Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1
...meters were confirmed by histopathological examination using hemotoxylin and eosin (H&E) and Mason trichrome stains (MTC). Immunohistochemical investigations for the expression of the proapoptotic protein (Bax) and the expression of macrosialin cluster of differentiation (CD68). APAP elevated of most of the previously measured parameters and decreased GSH, SOD, and total protein levels. Liver sections of H&E demonstrated liver injury characterized by c...
Mostafa A. Abdel-Maksoud1,2, Fathy A. Abdel-Ghaffar2, Azza El-Amir2, Gamal Badr3 and Saleh Al-Quraishy1*
...nfection has resulted in histopathological changes and increased apoptotic cell death in splenic tissue of infected mice. Moreover, infection with live P. chabaudi was accompanied with an increase in NO, H2O2, and MDA levels in splenic tissue of lupus mice in comparison to either control or gamma irradiated P. chabaudi- infected group. Our data reveal that infection of lupus mice with live P. chabaudi has several effects on the splenic tissue on the histologic...
Hui Zhang2, Yajing Wang2, Kun Li2, Mujeeb Ur Rehman2, Fazul Nabi2, Rui Gui2, Yanfang Lan2 and Houqiang Luo1,2*
...s confirmed by necropsy, histopathological examinations and PCR analysis. The results showed, 20 chickens as positive for ALV-A (2.73%, 95% CI 1.7-4.2) and these chickens were found to be positive for ALV-A with the further distribution of 2.91% (95% CI 1.0-6.7), 3.70% (95% CI 1.5-7.5), 2.48% (95% CI 0.5-7.1), 3.13% (95% CI 0.6-8.9) and 1.30% (95% CI 0.2-4.6) in Anhui province of Huaibei, Suzhou, Bozhou, Bengbu and Fuyang, respectively. The present survey show...
Cansu Akbulut1,*, Tuğba Kotil2, Burcu Öztürk1 and Nazan Deniz Yön1
...we have investigated the histopathological effect on zebrafish ovaries after exposure to TiO2 nanoparticles. Adult zebrafish individuals were exposed to 1, 2 and 4 mg/L TiO2 for 5 days, and then their ovaries were evaluated using light and transmission electron microscopy. Numerous degenerated follicles with cytoplasmic vacuolization, mitotic catastrophe in mitochondria , chromatin condensation, mitochondrial vesiculation and dispersion a...
Mustafa Cengiz1*, Jama Hussein Ali2, H. Mehtap Kutlu2, Djanan Vejselova2 and Adnan Ayhanci3
...fter D-GaIN, in terms of histopathological and biochemical values. In conclusion, EA might play an important role in repairing D-GaIN-induced liver damage both as a protective and a therapeutic agent.
...
Beenish Zahid1,*, Asim Aslam2, Zafar Iqbal Chaudhry2 and Raheela Akhtar2
...pare the biochemical and histopathological changes in response to pathogenic field infectious bursal disease virus (IBDV). The Bursa of fabricius was collected from poultry flocks of Punjab Pakistan for isolation of IBD virus by inoculating in embryonated chicken eggs through chorioallantoic membrane. The two hundred birds were divided into 4 groups A, B, C and D). The birds in group A were commercial broiler chicks having maternal derived antibodies and were ...
Sanjukta Chakrabarti1, Colin J. Barrow2, Rupinder K. Kanwar3, Venkata Ramana1*, Rakesh N. Veedu4,5 and Jagat R. Kanwar3*
...planted SCID mice and by histopathological and immunohistochemical analyses. Our results demonstrated that fusion protein VEGFR1(D1-D3)-Fc efficiently inhibited
the lung cancer growth in vivo. Although the aptamer RNV66 was not found to be as efficient in this study, the results were also not surprising as the aptamer was administered naked and at low dose. As these are only our preliminary studies, a detailed investigation is planned using multiple dos...
the lung cancer growth in vivo. Although the aptamer RNV66 was not found to be as efficient in this study, the results were also not surprising as the aptamer was administered naked and at low dose. As these are only our preliminary studies, a detailed investigation is planned using multiple dos...
Gamalat Osman1, Mansour Galal1, Abbas Abul-Ezz2, Ahmad Mohammed1, Mohammed Abul-Ela3 and Asmaa Mostafa Hegazy2
...s during metabolism. The histopathological observations of the gills and mantle of L. carinatus showed pronounced alterations at 24 hours and proliferated at the day 15 but showed a further decline at the day 30 of exposure. These findings seem to be time related and were classified as reversible and irreversible changes. Accordingly, it can be concluded that L. carinatusis a typical bioindicator for crude oil pollution....
Saara Ahmad1,*, Iftikhar Ahmed2, Saida Haider3, Zehra Batool3, Fatima Ahmed4, Saiqa Tabassum3,6, Syeda Madiha3, Tahira Perveen3 and Saad Bilal Ahmed5
...e collected, weighed and histopathologically evaluated for the development of cysts. It was seen that the ovaries of the group treated with caged chicken meat showed increased cholesterol levels, imbalanced steroidal sex hormone levels, increased ovary weight and development of the cysts upon histopathological examination as compared to the rats of other groups in the study.
...
Souheila Slimani1,*, Sonia Hamouda1, Chahrazed Souadi1, Sara Silini2, Cherif Abdennour2 and Leila Delimi3
...ereas semen quality, and histopathological profile were investigated at week 10.The obtained results reveal that under a long photoperiodthe sexual activity of the control lasted only 04 weeks, characterized by significant increase in the testicular volume, followed by spontaneous gonadal regressionup to week 10. Consequently, an azospermia and lack of germ cells in control birds was noticed,which confirm the testicular regression.In the treated groups, thiram...
Wajid Ali1,*, Asma Karim1, Muhammad Irfan2, Hafiz Abdullah Shakir3*, Ghulam Mustafa4, Zeeshan Shafique1, Ijaz Anwar1
Tahir Abbas*1, Khawaja Raees Ahmad2, Asmatullah3, Khalid Pervaiz Lone4, Muhammad Ali Kanwal2, Sadia Suleman2
Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice
...cted for biochemical and histopathological analysis.Cr+6 treated group showed severe histological changes like necrosis, cirrhosis and dehydration in liver evident by significant elevation of Serum Glutamic Pyruvic Transaminase (SGPT), Serum Glutamic Oxaloacetic Transaminase (SGOT), Alkaline Phosphatase (ALP), total protein, bilirubin, globulin, creatine and uric acid along with reduction of SGOT/SGPT, Blood Urea Nitrogen (BUN), urea and albumin as compared to...
Ihsan Ali1#, Asim Aslam1*, Habib-ur-Rehman2, Beenish Zahid3, Ishtiaq Ahmed1
Effect of fish oil on growth performance and immune response in experimentally infected broiler chicken with avian influenza virus H9N2
...id organs through
histopathology, growth performance and antibody response in H9N2 challenged
broilers. A total of 80 chicks were divided in to 4 groups A, B, C & D. Group A and
B were challenged with AI virus (H9N2) on 21 day of age, group B and C were
treated with 3% FO while group A and D were treated with cooking oil. For isolation
of virus, 21 samples were collected, out of which 8 (40%) were positive for H9. The
histopathology, growth performance and antibody response in H9N2 challenged
broilers. A total of 80 chicks were divided in to 4 groups A, B, C & D. Group A and
B were challenged with AI virus (H9N2) on 21 day of age, group B and C were
treated with 3% FO while group A and D were treated with cooking oil. For isolation
of virus, 21 samples were collected, out of which 8 (40%) were positive for H9. The
Hina Abrar1,2, S.N.H. Naqvi1,*, Muhammad Rashid Ahmed3, Asma Basharat Ali3 and Hina Yasin1,2
...s propranolol group. The histopathological examination reveals various features of hepatic architecture damage in CBZ treated group but the hepatic damage induced by CBZ was successfully ameliorated by propranolol. To conclude propranolol is effective in reducing the hepatoxic effects of CBZ probably by affecting hepatic blood flow.
...
Muhammad Kashif Maan1, Ghulam Mustafa1, Munibullah2 and Sajid Umar2,*
...ed upon the clinical and histopathological examination of the tumor sample. In all cases, tumor resection was performed followed by cauterization of the remaining surface with silver nitrate. No postoperative complications or local recurrence were reported by owner of each case.
... 
Muhammad Usman Ghani1*, Muti Ur Rehaman Khan1, Asim Aslam1, Zubair Shabbir2, Li Bo3 and Naveed Anwar4
...s sample for PCR. Gross, histopathological, hematological examination was carried out to rule out possible cause of infection and adopt preventive measure so that further losses may be avoided. 96 out of total were clinically positive with strong clue of contagious ecthyma. In current study 12 (25%) goats out of 48 were PCR positive. In case of sheep, 7 (14.58%) out of 48 were PCR positive. Tissues were taken for histopatholog
Rana Waqas Arshad1, Asim Aslam1, Muhammad Saeed Imran1, Kamran Ashraf2 and Raheela Akhtar1,*
... vaccines. Consistently, histopathological lesions of IBD were less evident in live vector vaccine group in comparison to other groups. In addition live vector vaccine improved the feed conversion ratio (FCR) by keeping the bird healthy and by decreasing the immunosuppression. These results indicated that live vector vaccine has overall positive impact in terms of immunity, histopathology of bursa of Fabricius and FCR. These...
De-Yong Zhang1, Xiao-Lu Xu1,*, Qin Ruan2, Xiu-Ying Shen3 and Yin Lu1
...age) resulted in visible histopathological changing in testis, including disorder and vacuolization of spermatogenic cells. Changed testicular organ coefficient (for dosage ≥ 55 mg/kg), decreased sperm concentration (for 110 mg/kg dosage), decreased motility (for 110 mg/kg dosage) and increased sperm malformation (for all of the treated groups) were also confirmed (p<0.05). Sperm malformation showed high sensitivity to PFOS exposure. A sperm malfo...
Nouf Alharbi*, Mai Elobeid and Promy Virk
... in liver and serum, and histopathological evaluation of liver and kidney. Results showed that low dose of quercetin was significantly (p≤0.05) more effective than the high dose. Low dose was more efficacious in reducing Cd accumulation in the tissues, reversing the effects of Cd toxicity on blood profile, and on the CAT and SOD activity in the liver and decreased the MDA levels in both serum and liver. Thus, the key findings suggest a profound antioxidativ...
Aqsa Pervaiz1*, Rukhshanda Afridi1, Zahra Pervaiz1, Rabia Masood1 and Hira Pervaiz2
..., behavioral changes and histopathological changes in the liver of Nile tilapia, Oreochromis niloticus after acute exposure to methylmercury. The toxicity of methylmercury of Nile tilapia was studied in a static renewal bioassay for 48 hours and 96 hours (96 hours L.C-50 0.22 mg/L). The study was conducted on 40 fish that weredivided into 4 groups A, B, C and D. Group A was considered as control group.Group B, C and D were exposed to sublethal concentra...
Zhijun Zhong1, Rui Tu1, Xichun Wang2, Yi Geng1, Qicheng Xiao1, Yinan Tian1, Bin Wei1, Jiaming Dan1, Ya Wang1 and Guangneng Peng1,*
Chaman Ara1*, Asmatullah1, Sehrish Kanwa1, Asma Chaudhary2, Ayesha Siddiqua1
Kadry A. El-Bakry1, Lamiaa E.M. Deef1*, Lotfy Z. Habbak1 and Samia S. El-Naeli2
...ixed in 10% formalin for histopathological studies. The present study showed that, PAT causes elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and significantly increases serum level of malondialdehyde (MDA) but decrease the activity of superoxide dismutase (SOD) enzyme. On the other hand, in patuilin injected rats and treated with ginger, the activity of ALT, AST and SOD were improved and level of MDA was decreased signi...
Sameh S. Tawfik, Ahmed A. Elkady* and Ehab T. Mohamed
...rradiated rat group. The histopathological-findings of renal tissues in the irradiated-group, showed nephrotoxicity; the renal cortex showed massive necrotic changes, the convoluted tubules showed distinctive pattern of ischemic renal injury and the cuboidal epithelium cells of proximal and distal renal tubules showed nuclear changes with leukocytes infiltrations. More over some cases showed atrophied glomeruli, widened Bowman’s space and thickened basem...
Ahsan Anjum1, Asim Aslam1, Raheela Akhtar1, Tahir Yaqub2, Muti-ur-Rehman Khan1, Rizwana Sultan3, Saba Usman1, Aneela Zameer Durrani4 and Muhammad Usman4*
... node were collected for histopathological examination. Of the 560 samples, 49 (8.25%) were found positive for CBPP. Maximum pathological lesions (50-75% of surface area) were seen in 34.69 percent lung samples, chronic type pleurisy in 97.96 percent, maximum aggregate pathological lesion score in 65.31%, while 48.98% lung samples had 6-10 numbers of sequestra. Besides, infiltration of inflammatory cells, congestion, hemorrhages, necrosis and other degenerativ...
Saara Ahmad1,*, Iftikhar Ahmed2, Saida Haider3, Zehra Batool4, Laraib Liaquat3, Fatima Ahmed5, Asra Khan1, Tahira Perveen3, Mirza Jawad ul Hasnain6, Saima Khaliq7 and Saad Bilal Ahmed8
...samples were weighed and histopathologically evaluated using a knodell score to assess portal hypertension and liver damage. Animals fed with commercial chicken meat and feed for six weeks showed development of inflammation, necrosis, apoptosis and cirrhosis on histopathological examination of the liver, and had raised plasma TNF-α and AFP-levels. This study shows that damage to liver cells is caused by consumption of ...
Meriem Msaad Guerfali1,*, Heitham Hamden1, Salma Fadhl1, Wafa Djobbi1, Lotfi Sillini1, Wafa Marzouki1 and Mohammed Ammar2
Muhammad Saeed Imran1, Asim Aslam1*, Muhammad Yasin2, Tahir Yaqoob2 and Beenish Zahid3
...t infection (dpi) showed histopathological signs of clinical infection. Overall, the severity of infection was higher in the co-infected birds as compared to host challenged with either of the viruses alone. Notably, moderate clinical infections raised concerns vaccine efficacies. The current study concluded that the commercially available vaccines may not provide enough protection particularly in the case of co-infection with NDV and IBV. Therefore, here is n...
Muhammad Anwarullah1*, Aneela Zameer Durrani1, Muhammad Ijaz1, Aftab Ahmad Anjum2, Ghulam Mustafa3, Muhammad Husnain1 and Muhammad Usman1
... basis of the changes in histopathological lesions, the effect of these therapeutic agents was noted. Amikacin showed marked differences in terms of decrease in severity of lesions weather used alone or in combination with cinnamon in rabbits. It was observed that amikacin and cinnamon having synergistic effect in rabbits and are economically important drugs in treatment of Johne’s disease.
...
Turgay Şişman1,*, Muhammet Çağrı Keskin1, Hatice Dane1, Şeymanur Adil1, Fatime Geyikoğlu1, Suat Çolak2 and Esra Canpolat1
... lung, liver, and kidney histopathologies were evaluated in marsh frog (Pelophylax ridibundus) in agricultural areas. The most prominent histopathological alterations observed in lung tissue were noted as epithelial hyperplasia, thickness of alveolar septa, dilatations and congestions of blood capillaries, and melanomacrophage accumulation. An increase in the number and widening of melanomacrophage centers were also n...
Muhammad Faisal Ayoob1,2, Zaheer Ahmed Nizamani1, Asghar Ali Kamboh3, Mansoor Ayoob4, Waseem Ali Vistro3 and Abdul Sattar Baloch3*
Naveed Akhtar1*, Muhammad Fiaz Khan1*, Sadia Tabassum1,
Munawar Saleem Ahmad2 and Khan Dil Badshah3
...cal components of blood, histopathological changes in different organs and DNA damage in Chirruh snow trout Schizothorax esocinus. WBCs, RBCs, hemoglobin, hematocrit, MCV, MCH, MCHC and platelets were significantly decreased in all treatedgroups compared to control. Monocytes showed significant increase in all experimental groups. Lymphocytes counts significantly decreased in all treated groups compared to control groups. Neutrophils count increased sig...
Hagar E. Mohammed1, Ranwa A. Elrayess2 and Heba N. Gad El-Hak2*
...ne induced severe testes histopathological lesions and histochemical alteration associated with a reduction in epididymis weight, abnormality in the sperm indices and a decline in serum testosterone levels which may have a bad impact on male infertility, on the other side, treatment the rats with the combined extract of different doses of A. monosperma or M. piperita attenuated the deleterious damage to the testes, the sperm index and the sex hor...
Saqib Nawaz1, Sher Bahadar Khan1*, Umar Sadique1, Muhammad Israr2,
Mumtaz Ali Khan3, Hameed Ullah Khan4, Muhammad Irshad5, Ihsan Ali1 and Haq Aman Ullah1
...pan>(23%). For gross and histopathological lesions a total of 50 animals were necropsied infected with C. perfringens type D. A total of 43 (86%) sheep were recorded having hemorrhages on serosa of intestine followed by gas filled small intestine in 41 sheep (82%), lesions in ileum and colon in 39 sheep (78%), soft kidney 27 (54%), dark congested liver 26 (52%), nephritis 23 (46%) and spleenitis 13 (26%). Microscopic lesions revealed a score of 10 of ki...
Safia Bibi1, Saima Naz1*, Saba Saeed1, Ahmad Manan Mustafa Chatha2
... and cadmium (Cd) causes histopathological variations and several diseases in various fishes of Pakistan. Extensive histopathological variations in gills, liver, kidney and skin of different fishes were noticed when exposed to heavy metals, thus indicating severity of heavy metal toxicity. The current study was focused on the toxicological effect of Cr, Hg, Ni and Cd in different type of fishes and it would be useful for the...
Maryam Yousaf1, Salman Ahmad1*, Romana Anjum2 and Muhammad Zeeshan Majeed3
...sectioned to observe the histopathological modifications. Wilted cross sections represented the cell wall disintegration and disruption of the tissues along with the blockage in xylem and phloem vessels due to the tylone production. Hyphal growth and proliferated hyphae inside the root cortex were also observed. We concluded that FOL fungus penetrated into the cell wall of the tomato seedlings through hyphae and proliferated into the cortex. Later on, it progr...
Safaa M. Mohammed*, Shahira A. Abdelwahab**,Fetaih,H⃰ ⃰ ,Neveen,R⃰ ,Abdel satar ,A⃰ and Mohamed S. Elshahidy**
...was examined clinically ,histopathologically and immunohistochemically. Turkey pox virus was isolated on CAM of embryonated chicken eggs and identified by agar gel precipitation test and polymerase chain reaction .Two main types of TKPV infection were observed in examined flocks ,cutaneous and diphtheritic forms. Morbidity rate ranged from 5-15%with no mortalities .75% of examined serum reacted positive to TKPV .All TKPV isolates were amplified using specific ...
Hanaa A. Elsamadony1, Laila A. Tantawy1, Sabry E. Omar2 and Heba A. Abd Alah1
...time PCR and
histopathological examination. The positive samples were prepared and inoculated in SPF chicks' oneday-
old then at aged 10-days post-inoculation collected organs for PCR, sequencing and
immunohistochemically examination.
Results: There's one positive farm of age 100-days-old from Qalubia governorate. The
histopathological examination of positive sample...
Ahmed K. El-Attar1, Samah A. Mokbel1 and Om-Hashem M. EL-Banna2
...uctural changes or other histopathological alterations in basil cells
following infection by AMV.
Methods: Studies were conducted to elucidate the etiology of the disease. The diagnostic tools
used were the transmission electron microscope for rapid diagnosis, host reactions, serological
double-antibody sandwich (DAS)-ELISA, reverse transcription (RT)-PCR and nucleotide
sequence determination. Ultra-s...
Md. Abdullah Al Mamun1,2*, Shamima Nasren1,3, Sanjay Singh Rathore1 and Kavalagiriyanahalli Srinivasiah Ramesh1
...his parasite resulted in histopathological changes in the skin and muscle, gill, liver, kidney, heart and different parts of gut tissues. According to the results obtained in the present study, it can be suggested that acute infestation of A. japonicus elicited direct effects such as eye opacity, fin rots, scale loss and severe histopathological alterations in catla. ...
Sajida Batool1, Saira Batool1, Sitara Shameem1, Fatima Khalid1, Tahira Batool2, Summera Yasmeen1, Saima Batool3*
...ed to the Cnt group. The histopathological findings in ATZ administered group included loosening hepatic tissue, massive degeneration of hepatocytes, deformed nuclei of hepatocytes, highly disordered trabecular arrangement, vacuolar degeneration, diffuse necrosis, congestion and degeneration of the hepatic portal vein. Micrometric data indicated a significant reduction in themean number of hepatocytes and oval cells per unit area in ATZ treated group as well a...
Chao-Qun Shi1, Hong-Ying Lin1, Jin-Qing Zheng1, Fan Yang1, Kwame Ayisi Lartey1, Dan-Ju Kang1, Hwa-Chian Robert Wang2, Ravi Gooneratne3*and Jin-Jun Chen1*
...n in duodenal villi, and histopathology of duodenum were also studied. TFCO significantly increased the IgA and IgG concentration (P<0.05), reversed the intestinal mucosal damage caused by E. coli, and increased the relative expression of TGF-β1 mRNA. Therefore, TFCO has potential to improve immune function against E. coli infection, restored the intestinal structure and cured the E. coli-induced diarrhoea in mice.
Rizwana Sultan1, Asim Aslam1, Muhammad Yasin Tipu1, Habib ur Rehman2, Saba Usman1, Ahsan Anjum1,*, Muhammad Saeed Imran1, Muhammad Usman3 and Muhammad Zahid Iqbal3
... serum biochemistry, and histopathology. Species specific PCR based on polymorphic site of the ITS1 gene was developed and used to identify the organism. Haematological examination of the blood demonstrated a decrease in total erythrocytes, packed cell volume, haemoglobin concentration, and red blood cell indices. Differential leukocyte analysis revealed leukocytosis, heterophilia, eosinophilia, monocytosis, and lymphocytosis. Serum biochemistry showed ...
Yonis Abukar Mohamed1, Md. Nazrul Islam1, Md. Haydar Ali1, Mahfuza Akther1 and Abdiaziz Idiris Mohamud2*
...er was noticed 13.3%. In histopathological study of acute Fascioliasis, there was lot of hepatocytic alterations like swelling of individual hepatocytes by increase in size and characterized by opaque cytoplasm. Sometime there was fatty change in which clear vacuoles appeared in the cytoplasm with peripherally located nuclei. Microscopically, depending on the duration and intensity of the infection, various changes were observed in the structures of fasciola i...
Ho-Seong Cho1 and Yeonsu Oh2,*
Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
Nacira Djabali1*, Souad Dougat2, Wahida Haddadi2 and Lamis Fadhli2
...perm, the weight and the histopathology of the testes were studied. The results obtained show a significant dose-dependent decrease in LH, FSH and testosterone in the treated groups compared to control. The administered solvent caused severe deterioration in sperm quality, decreased sperm concentration, mobility and vitality, with increased sperm morphological malformations. The treated individuals show hypogonadism and severe tissue damage, especially in grou...
Aly M. Ghetas1*, Dalia M. Sedeek1, Hanaa S. Fedawy1, M.A. Bosila1, Hoda M. Mekky1, Kh. M. Elbayoumi1, 3, Mohamed M. Amer2
Nour El-Hoda Khayrat Hammad1*, Yousef Y. El-Seady3, Azza E. Hassan1, Sara T. Elazab2, Magdy S. Amer2
...hich accompanied by some histopathological damage in testes and epididymis. On a molecular basis, mRNA expression of CYP17A1 and LHR genes were significantly reduced in testicular tissues of FCZ group while aromatase gene was elevated. The administration of LIN oil after FCZ treatment markedly improved the aforementioned alterations caused by FCZ. So linseed oil is capable to ameliorate the fluconazole induced fertility disorders.
Keywords | Male ferti...
Hong Yin*, Dan Yang, Ji-Jie Liu, Jing-Wei Ding and Dan-Dan Cui
Jocelín Selene Sánchez Cisneros1, Braulio Alejandro Fuantos Gámez1, Martin Herrik Ramón Kane1, Laura Miranda Contreras2, Camilo Romero Núñez2*
...n samples were taken for histopathology and compared with a healthy specimen of the same species and colour characteristics. The diagnosis was cutaneous collagen dysplasia suggestive of cutaneous asthenia. This is the first report of cutaneous asthenia in a baby albino Burmese python in Latin America.
Keywords | Burmese python, Histopathology, Ehlers-Danlos syndrome, Wounds, Cutaneous asthenia
...
Ameliorative Effect of GSPE Against AFB1 Induced Immunotoxicity and Hepatotoxicity in Japanese Quail
Maha Khalil1, Gamal Shams2, Hosny Abdel Fadil2, Nagah Edrees2, Mostafa Abonorag1, Nasser El-Sabbagh3, Eman A. Ahmed4*
...lammatory cytokines, and histopathological investigations were assessed. GSPE supplementation alleviated AFB1-induced hepatotoxicity as reflected in diminishing alanine transaminase, aspartate aminotransferase, alkaline phosphatase, lipid peroxidation, and raising TNF-α and IL-6 as pro-inflammatory cytokines. Moreover, elevating the reduced levels of glutathione peroxidase, catalase, and superoxide dismutase were reported. Conclusively, the results of ou...
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
...ncreas was dissected for histopathology. Results: biochemically, there was a significant increase in hepato-renal enzymes, cholesterol, glucose, and insulin in the STZ group, while, the other treated groups showed an improvement in such enzymes. Histopathology, STZ induced necrosis, and degenerative changes with vacuolation. Treated groups displayed moderate to mild vacuolation and congestion of the blood vessels. Conclusion...
Ahmed Alazzouni1, Ashraf Al-Brakati2,*, Sherif Rabie1, Mohamed Gabry1 and Basmaa Hassan1
...ability to alleviate the histopathological alterations in the mesenteric lymph nodes (MLNs) and spleen. In this study 70 rats were divided into seven groups as follow: control, benzene (0.2 ml twice/week), Moringa oleifera (100 mg/kg), curcumin (300 mg/kg), green tea (350 mg/kg), combined green tea and curcumin, and cyclophosphamide (7.5 mg/kg) groups. All groups were treated for one month after the induction of leukemia. We found that the extracts ameliorated...
De Hu, Jia Wang, Huan Wang, Xiang-Yang Leng, Tian-Yi Zhao* and Shu-Min Wang*
...stration. To observe the histopathological changes of gastric mucosa. the activities of pepsin, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) in gastric tissue and the levels of tumor necrosis factor (TNF–α) and interleukin (IL-6) in serum were measured through ELISA, and the contents of NLRP3, ASC, caspase-1 and IL-1β in gastric tissue were detected by Western blot. The results showed that FP of C. lilacina could effect...
Ikele*, Chika Bright, Ujunwa Aghaji, Mgbenka, Benard Obialo
Tri Untari1*, Sitarina Widyarini2, Michael Haryadi Wibowo1, Marla Anggita1
...r groups (p<0.05). No histopathological change was found in the livers and kidney suggesting there was no toxic effect of red ginger administration to the chickens. Red ginger powder could provide the highest immunostimulant effect on NDV vaccinated chicken with no toxic effect to the chickens.
Keywords | Antibody response, Immunostimulant, Newcastle disease, Red ginger, Broiler
...
Emtenan M. Hanafi1*, Fouad M. Tawfeek2, Walid S. El Nattat1, Moetazza M. Alshafei3, Seham S. Kassem3, Kawkab A. Ahmed4, Enas N. Danial5, Hagar Elbakry3, Hoda S. El-Sayed2
Asmaa Khamis1, Osama Abdalla1, Mohamed Hashem2, Noha Abdelnaeim1*
... markers, cytokines, and histopathological changes. Our results revealed a significantly increased MDA, caspase-3, p53, tumor necrosis factor-α, interleukin (IL)-1β, IL-18 and, IL-10, and a significant decline in glutathione and superoxide dismutase in the CCl4 group. However, intoxicated groups treated with PN and PM showed marked improvement in the measured parameters. Therefore, PN and PM have antioxidant and anti-inflammatory effects, especially...
Noha M El-Motaily1, Ossama M Abdou1, Heba S Farag1, Kawkab A Ahmed2, Mahmoud Saber1*
...logical, biochemical and histopathological alterations. Beside detection of the antioxidant trace elements (Zn, Cu, Se) levels in dogs suffering from demodicosis. Results showed significant decrease in the value of (PCV) and (TEC). Affected dogs also showed leukocytosis associated with lymphocytosis. Hypothyroidism demonstrated by reduced levels of free T4 and significant decrease in antioxidant trace elements level (Zn, Cu, Se).
Mohamed Lebdah1, Sahar Abd El Rahman2*, Ahmed Attia3, Reham Karam2, Naglaa Fathy Saeed Awad1, Mohamed Ibrahim El Bagoury1
...tent of the gizzard. The histopathological examination of lung, brain, liver, and trachea of these diseased quails revealed non-suppurative encephalitis, perivascular cuffing, congestion of hepatic sinusoids, degenerative changes in the hepatic cells and interstitial lymphocytic aggregations in the liver and focal pneumonic areas in the lung. Pooled samples from the investigated quails were inoculated in specific pathogen free embryonated chicken eggs (SPF-ECE...
Ahmed Mohamed Elmahdy1*, Naglaa Mohammed Alkalamawy2
...ignificantly reduced the histopathological effect of ivermectin on the liver and kidney. From our findings we concluded that the O.M. aqueous extract possessed a hepato-renal protective effect against ivermectin-induced adverse effects in rabbits.
Keywords | Hepato-renal, Ivermectin, Origanum Majorana, Rabbits
...
Ida Bagus Oka Winaya1*, Anak Agung Ayu Mirah Adi1, Putu Henrywaesa Sudipa2, I Gusti Ketut Suarjana2
...dy aims to determine the histopathological changes of meningoencephalitis and arthritis in post-weaning piglets suspected of streptococcosis. The samples were 35 cadaver of post weaning piglets that showed muscle spasm and swollen joint at several villages in Badung Regency, Indonesia. Samples of the brain and synovial tissue were processed using hematoxylin-eosin dyes (HE). On histopathological examination, congestion, edem...
Samia Azad1, Iram Liaqat1*, Riffat Iqbal1 and Uzma Rafi2
...ent study documented the histopathological changes in liver, kidney and intestinal tissues of Rohu (Labeo rohita) exposed to sub lethal concentrations of heavy metal cadmium (Cd). CdCl2 was used as cadmium (heavy metal) source. Five concentrations of CdCl2 (0.2, 0.4, 0.6, 0.8 and 1.0 ppm of Cd) were tested in glass aquaria having 35 Rohu fingerlings in each. After exposure for six week, sections of intestine, kidney and liver were excised and studied histologi...
Dalia M. Aboelhassan1*, Inas S. Ghaly1, Noha E. Ibrahim2, Nermeen M. Shaffie3, Mariam G. Eshak1, Aboelfetoh M. Abdallah4, Ibrahim M. Farag1
...induced genotoxicity and histopathology in rats. In the genetic study, the assaying of expressions of IkBα and COX-1 genes in liver tissues, as well as the expressions of mdr1a and COX-1 genes in kidney tissues are evaluated. In addition, the histological architectures of these organs are examined. Bisphenol A (BPA) treatment causes over-expressions of the above mentioned genes, and induces massive damage to the histological architectures of liver and ki...
Peyman Mohammadzadeh1*, Aida Rasuli2, Bahman Noroozi Gorgani2, Sajjad Mohammadi3
...umatic axonal injury. In histopathology, activated microglia and reactive astrogliosis were seen. The cause of death was TBI followed by eye blindness caused by toxoplasmosis, during which was the formation of a hematoma larger than 60 mL, a primary Glasgow coma scale less than 8, and basal nucleus ganglia dysfunction. A 40-ml intracerebral hemorrhage occurred followed by severe blood aspiration and asphyxia.
Keywords | Choroid b...
Mohammed A. Almujtaba1, Turky Omar Asar2, Salma Naqvi3, Vikas Kumar4, Fahad A. Al-Abbasi1, Abdulbasit I. Al-Sieni1 and Firoz Anwar1*
Hakan Kececi1*, Yasin Ozturk2, M. Bahaeddin Dortbudak3, Seda Yakut4, Gurdal Dagoglu5 and Merve Ozturk1
...ffects were analyzed. No histopathological change was detected in the liver and kidney tissues of the rats in the experimental groups. Both hematological and serum biochemical values (Ca, P, TBIL, ALT, AST, ALP, Urea, and Creatinine) were within the physiological limits in all groups. Consequently, in light of the obtained data, it was observed that the rats were not exposed to any toxic effect even when they consumed a stomach full of cocklebur fruit at once....
Heba S.S. Salem1, Hend M. Megahed2, Marwa M. Sarhan2, Maha M. El Alem3, Gehan N. Alagmy3*
...ogical, biochemical, and histopathological assessments. The obtained results revealed that S.aureus infection caused marked alterations in hematological and biochemical parameters compared to the negative control, while treatment with BV alone or combined with gentamicin revealed a significant improvement of these parameters. Likely, treatment with BV caused an improvement in the histopathology compared with the untreated gr...
Al-Hassan M. Mostafa1*, Gehan Mohammed Sayed2
...f abomasal specimens for histopathological examination and tissue estimation of Total peroxide, malondialdehyde (MDA), protein carbonyl (PC), Catalase, reduced glutathione (GSH) and superoxide dismutase (SOD). Garlic and coriander treated goats showed significant reduction of FEC as compared with control positive ones. Treated goats exhibit no changes in total peroxides while there were non significant changes of PC, MDA, Catalase and SOD, in contrast there wa...
Ahmed H. Massoud1, Mohamed S. Ahmed2, Moustafa Saad-Allah1, Aly S. Derbalah1, Ashraf Albrakati3* and Ehab Kotb Elmahallawy4*
...tly showed insignificant histopathological changes in treated rats. The observed values of biochemical enzymes with these low-doses were near to the control ones, whereas medium and high doses treated rats exhibited adverse signs and symptoms of toxicity. The results also depicted that cymoxanil was the most toxic of the tested pesticides, followed by Malathion and metalaxyl. The obtained histological lesions were correlated with the increased level of biochem...
Sajida Batool*, Sitara Shameem, Kainat Malik and Aneela Iram
Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5
Bnar Shahab Hamad1, Bushra Hussain Shnawa1*, Rafal Abdulrazaq Alrawi2
... apoptosis were detected histopathologically and by immunohistochemical markers staining. The infected livers with hydatid cysts from the mice were processed for routine paraffin block technique. The sections of infected livers that were embedded in paraffin underwent immunohistochemistry. Several immunolabeled liver sections with anti-CD3, CD4, CD8, CD20, CD68, and caspase-3 were examined under a light microscope. The histological alterations caused by the hy...
Muhammad Izhar ul Haque1, Farhan Anwar Khan1*, Umar Sadique1, Hamayun Khan1, Zia ur Rehman1, Salman Khan1, Hayatullah Khan1,2, Faisal Ahmad1,3, Mumtazur Rahman1, Faiz Ur Rehman1, Muhammad Saeed1, Mehboob Ali1 and Saqib Nawaz1
...ISA (iELISA), associated histopathological lesions and PCR in sheep (Ovis aries) and goats (Capra aegagru hircus) in district Peshawar. Serum and fecal samples were collected at random both from commercial farms and abattoirs. Additionally, tissue samples (intestine and mesenteric lymph node (MLN)) were collected at random from sheep and goats at abattoirs of district Peshawar. Analyses of serum samples by iELISA revealed the presence of antibodies against MAP...
Qingyue Han1, Ying Li1, Jichang Deng1, Kunxuan Huang1, Yanyang Yang1, Quanwei Li1, Zhuowei Zhang1, Na Qiao1, Yanju Ji2, Khalid Mehmood3, Sarfaraz Ali Fazlani4, Hui Zhang1 and Zhaoxin Tang1*
... heart was collected for histopathological examination and IGF, IGF1, IGF2, IGFBP3, PCNA and ki67 expression were analyzed. The results showed that low calcium supplementation decreased the cardiac index and development of myocardial muscle fiber, while vitamins D3 can improve the decrease of cardiac index and development of myocardial fiber due to low calcium supplementation. The expression profile of IGF1, IGF2, IGFBP3, PCNA and ki67 genes were down regulate...
Sara Magdy Hashim1, Elshaimaa Ismael2, Mohamed Tarek3, Faten Fathy Mohammed1*, Fatma Amer Abdel Reheem3, Rawhia Esawy Doghaim1
...g in clade 2.3.4.4b. The histopathological hallmarks, in H5N8 naturally infected ducks, included acute inflammatory, necrotic and vascular reactions that involve different tissues. The immunohistochemical characterization of viral antigen revealed direct relation between viral residence in tissue and developed pathology. The present study confirmed that H5N8 HPAI clade 2.3.4.4b, became a predominant strain during the period 2018-2020, causing severe outbreaks ...
Marwa S. Khattab1*, Ahmed H. Osman1, Huda O. AbuBakr2, Rehab A. Azouz3, Asmaa A. Azouz4, Heba S. Farag5
...y (HPLC) technique. Skin histopathology and immunohistochemistry of collagen were performed. Results: Ivermectin was detected in 36 samples, out of them 15 contained high ivermectin levels (100 ppb). Chlorpyrifos, piperonyl butoxide, and acetamiprid were below the limit of quantification in 3 samples only. Histopathology of tick-infested skin revealed severe multifocal eosinophilic dermatitis and inflammation of subcutaneous...
Farah Abid1,2, Mohammad Saleem1,3*, Tahir Maqbool4, Tania Ahmed Shakoori5, Faheem Hadi4, Tahir Muhammad4, Saira Aftab4, Yasir Hassan7 and Shabana Akhtar4,6*
...mutase and catalase) and histopathological examination were performed to determine the values of various parameters of inflammation and arthritis. Real-Time PCR technique was applied to analyze the expression levels of different cytokines and interleukins involved in inflammation. Real-Time PCR results showed a down-regulation of TNF-α, COX-2, IL-6, IL-1β, NF-κβ1and up-regulation of IL-4, IL-10 and I-κB genes. Levels of antioxidants...
Chunlan Shan1, Chaoying Liu1, Qin Lu1, Guowen Fu2, Syed Aftab Hussain Shah3, Rana Waseem Akhtar4, Ru Zhao2, Libo Gao2, Chang Liu2, Shushu Miao2, Hongdan Wang2 and Hong Gao2*
...ns, respectively for the histopathology examination. The higher organ damage was observed by E. coli HPI+ than HPI- strain in mice. This study postulates the predicted protein structures of major genes, and validates the HMWP expression under iron starvation and provides a theoretical basis for prevention and treatment of E. coli related diseases....
Mohamed M. Bahr1, Mohamed S. Amer1*, Khaled Abo-EL-Sooud2, Shaimaa M. Kamel3, Marwa A. Fouly4, Ahmed N. Abdallah5, Ashraf A. Shamaa1, Omar S. El-Tookhy1
...Exosomes, corneal-ulcer, histopathology, corneal-transplantation, AS-OCT, New-Zealand-rabbits, paracrine-signaling. ...
Rubab Malik, Nasira Khatoon* and Samina Waheed
...abad and to find out the histopathological changes caused by Heterakis gallinarum in the intestine of common quail. The overall prevalence of nematodes parasitic infection was 7.48% while the overall intensity was 9.62. The histopathological study revealed complete destruction of villi and crypt glands. The intestine showed heavy infiltration of inflammatory cells. Increase in apparent size of villi with blunt and pointed en...
Öznur Özil*, Öznur Diler, Mevlüt Nazıroğlu, Aşkın Atabay
...cribes the intensity and histopathology of the Clinostomum complanatum infection in Garra rufa used in the health and beauty industries in foot spas for ichthyotherapy. In total of 25 examined fish specimens 56% were infected with the metacercariae of C. complanatum. The mean intensity of the infection was 27.14 cysts per host, varying between 1-75 cysts. The parasites were determined encysted in the base of the fins, muscle, inner wall of the operculum, gill...
O.S. Osunlola† and B. Fawole1
... Lam.) were observed for histopathology
changes included cellular disorganization in the root cortex, endodermis and vascular cells. Female nematode
displaced root cells and occupied large cavities and the surrounding cells were compressed. The nematode induced
formation of an average of four giant cells each with 7 ± 0.5 nuclei around the head of nematode close to vascular
cel...
Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Mengli Jiang and Jicang Wang*
Hagar Magdy Ahmed1, Mohamed Mahrous Amer2*, Khaled Mohamed El-Bayoumi1, Ahmed Ali El-Shemy3, Mohamed Abd El-Rahman Bosila1, Gomaa Abd El-Rhim Abdel Alim2
...ith Lector showed milder histopathological changes than Orego solution and non-treated groups showed the most sever lesions. Chicken groups challenged with both virulent IBDV and NDV either treatment with Lector® or Orego® solution or non-treated showed no marked difference in histopathological lesions. The results of total and differential leucocytes indicated that lector had a great high effect in WBCs levels speci...
Hussein Jabar Jasim1*, Amer Murhum Al-Amery2
...recognized the gross and histopathological changes resulting from the invasive Fasciola spp. in the liver and gallbladder. The biochemical results showed statistically significant increases in the serum total bilirubin, creatinine, and active serum enzymes ALT, AST, ALP, and GGT. In contrast, the serum total albumin showed a significant decrease in infected buffaloes. Moreover, the results of the gross pathological examination revealed that cirrhosis and palen...
Esam A Razin1, Hassan Sobhy2, Tarek R. AboElnaga1, Asmaa A. Darwish1*, Rasha S. Mohammed1
...e 49th day, stained, and histopathologically examined. Although, both treatments presented a significant improvement (P<0.05) in their parasitological and clinicopathological results, DAG suffered from lower levels of GR than BG, and its organs microscopical examination clarified severe lesions similar to TG. While, BG clinicopathological parameters and histopathological results were so close to CG. CK, CK-MB, LDH, and GR...
Dalia Zaafar1*, Heba M.A Khalil2, Soha Hassanin3, Mohamed R. Mousa4, Mona G. Khalil1
...mma;, which improved the histopathological changes. Conclusion: Pio possesses ESC-specific anticancer abilities. However, more research is needed before it can be used as an adjuvant agent to boost the therapeutic efficacy of chemotherapy in the treatment of many types of cancer.
Keywords | Pioglitazone; Cisplatin; Ehrlich solid carcinoma; Oxidative stress; VEGF; PPARγ; anticancer agents; tumorigenesis; biochemical indices
...
Ghulam Jelani1, Muhammad Haris Raza Farhan2, Rida Asrar3, Muhammad Ahmad1,4*, Chanda Naseem5, Zafar Ali Khoso6, Majid Hussain Soomro7*
...overy of clinical signs, histopathological changes, mortality, and morbidity percentage. In this study, we represent a review with a descriptive analysis to identify the chronic respiratory poultry disease, method of prevention, their seasonal incidences, and the treatment by the use of good antibiotics and supportive therapy.
...
...
Abdirahman Barre*, Karanja D Njuguna, Bebora Lilly Caroline and George Chege Gitao
Khitam J. Yahya*, Mohammed T. S. Al-Zubaidi
...before and processed for histopathological evaluation. Improvement of tissue and the number of oocysts on the villi decreased after treatment. In comparison with G2, oocyst shedding was stopped at the end of the treatment period in both G3 and G4 without recurrence 10 days after drug withdrawal. The pre-patient periods (p.p) was 8-9 DPI. The maximum intensity was 11,000 oocysts per gram of feces. The first clinical sign was detected on 8 th DPI. Top of sheddin...
Oussama Zghari*, Mouloud Lamtai, Sofia Azirar, Mohamed Yassine El-Brouzi, Hajar Benmhammed, Aboubaker El-Hessni, Ali Ouichou, Abdelhalem Mesfioui
...ainst the behavioral and histopathological alterations induced by Al.
Keywords | Aluminum, Melatonin, Neurobehavioral alterations, Oxidative stress, Biochemical indices, Histopathology
...
Soedarmanto Indarjulianto1*, Alfarisa Nururrozi1, Yanuartono1, Sitarina Widyarini2, Dhasia Ramandani3
...bserves the clinical and histopathological features of cryptococcosis in a cat exhibiting chronic submandibular lymphadenopathy. A five-year-old female cat showed lethargy, partial anorexia, weight loss, and intermittent sneezing for several months before being examined. Clinical examination demonstrated mucopurulent discharge from both nostrils, swollen on the nasal bridge and maxillary sinus. Subsequently, the cat was diagnosed infected by cryptococcosis bas...
Shaimaa A.Tawfik2,3, EL S.T. Awad1*, Hoda O.Abu Bakr1, Amira M.Gamal-Eldeen4, Esmat Ashour2, Ismail M.Ahmed1
...X. Antioxidant activity, histopathological examination, immunohistochemical analysis of CYP3A4, MRP-1, and c-MYC proteins and expression of miRNAs were assayed. Results: Findings indicated that CSO treatment led to a suppression in hepatotoxicity, nephrotoxicity and cardiotoxicity induced by DOX in male albino rats evidenced by a significant enhancement in the activity of ALT, GGT, LDH, AST, also creatinine and uric acid. CSO induced antioxidant activity ...
Nawfal Hammadi Jasim1, Yasmeen Jassim Mohammed2 , Jala Amir Salman Alahmed1, Majdy Faisal Majeed3*
Zahra Abdulameer Al-Zayadi1, Hana Kadum Shanan1, Al Salihi Karima Akool2*
... groups revealed diverse histopathological changes compared to the control groups. Various histological features were also seen in low, moderate, and high-dose Sc-RE treatment groups, accompanied by regeneration related to the treatment dose. Severe damage comprising necrosis of the hepatic cells, renal tubules, congestion, and infiltration of inflammatory cells was seen in the chemotherapy-treated group and mice suffering from cancer without treatment. This s...
Munir Ahmad1, Abdul Ghaffar1, Riaz Hussain2* and Rifat Ullah Khan3*
...µg/L in water. For histopathological and hematological examinations, blood and other visceral tissues were obtained on days 10, 20, and 30 of treatments. Different physical and behavioral disorders were noted in terms of time and concentration manners. In comparison to control fish, the hematological profile including lymphocyte, hemoglobin erythrocyte and monocyte counts, was considerably (p < 0.05) lower. The final results on the serum biochemical p...
Falah Mahmood Hameed1*, Asaad Khalaf Talal AL-Shuwaili2, Eman Jawad Jabber3, Mayada Sahib Hassan1
Ibrahim Elmaghraby*, Abdel-Baset I. El-Mashad, Shawky A. Moustafa, Aziza A. Amin
...ristics of the different histopathologic pattern where, in the current study, the granulosa-theca cell tumor was the most frequently diagnosed tumor. Additionally, the use of vimentin and melan A are reliable markers in the differential diagnosis of sex cord-stromal tumors in the ovary of dromedary camels. ...
You-Ming Teng, Wen-Zhou Liu and Li Yang*
... staining were estimated histopathological changes. The protein and mRNA expression of PPAR-α, CPT-1 as well as PDK-4 were measured by western blot and qRT-PCR. The results showed that pioglitazone could reduced SBP, DBP, MCD, SA, HMI, LVMI as well as myocardial fibrosis and FFA and Ang II levels in serum. Moreover, pioglitazone inhibited the expression of HIF-1α protein and simultaneously enhanced the expressions of PPAR-α, CPT-1 as well as ...
Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1
Zaki Al-Hasawi1* and Reda Hassanine2
...ed abnormal due to sever histopathological alterations....
Zaki Al-Hasawi1* and Reda Hassanine2
...ed abnormal due to sever histopathological alterations....
Atef M. El-Sagheer1*, Aline F. Barros2, El-Sayed M. Abd El-Aal3, Mohamed M. Gad4, Doaa S. Mahmoud4 and Amr M. El-Marzoky3
Kazi Afsana Homayra Orchy1, Mst. Antora Akter1, Nelema Yesmin1, Md. Moshiur Rahman Khan1, Marzia Rahman2, Md. Mahmudul Alam1*
... biopsies were taken for histopathological assessment. In this study, the morphological and morphometric data revealed that in the animals of group A, wounds were healed up with improved morphological features significantly earlier than those of group B which was confirmed in the histological analysis of biopsy sample. Regarding the liver and kidney functions, the serum levels of liver enzymes (ALT, AST and ALP) and kidney function biomarkers (creatinine, BUN...
Mohamed Mahrous Amer1*, Hanaa Sayed Fedawy2, Hoda Mohamed Mekky2, Khaled Mohamed Elbayoumi2, Ahmed Ali El-Shemy3, Mohamed Abd El-Rahman Bosila2
Khalid M. Al-Syaad1,2
..., as well as significant histopathological abnormalities. Therefore, the present study investigated the toxic effect of CC and the protective effect of Propolis aqueous extract on CC-induced toxicity in male rats. A total of 24 Wistar albino rats were included in this study, divided into four groups; each group containing 6 rats and administered the treatment doses orally by gavage for 28 days. Control, treated with a physiological solution (5.0 ml/rat). CC-tr...
Muhammad Nasir Bhaya1,2* and Hikmet Keles2
... as compared to CP. Both histopathological and immunohistochemical findings revealed that EA has a protective effect against CP-induced renal damage in rats....
Chen Zhao, Lulu Ding, Ying Ye, Congying Kou, Haoran Xiao, Jing Zhu and Jicang Wang*
...treated for 4 weeks. The histopathological observation, oxidative stress index and autophagy-related gene expression level were detected of rat kidneys. The results showed that Cd caused the pathological changes of kidneys. And Cd also increased the content of glutathione and malondialdehyde and decreased the content of catalase and total superoxide dismutase. Instead, Nar significantly attenuated these Cd-induced toxic activities. Furthermore, the protein exp...
Nida Sadaqat1, Sheheyar Ahmed Khan1, Amna Bibi1, Sadaf Zahra1, Muhammad faisal Salamt1, Noreen Latief2 and Fatima Ali1*
...AC group. Wound size and histopathological changes of epidermis were evaluated for the various groups. Hydroxyproline was estimated in wound tissue. Wounded skin tissues were cut off and stored at − 20°C for PCR and ELISA analysis. The therapeutic effects of a NAC supplementation for a short period of time on rat skin wound healing were investigated. The NAC treatment promoted an improvement of wound healing by reducing the oxidative stress, i...
Frah Razzaq Kbyeh1, Ahmed N. Abedsalih2*
... eradicate infection. In histopathological examination clear damage in kidney tissue specimens from positive group control (PC,DC) observed, with hyperplasia endothelial cell swelling, ulcer in the lining membrane, compared with(CIP,COM1and COM2). Altogether, we can conclude that the diclofenac has the required anti-boiflim effects to support ciprofloxacin effect and the body responses against urinary tract infection consequences of E coli o157 :H7
...
...
Omar Berkani1*, Souheila Slimani2, Nora Sakhraoui3 and Cherif Abdennour1
...lformed or dead. Various histopathological alterations including a decrease in interstitial space, an enlarged lumen, a remarkable atrophy of Leydig cells and malformed spermatozoa were observed in the gonads of birds exposed to CYP. The FT4 concentration decreased significantly and none of the CYP groups was molting. Treatment with PO aqueous extract seems counteracted the toxic effects of CYP, which was confirmed histopatholog...
Ihab G. AL-Shemmari1*, Ali Hussein Fadhil1, Mohammed Assad S. Alkabi1, Eman Jawad Jabber2
... ewes and to examine the histopathological changes in the uterine tissue of ewes infected with Brucella melitensis. Methods. The study were conducted in Kerbala and Babylon provinces from November 2020 to July 2021, using Rose Bengal test (RBT), culture, and polymerase chain reaction (PCR) on blood and uterine tissue samples collected from 139 brucellosis-infected ewes. Results. The PCR identified 37 (26.61%) positive cases of brucellosis, which was less than ...
Zainab Sattar Ali* , Safa Azhar Razzaq , Layla Hammody Hashem
...ms DNA and alteration of histopathological section. In addition reduction the levels of testosterone, inhibin b, FSH and LH hormones in group that ingestion BTSeNPs comparing the remnant groups, also been noted this reduction in above hormones getting worse with time progresses of experimental. In group4 show the propolis was enhancer factor for adverse effect of BTSe where FSH, LH, testosterone and inhibin b hormones values are elevated than remnant groups, a...
Nusrat Habiullah1*, Shah Nawaz Kumbar1, Fahmida Parveen Samo1, Shamusuddin Bughio2, Asghar Ali Kamboh3, Burirah Rehman Talpur1
... collected for gross and histopathological examination. The mild clinical signs like reduced feed and water intake, and weight loss in group C, D, E and F was noted; whereas diarrhea, muscular tremors, and lethargy were observed in group C and D. Significantly increased (p <0.05) GGT, bilirubin, creatinine and uric acid levels were recorded in C and D (lead toxicity groups), as compared to control group; whereas group E and F (treated with selenium) showed...
Shafi Muhammad1, Bibi Nazia Murtaza2, Aftab Ahmad1, Muhammad Shafiq3, Nurul Kabir4 and Hamid Ali1*
...owards HCC by performing histopathology and immunohistochemistry (IHC) techniques in liver tissues in HCV patients from the southern districts of Khyber Pakhtunkhwa, Pakistan. In addition, the network of IL-17A and its KEGG pathway related gene IDs were constructed using GeneMANIA and STRING online web tools. IL-17A serum levels were significantly higher in fibrotic patients compared to chronic HCV patients and showed a positive correlation with age. The const...
Mohammed M. Jassim, Mohammed R. Abduljaleel*, Zainab B. Abdulkareem, Noor H. Sanad, Ibrahim M.H. Alrashid
...ach couple of weeks. The histopathological study has been carried out as well on the osteotomized femor upon the completion of experimental time. The radiographic recovery of the osteotomy sites was significantly improved in the rabbits that had been subjected to the SMF. When comparing to the controls, the SMF group’s cellular morphology ratings were significantly higher (P 0.050). These findings showed that using the osteotomy gap model with SMF enhanc...
Ahmed Al-Hasnawi*, Wafaa Kadhim Jasim
...st the hematological and histopathological alterations brought on by azathioprine. animals are evenly divided into four categories: (G1) group: were received distilled water. (G2) group: were administrating azathioprine (50mg/kg. b. w). (G3) group: were administrating Aloevera gel extract (500mg/kg b.w). (G4) group: were administrating azathioprine (50mg/kg. b. w) and aloe vera gel extract (500mg/kg b.w). after four weeks, blood samples from the rats were take...
Raed Hussein Salih Rabee1, Yahya Sabah Abdulameer1, Walla Farhan Obed1, Noor R Abady1, Adnan Mansour Jasim1*, Firas Hussein Albawi1, Mohammed Jasim Jawad2, Ahmed Samir Abukhomra3
...properties. Furthermore, histopathological examination of the intestinal broiler received BBR showed improvements and restore tissue near to normal.
Keywords | Enerofloxacin, Berberine, E. coli, Antibiotic residues, CYP450, Antioxidant, Drug docking
...
Haneen Imad Al-Sultani1*, Ahmed Obaid Hussain1, Hazar Shakir Saleh2
...te the physiological and histopathological effects of rosuvastatin in male albino rats. Thirty-two adult albino rats were used in the study. After acclimatization, the rats were randomly divided into four groups (8 rats in each group) as follows: The first control group was given normal saline solution, the second group 10 mg/kg rosuvastatin, the third group was given 20 mg/kg rosuvastatin, while the fourth group was given 40 mg/kg rosuvastatin. The dose ...
Md. Ariful Alam1, Mst. Misrat Masuma Parvez1, Md. Salauddin2*, Rakibul Islam1 and Md. Bazlar Rashid1
...tological parameters and histopathological changes. Sixty (60) sonali chickens of twenty-three days old were randomly divided into five groups and each group contained 12 chickens. All groups were supplied E. tenella orally except the T0 group and after 3 days T2 and T3 group was treated with yeast 1g/kg and 1.5g/kg feed for 14 days and T4 groups were treated with amprium-vet Powder (amprolium hydrochloride 20%) at a dose rate of 1g per 3 liters of drinking wa...
Md. Ariful Alam1, Mst. Misrat Masuma Parvez1, Md. Salauddin2*, Rakibul Islam1 and Md. Bazlar Rashid1
...tological parameters and histopathological changes. Sixty (60) sonali chickens of twenty-three days old were randomly divided into five groups and each group contained 12 chickens. All groups were supplied E. tenella orally except the T0 group and after 3 days T2 and T3 group was treated with yeast 1g/kg and 1.5g/kg feed for 14 days and T4 groups were treated with amprium-vet Powder (amprolium hydrochloride 20%) at a dose rate of 1g per 3 liters of drinking wa...
Jasir Hakim Hidayah1,2, Yos Adi Prakoso2, Sitarina Widyarini3*
...f calabash fruit against histopathology of the brain in a mouse model with artificially induced ischemic stroke. As many as fifty – rat models were used in this study. The rats were separated into P1 (sham-operated), P2 (ischemic stroke model (IS)), P3 (IS + 0.74 mg/kg BW of calabash), P4 (IS + 1.48 mg/kg BW of calabash), P5 (IS + 2.96 mg/kg BW of calabash). The P2 – P4 groups were artificially induced ischemic stroke using common carotid artery li...
Sara H. Zughayyar*, Amer H. Gyad
Rana Mahmood Ahmad*, Orooba M.S. Ibrahim
...the healing process. The histopathological observation showed that a section of a joint in groups treated with SaZnONPs had a normal joint cavity with normal articular cartilage compared with other treated groups. Accordingly, the findings of the present study suggested that ZnONPs reinforced with clove can be anti-arthritis treatments and may be utilized as a substitute for medicines currently on the market. ...
Oghenebrorhie M. Oghenochuko1,4*, Olubukola T. Adenubi3, Olusola L. Ajayi3, Fakilahyel M. Mshelbwala3, Johnny O. Olukunle3, Samson A. Rahman3 and Godfrey N.O. Ezeri2
... and kidney function and histopathology of some visceral organs were examined. Proximate composition of the bulb was determined. Onion bulb revealed presence of carbohydrate (7.82%), protein (4.48%), crude fiber (1.68%), iron (0.5mg/l), magnesium (210mg/l), flavonoids (0.46%), saponins (0.28%), tannins (0.95%). PCV, Hb, RBC and WBC were increased in all treatments but values were higher in bath treatment for RBC (3.0×1012/L), PCV (32.7%), Hb (10.7%). MCV...
Abd El-Razakl, A.G. and AboElkhair2, M.
...gainst bursal atrophy or histopathological changes after challenge. As well as RT-PCR-based viral IBD detection in bursa of Fabricius at day post challenge....
Eman, M. Abd El-Mottaleb.*; Ahmed, S.A."; Maysa, H.M.*; Salem, S.A.* and M. M. El-Shenawy
Abou zead, A.A., Ali, A.A.H.*and Abd El Hkeem M.M.
... post mortem lesions and histopathological changes were recorded. Serosurvey of 80 serum samples revealed 5 (6.25%) positive for the presence of IBDV precipitating antibodies. 3 out 12 pooled bursae (25%) were positive to the presence of IBDV precipitinogen. Trials for virus isolation on the CAM of chicken embryos revealed the isolation of 3 IBD viruses from diseased quails. Isolated IBDV viruses '.vere examined by electron microscopy. The disease was rep...
M. Osman1, Kh. El-Dougdoug2, E. T. Abd El-Salam3, R.M. Taha4 and R.M. El-Hamidl
Hanaa H.A.Gomaa1, A. F. Moustafal, Kh.A.El-Dougdoug2, A.A. Abou-Zeid3 and S. Y.M. Mahmoud4
M.R. Abd-El Wahab l, H.A. Hussein2, T.M. Asfourl and M.A. Shalaby2
Ahmed Kadhim Munahi1* , Hameed A. Al-Timmemi2
...osan nanoparticles group histopathological examinations revealed reduced cavitation, orientation of regenerative nerve fibers in white matter, increased number of regenerative neuron cells in grey matter, increased angiogenesis, and minimal scar tissue formation at the injured spinal cord site. In conclusion and based on clinical and histological data, chitosan nanoparticles could accelerate and promote regeneration of the injured spinal cord. ...
Rehan Ahmed Siddiqui1,2*, Shabana Usman Simjee2,3, Nurul Kabir4, Muhammad Ateeq3,5, Kevin Joseph Jerome Borges6, Muhammad Raza Shah3 and Rahman M. Hafizur2
...nine were tested. Kidney histopathology was done and damaged kidney areas were measured. Immunohistochemistry for actin and cyclooxygenase-2 (COX-2) were also carried out. Real time RT-PCR studies were performed to check mRNA expressions of nuclear factor-κB (NFκB) p50, inducible nitric oxide synthase (iNOS), kidney injury molecule-1 (Kim-1) and hemeoxygenase-1 (HO-1). CA and CA-AuNPs improved blood urea and creatinine levels when compared with the...
Salema Lafta Hassan1*, Taghred Jabbar Humadai1, Sabrin Ibraheem Mohsin2
Suhad Mohmmed Alrobyrai1 , Falah Muosa Al-Rekabi2*
...GGT, PT, INR), and liver histopathology. After 30 days, G5 showed a significant (P ≤ 0.05) increase in body weight (29.2±1.32) compared to the positive control (20.8±1.2). After withdrawal, G5 displayed a significant (P ≤ 0.05) increase in body weight(31.4±1.17) compared to all other experimental groups G1(29.2±0.37),G2(25.8±2.4), G3(25.0±1.38) and G4(27.2±1.02). Positive control (117 ± 42.9) had si...
Qamer J. Jadoaa, Raffal A. Omar*
... 3.75% of 20mg/Kg. B. W. histopathological specimens were taken at the end of the 7th,14th, and 21th day p.o. The results revealed rapid bone regeneration improvement and development in group I compared to group II and control group. In conclusion, intra-osseous injection of 2% Lidocaine Hcl 2mg/kg BW (body weight) has a stimulatory effect on bone healing in which osteogenic tissue and trabecular bone were noticed clearly at the end of 1st week, which achieves...
Wahid Hussein El-Dabae*, Eman Shafeek Ibrahim, Eslam Gaber Sadek, Mai Mohamed Kandil
Yaseen1, Asad Ullah2*, Imad Khan2, Maryam Begum3, Sumbal Bibi3, Umber3, Namra3, Abbas Khan4, Shumaila Gul5 and Raheela Taj6
...bodies and cause various histopathological, hematological, bio-chemical and enzymatic alterations in the bodies of aquatic organisms, especially fish, leading to huge economic loss. Consumption of the affected fishes also poses a serious health threat to humans. Pakistan being an agricultural country uses a variety of pesticides to protect its crops. The use of pesticides has substantially increased in Pakistan over the last decades, which when reach the water...
Tayfun Karatas1*, Betul Apaydın Yıldırım2 and Serkan Yıldırım3
...ss, immunity, apoptosis, histopathology and DNA damage caused by CMN....
Hongsen Xu*, Xiaoni Wang, Tie Tian, Changyu Zhao, Denghang Yu and Jun Liu
... CFU/g crayfish. Serious histopathological changes, such as cell degeneration and necrosis, hemorrhage and inflammatory cell infiltration, were found in diseased crayfish. In conclusion, this study confirmed the pathogen of whitish muscle disease in farmed P. clarkii, and preliminarily investigated the biological characteristic, pathogenicity and drug sensitivity of this bacterium. The results of this study will provide scientific guidance for the effective pr...
Ghaith Z. Hasan Al-Askari *, Eman H. Yousif Al-Taee
...c effects in addition to histopathological changes in the tissues of female rats. The methods included in the first experiment, the female rats were orally administered the following lethal doses: 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16 mg/kg b.w. of vitamin D. Survival and mortality numbers were observed following 24 hours of intoxication. In the second experiment, the selected groups were divided according to the doses they r...
Taghreed Jabbar Humadai*, Bushra Ibrahim AL-Kaisei
...r study the biochemical, histopathological investigations and Immunohistochemistry study. The results of this study showed oxidative stress elevation in Malon Di-Aldehyde concentration in testes, epididymis tissue treated with tetrodotoxin. The pathological lesion in testes of animals exposed to toxic dose of tetrodotoxin was characterized by obvious disruption of seminiferous tubules with absence of leydig cells and congestion, in epididymis tissue the ...
SYEDA NADIA AHMAD1, MEHWISH NASIR1, AQSA NAUREEN1, SHAGUFTA ANDLEEB4, KAUSAR RAEES3, TAHIR ABBAS2, ASMA YOUNIS1 & KHAWAJA RAEES AHMAD*1
... thyroid and parathyroid histopathology. Tissues were recovered following 48 h of DZ treatment. Micrometric data in terms of follicular size of thyroid, cellular, nuclear sizes of the follicular and chief cells were obtained from the histological sections. Statistical analysis has shown significant (p<0.001) variations in mean follicular size of thyroid indicating dose dependent depletion of colloid (thyroglobulin). Mean Cross-Sectional Area (MCSA) of folli...
NOREEN RAZA1*, TASNEEM A. SAQIB2, SYED NAEEMUL HASSAN NAQVI3, MUHAMMAD ZAHEER
KHAN2 & MAZHAR HIJAZI3
Youfang Li1, Xu Li2, Shaik Althaf Hussain3, Jayasimha Rayalu Daddam4 and Zhigang Chen5*
...d drug, Allopurinol. The histopathological analysis also confirmed the same. Although, EGCG has a potent inhibitory effect on urinary stone formation, and the antioxidative action of EGCG is considered to be involved. The combinational activity was enhanced along with quercetin....
Wasan Ali Hasan1*, Manal Abdulkhaliq Ibrahim2
...count. Additionally, the histopathological examination revealed that both of these groups showed reduced accumulation of inflammatory cells within the lungs and dilation of the bronchiolar wall across the lung tissue. In conclusion, famotidine has a protective effect against airway inflammation by the reduction of inflammatory cells and improvement in the histopathological picture. ...
Taghreed Jabbar Humadai*, Bushra Ibrahim Al-Kaisei
...ne the immunological and histopathological effects after intraperitoneal injection of tetrodotoxin (TTX) on liver of male albino rats. At the age of 8–9 weeks and weighing 190–200 gm, 60 male albino rats were separated into 3 groups: First group of 20 rats received distilled water and regular pellets. Second group of 20 rats received weekly injections of 0.5 µg/kg b.w. by I/P route, which was equivalent to 1/20 LD50 of tetrodotoxin. Third gro...
Samia S. Alkhalil1, Faisal Al-Sarraj2, Abeer S. Aloufi3, Zuhair M. Mohammedsaleh4, Mamdoh S. Moawadh4, Fayez M. Saleh5, Majid Al-Zahrani6, Waheeb Aggad7, Youssef S. Alghamdi8, Mutaib M. Mashraqi9, Saleh Alshamrani9 and
Mona H. Soliman10,11*
...ncentrations, along with histopathology of organs. Results of this study confirmed the immunomodulation and antioxidant capacity of Bacillus licheniformis against 28 µg/kg BW of aflatoxins. ...
Muhammad Wasif Gulzar*, Riffat Maqsood, Muhammad Zain, Muhammad Suleman, Tayyab Ur Rehman, Sana Asif, Abdul Wadood and Jawad Hussain
...Antibody Test (dFAT) and histopathology are still employed. The OIE and WHO both frequently propose the gold standard test, the Direct Fluorescent Antibody Test (dFAT), for the diagnosis of Rabies in fresh canine brain tissues. The preferred methods for routine diagnosis include PCR (Polymerase Chain Reaction), and Mouse Inoculation Test (MIT). In endemic locations, vaccinations with DNA, recombinant vaccines, and live, attenuated, or inactivated viruses can b...
Abeer Alahmari1,2*
... antioxidant status, and histopathology alterations in renal tissue were measured. Animals that received ethanol displayed nephrotoxicity, as confirmed by markedly increased serum creatinine, urea, and uric acid levels along with histological changes, including shrunken glomeruli, necrosis, inflammatory cell infiltration, congestion, and edema. They also exhibited significantly elevated lipid peroxidation and oxidant radicals with decreased antioxidant paramet...
Marah Salim Hameed1, Ali Ibrahim Ali Al-Ezzy2*
...ant that ameliorates the histopathological effects of sodium nitrate on renal tissue. Concentrations of blood urea and creatinine have no effect on potent scavenging activity of monocytes and macrophages.
Keywords | Vitamin E, Vitamin C, Sodium nitrate, Antioxidant, Nephroprotective, Immunomodulatory, Histopathology, Kidney, Mice, Biochemical indices
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