Investigation on Risk Factors of Acute Kidney Injury after Iodine Contrast Agent CT Examination
Investigation on Risk Factors of Acute Kidney Injury after Iodine Contrast Agent CT Examination
Shangmei Peng1 and Changhe Yu2*
ABSTRACT
The objective of this study was to explore the risk factors of contrast-induced acute kidney injury (PC-AKI) in patients examined by computed tomography (CT) with iodine contrast agent. A retrospective analysis was made on 1591 patients (809 cases in contrast-enhanced CT group and 782 cases in plain CT group) who underwent CT examination in Yanbian University hospital from May 2012 to May 2022. Binary logistics regression analysis was used to determine the risk factors of PC-AKI in different examination methods. There was no significant difference compared with that in contrast-enhanced CT group (4.90%, P>0.05). The serum creatinine, uric acid and urea nitrogen in the contrast-enhanced CT group decreased, while cystatin C and eGFR increased after the examination, with statistical significance (P<0.05). But there was no significant difference in creatinine, urea, urea nitrogen, cystatin C and eGFR between the two groups at the same time point (P>0.05). The incidence of eGFR 5 patients in the two groups was higher than that in other stages, and the difference was statistically significant (P<0.05). Excessive serum creatinine before CT, diabetes, and female gender are independent risk factors for secondary AKI (OR>1, P<0.05). The incidence of PC-AKI after enhanced CT examination is low, and it has nothing to do with intravenous contrast agent. It is obviously unreasonable to blame iodine contrast agent for PC-AKI, and the risk of PC-AKI will increase only in patients with eGFR5. Attention should be paid to patients with high serum creatinine, diabetes before examination or female patients to avoid acute kidney injury after examination.
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