The Bidirectional Relationship between Serum Uric Acid Levels and Kidney Function Markers: A Predictive Model for Chronic Kidney Disease Progression
The Bidirectional Relationship between Serum Uric Acid Levels and Kidney Function Markers: A Predictive Model for Chronic Kidney Disease Progression
Dunia Tahseen Nema Al-Aridhi
ABSTRACT
Numerous have examined the link among chronic kidney disease (CKD) and hyperuricemia, although the precise relationship is unknown. The present study aimed to discover whether they were directionally connected or not.
This study followed adults aged 18 and above with CKD stages (1-4) over a period of 12 months. It has been conducted in Al-Kindi Teaching Hospital- Baghdad / Iraq, during the period (2022-2023). Data, on demographics, clinical information and lab results including serum acid levels and estimated glomerular filtration rate (eGFR) were gathered at the beginning. The participants were monitored for changes in these factors over time. The study consisted of 342 individuals. A reciprocal association was identified between eGFR and levels of uric acid. (p<0.001). The receiver operating characteristic curve (ROC) showed that serum uric acid predicted renal function at 7.5 mg/dl. In a logistic regression model, elevated uric acid levels independently increased renal dysfunction risks.This study provides evidence for a bidirectional relationship between serum uric acid and kidney function markers. Uric acid demonstrated good predictive accuracy for identifying impaired renal function, highlighting its potential utility as a risk factor or prognostic marker for CKD progression. The development of a predictive model incorporating uric acid could inform clinical management strategies to mitigate CKD progression.
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