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Red Onion Extract Attenuates Aluminum Induced Toxicity in Swiss Albino Mice

Red Onion Extract Attenuates Aluminum Induced Toxicity in Swiss Albino Mice

Chaman Ara1*, Asmatullah1, Saima Hanif1, Shagufta Andleeb2, Beenish Zahid3 and Madeeha Arshad4

1Department of Zoology, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan 
2Department of Zoology, University of Education, Lahore, Pakistan
3Department of Pathobiology, Narowal Sub-Campus University of Veterinary and Animal Sciences, Lahore, Pakistan
4Department of Zoology, University of Lahore, Sub Campus Sargodha, Pakistan.

*      Corresponding author: dr.chamanara@yahoo.com

ABSTRACT

This study was planned to investigate the therapeutic potential of onion extract against aluminum (Al) induced toxicity in male albino mice, Mus musculus. Eighty, 8-9 week old mice were divided randomly into eight groups, each containing 10 mice and exposed to three sub-lethal concentrations (37.5µg/g; 18.7µg/g; 9.37µg/g B.W) of aluminum, with and without onion extract. Control and antidote groups were treated with distilled water and onion equous extract, respectively. Doses were administered orally by gavage for 30 consecutive days, once a day and mice were euthanized on the 31st day. Blood was collected in serum separating tubes through intracardiac puncture for biochemical analysis. Morphometric observations revealed significant decrease (P≤0.001) in body weight of mice in Al treated groups as compared to control but organs weight increased contrary to the body weight. Significant increase (P≤0.01-P≤0.001) was recorded in total alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) in liver and urea, and creatinine levels in kidneys, in Al exposed groups against control. In Al + antidote groups these deviations were less significant (P≤0.05). However, these morphometric and biochemical alterations improved to a great extent when onion extract was co-administered with Al. So it is concluded that Al caused morphological and biochemical disturbances in mice, whereas onion extract showed protective effects as well as regenerative potential against Al provoked toxicity in male mice.
 

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Pakistan Journal of Zoology

August

Vol. 53, Iss. 4, Pages 1201-1601

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