Effects of Gamma-Irradiated Aqueous Extract of Turmeric on Doxorubicin Induced Cardio-Nephrotoxicity in Male Rats
Effects of Gamma-Irradiated Aqueous Extract of Turmeric on Doxorubicin Induced Cardio-Nephrotoxicity in Male Rats
A.M. Abdul Azeem1, A.N. El shahat1, Mohamed H.M. Abd El Megid2 and Amal A. Mansour1*
ABSTRACT
This study was designed to investigate the effectiveness of gamma irradiation process (5 kGy) on the total phenolic contents, antioxidant activity and curcumin content of turmeric powder. Also, this study was aimed to investigate the influences of aqueous extract gamma-irradiated turmeric on doxorubicin (DOX)‑induced cardio-nephrotoxicity in male rats. The result indicates that the total phenolic content, antioxidant activity and curcumin content of turmeric powder were significantly increased by γ-irradiation. The results of biological study revealed that inoculation of DOX (3 mg/kg b.w./week/6 weeks) to rats induced cardiac and renal dysfunction, inflammation, and oxidative stress with significant reduction of cardiac and renal antioxidant parameters compared to control group. Co-administration of DOX with either raw (RTAE) or γ-irradiated turmeric aqueous extract (GTAE) (100 mg/kg b.w/ day/6 weeks) significantly reduced side effects of DOX which evidenced by significant reduction in the oxidative parameter (malondialdehyde), cardiac markers, kidney function and inflammatory factors (TNF-α and IL-6) associated with elevation in the antioxidant parameters (glutathione content, superoxide dismutase and catalase) in kidney and heart tissues compared to DOX-group. So, the results concluded that gamma irradiation (5 kGy) can be effective in increasing the in vivo and in vitro antioxidant potential as well as enhancing the medicinal value of turmeric against tissues damage.
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