Comparative Study of the Virulency of Different Serotypes of Foot and Mouth Disease Virus by Using Baby Hamster Kidney-21 Cell Line
Comparative Study of the Virulency of Different Serotypes of Foot and Mouth Disease Virus by Using Baby Hamster Kidney-21 Cell Line
Sania Subhan Qureshi*,1, Baitullah Khan1, Shahid Khan1, Hanif Ur Rahman1 and Muhammad Subhan Qureshi2
ABSTRACT
Foot and Mouth Disease (FMD) is a highly contagious and sometimes fatal viral disease affecting cloven footed animals including bovine, caprine and ovine. Globally, FMD production losses are up to 21 billion US dollars annually. Annual losses in Pakistan is 692 million dollars in terms of body weight loss, milk production, treatment cost and mortality. FMD is caused by 7 different serotypes of FMD virus having different virulence. To compare the virulence of various FMD serotypes the study was designed to propagate the virus on BHK-21 cell line. The results revealed that serotype ‘A’ virus virulence is more as compared to serotype ‘O’ and ‘Asia-1’. Although less virulence difference was found between serotype ‘A’ and ‘O’. Serotype ‘Asia-1’ was comparatively less virulent. Randomized Complete Block Design (RCBD) was used for determining the effect of incubation time, virus serotypes and virus titer producing CPEs on BHK-21 cells.
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September 2022
Vol. 38, Iss. 3, Pages 759-1159
