. 56, Iss. 3, pp. 1001-1500


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