Effect of Low Level Laser Therapy on Diabetic Experimental Animals
Effect of Low Level Laser Therapy on Diabetic Experimental Animals
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
ABSTRACT
Introduction: Diabetes mellitus is a metabolic disorder affecting the B-cells of the pancreas, that results in hyperglycemia. Streptozotocin (STZ) is a medical agent that could be used in experimental animals to induce diabetes. Nowadays, efforts have been directed and focused on complementary medicine. Aim: Our study was designed to assess the hypoglycemic activity of the laser on diabetic experimental animals. Methods: The present work was carried out on 40 albino rats, and equally divided into 4 groups, (10 rats/group) as following: Group 1, animals served as control. Group 2, animals received STZ. Group3, animals received laser. Group 4, animals received STZ+ laser. After the experiment, blood samples were collected for biochemical analysis. Also, the pancreas was dissected for histopathology. Results: biochemically, there was a significant increase in hepato-renal enzymes, cholesterol, glucose, and insulin in the STZ group, while, the other treated groups showed an improvement in such enzymes. Histopathology, STZ induced necrosis, and degenerative changes with vacuolation. Treated groups displayed moderate to mild vacuolation and congestion of the blood vessels. Conclusion: The experience showed the effectiveness of the laser and its few side effects in treating diabetic rats.
Keywords | Diabetes mellitus, Laser, Biochemical parameters, Histopathology.
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