Biochemical and Histological Effects of Long-Term Administration of Estrogen on Female Mice
Biochemical and Histological Effects of Long-Term Administration of Estrogen on Female Mice
Talal Jabal Hussen1, Sattar J.J. Al-Shaeli1*, Baidaa H.R. Al-Mahna2, Hasanain A.J. Gharban3
ABSTRACT
Estrogen is a steroid sexual hormone responsible for developing of female characteristics, treatment the symptoms of menopause, and as a replacement therapy for postmenopausal with controversial topic. Investigation the long-term effect of estrogen administration on some biochemical markers and histological structure of the liver, spleen and kidney. An overall 40 BALB/c adult female mice were selected, acclimated, and divided randomly and equally into control (non-received estrogen) group and estrogen group. After 35 days of estrogen therapy, blood samples and tissue sections were collected from all study animals for biochemical assays and histology detection. The obtained data show that the biochemical markers displayed significant increased in estrogen administration mice compared to control. These markers are including alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (Cr), and malondialdehyde (MDA). Whereas, administration estrogen to mice caused significant dropdown the activity of antioxidant markers including catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) compared to control mice. Histologically, tissue sections of liver, spleen and kidney in mice exposed to estrogen showed variable degrees of abnormalities in their histological architecture and textures in compared to normal mice. This study is unique as it estimates the influencing of the long-term administration of estrogen on several biochemical markers and the histological alteration of liver, spleen, and kidney. Nevertheless the obtained result, further specific qualitative and quantitative research is needed to provide more details about the impact of estrogen on various body organs.
Keywords | Estradiol, Hepatotoxicity, Renal toxicity, Spleen, Antioxidant, Iraq
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August 2024
Vol. 12, Iss. 8, pp. 1410-1621
