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Expression of the ZFX Gene in Mouse Kidney During Postnatal Development

Expression of the ZFX Gene in Mouse Kidney During Postnatal Development

Xiangzu Wang,1,2 Jifeng Xi,1,2 Bin Jia,1,* Yongsheng Zhang,1 Chaocheng Li1

1College of Animal Science and Technology, Shihezi University, ShiHeZi, XinJiang 832003, China
2Xinjiang Agricultural Vocational Technical College, ChangJi, XinJiang 831100, China
 
Xiangzu Wang and Jifeng Xi contributed equally to this article.

*      Corresponding author: jiabin@shzu.edu.cn

ABSTRACT

The relationship of cell proliferation and apoptosis is important in normal kidney development. The ZFX gene is important for regulation of growth, proliferation and differentiation in tissue cells while the Bcl-2 and BAX genes regulate apoptosis. This experiment adopted the real-time fluorescence quantitative technique to test ZFX, Bcl-2, and BAX expression in mice kidney tissue on 1 d, 7 d, 14 d, 21 d, 42 d, and 90 d after birth. The results showed that with the maturation of mouse kidney, the cell proliferation activity decreased, and the expression of ZFX, Bcl-2, and BAX were down regulated. The ZFX gene may participate in the developmental process of the kidney through the balance of cell proliferation and apoptosis regulation.
 

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Pakistan Journal of Zoology

October

Vol. 53, Iss. 5, Pages 1603-2000

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