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Biochemical Effect of Water Based Infusion of Withania somnifera in Broiler Production

Muhammad Mushtaq, Umer Sadique, Naila Chand, Iftikhar Ahmed, Said Sajjad Ali Shah, Ijaz Ahmad, Imran Ullah and Muqadar Shah

... high blood pressure and kidney failure. Hypercholesterolemia is mainly caused by high fat diet, obesity and diabetes.Hypolipidemic and hypoglycemic effect of water based infusion of Withania somnifera was investigated in broiler chicks. One hundred and twenty (120) day-old broiler’s chicks were alienated into four treatment groups namely WST-0, WST-I, WST-II and WST-III with three replication. Group WST-0 was kept as a control, while WST-I, WST-II and W...
Evidence of Clinicopathological Changes during Equine Leptospirosis
Muhammad Luqman Sohail1,*, Muhammad Sarwar Khan1, Muhammad Ijaz1, Muhammad Avais1, Muhammad Yasir Zahoor2, Omer Naseer1 and Muhammad Usman Saleem3
...cating tubular damage in kidneys. 
...
Molecular Cloning, Characterization and Expression Analysis of Wap65 Gene from the Crucian Carp
Jun Cui, Xiaoxu Zhou, Zhicheng Wang, Derong Kong, Xuemei Qiu, Hongdi Wang and Xiuli Wang*
...ine, skeletal muscle and kidney. CcWap65 was significantly up-regulated in the liver of crucian carp after heat stress, suggesting that increase in Wap65 gene may be related to high water temperature stress and play important roles in high water temperature environment of crucian carp.
...
Biochemical and Histopathological Changes in Immune and Non Immune Broilers after Inoculation of Field Infectious Bursal Disease Virus
Beenish Zahid1,*, Asim Aslam2, Zafar Iqbal Chaudhry2 and Raheela Akhtar2
...y damaging the liver and kidney tissues with histopathological effect on lymphoid organs of chicken.
...
Genomic Analysis of Glutathione S-transferases (GST) Family in Common Carp: Identification, Phylogeny and Expression
Baohua Chen1,2, Wenzhu Peng3, Jian Xu2, Jingyan Feng1,2, Chuanju Dong1,2 and Peng Xu2,3,*
...ng brain, heart, spleen, kidney, intestine, gill, liver, skin, blood and muscle of common carp. Expression profiles provided us more evidences to understand GST gene functions as well as their functional evolution post duplication. Overall, the whole set of GST genes provide essential genomic resources for future biochemical, toxicological and physiological studies in common carp.
...
Bioaccumulation of Cu and Zn in Schizothorax plagiostomus and Mastacembelus armatus from River Swat, River Panjkora and River Barandu in Malakand Division, Pakistan
Hazrat Ali1,*, Wajid Ali1, Karim Ullah1, Fazle Akbar1, Sher Ahrar1, Irfan Ullah1, Irum Ahmad1, Ashfaq Ahmad1, Ikram Ilahi2 and Muhammad Anwar Sajad3 
... Cu were in the order of kidneys > muscles > liver > gills > skin while for Zn the order was skin > kidneys > liver > gills > muscles.
...
Construction and Protective Efficacy of Egy-H5 DNA Vaccine from Local Egyptian strain H5N1 using Codon Optimized HA gene

Wesam Hasan Mohamed Mady1*, Bing Liu2, Dong Huang2, Abdel Satar Arafa1, Mohamed Khalifa Hassan1, Mona Mehrez Aly1, Pucheng Chen2, Yongping Jiang2* and Hualan Chen2

Assessment of Heavy Metals and Antioxidant Enzyme in Different Organs of Fish from Farm, Hatchery and Indus River of Pakistan

 Zeenat Bano1,*, Sajid Abdullah1, Waqas Ahmad2, Muhammad Anjum Zia3 and Wardah Hassan1

...organs (gills, liver and kidney) of fish, Cirrhina mrigala. The 3 different representative water samples and 60 fish samples (20 fish from each site) were collected from three sites i.e. fish-farm, hatchery and Indus River of Punjab, Pakistan. The results showed differences in physico-chemical parameters of water samples collected from all the sites. The concentrations of Zinc (Zn), copper (Cu) and nickel (Ni) were higher in river water as compar...
Cloning, Expression and Molecular Characterization of Glutathione Transferase P1-1 Gene from the Camel, Camelus dromedarius
Farid S. Ataya,1,2,* Dalia Fouad,3,4 Ajamaluddin Malik,1 Nikolaos E. Labrou,5 Mohamed S. Daoud1,6 and Hesham M. Saeed7
...llowed by liver, spleen, kidney and lung. CdGSTP1-1 was heterologously expressed in Eschericia coli BL21(DE3) as a ~24 kDa soluble protein and showed to be catalyticly active towards the model substrate 1-chloro-2,4-dinitrobenzene. The results of the present study provide new information into camelid evolution and give further insights into the diversity and complex enzymatic functions of GST superfamily.
...
Purification and Bioactivity of Placental Lactogen from Water Buffalo, Bubalus bubalis
Amtul Jamil Sami1,*, Madeeha Khalid1, Rehman Shehzad1, Sana Mughal1 and A.R. Shakoori2 
...or visceral tissues like kidney, liver, muscle and lungs was also observed, as compared to control subjects. It was also recorded that the exogenous supply of bubaline PL reduces fat cells in the hypodermal layer of skin.
...
Peroxidase Activity in Liver and Kidney of Labeo rohita exposed to Zinc Chloride
Toshina Mushtaq, Muhammad Javed and Sidra Abbas*
...reased both in liver and kidney after ZnCl2 treatments. Statistically significant increase in the liver and kidney peroxidase activity of 96-h LC50 exposed fish were found as 0.621±0.004UmL-1 and 0.219±0.002UmL-1, respectively as compared to the control fish liver (0.123±0.002UmL-1) and kidney (0.056±0.004Um...
Comparative Study on BPI Gene Expression in Various Tissues between Rongchang Pig and Landrace
Jing Xin Mao1,2, Guo Wei Wang2, Yuan She Huang3, Rui Wang2, Guo Ze Wang4, Bing Zeng1 and Fu Yuan Zuo1,*
...rmal liver, heart, lung, kidney, spleen and small intestine. The results showed that: The expression level of BPI in lung of Rongchang pig was relatively higher level compared to that in heart, liver, kidney, spleen and small intestine. The expression level of BPI in liver of Landrace was relatively higher level compared to that in heart, lung, kidney, spleen and small intestine. Real-time...
Effect of Iron Chloride on Peroxidase Activity in Kidney and Liver of Labeo rohita
Rimsha Nawaz1, Muhammad Javed1, Sidra Abbas1* and Safina Kousar2
... fish organs viz. kidney and liver were isolated and the peroxidase enzyme activity was analyzed. Activity of peroxidase was assessed by measuring the conversion of guaiacol to tetraguaiacol, spectrophotometrically, at a wavelength of 470 nm. The peroxidase activity was measured in the selected organs exposed to various sub-lethal concentrations of iron chloride. The results revealed that peroxidase activity was increased significantly in both
Purification and Partial Characterization of Superoxide Dismutase from Kidney of Hypophthalmichthys molitrix under Exposure of Metals Mixture
Anum Rafique, Sajid Abdullah, Khalid Abbas, Huma Naz* and Wardah Hassan
...se (SOD) enzyme from the kidneyof silver carp(Hypophthalmichthys molitrix) was studied. Fish was divided into two groups. One group kept under chronic exposure of metals mixture (Pb+Cr) for 15 days and other group of fish was kept under controlled conditions. Partial purification of SOD was done by Ammonium sulphate precipitation. Ion-exchange column chromatography was used to purify enzyme for further partial characterization against different range of...
Effect of Organic Selenium Supplementation in Diet on Gastrointestinal Tract Performance and Meat Quality of Goat
Saba Parveen Samo1, Moolchand Malhi1,*, Javed Gadahi2, Yan Lei3, Allah Bux Kaciwal1 and Saeed Ahmed Soomro1
...weights of liver, heart, kidney and spleen were not significantly different (P > 0.05) between the groups, however, the lung weight increased in B (1.15 ± 0.04 vs 0.99 ± 0.04, P < 0.05) compared to A. Digestibility trails revealed that utilization of dry matter (DM), crude protein (CP) and crude fiber (CF) increased (P < 0.05) by 13.71, 12.02 and 4.78% at week 3 and by 11.11, 11.8 and 3.46 % at week 6 in B compared to A. Among carcass ch...
Comparative Assessment of the Acute Toxicity, Behavior and Catalase Activity in Cirrhina mrigala Exposed to Fe+Ni+Pb+Zn Mixture
Huma Naz1,*, Sajid Abdullah2, Sidra Naz3, Sidra Abbas2, Wardah Hassan2, Shakeela Perveen2, Moazama Batool1, Laiba Shafique2
...alase activity in liver, kidney, gills, brain and muscle of the fish were also studied. The mean 96 h LC50 and lethal value for C. mrigala was determined as 47.56±0.04 and 93.89±0.07 mgL-1, respectively. The selected concentration of Fe+Ni+Pb+Zn concentrations showed strong and direct relationship with, fin movement followed by mucous secretion, hyperactivity and swimming rate for C. mrigala with R2 ...
Impact of Feeding Different Levels of Neutral Detergent Fiber as Total Mixed Rations on Sensory Attributes, Carcass Characteristics and Meat Quality of Growing Lambs
Mutassim M. Abdelrahman1,*, Ibrahim A. Alhidary1, Gamaleldin M. Suliman1,2, Abdullah H. Alyemni3, Mohamed Y. Al-Saiady3, Faisal A. Alshamiry1,Mohsen M. Alobre1 and Riyadh S. Aljumaah1
...respectively), while the kidney knob and channel fat (KKCF) was significantly lower for lambs fed TMR2. In conclusion, feeding growing lambs a total mixed ration (TMR) with around 30% NDF improve the general performance and most of the required meat quality measurement.
...
Detection and Characterization of Clostridium perfringens Serotype D from Small Ruminants of Balochistan
Imran Taj1,*, Ferhat Abbas1, Zafar Ahmad1, Mohammad Kamran Taj1, Deedar Ahmad2, Zahoor Ahmed2, Ghulam Mohammad2, Ajaz-ul-Haq1, Farooq Shahzad1 and Sabiha Azam3
...omach, intestine, liver, kidney, pancreas and gall bladder of mice. 
...
Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice

 Tahir Abbas*1, Khawaja Raees Ahmad2, Asmatullah3, Khalid Pervaiz Lone4, Muhammad Ali Kanwal2, Sadia Suleman2

Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice
...6th day blood, liver and kidney were collected for biochemical and histopathological analysis.Cr+6 treated group showed severe histological changes like necrosis, cirrhosis and dehydration in liver evident by significant elevation of Serum Glutamic Pyruvic Transaminase (SGPT), Serum Glutamic Oxaloacetic Transaminase (SGOT), Alkaline Phosphatase (ALP), total protein, bilirubin, globulin, creatine and uric acid along with reduction of SGOT/SGPT, Blood Urea Nitro...
Deranged biochemical and hematological profile of septicemia patients in Mayo hospital, Lahore

Riffat Mehboob1*, Sami Ullah Mumtaz2, Zoya Manzoor3, Sajid Abaidullah2, Fridoon Jawad Ahmad1

Deranged biochemical and hematological profile of septicemia patients in Mayo hospital, Lahore
...rum biomarkers of liver, kidney and blood in the diagnosis of septicemia. 101 confirmed patients of septicemia from a tertiary care hospital in Lahore were included. Liver and renal function tests were performed for all patients. Patients were divided into 3 age groups on the basis of age: 30-50, 51-70 and 71-90 years. In Liver function Tests, ALT (37.62%), AST (50.49%) and ALP (99%) were elevated, Bilirubin was normal in majority of patients while total prote...
Detection of Heavy Metals in Three Micro-Bat Species from Central and Northern Punjab
Shagufta Nighat1, Muhammad Sajid Nadeem1,*, Syed Israr Shah1, Amber Khalid1, Tariq Mahmood2, Ayesha Aihetasham3 and Muhammad Asif4
...ntrated in the liver and kidneys, Zn and Pb showed high mean values as compared to other metals but these values were below the lethal levels. Within the regions and sexes no significant variations were found in metal concentrations; however within three bat species metal concentrations varied significantly. This study provides baseline data for future comparisons and management of bats and metal concentrations in environment.
...
Effect of Phytase Supplementation on Growth Performance in Broiler Chickens
Kalimullah Khan1,*, Hafsa Zaneb2, Zia Ur Rehman3, Hamza Maris4 and Habib ur Rehman1
...weights of heart, liver, kidneys, spleen, gizzard and intestines. Results showed that supplementation of phytase enzymes affected the weight and length of small intestine and feed conversion ratio (FCR) and did not affect the other zoo technical variables like body weight, feed consumption, and weight gain during the whole experimental period. Application of phytasefailed to exert any influence on the weights of gizzard, provetriculus, heart, liver, spleen and...
Inter-Specific Differences in the Sensitivity, Accumulation and Antioxidant Capacities of Three Cyprinids Exposed to Heavy Metals Mixture
Fariha Latif* and Muhammad Javed
...ity in the gills, liver, kidney, muscles and brain. Among the fish species, C. mrigala accumulated significantly higher concentration of all metals as compared to L. rohita and C. catla. Bioaccumulation of all metals among the organs followed the order: liver>gills>kidney>brain>muscles, however, metals followed the trend for their accumulation: Cd>Cr>Cu>Pb. Antioxidant (catalase) act...
Thermodynamic Characterization of Kidney Superoxide Dismutase from Labeo rohita Exposed to the Mixture of Lead and Chromium

 Huma Naz1,*, Sajid Abdullah2, Khalid Abbas2 and Muhammad Anjum Zia3

...ide dismutase (SOD) from kidney of Labeo rohita exposed to sub-lethal concentration for 14 days was evaluated. After purification, specific activity of enzyme was 1750.13 and 1272.72 U mg-1 in kidney of metal exposed and control fish, respectively. The enzyme from metal exposed kidney was 2.68 fold purified with 58.73 % age recovery. Results of characterization showed tha...
Effect of Dietary Vitamin E, Selenium and Their Combination on Concentration of Selenium, MDA, and Antioxidant Enzyme Activities in Some Tissues of Laying Hens

 Ĺžaban Çelebi

...tration in liver, heart, kidney and breast muscle. In addition, malondialdehyde (MDA) concentration and enzyme activities of glutathioneperoxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) in liver, heart, breast and thigh tissues of laying hens were determined in present study. A total of 96 White Lohman laying hens, aged 24 weeks, were randomly divided into 4 groups (n=24), each of which was composed of 6 subgroups. The control group received t...
Toxic Effect of Insecticides Mixtures on Antioxidant Enzymes in Different Organs of Fish, Labeo rohita
Huma Naz1,*, Sajid Abdullah2, Khalid Abbas2, Wardah Hassan3, Moazama Batool4, Shakeela Perveen5, Sadia Maalik4 and Sajida Mushtaq4
...nt organs (liver, gills, kidney, brain, heart and muscle) of fish, Labeo rohita. The LC50 of chlorpyrifos+endosulfan mixture was calculated as 1.95±0.02 μgL-1 for 96 h with the 95% confidence limits. The fish expose to the mixture (1:1) for 96-h. The results obtained from this study showed that superoxide dismutase, peroxidase and glutathione S-transferase activities in the liver, gills, kidney
Houttuynia cordate Thunb Boosts the Non-Specific Immune Response and Enhances Resistance to Edwardsiellosis in the Olive Flounder (Paralichthys olivaceus)
Fan Yi1,2, Xiaobin Yang1, Shigen Ye1, Hua Li1 and Ruijun Li1,*
...y burst activity of head kidney cells, compared with the basal feed group (P<0.05 or P<0.01). The challenge test results also showed that the 0.5% and 1% HCT feeding had higher immune protection against Edwarsiella tarda infection; and the relative protection ratios were 60% and 50%, respectively. It was also obtained that interval feeding experiments also significantly boost non-specific immunological function of P. olivaceus...
Distribution of Phenotypic and Genotypic Antibiotic Resistance in E. coli Isolates along the Production and Supply Chain of Pork around Hubei Province of China
Sher Bahadar Khan1,2,*, Zou Geng1, Cheng Yu-ting1, Asad Sultan3, Mumtaz Ali4,5, Irshad Ahmad6 and Rui Zhou1
...testine, liver, meat and kidney), and 80 samples from super- and wet-markets (each 20 meat and liver) collected both in summer and winter. Isolates were tested for 15 antibiotics (CRO, AMX, GEN, STR, TET, CHL, CLR, LVX, OFX, GAT, CIP, SXT, AMP, LIN and AZM) according to the disc diffusion method and antibiotic resistant genes {tet(A), tet(B), tet(C), strA/strB, aadA, aac(3)IV), aadB, sul1, sul2 and sul3, blaCMY-2, blaTEM and blaSHV} using mPCR. Resistance for ...
Protective Effect of Quercetin Treatment against Cadmium-Induced Oxidative Stress in a Male Rat Model
Nouf Alharbi*, Mai Elobeid and Promy Virk
... evaluation of liver and kidney. Results showed that low dose of quercetin was significantly (p≤0.05) more effective than the high dose. Low dose was more efficacious in reducing Cd accumulation in the tissues, reversing the effects of Cd toxicity on blood profile, and on the CAT and SOD activity in the liver and decreased the MDA levels in both serum and liver. Thus, the key findings suggest a profound antioxidative potential of the low dose of querectin, ...
Tissue Specific Changes in the Antioxidant Enzyme Activity of Manganese Exposed Labeo rohita
Maliha Ayub1, Muhammad Javed1, Fariha Latif 1*, Faiza Ambreen2, Komal Sabir1
...sured in the fish liver, kidney, gills and brain and then compared with control group. The results showed that the antioxidant activity increased significantly in all organs of metal stressed fish as compared to the control fish. Among all test concentrations, the activity of antioxidant enzyme (peroxidase) was significantly higher in the fish liver under 96-hr LC50 manganese exposed fish as evident from its mean value as 0.685±0.005UmL-...
First Isolation of Brucella canis from Pet Dogs in Sichuan Province, China: Molecular Characterization, Pathogenicity and Antigen Location Analysis
Zhijun Zhong1, Rui Tu1, Xichun Wang2, Yi Geng1, Qicheng Xiao1, Yinan Tian1, Bin Wei1, Jiaming Dan1, Ya Wang1 and Guangneng Peng1,*
...the liver, lung, spleen, kidney, testicle, and lymph nodes, among which changes in the spleen were the most serious. Immunohistochemistry results demonstrated the detection of B. canis antigens in the lesions of all examined tissues. Strong positive staining was primarily found in the spleen, liver, and testicle. In conclusion, this study was the first to report the isolation of two B. canis strains from pet dogs in Sichuan province, southwestern...
Toxicological Effects of Heavy Metal (Pb+2) on Peroxidase Activity in Freshwater Fish, Catla catla

Nosheen1, Sajid Abdullah1, Huma Naz2* and Khalid Abbas1 

...ssues viz. liver, gills, kidney, muscle, heart and brain of fish Catla catla exposed for 4-day. After each sampling (24-hr interval) fish were dissected and required organs were obtained. Results showed that the POD activity was augmented in all selected organs of Pb+2 exposed fish in relation to control. The POD activity in organs of fish followed the order: brain>liver>gills>kidney>heart>muscle. Regression a...
A Review on Diagnostic and Prognostic Techniques Employed During Bovine Uterine Torsion

Ankur Abrol, Madhumeet Singh, Akshay Sharma* and Pravesh Kumar 

...terioration of liver and kidney functions resulting in toxaemia followed by dam as well as fetal mortality. So, the most important aspect in successful management of uterine torsion lies in the correct and efficient diagnosis which can mainly be achieved by anamnesis, vaginal and rectal examination. However, prognosis of uterine torsion is mainly dependent on the degree and duration of condition and can be categorised into 3 successive stages i.e. stage of pos...
Haematological and Histopathological Analyses of Levofloxacin Induced Toxicity in Mammals
Chaman Ara1*, Asmatullah1, Sehrish Kanwa1, Asma Chaudhary2, Ayesha Siddiqua1
...eable increase in liver, kidney and testis weights. Significant increase in levels of total alkaline aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and bilirubin was observed in blood plasma. Urea level showed a remarkable decrease, whereas creatinine level increased but not significantly. Histological examinations exhibited pyknosis, necrosis, vacuolations, increased sinusoidal spaces, karyomegaly, glomerulosclerosis, glomeru...
Turmeric Plays Protective Role against Paraben Induced Hepatic and Renal Lesions in Albino Mice
Chaman Ara1*, Asmatullah1, Zainab Riaz1, Memoona1, Asma Chaudhary2, Shagufta Andleeb2
...scular pole in liver and kidney respectively. But when turmeric powder was coadministered with BP, these damages were reversed to a great extent. So, this study has proved the protective role of turmeric against toxicity induced by BP in female albino mice.
 
Novelty Statement | Curcumin, an active component of turmeric along with its proven anti-fungal and antimicrobial activities also detoxify Paraben (suspected car-cinoge...
Primary Evaluation of Seed Characteristics of Common Bean Landraces Collected from Himalaya Region of Pakistan

Iffat Nawaz1*, Farhatullah1, Fida Muhammad1, Sajid Ali2 and Ghulam Muhammad Ali3 

...truncate fastigiated and kidney shape. Cuboid seed shape was predominant with a frequency of 46.8%. Seed coat pattern was absent in 51% accessions. Five different seed coat patterns i.e., constant mottled, stripped, circular mottling, rhomboid spotted and speckled were recorded in remaining 49% accessions. Cluster analysis was performed and 96 accessions were grouped in four clusters (G1, G2, G3 and G4) based on primary seed characters. The G4 was further divi...
Lead Induced Oxidative Stress in Cirrhina mrigala
Fariha Latif1*, Muhammad Javed2, Hammad Ahmad Khan2 and Khalil-Ur-Rehman3
...ive stress in the liver, kidney, gills, muscles and brain of Cirrhina mrigala. The 120-days old fish were exposed to 1/4th (11.81mgL-1) and 2/3rd (31.49mgL-1) of 96-h LC50 of water-borne Pb for three fortnights (42 days) in glass aquaria at pH 7.5, temperature 30°C and total hardness 250mgL-1. After each fortnight, fish were sampled from each treatment and different organs such as liv...
Bioaccumulation of Some Potentially Toxic Heavy Metals in Freshwater Fish of River Shah Alam, Khyber Pakhtunkhwa, Pakistan
Hazrat Ali1,2,*, Ezzat Khan1,* and Muhammad Jamal Nasir3
...s skin, gills, liver and kidneys of two fish species i.e., Clupisoma naziri and Mastacembelus armatus. Cr concentrations in fish muscles ranged from 30.5±41.9 to 70.8±12.1 mg kg−1 wet weight, Ni from 16.7±10.2 to 103.5±114.1 mg kg−1 wet weight, Cd from 1.1±0.18 to 2.5±0.21 mg kg−1 wet weight and Pb from 29.7±18.3 to 97.7±95.4 mg kg
Hepato-renal Toxicity of Patulin and its Modulation by Ginger (Zingiber officinale) in Rats
Kadry A. El-Bakry1, Lamiaa E.M. Deef1*, Lotfy Z. Habbak1 and Samia S. El-Naeli2
...ificantly. The liver and kidney tissues showed markers of improvement after treatment the patulin rats with ginger. In conclusion, treatment with ginger can protect liver and kidney form the toxicity induced by patuilin.
...
Molecular Detection and Pathological Investigation of Contagious Bovine Pleuropneumonia in Selected Districts of Punjab, Pakistan
Ahsan Anjum1, Asim Aslam1, Raheela Akhtar1, Tahir Yaqub2,  Muti-ur-Rehman Khan1, Rizwana Sultan3, Saba Usman1, Aneela Zameer Durrani4 and Muhammad Usman4*
...rthermore, lungs, liver, kidney and lymph node were collected for histopathological examination. Of the 560 samples, 49 (8.25%) were found positive for CBPP. Maximum pathological lesions (50-75% of surface area) were seen in 34.69 percent lung samples, chronic type pleurisy in 97.96 percent, maximum aggregate pathological lesion score in 65.31%, while 48.98% lung samples had 6-10 numbers of sequestra. Besides, infiltration of inflammatory cells, congestion, he...
Effect of High Dietary Consumption of Locally Available Ghee on Renal Function in Mice
Dilara Abbas Bukhari*, Mehwish Faheem, Shamoona Arshad and Khalid P. Lone
...mice were sacrificed and kidneys were taken out. Biochemical parameters e.g., lipid peroxidation (LPO), catalase (CAT), glutathione-S-transferase (GST), reduced glutathione (GSH) were determined to evaluate oxidative stress while urea and creatinine, was used to evaluate kidney function. It was found that there was an increase in weight (p<0.05) of both males and female mice fed with diet containing ghee.
Effect of Zinc Supplementation on Haematological Parameters, Biochemical Components of Blood and Rumen Fluid, and Accumulation of Zinc in Different Organs of Goats
Elmas UlutaĹź1,*, Abdullah Eryavuz2, Aziz Bülbül2, Abdur Rahman3,*, Ä°smail Küçükkurt4 and Cangir Uyarlar5
...levels but decreased the kidney Cu concentrations. It was concluded that the goats can tolerate the supplementation of high zinc in diet.
...
The Influence of N-Acetylcysteine Alone and in Combination with Angiotensin Converting Enzyme Inhibitor and Angiotensin Receptor Antagonist on Systemic and Tissue Levels in Rats with Experimentally-Induced Chronic Renal Failure
Ahmet Ozer Sehirli1,2, Serkan Sayiner3*, Ayliz Velioglu-Ogunc4, Nedime Serakinci5, Emel Eksioglu-Demiralp6, Berrak Yegen7, Feriha Ercan8 andGoksel Sener2
... brain, heart, aorta and kidneys were used for analysis of the collagen content besides tissue luminol, lucigenin, malondialdehyde (MDA) and glutathione (GSH) levels. A significant difference was determined between the CRF group and the control group with regard to heart rate, blood pressure, serum creatinine, BUN, LDH, cytokines and urinary electrolyte levels. Furthermore, monocyte and neutrophil apoptosis, tissue luminol, lucigenin, malondialdehyde and colla...
Investigation of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Activity in Some Inflammatory Conditions in Barki Sheep

Asmaa A. Darwish 

...er enzymatic activities, kidney function tests, total lipids, triglycerides, MMP-2 and MMP-9 concentrations was depicted in the three diseased groups. On the contrary, the total cholesterol, HDL-cholesterol, LDL-cholesterol, minerals, electrolytes, trace elements and total antioxidants capacity concentrations significantly (P< 0.05) decreased in the three diseased groups. Both of MMP-2 and MMP-9 yielded a sensitivity and NPV as 100% in the sheep pneumonia, ...
Renal Dysfunction in Ischemic Stroke Subjects

Saima Sharif*, Farkhanda Manzoor, Tasnim Farasat, Shaugfta Naz and Raheela Tabasum 

...ermine whether decreased kidney function is a risk-factor in first-ever ischemic stroke. The study was conducted from Jan, 2013 to Jan, 2014 in Services and Jinnah Hospital Lahore, Pakistan. A total of 150 subjects were included in this study, divided into ischemic stroke group (n=100) and control (n=50). Kidney function estimation was done using serum creatinine and blood urea along with eGFR calculation by MDRD equation. <...
Molecular Detection of Hepatitis E Virus in Tibetan Swine
Gong Ga1,2 and SuoLang Sizhu2,*
...including liver, spleen, kidney and intestine, n=21) by nested RT-PCR and qRT-PCR. HEV antigens were detected in tissues by immunohistochemistry analysis. Overall, we found that that eight serum samples (4.6%, 8/173) were positive to anti-HEV IgM antibody and Seventeen serum sample (9.8%, 17/173) were positive for anti-HEV IgG antibody. The HEV RNA positive rate was of 4.6% (8/173) in feces and serum. Moreover, the prevalence of HEV RNA was 9.5% (2/21) in...
Changes in Glutathione S-transferase Activity and Total Protein Contents of Labeo rohita
Qaisra Siddique1, Sajid Abdullah1, Huma Naz2*, Khalid Abbas1, Laiba Shafique3

 

...ssues viz. brain, gills, kidney, heart, muscle and liver of Labeo rohita kept under sub-lethal dose (4.13 µgL-1) of chlorpyrifos. Fish was kept under chlorpyrifos stress for two months and samples were collected on weekly basis. It was noted that GST level varied significantly with duration. The GST level was raised in first 28 days after that it was dropped off up to 56-day. The trend of GST in fish tissues was observed as muscle<he...
Muscular Tissue Bioaccumulation and Health Risk Assessment of Heavy Metals in Two Edible Fish Species (Gudusia chapra and Eutropiichthys vacha) in Padma River, Bangladesh
Dil Afroza Khanom1, Amirun Nesa1, Muhammad Abu Sayed Jewel1, Muhammad Ayenuddin Haque1, Alok Kumar Paul1, Sonia Iqbal2, Usman Atique2,3*, Lubna Alam4
...g to mental retardation, kidney tissue damages, cancerous cell growth, and even death in case of chronic exposure. 
 
Morphological and Pathological Effects of Aspergillosis in Silver Carp, Hypophthalmichthys molitrix
Saira Saleemi1*, Zafar Iqbal1, Abdul Nasir Khalid2
...lls, fins, heart, liver, kidney and intestine of fish and culturing it on four different culture media; Malt extract agar (MEA), Corn meal agar (CMA), Sabouraud dextrose agar (SDA) and Potato dextrose agar (PDA). The inoculated culture plates were incubated for 5-8 days at 28-32 oC. The fungal growth in the form of colonies of different shapes and colour appeared in agar plates. Four Aspergillus spp.; Aspergillus terreus (8.40%), A....
Bioaccumulation of Metals in the Organs of Fish inhabiting Ravi River: Serious Threat to Fish and Consumer’s Health
Zarish Yaqoob1, Saleema Bashir Shams2, Gaitee Joshua2 and Bibi Nazia Murtaza2,3*
... fish followed by liver, kidneys, muscle and fat cells. Overall, seventeen fish species were recorded in the study areas indicating a decrease in the number of species in Ravi. The results have shown that the water of Ravi is unsafe for aquatic life and irrigation. Metal concentration in the fish meat is higher than the recommended dietary allowance (RDA) parameters indicating a serious health threat to both, the fish and human population.
...
Physiological Effects of Ethanolic Leaf Extract of Duranta erecta (L) on Albino Rat, Rattus norvegicus
Gregory Ejikeme Odo1,*, Juliana Ekenma Agwu1, Nkechi Nweze2, Clara Ikegbunam2,Felicia Ekeh N1, Vincent Ejere1, Ngozi Ezenwaji1, Reginald Njokuocha2, Godwin Ngwu1 and Fabian Okafor1
... D. erecta to the kidney.
...

Ghulam Akbar1*, Ali Ahmad2, Neha Arooj1, Muhammad Anjum Zia1, Aamna Rafique1, Sania Riasat1, Mohsin Raza1, Mahpara Qamar1, Shahneela Nusrat1 and Shakila Hanif1

Critical Update for the Treatment of Anemia by using Advanced Genome Editing Crispr Cas Technology
...blems such as persistent kidney disease, cancer, ischemic heart ailment and inflammatory bowel disorder. However, with the development in generation at genome editing level have made feasible to accurate mutations in human genome. A site oriented specific break in double stranded DNA is induced by CRISPR/Cas9, whereas different oligonucleotides are provided to make accurate DNA template for genome correction. It is of importance to knowledge about types of CRI...
Marsh Frog (Pelophylax ridibundus) as a Bioindicator to Assess Pollution in an Agricultural Area

Turgay ĹžiĹźman1,*, Muhammet ÇaÄźrı Keskin1, Hatice Dane1, Ĺžeymanur Adil1, Fatime GeyikoÄźlu1, Suat Çolak2 and Esra Canpolat1

...tes and lung, liver, and kidney histopathologies were evaluated in marsh frog (Pelophylax ridibundus) in agricultural areas. The most prominent histopathological alterations observed in lung tissue were noted as epithelial hyperplasia, thickness of alveolar septa, dilatations and congestions of blood capillaries, and melanomacrophage accumulation. An increase in the number and widening of melanomacrophage centers were also noted for liver, in parallel w...
Effects of Cypermethrin on the Hematological Parameters, Biochemical Components of Blood and Histopathological Changes in Different Organs of Chirruh Snow Trout (Schizothorax esocinus)
Naveed Akhtar1*, Muhammad Fiaz Khan1*, Sadia Tabassum1, 
Munawar Saleem Ahmad2 and Khan Dil Badshah3
... in gills, liver, brain, kidney, intestine and muscles related with oxidative stress damage was observed. Genotoxicity increased with increase in time and concentration of cypermethrin. Cypermethrin is therefore extremly harmful to aquatic life.
...
Bioaccumulation of Selected Toxic Heavy Metals in Mastacembelus armatus from Three Rivers of Malakand Division, Pakistan
Hazrat Ali1, 2* and Ezzat Khan1*
...f M. armatus was: kidneys > liver skin > muscles > gills. Bioaccumulation factor (BAF) values of the metals in muscles of M. armatus were in the order: Cr > Pb > Ni > Cd. BAF values show that these metals are accumulated in the fish tissues and may pose a potential health risk to regular consumers. 
...
In-vivo Evaluation of Anti-urolithiatic Activity of Different Extracts of Peel and Pulp of Cucumis melo L. in Mice Model of Kidney Stone Formation
Aneeqa Saleem1, Muhammad Islam1, Hamid Saeed1* and Mehwish Iqtedar2
Intervention Effect of Total Glucoside of Paeony on Mesangial Proliferative Glomerulonephritis in Rats
Xiujun Yao1, Haofeng Wang 2, Ligong Zhang3, Jingzhang Wu4 and Lijun Wang1*
...gamma;, and TNF-α ,kidney ROS and MDA levels, relative content of TGF-β1 and CTGF in TGP group were lower than that in model group (P <0.05); serum levels of IL-2 and CTLA-4,SOD levels in TGP group were higher than that in model group (P <0.05).These results indicated that TGP could reduce urinary protein quantity, inhibit inflammatory response, and reduce expression of TGF-β1 and CTGF in kidney tissue ...
Red Onion Extract Attenuates Aluminum Induced Toxicity in Swiss Albino Mice
Chaman Ara1*, Asmatullah1, Saima Hanif1, Shagufta Andleeb2, Beenish Zahid3 and Madeeha Arshad4
...and creatinine levels in kidneys, in Al exposed groups against control. In Al + antidote groups these deviations were less significant (P≤0.05). However, these morphometric and biochemical alterations improved to a great extent when onion extract was co-administered with Al. So it is concluded that Al caused morphological and biochemical disturbances in mice, whereas onion extract showed protective effects as well as regenerative potential against Al provok...
Molecular Characterization and Pathogenesis of Local Isolates of Clostridium perfringens Type D from Sheep in District Peshawar
Saqib Nawaz1, Sher Bahadar Khan1*, Umar Sadique1, Muhammad Israr2, 
Mumtaz Ali Khan3, Hameed Ullah Khan4, Muhammad Irshad5, Ihsan Ali1 and Haq Aman Ullah1
... in 39 sheep (78%), soft kidney 27 (54%), dark congested liver 26 (52%), nephritis 23 (46%) and spleenitis 13 (26%). Microscopic lesions revealed a score of 10 of kidney tissue out of 15 while the lesion score of intestine revealed 08 out of lesion score of 15.
...
A Review on Histopathological Alterations Induced by Heavy Metals (Cd, Ni, Cr, Hg) in Different Fish Species

Safia Bibi1, Saima Naz1*, Saba Saeed1, Ahmad Manan Mustafa Chatha2

...iations in gills, liver, kidney and skin of different fishes were noticed when exposed to heavy metals, thus indicating severity of heavy metal toxicity. The current study was focused on the toxicological effect of Cr, Hg, Ni and Cd in different type of fishes and it would be useful for the scientific community to restore different metals contaminating water. 
 
Novelty Statement | Histopathologica...
Expression of the ZFX Gene in Mouse Kidney During Postnatal Development
Xiangzu Wang,1,2 Jifeng Xi,1,2 Bin Jia,1,* Yongsheng Zhang,1 Chaocheng Li1
...s is important in normal kidney development. The ZFX gene is important for regulation of growth, proliferation and differentiation in tissue cells while the Bcl-2 and BAX genes regulate apoptosis. This experiment adopted the real-time fluorescence quantitative technique to test ZFX, Bcl-2, and BAX expression in mice kidney tissue on 1 d, 7 d, 14 d, 21 d, 42 d, and 90 d after birth. The results showed that with the maturation...
Investigation of lumpy skin disease virus infection in young calves from cows vaccinated with sheep poxvirus vaccine

Yasser F. Elnaker 1, Mohamed El-Tholoth 2, Sahar Saber 3, Amira A- Elsaid4, Mohamed A. Saad 3, Emad E. Younis 5

Rapid Virological and Molecular diagnosis of Lumpy skin disease virus

Hanaa A. Ahmed1 and Eman M. AboHatab2

...y and Madin Darby bovine kidney (MDBK) cell culture. Identification of virus by indirect immuno fluorescent antibody technique (IFA) which was considered a rapid and accurate method for LSD antigen detection. nodules were subjected directly to PCR and Real time PCR for rapid and specific detection of LSDV, sixteen out of the twenty one nodular samples were confirmed positive by molecular methods. Eleven out of twenty one nodular samples were positive by (IFAT)...
Protective Efficacy of Combined Vaccines against Newcastle Disease and Infectious Bronchitis Viruses in Broiler Chickens in Egypt

Amir M. Walaa1 ; Ausama Yousif1; Walid H. Kilany2; Magdy El-Sayed1; Ahmed A. El-Sanousi1

...ed (trachea, bronchi and kidneys) for PCR at 3, 7 and 10 days post vaccination and post challenge as well. Groups 3 &4 showed high protection with all serological tests. Based on our findings Vaccine Manufactured with the Local Strains & Montanide ISA 71 proved to be a good Vaccine as the groups received it as booster after priming with live vaccination, showed high and good protection against IBV especially after challenge with wild live IBV virus whe...
Different culturing systems of IBV-Eg-F170-2015 strain of Egypt variant 2 infectious bronchitis virus

Ahmed A. Azab, Wesam H. Mady, Ali Zanaty, Mahmoud Samir

...ggs ECE), chicken embryo kidney
cell (CEK) and in Vero cell line and was confirmed for IBV detection by Reverse Transcriptase Real
time PCR (RRT-PCR) using IB specific primers. Comparison of different isolation methods was done
by generating a standard curve by real time PCR.
Results: The results revealed that the propagated virus in CEK showed the highest virus titer (5.952 x
106 and 3.245 x 106) tha...
Coronavirus Disease (COVID-19) with Special Reference to Pakistan: A Review on its Different Aspects
Sahar Mubashar*, Tariq Mukhtar and Nasir Ahmad Khan
... organs of the body like kidneys and heart. It is spread from human to human through respiratory droplets or direct contact. Moreover, there have been reports of the mixed infection of coronavirus with other bacteria, fungi and viruses. Various methods are used for the detection of the virus such as nucleic acid and immunological methods but RT-PCR is considered as the most reliable. Some antiviral drugs have shown to be effective against the virus like Favila...
Lumpy skin disease is circulating among sheep pox vaccinated cattle in Egypt 2017

Akram I. Aboelkhair1, Ayman H. El-Deeb2, Momtaz A. Shahin1 and Hussein A. Hussein2

...iv>on Madin-Derby bovine kidney cell line ( MDBK ); confirmation of LSD isolated virus was done by
using Electron microscopy (EM) on suspension of cell culture passage of the virus, Serological
identification was done by serum neutralization test ( SNT ) using reference antisera which confirm
presence of LSDV . By nucleotide sequences and genetic characterization was conducted on (G-PCR)
gene segment of these iso...
Formulation and evaluation of inactivated lumpy skin disease virus vaccine using ISA 50 and ISA 206 adjuvants.

Youssef A. Elgharbawy1, Mervat M. Ali1, Ayman H. El-Deeb2, Mohamed A. Shalaby2

Evaluation of Growth Performance and Bioaccumulation Pattern of Metals in Catfish Species, Channa marulius and Wallago attu under Cadmium and Chromium Toxicity

Moazama Batool1*, Sajid Abdullah2, Huma Naz3, Mubashar Hussain4, Sadia Maalik1, Sajida Mushtaq1, Tanveer Ahmed5 and Laiba Shafique6

...h species was studied as kidney>liver>gills>skin>fins>bones>muscle.
 
...
Histopathological Studies of Pond Reared Indian Major Carp, Catla catla Infested with Argulus japonicus and Trial for Argulosis Treatment

Md. Abdullah Al Mamun1,2*, Shamima Nasren1,3, Sanjay Singh Rathore1 and Kavalagiriyanahalli Srinivasiah Ramesh1

...and muscle, gill, liver, kidney, heart and different parts of gut tissues. According to the results obtained in the present study, it can be suggested that acute infestation of A. japonicus elicited direct effects such as eye opacity, fin rots, scale loss and severe histopathological alterations in catla. 

...
Tissue-Specific Response of Peroxidase Activity in Channa striata under Acute Exposure of Pesticides (Deltamethrin + Endosulfan) Mixture

Aliya Munir1, Sajid Abdullah1*, Huma Naz2*, Khalid Abbas1, Tanveer Ahmed3 and Zahid Farooq2

...evel in gills, liver and kidney of fish in a time dependent manner.  

...
Analysis of Genomic DNA Methylation in Six Tissues of the Greater Horseshoe Bat (Rhinolophus ferrumequinum)
Sen Liu1,2, Yue Zhu2, Haixia Leng2, Ying Wang1, Xiangju Yin1 and Yajun Zhao1*
...), brain (B), heart (H), kidney (K), liver (L), and muscle (M) tissues. An average of 67.0% CCGG loci was methylated in each tissue. There were significant methylation differences among tissues in full-methylation (p < 0.001) and total methylation (p = 0.001). Moreover, various unique methylated loci (15–59) were also detected. Non-negligible level of hemi-methylation (31.4%) existed, indicating that CHG methylation may also play a poten...
A Review on the Adverse Impacts of Cadmium on Ecosystem and its Refinement Strategies

Khaliq Dad1, Muhammad Nawaz2*, Muhamamd Ibrahim3, Fengliang Zhao4, Rumsha Hassan2, Humaira Nawaz5, Muhammad Usman Saleem6, Kinat Javed2, Ayesha Komal2 and Hajra Naz2

... produces heart disease, kidney failure, lung cancer, orthopedic disease, nervous system failure, low immunity level, mental retardation and growth retardation. Different environmental friendly and low cost biological remedies are used nowadays to control Cd toxicity such as phytoremediation phytostabilisation, rhizofilteration, phytoextraction. This review paper has summarized the impact of Cd on soil, plants and humans and strategies to remove or minimize it...
Cholangiocarcinoma with Multiple Organ Metastasis in a Captive Puma (Puma concolor)
Ho-Seong Cho1 and Yeonsu Oh2,*
...nd in the lung, stomach, kidney, heart and diaphragm, which were growing together, suspiciously metastatic, projecting, 5 to 40 mm in diameter and tawny to white in color. Histopathologically, the tumor was composed of prominent papillary-acinar structures and the cells had a resemblance to the biliary epithelium. Immunohistochemically, the tumor cells were strongly reactive for cytokeratin and CD10 and were negative for carcinoembryonic antigen, fetoprotein a...
Inflammatory Process and Role of Cytokines in Inflammation: An Overview

Ayesha Muzamil, Hafiz Muhammad Tahir, Shaukat Ali, Iram Liaqat, Aamir Ali, Muhammad Summer

...ers, dizziness, liver or kidney problems etc. Cytokines play an important role in the induction and suppression of inflammation. Cytokines are diverse form of proteins that act pro- and anti-inflammatory cytokines. The main component of immunity is IL-1. IL-6 cytokine play its role in regulation of metabolic reactions. The activity of various leukocytes is suppressed by IL-4 and IL-10 (anti-inflammatory cytokines) that triggers the production of pro-inflammato...
Ameliorative Effect of Graviola Fruit Juice on the Damaged Tissues of Gamma-Irradiated Male Rats
Amr N. El-Shahat1, Refaat G. Hamza1,*, Ashraf M. Mounir1 and Madeha N. Al-Seeni2
...rations in the liver and kidney of male albino rats.In the present study, gamma- irradiation (2 Gy every 3 days up to 8 Gy total doses) induced biochemical and oxidative damage in rats when compared to control group. In GFJ (10ml/Kg B Wt. /day) treated irradiated group, there were noticeable decreases recorded in lipid contents, concentration of serum urea, creatinine and uric acid, glucose level, activity of some liver enzymes and liver and
Comparison of Heavy Metals Concentration in Different Tissues of Four Wild Bird Species

Noha M. El-Shabrawy1, Atef M. Kamel2, Aza S. Goda1, Gehad R. Donia1, Ahmed M. Salah-Eldein2* 

... in their muscle, liver, kidney and feather. Also, 16 water samples were collected to assess the level of heavy metals pollution in the study area. The result revealed that the kidney is the most tissue burdens the highest concentration of heaviest metals among the examined tissues. Egyptian barn swallow and house sparrow have a great tendency to accumulate heavy metals in their tissues among other examined birds. Levels of ...
Characterization of CLCN5 and Expression Profile under Low-Salinity Stress in Takifugu rubripes
Lin Ye, Jie-Lan Jiang*, Jia Xu, Rui-Ting Liu, Yin-Qiu Tian, Qing-Qing Zang, Jia-Yi Cao and Ming-Guang Mao*
...ressed in the intestine, kidney and liver, and up-regulated in gills under low-salinity stress in 3h to 6h, which indicates that TrCLCN5 may play an important role in the responses to acute low-salinity stress and would be useful in further understanding low-salinity adaption in T. rubripes.

...
Interferon Status and Expression of P53 and gadd45g Genes in Leukaemogenic Felv Infection in Domestic Cats

Alexander Tsybulsky1*, Tatyana Tabakaeva1, Anna Klimovich2, Michail Shchelkanov1, Eduard Kostetsky1, Maksim Aliev1, Anton Degtyarenko3 

...l characteristics of the kidneys and liver, whose disorders are most critical in the progression of the leukaemic process; 3) Replicative and expressive activity of provirus FeLV in blood white cells (WBC); 4) Concentration of the IFNs and viral p27-FeLV-specific antigen in the blood plasma; 5) Expression of ifnα6, ifnα7, ifnβ1, ifnγ and ifnλ1 genes in WBC; 6) Expression of p53 and gadd45g genes in WBC. The concentration of the vi...
Leverage of Chromium Methionine Supplementation in Laying Japanese Quail’s Diets on Performance, Quality, and Blood Traits Challenged by Heat Stress

Ayman M. Khalifah1*, Walaa A. Kashyout1, Sara A. Abdalla2, Hassan S. Zeweil3, Soliman M. Zahran3, Tarek A. Ebeid4, Waleed M. Dosoky3 

...cluding a lipid profile, kidney functions, and antioxidant profile of laying quails. In conclusion, Cr-Met supplementation to laying quails diets at 0.4 and 0.6 g Cr-Met/kg under HS enhances performance traits, yolk lipid Profile, and blood traits of quails.

Keywords | Heat stress, Quails, Blood traits, Yolk fatty acids, Chromium  

...
Review - Gout In Chicken

Kanakuntla Sandhyarani*, Dhoppalapudi Madhuri, Yadala Ravikumar 

...l damage to tissues like kidneys, heart, lungs, intestine (visceral gout) and also in the joints (articular gout). Gout is a multifactorial metaboic disease which involves infectious agents, nutritional factors and managemental prcatices. Infectious agents include Nephropathic Infectious Bronchitis Virus (IBV), Avian Nephritis Virus (ANV), Chicken Astrovirus (CAstV) and nutritional factors like high dietary calcium (>2%), high crude protein (> 30%), Hypo...
Assessment of Three Dimensional Color Power Doppler Technique for Detecting Fetal Renal Vascular Perfusion in Pregnant Women with Gestational Hypertension

Hong Liu and Rui Xu*

... index (FI) of the fetal kidney and the vascularization flow index (VFI) in the early pregnancy. In addition, blood flow parameters of the uterine artery and fetal umbilical artery of the pregnant woman were correlated at the 12th week and the 22nd week. We found that FI, VI and VFI decreased in the mild and severe prehypertension groups were compared with the control group (P<0.05). There was a certain correlation of blood flow parameters of pregnant women...
The Impact of Physical Load and Adaptogens on the Animal Work Capacity
Ilvir Khabibullin1*, Ruzel Khabibullin1, Irina Mironova1, Lyalya Musina2, Elmira Akhmadullina1, Victoria Morozova1 
..., lung tissue, liver and kidneys, where immunity and blood cells develop. Although the swimming test at the beginning of the experiment showed that mice and hamsters had approximately the same indicators of physical endurance, by the end of the experiment, the swimming time of the experimental group animals was significantly longer. The animals receiving pantocrine turned to be stronger. Their interval time increased by 267 seconds (Đ ≤0.05) while the swim ...
Effects of Genotype and Age on Growth Performance and Carcass Traits of Chickens in Southern Ethiopia

Shewangizaw Wolde1,2*, Tadele Mirkena1,3, Aberra Melesse1, Tadelle Dessie4, Solomon Abegaz5 

...breast, back, heart, and kidney were increased with age. The dressing percent was not affected by genotype for male chickens, but it was higher for LL, lower for SRSR, and in-between for LSR hens. Moreover, it was not affected by age except for LSR chicken. In conclusion, the values of body and carcass weights were significantly improved by cross-breeding of Sasso-RIR chicken with Normal Feathered local chicken. The weights of most carcasses were increased wit...
Prevalence, Virulence Determinants and Antimicrobial-Resistant Profile of Edwardsiella tarda Isolated from Nile Tilapia (Oreochromis niloticus) in Egypt

Samah Samir, Amal Awad*, Gamal Younis 

...ssue samples from liver, kidneys, gills, skin and spleen were examined bacteriologically for the presence of E. tarda; and confirmed by PCR targeting gyrB1 gene. Disk diffusion was used to test their antimicrobial susceptibility, and PCR was used to screen E. tarda isolates for the presence of four virulence-related genes (cds1, edwI, qseC, pvsA). In addition, the ability of E.tarda to form biofilm was tested by tube test. E.tarda was detected in 15 fish (6%) ...
Comparative Study of Curcumin and Garlic Extracts as Antioxidants in Growing Rabbit Diets on Productive Performance and Antioxidant Status

A. Samy1*, H.M.A. Hassan1, Fatma T.F. Abd-El Ghany2, Shama H. Morsy2 

...ent, while liver, heart, kidney, giblets, and spleen percentage were not affected. When curcumin or garlic extract were added at 200 or 400 ppm, Improved the antioxidants status by enhanced total antioxidant capacity also, significantly (P<0.05) enhanced hepatic antioxidants enzyme (superoxide dismutase, catalase, and glutathione peroxidase) compared with the control. Slightly (P>0.05) decreased in malondialdehyde of all treatments compared to the contro...
Polymorphisms of the DHCR24 Gene are Associated with Carcass and Fat Deposition in Chinese Simmental Steers

Pan Ziyi1, Ambreen Iqbal1, Gao Zhen1, Liu Juan1, Fang Xibi2, Jiang Ping1* and Zhao Zhihui1* 

...5 G > A of DHCR24 the kidney fat weight of GG was higher than that of GA and AA individuals. Steers of the GG and AA genotype having high backfat thickness (p < 0.05) and a higher carcass fat coverage rate (p < 0.05). Furthermore, GG genotype individuals had higher marble grade than GA genotype individuals (p < 0.05). It is predicted through bioinformatics analysis that bta-miR-12059 can bind to 3’UTR of the DHCR24 gene. Our results indicate ...
Insight into the Mechanism of Doxorubicin-induced Nephrotoxicity through Gene Expression Analysis of Oxidative Stress, Kidney Injury and Inflammation Markers

Uzma Jabeen1, Asmat Salim2*, Irfan Khan2, Nadia Naeem3 and Rubina Mushtaq4

...h1) were analyzed in the kidney tissues by RT-PCR. Extent of injury was analyzed by the change in expression of kidney injury biomarkers, kidney injury molecule-1 (KIM-1) and osteopontin (OPN), while the effect of DOX was also analyzed in terms of changes in the anti-inflammatory cytokine, interleukin-10 (IL10). Of the oxidative stress induced genes analyzed, the expression of Gpx1 was fou...
Therapeutic Evaluation of Fipronil and Doramectin against Brown Tick Infestation of Dogs

Wael Felefel1*, Mohamed EL-Beskawy2, M. F. El -Dakroury3, Mohamed Morsi Elkamshishi4, Eman Sayed Mohammed5 

... safer where it improved kidney and liver function tests in addition to the velocity of killing ticks with injection.

Keywords | Doramectin, Fipronil, Hard Ticks, Stray dogs, ROC curve  

...
Prevalence and Socio-Economic Incidence of Bovine Tuberculosis in a Slaughter Area in the Northern Sudan Region of Burkina Faso

Ouedraogo Oumar1,2, Tianhoun Denté Fidèle2,4*, Séré Modou3, Kaboré Adama2, Tamboura H. Hamidou2 and Belem Adrien Marie Gaston4

...lowed by liver (17.57%), kidneys (8.10%) and heads (4.05%). Following the inspection of all the animals during the study period, the urban commune of Koudougou received a total of 1,029,600 CFA francs in slaughter fees. In addition to the considerable losses in animal protein, the financial losses linked to the seizure of organs affected by tuberculosis were evaluated at 206,949.968 CFA francs for butchers without any compensation during the same period. The s...
Chemical Composition and Fatty Acid Profiles of organic Moringa oleifera: Effects on Modulation of Blood and Plasma Parameters of Ewes in Subtropics

Aiman Al Mufarji, Abd El-Nasser Ahmed Mohammed* 

...ose, proteins, liver and kidney functions and minerals values. The results indicated that organic M. oleifera leaves contain protein (28.28%), carbohydrate (47.82%), fat (7.57) and fiber (28.35%). In addition, fatty acid profiles were saturated fatty acids (3.76%), unsaturated fatty acids (3.79), monounsaturated fatty acids (2.39%), polyunsaturated fatty acids (0.76%) and trans fatty acids (0.64%). Upon supplementation to ewes, M. oleifera leaves caused signif...
Comparative Study of the Virulency of Different Serotypes of Foot and Mouth Disease Virus by Using Baby Hamster Kidney-21 Cell Line

Sania Subhan Qureshi*,1, Baitullah Khan1, Shahid Khan1, Hanif Ur Rahman1 and Muhammad Subhan Qureshi2

Hepato-Nephrotoxic Effects of Induced Fluorosis in Rabbits and Broilers

Barirah Rehman Talpur1, Zaheer Ahmed Nizamani1*, Imdad Hussain Leghari2, Mansoor Tariq1, Aisha Rehman3, Shahnawaz Kumbhar1 

...f fluorosis on liver and kidneys in rabbits and broilers. Sixteen rabbits and sixteen broilers of four weeks age were divided into four subgroups each were given 0mg (control),50 mg, 100 mg and 200 mg Sodium Fluoride /liter in water daily for 18 days. The clinical signs and mortality were noted. Blood was collected at days 0, 5, 10, 15 and 18 of experiment, for evaluation of liver and kidney functions. Dose and time dependen...
Immunostimulant Effect of Red Ginger (Zingiber officinale Roscoe) in Broiler Vaccinated and Challenged with Newcastle Disease Virus

Tri Untari1*, Sitarina Widyarini2, Michael Haryadi Wibowo1, Marla Anggita1 

...o the chicken livers and kidneys. Antibody titers in group I, II, III and IV were determined as HI (log)2 average and were recorded 3.81, 2.91, 3.13 and 0.95, while the geometric mean titers (GMT) were 13.9, 8.6, 7.5 and 1.9 respectively. The unvaccinated groups (V, VI, VII) exhibited 0 and 1 as HI (log)2 and GMT respectively. There was a significant difference between the measured antibody titer of group I and other groups (p<0.05). No histopathological ...
Hepato Renal Protective Effect of Origanum Majorana against Adverse Effect of Ivermectin in Rabbits
Ahmed Mohamed Elmahdy1*, Naglaa Mohammed Alkalamawy2
...xamination of the liver, kidneys were done. Results showed that the administration of O.M. extract restored the severely disrupted liver and kidney functions caused by ivermectin’s unfavorable effect to almost normal levels as well as the co-administration of O.M. extract significantly reduced the histopathological effect of ivermectin on the liver and kidney. From our findings we co...
Histopathological Effects of Cadmium on Various Tissues of Rohu (Labeo rohita) Fingerlings

Samia Azad1, Iram Liaqat1*, Riffat Iqbal1 and Uzma Rafi2

...ogical changes in liver, kidney and intestinal tissues of Rohu (Labeo rohita) exposed to sub lethal concentrations of heavy metal cadmium (Cd). CdCl2 was used as cadmium (heavy metal) source. Five concentrations of CdCl2 (0.2, 0.4, 0.6, 0.8 and 1.0 ppm of Cd) were tested in glass aquaria having 35 Rohu fingerlings in each. After exposure for six week, sections of intestine, kidney and liver were excised and studied histologi...
Immunological Responses of Chitosan and Aluminum Phosphate Nanoparticles as Novel Adjuvants for Inactivated Rift Valley Fever Vaccine in Sheep

Mohamed A. Hussein1, Bahgat A. Abd El-Rehman2, Kareem A. Eldin2, Mohamed Fouad Mansour1* 

... between groups in serum kidney function enzymes. Cytokine profile including IL-2 was markedly increased from 1st day after inoculation and elevated moderately till arrived to the peak at the 5th, 7th and 10th days post-vaccination in groups vaccinated with Ch-NPsV, AlP-NPsV and AlHV respectively. The results IFN-γ mRNA expression level was consistent with the results of cytokine profile including IL-2. Neutralizing antibody was increased from the 2nd we...
Effects of Green Anise (Pimpinella anisum) Ration Supplementation on Haematological and Biochemical Parameters and Liver and Kidney Structure in Guinea Pigs

Nkana Kontchiachou J. Gwladys1, Kouamo Justin2, Vemo Bertin Narcisse3*, Mweugang Ngouopo Nathalie4, Wang-Baa Temoa Christophe1, Awantu Christian Funwi1, Semi Yam Alphonsius1, Kenne Noubissie Christèle5, Tendonkeng Fernand5

...ections of the liver and kidney showed that their structures were not affected, following the green anise supplementation. Hence, the feed supplementation with green anise powder at 0.50% in guinea pigs boosted their immunity without side effects on the body functions.
 
Keywords | Green anise, Guinea pigs, Haemato-biochemical parameters, Kidney and liver histology, Supplementation
...
Modulation Impacts of Moringa oleifera on Thermo Tolerance Parameters and Blood Indices in Subtropical Ewes under Heat Stress
Aiman Al Mufarji1, Abd El-Nasser Ahmed Mohammed1*, Rashid Al Zeidi2, Haitham Al Masruri3
...tabolites, and liver and kidney functions. M. oleifera supplementation with a rate of 50 and 100 g to stressed ewes especially during high ambient temperatures and in subtropics is recommended.
 
Keywords | Blood, Heat stress, Moringa oleifera, Metabolites, Plasma
...
Ameliorative Role of Ethanolic Extract of Fagonia cretica on BPA-Induced Genetic Alterations and Histological Changes in Liver and Kidney Tissues of Rats
Dalia M. Aboelhassan1*, Inas S. Ghaly1, Noha E. Ibrahim2, Nermeen M. Shaffie3, Mariam G. Eshak1, Aboelfetoh M. Abdallah4, Ibrahim M. Farag1
...mdr1a and COX-1 genes in kidney tissues are evaluated. In addition, the histological architectures of these organs are examined. Bisphenol A (BPA) treatment causes over-expressions of the above mentioned genes, and induces massive damage to the histological architectures of liver and kidney tissues. In contrast, FCE treatment with different doses (3.3 g/Kg., 4.2 g/kg. and 5.0 g/kg) can inhibit the upregulation of such gene e...
Regulatory Effect of Angelica sinensis Polysaccharide on BMP-7/Smads/TGF-β1 Signal Pathway in Kidney of Rats with Radiation Injury

Xiaowei Huang1, Jinji Wang1, Zhun Yu2, Minghua Duan1* and Zhe Lin1*

...its protective effect on kidney injury and its influence on BMP-7/Smads/TGF-β1 signal pathway in irradiated rats. Total 60 Sprague Dawley (SD) rats were randomly divided into 5 groups: the normal (normal saline), model (normal saline), and low, medium, high dose of ASP groups (9.0, 18.0 and 36.0 mg/mL, 2.0 mL/kg·d, intragastric gavage once a day for 14 days). On the 15th day, all other groups received 60Co γ-ray irradiation with a total dose ...
Effects of Tetrahydroxystilbene Glucoside on VEGF and MMP-9 Protein Expression in Kidney Tissues of Rats with Diabetic Nephropathy

Xiaojing Liu and Zhongxin Li*

... 9 protein expression in kidney tissues, in order to reveal the mechanism of TSG. After 12 weeks of administration, compared with those in the DN modeling group, 24 h urine protein, serum creatinine (Scr), blood urea nitrogen (BUN), blood uric acid (UA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) significantly reduced in rats treated with TSG (20 mg/kg) (P<0.05), blood total protein (TP) and albumin (ALB) significantly increased (P&...
Time-Based Effects of Xanthium strumarium Extract on Rats

Hakan Kececi1*, Yasin Ozturk2, M. Bahaeddin Dortbudak3, Seda Yakut4, Gurdal Dagoglu5 and Merve Ozturk1

...etected in the liver and kidney tissues of the rats in the experimental groups. Both hematological and serum biochemical values (Ca, P, TBIL, ALT, AST, ALP, Urea, and Creatinine) were within the physiological limits in all groups. Consequently, in light of the obtained data, it was observed that the rats were not exposed to any toxic effect even when they consumed a stomach full of cocklebur fruit at once.

...
Effect of Metformin on P53 and its Interacting Partners in Breast Cancer Cell Line MCF-7

Mehroze Amin1, Afifa Yaqub1, Qindeel Fatima1, Rabail Hassan Toor1,3 and Abdul Rauf Shakoori1,2*

... MCF-7 and non-cancerous kidney cell line HEK2093. Analysis of the cytotoxicity and proliferation parameters showed that higher concentrations of metformin were cytotoxic for the breast cancer cells with EC50 of 22.75µM. Analysis of expression of p53 and the interacting partner genes showed that metformin upregulated p53 expression in a dose-dependent manner, while the expression of interacting partners is downregulated indicating that metformin exhibits...
Effect of Inhibitor UNC0642 on Expression of G9a and Its Proliferative and Apoptotic Markers in Breast Cancer Cell Line MCF-7
Afifa Yaqub1, Mehroze Amin1, Qindeel Fatima1, Rabail Hassan Toor1,3, Saira Aftab1 and Abdul Rauf Shakoori1,2*
...d normal human embryonic kidney HEK-293 cell lines were studied in response to treatment with different concentrations of UNC0642. Inhibition of G9a expression was observed in a dose-dependent manner in both cell lines with increasing UNC0642 concentrations. A dose-dependent downregulation of gene expression of proliferation marker genes (FGF-1, CCND1, and ENO2) was observed in both cell lines, whereas upregulation of tumor suppressor genes (AMPKα2 and E...
Interrelationship Between Rumen Fluid Minerals and Biological Tissues of Growing Lambs Fed Complete Feed Supplemented with Clionptilolite

Mutassim Abdelrahman1, Ibrahim Alhidary1, Majdi Bahaddi1,2, Mohsen Alobre1,3, Riyadh Aljumaah1 and Rifat Ullah Khan4, *

... and rumen fluid, liver, kidney, and meat were collected for mineral analysis by inductively coupled plasma optical emission spectrometry. Results indicate that there is no significant difference (P >0.05) between the concentration of all the elements in all lambs’ tissues, except for the concentration of aluminum in kidney and rumen fluid, as well as Mn in rumen fluid. Moreover, Mn concentration in rumen fluid was ...
Use of Growth Promoter in Feed: Tylosin Phosphate and Oxytetracycline Di-Hydrate Show Synergistic Effect on the Haematological Parameters and Biochemical Components of Broiler Chicken Blood
Irfan Shahzad Sheikh1, Syed Haseeb Shah1, Niamatullah Kakar2*, Mohammad Masood Tariq1, Muhammad Essa Kakar3 and Muhammad Zahid Mustafa1
...cal profile of liver and kidney of broiler chicken on days 14th and 28th. In conclusion, the study showed significant synergistic effect of TP and OXY on the Hb, RBC and liver enzymes such as ALT and AST that ultimately lead to promote the growth and can be used safely at sub-therapeutic levels in food and/or water of broiler chicken. The result further determined that the longer use (6 weeks) of AGPs had no harmful effect on blood, liver and
Nutritional Characterization of Edible Viscera of an Autochthonous Swine Breed of Assam, India

Rijumoni Daimari, Silistina Narzari, Jatin Sarmah* 

...e viscera namely, liver, kidney, spleen, heart, large intestine and small intestine of Doom pig of Assam, India. The samples were collected from semi-extensively reared pig farms of Kokrajhar district, Assam. The approximate composition range of these edible viscera was found to be: moisture 50.67-68.47%, fat 0.47-9.85%, ash 0.16-0.92%, protein 6.85-22.36%, carbohydrate 10.18-24.65% and calorie 124.31-198.16 k/cal/100g. Among the samples the maximum protein, c...
The Comparison of Moringa oleifera Seeds Oil and Fish Oil in Organ Weight and Blood Haematological Profile in Subchronic Male Mice

Andi Hiroyuki1,2,*, Refina Sastya Qomariyuti1, Najmah Nur Islami3, Vanessa Ayu Sumirat4, Neni Anggraeni5, Mas Rizky A.A Syamsunarno2,6 

...r, white fat tissue, and kidneys were weighed. The results showed that the average heart weight (0.120 grams) and white fat tissue (0.145 grams) decreased in the KSO group, as did RBC (8.285×106/μl), WBC (2,943×103/μl) and platelets (506 ,5×103/μl), but statistically there was no significant difference in hematological parameters, body temperature, GDP, body weight and liver and kidney weight p(>...
Effect of Microwave Exposed Feed in Different Containers on Histological Structure of Liver and Kidney of Adult Mice

Sajida Batool*, Sitara Shameem, Kainat Malik and Aneela Iram

...stology of the liver and kidney of mice. Forty adult male mice were randomly divided into four groups each of 10: Control group was given normal untreated feed, Direct group was fed on food pellets exposed to microwaves in oven tray directly, Glass group was given feed processed in the microwave oven within a glass container and Plastic group was given feed exposed to microwaves in a plastic container. The microwaves exposed feed of all treated groups was heat...
Effect of Cajanus cajan (L.) Supplementation on Growth, Nutrient Digestibility and Biochemical Indices of Giant Rat (Cricetomys gambianus Waterhouse, 1840)

Ekechukwu Esther1, Ohanu Chinenye1, Ossai Nelson1*, Elijah Okwuonu1, Hinmikaiye Funmilayo1, Ngene Innocent1, Andong Felix1, Ikegbunam Clara2, Echude Daniel1, Ekeh Felicia1 and Odo Gregory1

... the relative weights of kidney, liver and carcass cut parts. This study recommend that C. cajan be included in growing giant rats diets up to 25% of the dry matter.

...
In Vitro Antiviral Effect of Interferon Produced by Bovine Ephemeral Fever Virus against Rift Valley Fever Virus

Sahar M. Saber1*, Ahmed M. A. Albehwar2, Amani M. Abas3, Omaima A.A. Alshamandy2, Noha A. El said4 and Marwa Y. Hamad4

...and African green monkey kidney (Vero) cell cultures against RVFV. Such interferon was successfully obtained with high concentrations by both cell cultures up to a dilution of 10 -5 yielding positive antiviral effect against RVFV, especially when inoculated one hour post virus infection or simultaneously with the virus. So, we could conclude that the prepared interferon has an antiviral activity against RVFV and further studies are needed to provide more under...
Application of Various Diagnostic Approaches for Detection of Chronic Kidney Disease in a Local Household Cat

S. M. Ashraful Karim1, Md. Shohel Al Faruk2* 

...phy. 

...
Antidiabetic Efficacy of Zinc Oxide Nanoparticles and Empagliflozin Combinations

Saydat Saad Abd El-Megeed1, Walaa Yehia El-Sayed1*, Tarek Khamis2 

...d profile, and liver and kidney functions. A reduction was recorded in malondialdehyde (MDA), as well as improved catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). A reduction was found in the gene expression in the hepatic homogenate of Patched 1, hedgehog-interacting protein (Hhip-1), smoothened (SMO), glioma-associated oncogene homolog 1 (GLI1), and extracellular signal-regulated kinases 1 (ERK1). On the other hand, there was a s...
Effect of Fungicide Toxicity on Apoptosis, DNA Damage, and Antioxidant Enzymes in Van Fish

Aslı Çilingir Yeltekin

...Px) activity in Van fish kidney and muscle tissue after 24., 48., 72., and 96. h of tebuconazole exposure at a concentration of 2.5 mg/L. The obtained results indicated that caspase-3, 8-OHdG, and MDA levels significantly increased compared to the control (p < 0.05). The kidney and muscle tissues indicated a significant decrease in antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT), and glutathione ...
A Review on Effects of Heavy Metals on Aquatic Animals and Public Health Significance

Maria Al Mazed1*, Md. Ashikur Rahman1 and Sk. Istiaque Ahmed2

... in liver and damages in kidney. They are also causing infertility in animals. Chronic exposure and excessive concentrations are also deleterious for the normal physiological functions of human. Consumption of fishes contaminated with toxic metals are neurotoxic and carcinogenic to blood, lungs, kidneys, bones, liver and other vital organs of human. The present review outlines the contamination of aquatic environment with he...
Growth and Haematological Response of Broilers Raised at High-Density Pens and Fed Germinated Papaya Seed and Chitosan Blend

Sugiharto Sugiharto*, Ikania Agusetyaningsih, Endang Widiastuti, Hanny Indrat Wahyuni, Turrini Yudiarti, Tri Agus Sartono 

...oduction performance and kidney health while alleviating muscle protein catabolism in high-density pens from days 15 to 28.

Keywords | Broiler, Chitosan, Germinated seed, High stocking density, Stress 

...
Sappan Wood Ethanol Extract (Caesalpinia sappan L.) as Adjuvant and Substitute of Iron Chelator in Acute Iron Overload Rat Model

Rezqita Putri Pitaloka1, Kartiawati Alipin1, Mas Rizky A.A Syamsunarno2, Gemilang Lara Utama3, Ramdan Panigoro2, Ratu Safitri1* 

...m, liver, heart, spleen, kidney, and brain. The results showed that the effective dose was the combination of 75 mg/kg BW DFP and 50 mg/kg BW SWEE as an adjuvant, while 200mg/kg BW SWEE can be used as a substitute for chelators, especially in the heart. The decrease in serum and organ iron levels due to the combination of DFP and SWEE showed their ability to act as an adjuvant and substitute for chelators.

Keywords | Adjuvant, Deferiprone, Iron levels,...

Physiological Activity and GC-Mass Analysis of Trigonella strangulata, Trigonella filipes and Trigonella uncinata Against Ethanol-Induced Hepatorenotoxicity in Rats
Shahrokh Mojarradgandoukmolla* and Hasan Akan
...he function of liver and kidney and antioxidants status against ethanol-induced hepatotoxicity.
...
Developmental and Pluripotent Genes in Rat Adult and Neonatal Kidney

Sumreen Begum, Atta-ur-Rahman and Asmat Salim*

...ing the role of genes in kidney with respect to their specific mechanism in renal development is imperative to regeneration. The purpose of this study is to analyze systematic identification of genes with respect to nephron lineage and pluripotency during postnatal renal development and at adult stage of rat kidney. In the current study, the mRNA levels of nephron genes were analyzed by reverse transcriptase PCR in neonatal ...
Effects of Naringenin on Cadmium-Induced Changes in Blood Physiological and Biochemical Indices and Kidney Damage Among Rats

Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Mengli Jiang and Jicang Wang*

... biochemical indices and kidney damage among rats were studied. Twenty-four male Sprague–Dawley rats were randomly divided into four groups: control group, Cd-treated group (1 mg/kg b.w. CdCl2), Nar-treated group (100 mg/kg b.w.), and Cd + Nar-treated group (1 mg/kg b.w. CdCl2 + 100 mg/kg b.w. Nar). They were treated for 4 weeks, and then the blood physiological and biochemical indicators were assessed. The levels of glutathione (GSH), malondialdehyde (M...
Antidiabetic and Antioxidative Potentials of Aqueous Extract of Cola Acuminata Leaves in Alloxan-Induced Diabetes Mellitus in Male Albino Rats

Owolabi Olutunmise Victoria1*, Saka Olusola Stephen2, Olashinde Oluwaseun Ruth1, Alli Smith Yemisi Rufina3

...ody organs (eyes, liver, kidney and testes) eventually suffer damage as a result of elevated blood glucose levels, which are a defining feature of the metabolic disorder known as diabetes mellitus. Researchers are in search for safe drugs that can bring a total recovery from diabetes. Thirty (35) male wistar rats were divided into six (7) groups of five animals each to study the antidiabetic and antioxidative properties of young Cola acuminata leaves aqueous e...
Effect of Different Management Systems on Growth and Carcass traits of Post Weaned Male Kachhi Lambs

Shakeel Ahmed Tunio1, Muhammad Naeem1*, Atique Ahmed Behan1, Asmatullah Kaka2 

...x, loin and flank, legs, kidneys, and weight of liver of lambs in group B was recorded significantly (P<0.05) higher than the lambs of group A managed under intensive and semi-intensive management systems respectively. Based on the present study, it was concluded that weight gain, body length, chest girth and height at withers were significantly increased in the lambs of group B kept under a semi-intensive management system as compared to lambs in group A r...
Toxicity Studies of Pimpinella anisum in Albino Mice

Aamir Mushtaq1*, Fatima Habib2, Umar Farooq Gohar3, Abdul Malik4 and Mobasher Ahmad2

...duce considerable liver, kidney and blood toxicity. So, its use in therapeutic doses is considered safe for the treatment of different disorders. However, more scientific work is needed to explore its fetotoxicity and genotoxicity.
 
Novelty Statement | In this article, we contributed a new thing by providing scientific evidences regarding acute and chronic toxicity of Pimpinella anisum that P. anisum i...
In Vivo Anti-Trypanosomal Activity of Basil Extract on Trypanosoma evansi

Esam A Razin1, Hassan Sobhy2, Tarek R. AboElnaga1, Asmaa A. Darwish1*, Rasha S. Mohammed1

...obtained from the liver, kidney, heart, lung, spleen, and brain on the 49th day, stained, and histopathologically examined. Although, both treatments presented a significant improvement (P<0.05) in their parasitological and clinicopathological results, DAG suffered from lower levels of GR than BG, and its organs microscopical examination clarified severe lesions similar to TG. While, BG clinicopathological parameters and histopathological results were so cl...
Clinicopathological Studies on Brucellosis in Sheep and Goat at Matrouh Governorate, Egypt

Asmaa A. Darwish*, Mona A. Mahmoud, Adel M. El-Kattan 

... hypoglycemia, increased kidney function tests, and oxidative stress than the diseased does. Total antioxidant capacity (TAC) and Zn had the highest likelihood ratios among the suggested markers with acceptable sensitivity, specificity, PPV, NPV, and accuracy rates, and their combination yielded better values. The study concluded that the clinicopathological alterations associated with ovine and caprine brucellosis are a mirror for the immune response against ...
Comparative Prevallance and Pathological Changes on Camel Brucelosis at the Selected Slaughterhouses in Garissa County, Kenya

Abdirahman Barre*, Karanja D Njuguna, Bebora Lilly Caroline and George Chege Gitao

...isceral organs (lung and kidney) 6 (3.7%). Histopathology of sero-reactors revealed; cellular infiltration in lymph node 9 (5.6%), hypoplasia of lymphocytes 6 (3.7%), collapse of alveoli 5 (3.1%), oedema, congestion 4 (2.5%), fatty degeneration in liver 3 (1.8%) and haemorrhages in kidney1 (0.6%). In conclusion, brucellosis is prevalent in camel in Garissa County. Further extensive research should be done in the whole countr...
Effect of various concentrations of Zinc on Peroxidase activity of Catla catla

MARIUM ASLAM, MUHAMMAD JAVED, FAIZA AMBREEN* & FARIHA LATIF

...ctivity in the liver and kidney of Catla catla. To check the concentration based effect, C. catla were exposed, separately, to 96-hr LC50 of zinc and its sub-lethal concentrations viz. 2/3rd, 1/4th and 1/5th of LC50 for 30 days at constant laboratory conditions. After 30-day, the fish were sacrificed and their liver and kidney were analyzed for peroxidase enzyme activity. Change in activity of peroxidase enzyme in the fish e...
Label-Free Quantification based Proteomic Analysis of Serum Obtained from Henoch–Schönlein Purpura Patients before and after Zhenbao Pill Treatment

Wuritunashun*, Burenbatu, Narenqiqige, Jiuguniang, Eerdunduleng, Shuanglian Wang, Cuiqin Gong, Hashengaowa, Huizhi Jin, Baiwurihan and Chunhaizi

... joints, intestines, and kidneys. The most distinctive characteristic of this type of vasculitis is a purple rash that often affects the thighs and buttocks. The Zhenbao pill, containing several medicinally important compounds, has been found to be effective against a variety of neurological and immunological illnesses. We used a label-free quantification (LFQ) proteomics approach to investigate the effect of the Zhenbao pill on the differential serum protein ...
Chia Seeds Oil Inhibits Hepatic Resistance to Doxorubicin Via Suppressing Cyp3-A4 and Mrp-1 in Male Albino Rats

Shaimaa A.Tawfik2,3, EL S.T. Awad1*, Hoda O.Abu Bakr1, Amira M.Gamal-Eldeen4, Esmat Ashour2, Ismail M.Ahmed1  

...on in sections of liver, kidney and heart tissues were confirmed these findings. In liver tissues, DOX resulted in an observable induction in CYP3A4 and MRP-1, while CSO/DOX showed an inhibition in both proteins. c-MYC was dramatically decreased in DOX group, while CSO/DOX group restored cellular c-MYC. CSO/DOX group resulted in a remarkable inhibition in the tumor suppressor miRNA (let-7a) compared to DOX-induced expression. Moreover, miR-122, as negative re...
Therapeutic Effects of Rocket Leaves (Eruca sativa) against Hepato-Renal Toxicity Caused by Xylene in Wistar Rats

Rahma Boukarine*, Leila Hamdi and Kamel Khelili

...cal changes in liver and kidney tissue were characterized by sinusoidal and tubular dilatation, hemorrhage, hepatocyte necrosis and glomerular degeneration, the effect of ESAE was effective in modified these damages into semi normal.To conclude, xylene administration induced hepatotoxicity and nephrotoxicity in wistar rats, while the combination of this solvent with rocket aqueous extract (Eruca sativa) attenuated this toxicity thanks to its antioxidant proper...
Genetic Polymorphism of ACE (I/D) is Associated with Diabetic Nephropathy in Pakistani Subjects
Umara Amir ud Din1, Waqas Ahmed Khan1*, Khurrum Shahzad1,2, Basharat Ali3, Misbah Hussain1,4 and Fazli Rabbi Awan4
..., also known as diabetic kidney disease (DKD), is a leading cause of morbidity and mortality in diabetic patients. A major cause of DKD is high blood pressure (hypertension) which remains uncontrolled chronically. Renin angiotensin aldosterone system (RAAS) is a major regulator of the blood pressure, electrolytes and fluid homeostasis. RAAS plays a key role in modulating the sodium metabolism, vasoconstriction, vascular tone and renal hemodynamics. Angiotensin...
Evaluation of the Anticancer Effect of Saussurea costus Root Extract Against Induced Hepatic and Renal Cancer in White Mice: A Histopathological Study

Zahra Abdulameer Al-Zayadi1, Hana Kadum Shanan1, Al Salihi Karima Akool2* 

...E/ high dose). Liver and kidney samples were collected from all mice during different experiment periods, kept in 10% neutral buffered formalin, and sent for histological analysis. No abnormal histological features were seen in liver and kidney sections from the control and other mice groups before various treatments. The various treatment groups revealed diverse histopathological changes compared to the control groups. Vari...
Pymetrozine Causes Physical, Haematological, Blood Biochemical and Histopathological Abnormalities in Bighead Carp (Aristichthys nobilis)

Munir Ahmad1, Abdul Ghaffar1, Riaz Hussain2* and Rifat Ullah Khan3*

...l profile, biomarkers of kidneys, triglyceride, glucose, and cholesterol in fish treated with pesticide. Histopathological examination showed renal tubular degeneration, widening of Bowman’s space and necrosis in kidneys. Different histopathological lesions in liver of treated test specimens including edema, hemorrhages, atrophy of hepatocyte and hepatocyte having eccentric nuclei. In the brain, different histological ...
Erlotinib and Garcinia Cambogia Prevent Adenine Induced Nephrotoxicity in Adult Male Albino Rats Through Modulating EKR1/2, STAT3, and p53 Apoptotic Pathways

Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1 

...enine on the rat’s kidneys. Methods: Forty animals were divided into four groups: Control group: received normal vehicle, adenine group: received orally (50 mg/kg/day) that is subdivided into 3 groups: adenine group, garcinia cambogia (GC) group: received orally GC (200 mg/kg/day)+adenine, and erlotinib (E) group:  received 80 mg/kg/day + adenine. Antioxidant biomarkers and renal function tests were evaluated. Hist...
Therapeutic Effect of Heterologous Platelet-Rich Plasma on Third-Degree Burn Wound in Rabbits

Kazi Afsana Homayra Orchy1, Mst. Antora Akter1, Nelema Yesmin1, Md. Moshiur Rahman Khan1, Marzia Rahman2, Md. Mahmudul Alam1* 

... Regarding the liver and kidney functions, the serum levels of liver enzymes (ALT, AST and ALP) and kidney function biomarkers (creatinine, BUN) showed a significant increase in burn patients of the saline-treated control animals, whereas, the animals treated with hPRP exhibited the normal range of these functional biomarkers. On the basis of morphology, histopathology, and biochemical analysis, it can be concluded that PRP,...
Mineral Supplementation in Diseased Buffalo Calves and Impact on Health, Behavior, and Clinical Blood Profiles

Walaa I. Mohameden1, Haidy G. Abdel-Rahman2, Ibrahim M. Hegab3* 

...onditions, and liver and kidney functions. Significant (P < 0.05) increases in plasma proteins, zinc, and copper were recorded, while malondialdehyde, TNF-α, and MMP-9 significantly (P < 0.05) decreased. Furthermore, buffalo calves showed significant ( P < 0.05) increases in both ingestive and locomotor activities, while grooming and lateral recumbency significantly (P < 0.05) declined. Mineral supplementation had a favorable effect on anima...
Will Typhoon Cause Great Damage to Juvenile Hybrid Grouper (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀) under Indoor Flowing Seawater Aquaculture Model?

Jing Hu1,2,3 and Zhenhua Ma1,2,3*

...damage of gills and head kidneys and the changes of serum indicators of hybrid grouper (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀) in 96 h. The results showed that the survival rate of each group was 100%, and no abnormal behavior was observed in juvenile fish. The damage performance in gill generally deepened over time. Lamellar fusion and curling of secondary lamellae also deepened from C group to T3 group. The proportion of interrena...
Experimental Induction and Control of Cellulitis in Broiler Chickens

Mohamed Mahrous Amer1*, Hanaa Sayed Fedawy2, Hoda Mohamed Mekky2, Khaled Mohamed Elbayoumi2, Ahmed Ali El-Shemy3, Mohamed Abd El-Rahman Bosila2

...al parameters, liver and kidney functions were also recorded. Colistin+ Doxycycline combination (Doxyforte®) was used to control the infection. Clinically, site of infection was appeared red, swollen accompanied with increased skin thickness, postmortem lesions in the 3rd day post infection with s.c. yellowish suppurative exudates, pericarditis and perihepatitis were prominent E. coli infected with hepatic subcapsular hemorrhage mostly in S. aureus groups....
The Possible Protective Role of Aqueous Extract of Propolis against Hepatotoxicity, Renal and Testicular Toxicity Induced by Cadmium Chloride in Male White Rats

Khalid M. Al-Syaad1,2

... causes decreased liver, kidney, and testicular functioning, as well as significant histopathological abnormalities. Therefore, the present study investigated the toxic effect of CC and the protective effect of Propolis aqueous extract on CC-induced toxicity in male rats. A total of 24 Wistar albino rats were included in this study, divided into four groups; each group containing 6 rats and administered the treatment doses orally by gavage for 28 days. Control...
Deleterious Effects of Mercuric Chloride Toxicity Initiated Partially from Physiological Disorder of Kidney, Immunocytes and Redox System, can be Reversed by Resveratrol Administration

Rusul Adnan Dawood, Hasan F.K. Alghetaa*

The Protective Effect of Ellagic Acid on Cyclophosphamide Induced Renal Damage in Rats

Muhammad Nasir Bhaya1,2* and Hikmet Keles2

...hological examination of kidneys revealed hyperemia, epithelial degeneration, swelling, cystic dilatation and luminal proteinaceous material in tubuli, congested and hypercellular glomeruli and also inflammatory cells infiltration in the cortical and medullary area in CP group. Significant decrease of pathological lesions was found in CP+EA groups especially in the CP+EA75 group. In immunohistochemical sections, 8-hydroxy-2-deoxyguanosine (8-OHdG) and hypoxia-...
Evaluation of Protective Effect of Naringenin on Cadmium-Induced Kidney Injury in Rats

Chen Zhao, Lulu Ding, Ying Ye, Congying Kou, Haoran Xiao, Jing Zhu and Jicang Wang*

...induced autophagy in the kidney and the antagonistic effect of Nar on Cd are still unclear. In this study, SD rats were treated with Cd and/or Nar to investigate the protective effect of Nar on Cd-induced toxicity. The rats were treated for 4 weeks. The histopathological observation, oxidative stress index and autophagy-related gene expression level were detected of rat kidneys. The results showed that Cd caused the patholog...
Shenhong Buxue Granules Improve the Vascular Endothelial Injury and Hematopoietic Function in Rats with Aplastic Anemia

Xiaowei Huang, Yajie Wang, Jia Zhou, Junxiu Liu, Zhe Lin and Ruili Li*

...a;B (NF-κB) p65 in kidney were significantly decreased. HandE staining on renal showed that SBG groups had a certain protective effect on renal injury, especially the high-dose group. In conclusion, SBG may improve hematopoietic function and improve vascular endothelial injury in AA model rats by regulating TLR4/NF-κB signaling pathway.

...
Antibacterial Effect of Co-Administration of Diclofenac and Ciprofloxacin against Infection Induced by Resistance E coli (O157-H7) in Female Rabbits

Frah Razzaq Kbyeh1, Ahmed N. Abedsalih2* 

...ination clear damage in kidney tissue specimens from positive group control (PC,DC) observed, with hyperplasia endothelial cell swelling, ulcer in the lining membrane, compared with(CIP,COM1and COM2). Altogether, we can conclude that the diclofenac has the required anti-boiflim effects to support ciprofloxacin effect and the body responses against urinary tract infection consequences of E coli o157 :H7
 

...
Review on Commonly Used Veterinary Anesthetic Drugs in Small Ruminants

Abnet Mekonnen1*, Kadir Abderehman1 and Feti Seyaka2

...iver and excreted by the kidneys. Monitoring vital signs continuously during anesthesia will provide early warning of potential problems and emergencies that may be averted by appropriate and quick corrective actions.

...
Polymorphisms of Somatostatin Receptor (SSTR-1) Gene and its Relationship with Carcass Traits in Iraqi Awassi Sheep

Dhurgham K. Seger1, Rahman H. H. Al Qasimi2, Azhar A. Jaffar3, Salah H. Faraj4, Ahmed I. Ateya5* 

...rcentage, and spleen and kidneys weights. This study highlights the possible efficiency of using SSTR1 as candidate marker for carcass traits in sheep. 

...
Administration of Bee Pollen, Nigella sativa Oil, and their Combination as a Strategy for Improving Growth Performance, Immunity, and Health Status of Newborn Friesian Calves During the Suckling Period

H.A. El-Nagar1, A.M. El-Hais2, M.S. Mandouh2, W.M. Wafa1*, A.H. ABD El-Aziz, K.A. Attia4 

..., weight gain, immunity, kidney and liver functions, and antioxidant status of female newborn Friesian calves. This administration is considered a good strategy for raising dairy calves in dairy farms.  

...
Effectiveness of Cinnamomum cassia against Liver and Kidney Biochemical Assay and Hematology in Bisphenol-A Induced Rats

Tehreem Iqbal1, Roheela Yasmeen1* and Faheem Hafeez2

...e amino transferase) and kidney (Blood Urea Nitrogen, Creatinine, and Uric acid) biomarkers were assessed. The highest levels of ALT and ALP were linked to liver injury and a higher weight in the liver were observed in BPA treated rats as compared to the control group. Similarly, an increase in blood parameters were recorded in BPA treated rats followed by post -treated rats and pre- treated group. It was concluded by the study that BPA have pronounced adverse...
Clinicopathological Studies on Urine Retention in Barki Rams

Asmaa A Darwish* 

...globulin, triglycerides, kidney function tests, and liver enzymes concentrations and a significant (P<0.05) decrease in IL-10, antioxidants, total protein, albumin, glucose, total lipids, cholesterol, minerals, electrolytes, and trace elements concentrations. The DG hemogram clarified a significant (P<0.05) microcytic hypochromic anemia accompanied by neutrophilic leukocytosis and lymphocytopenia, and their iron profile characterized by a significant (P...
Effect of Lead Toxicity on Japanese Quail and its Alleviation with Dietary Selenium

Nusrat Habiullah1*, Shah Nawaz Kumbar1, Fahmida Parveen Samo1, Shamusuddin Bughio2, Asghar Ali Kamboh3, Burirah Rehman Talpur1 

...amination, the liver and kidney samples were collected for gross and histopathological examination. The mild clinical signs like reduced feed and water intake, and weight loss in group C, D, E and F was noted; whereas diarrhea, muscular tremors, and lethargy were observed in group C and D. Significantly increased (p <0.05) GGT, bilirubin, creatinine and uric acid levels were recorded in C and D (lead toxicity groups), as compared to control group; whereas ...
Identification of ADPKD-Related Key miRNAs by Constructing a miRNA-mRNA Interaction Network and Experimental Verification

Hui Fang*, Kai Xue and Teng Yang

...omal dominant polycystic kidney disease (ADPKD). Fifty RNA samples from Gene Expression Omnibus (GEO) database were obtained to identify differentially expressed miRNAs (DEMs) and genes (DEGs) in the progression of ADPKD. Functional annotation and enrichment analysis of DEG were performed. iRegulon was used to construct the miRNA-mRNA network and predict related transcription factors (TFs) associated with ADPKD. The function of miRNA network was explored by an...
Residual Levels of Toxic Metals and Estimation of their Dietary Intakes, and Non-Carcinogenic Risks Associated with the Consumption of Meat and Edible Offal of Camel in Egypt and Saudi Arabia
Saad Ibrahim Al-Sultan1, Mariam H.E. Khedr2, Ahmed S. Abdelaziz3, Mostafa M. Abdelhafeez4, Tamer Mohamed Gad5, Sabry Mohamed El-Bahr6,7*, Sherief Abdel-Raheem1,8 and Hesham A. Khalifa3
... including round, liver, kidney, and tongue in samples collected from Zagazig slaughterhouse, Egypt and Al-Ahsa slaughterhouse, Saudi Arabia. Dietary intakes and potential health risks associated with the consumption of camel meat and edible offal among Saudi and Egyptian populations were additionally calculated in a comparative way. The obtained results indicated that edible offal including liver, kidney and tongue had high...
Impact of Usage of Fruit Waste on Growth Performance, Carcass Characteristics, Organs Weight and Blood Chemistry in Broilers

Muhammad Shahid Nisar1*, Ahmad Kamran Khan1, Ghulam Fatima2, Irfan Ahmed4, Khizar Sami Ullah2 and Syeda Amber Hameed2,5

...creas, lungs, spleen and kidney) resulted significantly difference (p<0.05) and affected with FW supplementation. Broiler fed with 25% and 50% FW affected positively (p<0.05) to lymphocytes, granulocytes, red blood cells, hemoglobin, mean corpuscular hemoglobin and mean platelet volume while D3 also resulted positively in results of mid-range absolute count. While birds fed D4 (75% FW) resulted significant difference (p<0.05) in mean platelet volume. ...
Growth Performance, Immunity, and General Health Status of Newborn Friesian Calves Fed Milk Supplemented with Propolis, Thyme, or their Combination, as Antioxidants, During the Suckling Period

Hamdy Abdala El-Nagar1, Abdelaziz Mohamed Elhais2, Ayman Hassan Abd El-Aziz3, Wael Mohamed Wafa1, Mohamed Sobhy Elsayed Farrag2, Moataz Ibrahim Badawy1, Safaa Elsayed Salah Atia2

...iciency, liver function, kidney function, total antioxidant capacity, and immune response of Friesian calves from 7 to 105 days of age as an experimental period. Newborn male calves (n=20) weighing 37.92±0.63 kg were divided into 4 groups, five calves/group. The first group (G1, control) included animals without treatment. During the whole suckling period each animal in G2, G3, and G4 daily received milk supplemented with propolis (5 g), thyme oil (2 ml...
Effect of Inorganic Selenium Supplementation on Thyroid Hormone and Redox Status in Broiler under Dexamethasone Induced Stress

Afshan1, Asad Ullah2*, Imad Khan2, Rafiq Ullah1, Tahira Tayyab1, Fatima Syed3, Raheela Taj3, Shumaila Gul4, Faiza Khan5, Ibad Ullah Jan6, Syed Weqas Ali7 and Assad Ullah8 

...ted from liver, muscles, kidney and whole blood. The whole blood was centrifuged for further analysis. The redox status and thyroid hormones were measured through commercially available kits. The current study resulted that selenium supplementation improved(P≤0.05) the catalase level in the liver and muscles which fight against the free radical and reduce oxidative stress. In the blood serum the catalase and Malondialdehyde (MDA) both shows significant (P&l...
Histophysiological Effect of Rosuvastatin on the Kidney in Male Albino Rats

Haneen Imad Al-Sultani1*, Ahmed Obaid Hussain1, Hazar Shakir Saleh2 

...lyses were performed for kidney function, including cystatin C and vitamin D3. Then, the rats were dissected, and kidney tissues were taken for histological study. Male rats treated with rosuvastatin showed an elevated cystatin C level and increased vitamin D3. At the same time, the results of the microscopic examination showed significant histopathological changes in the kidneys of t...
Effect of Nutritional Content on Artificially Supplied Seed Utilization of Wintering Birds in a Mixed Forest, South Korea
Hyun-Su Hwang1, Jae-Kang Lee2, Tae-Kyung Eom2, Seung-Hun Son3, Dong-Ho Lee2, Hyeongyu Ko2 and Shin-Jae Rhim2*
...types of food resources (kidney beans, brown soybeans, and peanuts) based on their energy per 100 g. We supplied 200 g of each food type at the feeders. Feeders were recorded with a digital camera (HDR AS15, Sony, Tokyo, Japan) for 2 h. This was conducted 3 times per day. The videos were then analyzed to determine the frequency of visits, duration of stay at the feeder, frequency of pecking on food items, and number of consumed food items. Moreover, social beh...
Virologic Detection and Molecular Characterization of Rabies Virus in Delta Region, Egypt
Morcos Ibrahim Yanni1* and Eid Elsaid Abdelaziz2
...isolated on baby hamster kidney cell culture. Of them, three confirmed rabies samples were picked to determine their N and P genes by sequencing further (at the level of nucleotide and amino acid). The N and P genes in this study isolates have a great similarity to previous isolates from Egypt as well as adjacent bordering countries. At the N and P genes level, the isolates bear little resemblance to the vaccinal strains (Evelyn-Rokitnicki-Abelseth, Pasteur, t...
Effect of Whole Allium cepa Linn. Bulb Slurry on Haematological and Biochemical Components of Clarias gariepinus Juveniles

Oghenebrorhie M. Oghenochuko1,4*, Olubukola T. Adenubi3, Olusola L. Ajayi3, Fakilahyel M. Mshelbwala3, Johnny O. Olukunle3, Samson A. Rahman3 and Godfrey N.O. Ezeri2

...moral changes, liver and kidney function and histopathology of some visceral organs were examined. Proximate composition of the bulb was determined. Onion bulb revealed presence of carbohydrate (7.82%), protein (4.48%), crude fiber (1.68%), iron (0.5mg/l), magnesium (210mg/l), flavonoids (0.46%), saponins (0.28%), tannins (0.95%). PCV, Hb, RBC and WBC were increased in all treatments but values were higher in bath treatment for RBC (3.0×1012/L), PCV (32....
Lumpy Skin Disease Virus Identification in Different Tissues of Naturally Infected Cattle and Chorioallantoic Membrane (CAMS) of Emberyonated Chicken Eggs Using Immunofluorescence, Immunoperoxidase Techniques and Polymerase Chain Reaction

El-Kenawy, A. A. and El-Tholoth, M. S.

...mph nodes (6), lung (4), kidney (3) and liver (3)). Hyperimmune serum was prepared against reference LSDV (Ismailyia88 strain). Immunofluorescence (IF), immunoperoxidase (IP) techniques and polymerase chain reaction (PCR) were used in our study. Chorioallantoic membranes (CAMs) of embryonated chicken eggs (ECEs) were inoculated with Known previously isolated and identified LSDV of 104 8 EID5d0.1 ml for virus follow up in these CAMs by using IF and IP technique...
The Effect of Some Electrolytes on the Susceptibility of BHK to FMD Virus

Mansour, Abeer E.M.; Khodeir, M.H. and Hussein, A.M.H.•

...usly seeded baby hamster kidney (BHK21) cell culture. Each batch was composed of 15 roller cell culture vessels where the first batch represents the blank virus while the second batch was treated with 1ml of 1 mM calcium chloride (CaC12)/bottle in the inoculum's medium and the third batch received 1gm of mono basic sodium glutamate (MSG) /liter. Titration of individual bottles and pooled harvests of FMDV and complement fixing antigen revealed that CaC12 and MS...
Pathological and Virological Studies on Bovine Ephemeral Fever

Eman, M. Abd El-Mottaleb.*; Ahmed, S.A."; Maysa, H.M.*; Salem, S.A.* and M. M. El-Shenawy

...d tissues (bovine liver, kidney, lymph nodes and lung) for BEFV isolation and propagation on Vero, BHK21 cell lines and baby mice. Identification was done by both Indirect Fluorescence Antibody Technique (IFAT) on tissue culture and inoculated mouse brain, while immunoperoxidase technique was done on bovine lung. Haematological examination revealed leucocytosis accompanied with neutrophilia (immature form) and lymphopenia. Histopathological examination clarifi...
Effect of Production Systems on Carcass Traits, Visceral Development and Meat Quality in Fattening Rabbits

Divanildo Outor-Monteiro1,2,3*, José António Silva2,3,4, José Luís Mourão1,2,3, Victor Pinheiro1,2,3

...ve organ weights (liver, kidney, lung and heart), decreased hind part proportions and lower cooking loss values. Furthermore, the hind legs of these rabbits had a greater proportion of muscle and less bone, along with increased luminosity and reduced redness. In conclusion, production systems exert influence on specific carcass and meat characteristics.
 
Keywords | Rabbit, Housing system, Slaughter-age, Carcass, Meat
...
Prevention of Rhabdomyolysis-Induced Acute Kidney Injury via Attenuation of Oxidative Injury and Inflammation by Cinnamic Acid Coated Gold Nanoparticles in Mice
Rehan Ahmed Siddiqui1,2*, Shabana Usman Simjee2,3, Nurul Kabir4, Muhammad Ateeq3,5, Kevin Joseph Jerome Borges6, Muhammad Raza Shah3 and Rahman M. Hafizur2
...t-align: justify;">Acute kidney injury (AKI) is a life-threatening condition which may result from extensive injury to the kidney due to various causative agents. Renal insult can result from ischemia, drugs, renal obstruction, inflammation, or extensive muscle injury. The current study focused only on Rhabdomyolysis-induced AKI. We make an attempt to uncover the preventive efficacy of cinnamic acid (CA) and CA-conjugated go...
The Hypoglycaemic Mechanism of Camel Placenta Powder on Streptozotocin Induced Type 2 Diabetic Rats

Xiangmei Chen, Burie Bao* and Mo Degema

...the weight of the liver, kidney, or pancreas. After STZ modelling, the blood glucose levels of rats noticeably increased. However, the blood glucose values of rats decreased substantially due to camel placenta treatment from the 4th to the 6th week. Camel placenta dramatically reduced the serum HbALc and GLUC3 content in hyperglycaemic rats. Dry CPP had a down-regulating effect on the levels of SGLT2 and GLUT2 protein, SGLT2 mRNA and GLUT2 mRNA in the
Impact of Dietary Arginine Supplementation on Hemato-Biochmical, Histological, Antioxidant, and Immunity Variables of Geese under Heat Stress Condition in Egypt

Eman Said El-Hadad*, Hesham Ahmed Madian, Mahmoud A.E. Hassan, Mohamed Fahmy Saad, Abdelghany M. El-Shhat, Entesar Zakaria Eliraqy

...al parameters, liver and kidney function, and antioxidant markers were determined. Results showed that RBCs and lymphocyte increased, while neutrophils and Neut./Lymph ratio decreased in G2, however, Hb, PCV, RBCs, MCH, and lymphocyte increased, while WBCs, neutrophils, and Neut./Lymph ratio decreased in G3 in comparison with G1. Plasma total protein and albumin increased, while total cholesterol, triglycerides, LDL, urea, creatinine, AST, and ALT decreased in...
Effect of Inorganic Selenium on Blood Biochemistry under Dexamethasone Induced Stress in Broiler Chicken

Irfan Ullah1, Asad Ullah2*, Tahira Tayyeb1, Rafiq Ullah1, Muhammad Hanif1, Faiza Khan3, Imad Khan2, Raheela Taj4, Fatima Syed4, Shumaila Gul5, Muhammad Sadeeq6, Muneeb Islam7, Arsalan Khan8 and Khudija Ghani9

...um on the liver enzymes, kidney function and changes in biochemical parameters of broiler chicken under dexamethasone (DEX) induced stress. The day old, two hundred (n=200) chicks were bought from commercial hatchery and randomly divided into five groups with eight replicas(n=5) in each group. Broiler chickens were fed with starter and finishing commercial corn based basal diet (BD) with different doses of inorganic Selenium (Se) powder. Group-A was kept negat...
The Effect of Dried Probiotics on Broiler Performance and Kidney Function

Diding Latipudin*, Chitra Kumalasari, Lovita Adriani

...d probiotics can protect kidney cells from stress and free radicals in late-phase laying hens, which can be demonstrated by normal levels of creatinine, uric acid, and urea, thereby increasing productivity. The treatment consists T0: basal rations, T1: basal rations + 100% CM dried probiotic, T2: basal rations + 75% CM + 25% fermented MBM dried probiotic, T3: basal rations + 75% CM + 25% SM dried probiotic, and T4: basal ration + 50% CM + 25% MBM + 25% SM. Eac...
The Immune Response and Passive Protective Abilities of the Outer Membrane Lipoprotein Slp of Aeromonas hydrophila against the Major Pathogenic Bacteria of Freshwater Aquaculture in Fish
Sijie Jian1,2,3,4, Wei Sun1,3, Jia Chao1,2, Na Rong1,4, Xiang Liu1,2,3,4* and Chen Chen1,2,3,4*
...creased (p < 0.05) in kidneys and spleens after challenging with A. hydrophila and P. fluorescens; and reduced injury to the kidneys, spleens and intestines; there was no significant change in the antioxidant-related factors of MDA, SOD, CAT and GSH-PX. Therefore, Slp has passive protection (A. hydrophila) and passive cross-protection (P. fluorescens) abilities and it can boost resistance to infection using major freshwat...
Histopathological and Cytogenetic Effects of Hyperdoses of Vitamin D in Female Rats

Ghaith Z. Hasan Al-Askari *, Eman H. Yousif Al-Taee

...ls. Some sections of the kidneys show vacuolation of mesangial cells in the glomerular tuft. Muscles of treated rats revealed severe histopathological changes under stress from both doses of toxic cholecalciferol, also showing the widespread mineralization of muscle fibers. From this study concluded that both doses of vitamin D can be toxic to organisms at higher levels, so they need to be used carefully and should not be taken excessively.
 <...
Health comparison of farm-raised and wild-caught Labeo rohita (Cypriniformes: Cyprinidae)

NAILA MALKANI*, IRFAN ISHAQUE, KHALID SHAHBAZ, RIZWAN ULLAH KHAN, ARIFA SHABBIR & ATIF YAQUB

...he two groups to perform kidney and liver enzymes profile and histological analysis. The results showed that the values concerning liver function enzymes were significantly altered in wild-caught fish as compared to farm raised fish. Also, significant difference was noted in serum creatinine and urea values between the two groups. Histology of liver and kidney tissues revealed signs of chronic damage in the wild captured fis...
Histopathological effects of Lead Nitrate on body tissues of Herring gull (Larus argentatus)
NOREEN RAZA1*, TASNEEM A. SAQIB2, SYED NAEEMUL HASSAN NAQVI3, MUHAMMAD ZAHEER
KHAN2 & MAZHAR HIJAZI3
...e on liver, gizzard, and kidney of Herring gull (Larus argentatus) were studied. Significant changes were observed after high and low concentrations of Lead nitrate were injected to Larus argentatus. Paraffin sections showed major alterations at high and low concentration of Lead nitrate in liver, gizzard and kidney. High concentration of Lead nitrate induced, severe dystrophy along with hepatic necrosis; reduction in thickn...
Histological responses in Intestine, Kidney and Liver tissues of Labeo rohita during acute and chronic exposure to Pesticide, Chlorpyrifos

ADEEBA SYED1, DILAWAR HUSSAIN2, UZMA RAFI1 & SUMAIRA MAZHAR1*

...ike intestine, liver and kidney were collected and sections were examined under digital microscope. Pronounced histological changes like necrosis, infiltration, atrophy, shrinkage and degeneration of intestine was observed for different CPF concentrations. Kidney sections of Labeo rohita under different CPF concentrations exhibited nuclear hypertrophy, vacuolar degeneration of glomeruli, and occlusion of tubular lumen, cloud...
Therapeutic Effect of Epigallocatechin-3-Gallate and Quercetin on Renal Stone Formation in Rats

Youfang Li1, Xu Li2, Shaik Althaf Hussain3, Jayasimha Rayalu Daddam4 and Zhigang Chen5*

...ollection, and blood and kidneys were removed for urine and serum biochemical analysis, tissue anti-oxidant, miR-21 as well as morphological examination. We found that administration of Sodium oxalate induced induced oxidative stress, alteration in the serum as well as urinary biochemical alterations as well as spiked expression of miR-21. The alterations were reversed in all the treatment group especially EGCG and EGCG-Quercetin. The reversal potentials of co...
Aqueous Myrrh Extract Relieves Oxidative Stress-Dependent Nephrotoxicity Induced by Ethanol in Male Rats

Abeer Alahmari1,2*

...ext-align: justify;">The kidney is one of the target organs whose structure and functions are significantly influenced by toxins. Because the protective impact of myrrh resin on renal damage induced by alcohol intake has not been previously evaluated, this study was designed to investigate the in vivo antioxidant activity of aqueous myrrh extract (AME) on oxidative stress-dependent nephrotoxicity caused by ethanol in rats. Male Sprague‒Dawley rats orally rec...
Cloning and Expression of Human Interleukin 2 (IL-2) in E. coli and its Antitumor Activity

Qurrat ul Ain Shafique1, Sana Batool2, Hanfa Ashfaq2, Asima Tayyab2, Roquyya Gul3 and Mahjabeen Saleem1*

...munotherapy particularly kidney and skin cancer. Interleukin-2 (IL-2) is a 4-helix-bundle type I cytokine possessing a cytokine receptor chain essential for the immune response. The current study presents a vector/host combination (pET28a(+)/IL-2) and optimization of expression in LB,TB and M9 media with varying concentrations of inducers (IPTG and lactose) and post induction time. Maximum expression of IL-2 was achieved in LB with 0.5 mM IPTG for 6 hours post...
Evaluation of Antioxidant, Nephroprotective and Immunomodulatory Activity of Vitamins C and E -Sodium Selenite in Mice Intoxicated with Sodium Nitrate

Marah Salim Hameed1, Ali Ibrahim Ali Al-Ezzy2*

...logical changes of mouse kidney for T1 and T2 revealed a congestion of renal blood vessels, perivascular cuffing, and infiltration of inflammatory cells in the dilated blood vessels. Congestion of glomerular capillaries. While (T3) revealed sever congestion of renal blood vessels, perivascular cuffing, and infiltration of inflammatory cells in the dilated blood vessels. Extensive distension of Bowman’s space with sever congestion of glomerular capillarie...
Investigation on Risk Factors of Acute Kidney Injury after Iodine Contrast Agent CT Examination

Shangmei Peng1 and Changhe Yu2*

...f contrast-induced acute kidney injury (PC-AKI) in patients examined by computed tomography (CT) with iodine contrast agent. A retrospective analysis was made on 1591 patients (809 cases in contrast-enhanced CT group and 782 cases in plain CT group) who underwent CT examination in Yanbian University hospital from May 2012 to May 2022. Binary logistics regression analysis was used to determine the risk factors of PC-AKI in different examination methods. There w...
Trigonella foenum-graecum Extract’s Effectiveness of Improvements in Renal Functions and Histological Profiles in Male Rats with Streptozotocin-Induced Diabetes

Eman Ali Hussein1*, Majdy Faisal Majeed2

...xtract could protect the kidneys from the effects of (SZ). The goal of the current study was to determine if the ethanolic extract of (TFG) exhibited antioxidant activity against nephropathy resulting from the effects of diabetes due to (SZ). Animals in groups 2, 3, 4, and 5 were employed as experimental groups, whereas rats in group 1 received orally gavages of tap water and served as negative controls. Group 2 developed diabetes as a result of a single intra...
Yucca schidigera Liquid Extract Enhances Growth Performance, Nutrient Utilization, Liver Antioxidative Function, and Welfare Indices of Broilers

Asad Sultan1, Ziaul Islam2*, Faiza Shahzadi3, Sarzamin Khan1, Rafiullah Khan1 and Ihsan Ali4

...mful effect on liver and kidney function. In conclusion, the use of natural additives is necessary to improve growth performance, and nutrient digestibility, decrease nitrogen losses, feed cost, and environmental pollution.

...
Adverse Histo-Physiological Damages of Increasing Consummation of Puma (Super Fat) on Female Rats

Fatima Aziz Mahdi Al-Badry

...s of Puma (super fat) on kidney and liver functions and histopathological alterations of these organs. The total number of animals in present experiment was thirty two of adult female rats, It were divided into two groups (16/each), the first group which gave distilled water as control group while the second group was divided into three subgroups (A, B and C) which treated with nutritional supplement Puma (super fat) at (250 mg/kg body weight) for three period...
The Bidirectional Relationship between Serum Uric Acid Levels and Kidney Function Markers: A Predictive Model for Chronic Kidney Disease Progression

Dunia Tahseen Nema Al-Aridhi 

...d the link among chronic kidney disease (CKD) and hyperuricemia, although the precise relationship is unknown. The present study aimed to discover whether they were directionally connected or not.
This study followed adults aged 18 and above with CKD stages (1-4) over a period of 12 months. It has been conducted in Al-Kindi Teaching Hospital- Baghdad / Iraq, during the period (2022-2023). Data, on demographics, clinical information and lab results incl...
Modifying the Design of Pond Production Systems can Improve the Health and Welfare of Farmed Nile Tilapia, Oreochromis niloticus
Wasseem Emam1, Mohamed E. Bakr2*, Marwa F. Abdel-Kader3, Mohamed M. Abdel-Rahim4, Ashraf I.G. Elhetawy4 and Radi A. Mohamed1
... (i.e., better liver and kidney function, higher antioxidant activity and lysozyme count; p < 0.05). The results of this study suggest that low-cost interventions that introduce thermal gradients in aquaculture systems may hold promise for improving health and welfare status of farmed fish in developing countries.

...
Morphological and Morphometrical Comparative Study of Thyroid and Adrenal Glands Between Suckling and Adult Local Male Cats (Felis catus)

Diyar Mohammad Hussein*, Iman Mousa Khaleel

...entral pole of the right kidney, while the left one situated more away from the left kidney anterior pole. Statistically, there were significant difference between right and left adrenal glands in suckling and adult cats. The weight, length, width and thickness of right adrenal gland were greater significantly than those of left adrenal at p <0.05, these variations in may be due to the age of animal that. Concluded, the c...
Toxicity Assessment Due to Chronic Exposure to Manganese in Male Wistar Rat

Hala Harifi*, Mouloud Lamtai*, Siham Ait Salhi, Fatima-Zahra Azzaoui, Omar Akhouayri, Abdelhalem Mesfioui, Leila Bikjdaouene

...organ weights (liver and kidneys) were recorded. Our results indicate signs of intoxication resulting from chronic exposure to Mn. Specifically, doses of 25 mg/kg and 30 mg/kg were found to be toxic and adversely affect the general condition of the rats. In contrast, the 6 mg/kg dose showed no adverse effects when compared to the 25 mg/kg and 30 mg/kg doses. Additionally, the 40 mg/kg dose proved to be lethal. Weight changes were observed in rats injected with...
Functional and Histological Signs of Early Detection of Liver and Kidney Stress Under the Influence of Tramadol Oral Administration in Male Rats

Hawraa F.H. Alowaid1*, Afrah Adil Hassan1, Majdy Faisal Majeed2

...ML damages the liver and kidneys. The goal of the current investigation was to assess the potential contribution of oxidative stress dysfunction to the etiology of renal and hepatic injury brought on by TML. For this purpose, male adult rats were treated with TML (15 and 30 mg/kg/day oral administration) 30 days in a row. A significant decrease in liver and kidney tissue SOD, CAT, NO, and MAD was detected in TML groups, whil...
Biochemical and Histological Effects of Long-Term Administration of Estrogen on Female Mice

Talal Jabal Hussen1, Sattar J.J. Al-Shaeli1*, Baidaa H.R. Al-Mahna2, Hasanain A.J. Gharban3

...of the liver, spleen and kidney. An overall 40 BALB/c adult female mice were selected, acclimated, and divided randomly and equally into control (non-received estrogen) group and estrogen group. After 35 days of estrogen therapy, blood samples and tissue sections were collected from all study animals for biochemical assays and histology detection. The obtained data show that the biochemical markers displayed significant increased in estrogen administration mic...
Enhancing Growth Performance, Immunity, and Gut Morphology in Quails through Oyster Mushroom Stem Waste Supplementation

Jamal Abdul Nasir1, Naila Chand1, Abdul Hafeez1 and Rifat Ullah Khan2*

...hout affecting liver and kidney functions. The most favorable outcomes were achieved when oyster mushroom stem waste was incorporated at a 3% level in the feed.

...
Unveiling the Mysteries of Oxidative Stress: An Insightful Review of Recent Studies

Baraa Najim Al-Okaily 

...ive stress on the liver, kidneys, and other organs. Achieving a full understanding of the fundamental concept of stress is crucial as it facilitates an intimate understanding of the causes of stress. Oxidative stress refers to an imbalance between the levels of oxidants and antioxidants, resulting in a disturbance of regulation and potential damage to molecules and cells. Thus, this review is designed to highlight the important roles of oxidative stress on var...
Protective Effects of Vitamin C on Nrf2 and TSPO Genes Expression in the Urinary System of Ovariectomized Rabbits

Mohammed H. Asker*, Nagham S. Mohammed, Zinah S. Zamil  

...s were anesthetized, and kidney tissues were collected for RNA isolation. The expression of genes encoding translocator protein (TSPO) and nuclear factor erythroid 2 related factor 2 (Nrf2) was analyzed in the kidney tissues. Vitamin C significantly reduced blood levels of urea, creatinine, salt, potassium, and calcium in both intact and ovariectomized groups (p≤0.05). Additionally, gene expression decreased significantly...
Renoprotective Impact of Dapagliflozin and Mulberry Extracts Toward Fr-STZ Induced Diabetic Nephropathy in Rats: Biochemical and Molecular Aspects

Emad M. Gad1, Haidy G. Abdel-Rahman2, Mohy Eldin Abd-El-Fattah1, Merna M. Kamal1, Ahmed Shaker Eltahan3, Amina A. Dessouki3*

... and needing dialysis or kidney transplantation. So,the development of new prevention and treatment strategies of diabetic nephropathy is required. The existent study looked at the impact of dapagliflozin, mulberry fruit and leaves extracts and their combination on the kidney of diabetic rats. To induce diabetic nephropathy, experimental rats were supplied with 10% fructose (Fr) in drinking water for the first two weeks. Eac...
Protective Effect of Grape Seed Extract on Meloxicam-Induced Hepato-Renal Toxicities in Rats with relation to their Biochemical, Histological, and Immunohistochemical Confirmation

Adham Omar Mohamad Sallam1*, Ashraf Abd El-Hakem Ahmed El-Komy1, Enas Abdulrahman Hasan Farag2, Samar Saber Ibrahim3

...cal changes in liver and kidney tissues. This study addresses a significant gap in understanding how GSE can counteract NSAID toxicity, with potential clinical implications for safer long-term NSAID use. GSE administration significantly reversed the elevated levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, urea, and creatinine caused by Meloxicam toxicity. Additionally, oxidative stress markers such as malondialdehyde...
Investigation of Prevalence and Risk Factors of Infectious Bursal Disease in Broiler Chicken at Selective areas of Barishal Region in Bangladesh

Dipa Rani Pal*, Injamamul Haque Rasel, Tarun Chandra Mondal, Mohammed Lalmoddin Mollah and Shampa Rani 

... breast muscles, swollen kidneys and principal findings were in the bursa of fabricious which appeared inflamed, edematous, hyperaemic and finally hemorrhagic and atrophied. The prevalence of IBD was 13.28%, 13.33%, 19.48% and 14.30% in Banaripara, Nesarabad, Babugonj and Barishal sadar respectively. The overall mortality was 4.46%. The mortality was 4.29% in Banaripara, 4.93% in Nesarabad, 4.70% in Babugonj and 3.91% in Barishal sadar upazila. The highest pre...
Impact of Empagliflozin on the Kidneys of Male Albino Rats

Amal Mahmood Alwan1*, Thekra Atta Ibrahim1, Ghalib Idrees Atiya Ali2 

...logical structure of the kidneys of male rats, however, mechanistic insights remained unknown. To investigate generic impact of the drug in animals, 15 adult male rats were randomly divided into two groups. The control group consisted of 5 rats, while the treatment group was divided into two subgroups, each consisting of 5 rats. Diabetes condition was induced in all animals of treatment sub-groups with alloxan with 5 mg/kg concentration of empagliflozin, once ...
Toxicity and Behavioral Outcomes of the Ethanolic Extract of Schinus Terebinthifolius Raddi fruits in Wistar Rats

Soumia Ed-Day1*, Meryam Laanaya1, Chaimae El Kourchi3, Radia Elgui1, Fatima Ezzahra Kacimi2, Latifa Didou1, Samira Boulbaroud2, Hicham Harhar3, Fatima-Zahra Azzaoui1

...effects on the liver and kidneys. Conclusion: The acute administration of the ethanolic extract of Schinus terebinthifolius Raddi fruits did not elicit any toxic effects in Wistar rats, thus contributing valuable insights into this plant’s safety and physiological impact.
 
Keywords | Acute toxicity, Schinus terebinthifolius Raddi, Glycemia, Lipid profile, Behavioral assessments, Wistar rats
...
Effect of Dietary Supplementation of Fish Oil as a Source of Omega-3 Fatty Acid on Growth Performance and Physiological Parameters of Growing Rabbits

Y. Eid1, S. Abo El-Sood1, A. Fawzi1, W.A. Morsy2* and H. Mehany3

...ful effects on liver and kidney functions, under Egyptian environmental conditions.

...
Effects of Bee Venom on Cadmium Toxicity in Albino Rats

Mariam Ismail Ali1*, Rania Helmi Abdou1, Mary Ayad Sargious2, Omnia Mohamed Khattab2, Kawthar Abdelwahed Elhady1

...hological lesions in the kidney of cd-treated rats. Bee venom showed nephroprotective effects, decreasing serum creatinine and urea by 16.9% and73.4% respectively and also improving histopathologic lesions in the kidney. Also, the neuroprotective effect of bee venom appeared in the improvement of the histopathological lesions in the brain.
 
Keywords: Cadmium, Bee venom, Oxidative stress, Inflamm...
Antibiotic Resistance and Virulence Genes of Vibrio alginolyticus from Asian Seabass in the East Coast of Peninsular Malaysia
Mat Zin Ain-Auzureen1, Maizan Mohamed1, Tan Li Peng1, Mohd Faizal Ghazali2, Choong Siew Shean1, Kamaruddin Mardhiah3, Najiah Musa4, Nora Faten Afifah Mohamad5, Chai Min Hian2 and Ruhil Hayati Hamdan1*
...ssected and a loopful of kidney and liver samples were inoculated on thiosulphate-citrate bile-salt sucrose (TCBS) agar and CHROMagarTM Vibrio. Polymerase chain reaction (PCR) was used to identify the isolates and detect the twelve virulence genes associated with V. alginolyticus. Antibiotic resistance tests were conducted using 17 antibiotics. The difference in index scores between locations was tested using one-way ANOVA, while the index sc...
Histological, Immunohistochemical Expression and Biochemical Changes in the Liver and Kidney of Wistar Rat Neonates after Prenatal Exposure to Copper Oxychloride

Sherine Abbas1, Hadeer M. Shosha2, Hala M. Ebaid2, Heba Nageh Gad El-Hak2, Heba M. A. Abdelrazek3*

...les, including liver and kidney, were taken from both male and female newborns. The blood samples were analyzed using a biochemical assay, while the kidney and liver tissues were investigated for histopathological and immunohistochemical expression. The results indicated there was significant tolerance of female offspring than male as indicated by ALT, urea and creatinine. A notable alteration in the biochemical parameters o...
Biochemical Evaluation of Bone Marrow Mesenchymal Stem Cells and GLP-1 Therapy as a New Approach for Type II Diabetes Treatment in Rat Model

Ashraf B. Said*, Ibrahim A. Ibrahim, Hoda I. Bahr, Marwa A. El-Beltagy

...also measured. Liver and kidney tissues examinated for histopathological and Immunohistochemistry. Untreated diabetic group showed significant (P≤0.05) hyperglycemia, hyperinsulinemia, and elevation in inflammatory cytokines with hepatic and kidney tissues disruption. At the same time, treatment alleviated hyperglycemia and IR with a significant (P≤0.05) decrease in inflammatory biomarkers levels and tissue expressions...
Protective Effect of Propolis Extract Against Nickel Chloride and/or Carbon Tetrachloride Induced Alterations in Physiological and Endocrine Functions in Adult Male Rats

N. M. Abed 

...l4) damage the liver and kidneys. On the other hand, propolis has antioxidant, anti-inflammatory, anti-cancer, antibacterial and hepatoprotective properties. Propolis protects thyroid and gonadal function from NiCl2 and CCl4. In order to assess the protective impact of propolis extract against NiCl2 and CCl4, 80 adult male albino rats were divided into eight groups including control group, the propolis-treated group, the NiCl2-treated group, the CCl4-treated g...

Journal of Animal Health and Production

November

Vol. 12, Sp. Iss. 1

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