Mudasir Irfan Dar*, Fareed Ahmad Khan and Farha Rehman
E-mail | irfanmudasir@gmail.com
...nthetic pigments and antioxidative enzymes in Brassica juncea L. cv. alankar was investigated. Forty-day-old pot plants were exposed to different concentrations of the insecticide, ranging from 0 to 40 grams active ingredient per hectare (g.a.i ha-1) through foliar spray. Analyses were done at days 3, 7, and 15 after treatment. Lipid peroxidation rates and contents of proline, ascorbate (ASC), glutathione (GLU), antioxidative
Mukhtiar Ahmed, Jana Pickova, Taufiq Ahmad, Muhammad Liaquat, Abid Farid, Muhammad Jahangir
Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1
...induced by inflammation, oxidative stress in response to APAP toxicity in rats. Serum aminotransferases (ALT and AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, total bilirubin, hepatic glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD) and lipid peroxides (LP) levels were estimated. Moreover these biochemical parameters were confirmed by histopathological examination using hemotoxylin and eosin (H&E) and Mason t...
Asma-ul-Husna1, Muhammad Sajjad Ansari2, Bushra Allah Rakha3, Rabea Ejaz1, Nemat Ullah1 and Shamim Akhter1*
Mostafa A. Abdel-Maksoud1,2, Fathy A. Abdel-Ghaffar2, Azza El-Amir2, Gamal Badr3 and Saleh Al-Quraishy1*
G.E. Odo1*, E.J. Agwu1, N.I. Ossai2, C.O. Ezea3, J. Madu1 and V. Eneje2
... behaviour, haematology, oxidative stress biomarkers and biochemistry of African catfish (C. gariepinus) juvenile on days 7, 14, 21 and 28. Fish were exposed to 0.175, 0.0875 and 0.035 mg/L corresponding to 1/10, 1/20 and 1/50 of the 96 h LC50 value (1.75) of the pesticide. Behavioral responses which include colouration of the fish skin and opercula colouration were observed. Aluminium phosphide elicited effects on the haematological parameters of the fish suc...
Shazia Irfan1*, Asima Rani1, Muhammad Arshad2 and Razia Bashir1
...als and minerals creates oxidative stress may play some role in progression and pathogenesis of RA. The objective of this study was to investigate the role of Superoxide dismutase 1 (SOD1) gene polymorphism [rs2070424 (–251A/G)] in RA and to compare the levels of metals and minerals among its various genotypes in RA patients. A total of 400 individuals including age and gender matched healthy individuals (control group) and RA patients were genotyped. De...
Sidra Ilyas1, Abdul Rehman1* and Qasim Ilyas2
Hamayun Khan1,*, Momen Khan2, Muhammad Subhan Qureshi3, Shakoor Ahmad1, Ali Gohar4, Hameed Ullah5, FarmanUllah6, Arab Hussain7, Pershotam Khatri8, Said Sajjad Ali Shah1, Hamid Rehman1 and Azmatullah Khan1
...y was to explore the antioxidative effect of green tea extract on the cryopreserved bull semen. Experiments were carried out on Achai breeding bulls of similar age at the Semen Production Unit, Harichand, District Charsadda, Khyber Pakhtunkhwa. Collection of semen was done using artificial vagina (42°C) for three weeks. Semen was extended in egg yolk extender at various inclusion levels (0.0%, 0.25%, 0.5%, 0.75 and 1.0%) of green tea extract. Testing was c...
Baohua Chen1,2, Wenzhu Peng3, Jian Xu2, Jingyan Feng1,2, Chuanju Dong1,2 and Peng Xu2,3,*
...lular detoxification and oxidative stress tolerance. Comparing with that in mammals, investigation of GSTs is more complicated in teleosts because of the greater pressure they suffer in aquatic environment. In this study, we identified a set of 27 GSTs including 8 classes of members in common carp genome. Both sequences alignment and phylogenetic analysis exhibited that genes derived from the same GST class from different species share more similarity than gen...
Zia-ur-Rehaman1, Naila Chand1, Sarzamin Khan1 and Rifat Ullah Khan2,*
...) on immune response and oxidative status of four broiler strains. Day old broiler chicks (n=242) of four different commercial strains (Ross, Hubbard, Cobb and Arber Acer) were placed in brooding room in first two weeks and then chicks were divided into two groups: TN and HAT zones. Chicks in TN group were housed at constant room temperature, while chicks in HAT zone were kept at high ambient temperature. Chicks in each group were further divided into fou...
Guang-Xin E1, Yong-Ju Zhao1, Yue-Hui Ma2, Ming-Xing Chu2, Jia-Hua Zhang1, Zhong-Quan Zhao1, Hui-Jiang Gao2, Huai-Zhi Jiang3, Di Liu4, Li Liu5, Yan-Bin Zhu6, Wang-Dui Basang6, Luo-Bu Danjiu7, Tian-Wu An8, Xiao-Lin Luo8, Shi-Cheng He7 and Yong-Fu Huang1,*
...3 signaling pathway, and oxidative phosphorylation. The results of the present study confirmed that the selection of the dominant follicle involved the regulation of various physiological systems. These results provided helpful data to understand on the molecular mechanisms of dominant follicle selection in goats.
... 
Soraya Khosravian Dehordi*, Abdolnaser Mohebbi and Kahin Shahanipour
...fects. The generation of oxidative stress creates by the common mechanism their carcinogenicity and toxicity. The present study was planned to determine whether an oral administration of nano-selenium (nano-Se) influencing on biomarkers of oxidative status in the rats spleen exposed to the cadmium (Cd) metal. For this purpose, thirty male rats equally divided into six groups, group I received nano-Se (0.1mg/kg) alone as dose...
Nazish Shaukat1, Muhammad Javed1,Faiza Ambreen2* and Fariha Latif1
...re important inducers of oxidative stress in aquatic animals, promoting the formation of reactive oxygen species (ROS) which ultimately leads to tissue damage and oxidation of biomolecules. Aquatic organisms possess antioxidant system to cope with the oxidative stress. This research was conducted to see the effect of lead on peroxidase activity (antioxidant enzyme) in the gills and liver of Labeo rohita. Experiment wa...
Kaori Sasaoka1, Takahiro Kataoka1, Norie Kanzaki1, Yusuke Kobashi1, Akihiro Sakoda2, Yuu Ishimori2 and Kiyonori Yamaoka1,*
...nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m3 and 2000 Bq/m3 for 24 h. Radon ...
Fazul Nabi1,2, Hui Zhang1, Muhammad Kashif Iqbal1 , Mujeeb ur Rehman1, Muhammad Shahzad3, Khalid Mehmood1,3 and Jiakui Li1,*
...rowth plate width, liver oxidative stress and toxicity in avian TD. One hundred and fifty broiler chicks were equally distributed into three groups: Control, Thiram (50 mg/kg/d) and SM (10 mg/kg/d) treated. Results showed that thiram caused lameness, decrease in alkaline phosphatase (ALP) activity and increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in the serum along with decrease in level of antioxidant enzymes and s...
Ä°nan Kaya1,*, Muhitdin Yılmaz2, Müge MavioÄŸlu Kaya3,Abdulsamed Kükürt4 and Mahmut Karapehlivan5
...dy is to investigate the oxidative stress index in Capoeta capoeta treated with carbaryl and 2,4-dichlorophenoxyacetic acid (2,4-D). Fifty Capoeta capoeta fish caught in Kars Creek were equally divided into five groups and acclimatized in separate tanks for 10 days. The fish were kept in tanks as follows: Group I (control) was kept in normal water. Group II, III, IV and V were kept in separate tanks containing 0.3 mg/L carbaryl, 0.6 mg/L carbaryl...
Ashraf M. Mounir, A.N. El shahat* and A.M. Abdul Azeem
...rats resulted in cardiac oxidative stress, inflammation, hyper-lipidemia and increase cardiac marker enzymes. Treatment of rats with GFAE (45 mg/kg/day) prior to injection of ISO provide significant cardio-protective effects evidenced by an obvious reduction in the level of cardiac marker enzymes, inflammatory factors and lipid contents with marked improvement in the cardiac antioxidant status and reduction of lipid peroxidation relative to untreated in...
Umair Riaz1*, Muhammad Ali Kharal2, Ghulam Murtaza3, Qamar uz Zaman4, Sana Javaid4, Hina Ahmed Malik3, Humera Aziz3 and Zafar Abbas1
...y as well as osmotic and oxidative anxiety. The most effective mechanism is the biosynthesis of secondary metabolites at cellular level which included organic compounds that help plants to cope with stress conditions by reducing the intensity of stress through enhancing antioxidants activities, detoxifying toxic ions, regulating the uptake of nutrients and by mediating the transport and distribution of different hormones. Caffeic acid is actively involved in p...
Tünay KontaÅŸ AÅŸkar1,*, Åžinasi AÅŸkar1, Olga Büyükleblebici2 and Murat Güzel3
...tudy is to determine the oxidative stress and inflammatory changes in naturally occurring canine visceral leishmaniasis (CVL). A total of 30 dogs, comprising 10 clinically healthy and 20 dogs with leishmaniasis were enrolled in this study. The diagnosis of canine visceral leishmaniasis was performed by the immune fluorescence antibody test with antibody titter ≥1:128 and lymph node smear examination. In blood samples of dogs with visceral leishmaniasis, lev...
Tahir Abbas*1, Khawaja Raees Ahmad2, Asmatullah3, Khalid Pervaiz Lone4, Muhammad Ali Kanwal2, Sadia Suleman2
Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice
...d chain might be causing oxidative stress. That study was conducted to evaluate the protective effects of Jambul (Syzygium cumini) against Cr induced reno-hepatic anomalies. Male albino mice (Mus musculus) were equally divided (n=10) as C; control, Cr-treatedandCr-JgroupsreceivingCr+6 in the form of potassium dichromate (K2Cr2O7) 50ppm for 10days ad-libitum while Cr-J group additionally given 0.25ml/12h Jambul Fruit Extract (JFE) for next 5days by oral gavage....
Sahar Shibli1,2*, Farzana Siddique1, Saeeda Raza2, Zaheer Ahsan3 and Irum Raza4
...) that attributed to its oxidative instability. Sensory evaluation of peanut butter samples showed overall good acceptability of product among the people. Storage study of peanut butter samples demonstrated shelf stability of product up to three months at room temperature. ...
Tafail Akbar Mughal1, Muhammad Zubair Saleem2, Shaukat Ali3,*, Khawaja Khurshid Anwar1, Muhammad Majid Bashir1, Muhammad Babar4 and Muhammad Adeeb Khan1
...er damage caused by both oxidative and non-oxidative mechanisms.
...
Xu Lijie, Obaid Ullah, Liu Haixing, Ihsan Ali, Zhongshu Li* and Nan-Zhu Fang*
... used an embryo model of oxidative damage by H2O2. We found that H2O2 exposure significantly decreased embryo development, increased the intracellular ROS level, and upregulated the expression levels of the NADPH oxidase genes NOX2, DUOX1, and NOXA1. By contrast, embryo treatment with pioglitazone after H2O2 exposure promote embryo development, significantly decreased the ROS level, downregulate...
Mahroze Fatima1*, Muhammad Afzal2 and Syed Zakir Hussain Shah3
...vitamin E showed the pro-oxidative effect which promoted lipid peroxidation....
Iqra Jaffar, Zainab Sehzadi, Muhammad Adeel, Khalid P. Lone and Mehwish Faheem*
...) for 7 days to evaluate oxidative stress in liver and gills by analyzing activity of glutathione-S-transferase (GST), catalase (CAT), glutathione (GSH) and by measuring lipid peroxidation (LPO). Catalase activity increased significantly in liver and gills of fish exposed to 10μg/l of DBP. Level of GSH and LPO increased significantly in gills while a non-significant decrease was recorded for GSH and GST in liver. These results showed that exposure to low co...
Xiaona Cao1,3-5, Yuanyuan Ren2-5, Xiaoteng Cui2-5, Baoxin Qian2-5, Chunyan Zhao 2-5, Jie Yang2-5, Chao Su2-5,* and Xingjie Gao2-5,*
... during arsenite induced-oxidative stress. Increased hnRNP A1 fluorescence signal within cytoplasm was detected from 3% of normal cells to the 28% of stressed cells; in contrast, 87% of cells with strong hnRNP A1 signal within nucleus reduced to 50% during stress. In addition, transport receptor importin-β pathway seems to be involved in the nuclear import of hnRNP A1, rather than HuR and TIA1. However, the slightly enhanced cytoplasmic accumulatio...
Muhammad Naveed Sheas1, Haris Rasool2, Muhammad Nouman Rafique2, Muhammad Rizwan Tariq1*, Abid Muhammad1, Khubaib Ali1
...chanisms of body against oxidative stress which is a key factor in elevating depression. This study is designed to reveal the efficacy of honey and curcumin against depression in rat model. 24 male wister rats were randomly divided into 4 groups. After the trial, blood biochemistry was done in which antioxidant enzymes like SOD, Catalyze, Glutathione peroxidase were performed that shows significantly high levels in the blood than the group that was treated wit...
Uzma Jabeen1, Irfan Khan2, Nadia Naeem2, Asmat Salim2,* and Waseem Ahmed1
...e induced in response to oxidative stress in heart and liver tissues following DOX administration to rats. In this study, DOX was administered to rats intraperitoneally (i. p.) at 3 mg/kg at alternate days for two weeks. Heart and liver tissues were harvested and the mRNA levels of NAD(P)H quinone dehydrogenase 1 (Nqo1), glutathione peroxidase (Gpx1) and isocitrate dehydrogenase-1 (Idh1) were analyzed by RT-PCR. We observedvariable pattern of gene expression w...
Zeynep Soyer Sarıca1*, Meryem Eren2 and Meryem Senturk2
...ssium dichromate induced oxidative damage in the brain tissue of Sprague Dawley rats. Malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) enzymes were estimated in the brain tissues of the Sprague Dawley rats. Compared to the control groups, a significant increase in the brain tissue MDA level of the group which received only 10 mg/kg K2Cr2O7 was observed...
Chukwuemeka Calistus Okolo1*, Ikenna Onyema Ezeh2, Chinelo Nnenna Uju3 and Nwakaego Ernestina Nweze1
... haematobiochemical, and oxidative stress markers were determined. At day 13 PS, there were no significant (p< 0.05) variations in mean parasitaemia of groups A, B and D. At day 16 PS, the parasites had cleared from the peripheral blood of rats in groups A and B, but remained detectable in group D. Although group D had significantly higher total erythrocyte count and haemoglobin concentration compared to groups A--C, and E, no significant variation was seen...
Nouf Alharbi*, Mai Elobeid and Promy Virk
...ium-induced toxicity and oxidative stress in a male Sparaque Dawley rat model. There were four experimental groups with 6 rats in each: Group I control orally received normal saline, Group II orally administrated cadmium chloride (5 mg/kg bw/d), Group III orally administrated cadmium chloride (5mg/kg bw/d) and treated with low dose of quercetin (50 mg/kg bw/d), Group IV orally administrated cadmium chloride (5mg/kg bw/d) and treated with high dose of quercetin...
Sabbah M. Allam, T.M. El-Bedawy, M.H. Bakr and A.E.M. Mahmoud*
...garded as a biomarker of oxidative stress in cows, was insignificantly (P>0.05) affected by feeding experimental rations and ranged from 0.420 to 0.433 mm/l. Salmonella spp. was not detected and E. coli was insignificantly (P>0.05) affected by feeding DOP rations. It could be concluded that DOP can be used as an alternative source of energy in Holstein dairy cow’s rations, replacing up to 75% of yellow corn grains without negatively e...
Nosheen1, Sajid Abdullah1, Huma Naz2* and Khalid Abbas1
...tic system and can cause oxidative stress in fish. Evaluation of antioxidant in fish can reveal metal toxicity in the water ecosystem. Therefore, this experiment was planned to assess the acute affect of lead (Pb+2) on peroxidase (POD) activity in tissues viz. liver, gills, kidney, muscle, heart and brain of fish Catla catla exposed for 4-day. After each sampling (24-hr interval) fish were dissected and required organs were obtained. Results showed that the PO...
Sibgha Noreen*, Sumrina Faiz, Muhammad Salim Akhter, Kausar Hussain Shah
...ield, physiological, and oxidative activity of sunflower crop could be enhanced by aerial spray of proline at the rate of 200 mgL-1 under saline environment. ...
Shaukat Ali1,*, Sadia Batool2, Fatima Javed Butt2, Sundas Nasreen1, Hafiz Muhammad Tahir1
...omoter; as they have antioxidative, immunomodulatory, antipathogenic and anti-cancerous properties. Review based on the futuristic and modern aspects of cancer treatment, we believe that probiotics based cancer treatment would be supportive to overcome the chemotherapeutic and radiological drawback sand provides an appropriate cancer treatment strategy. Anticipating various challenges, we expect that probiotics may become a potential cancer bio-theranostic in ...
Hafiz Muhammad Arsalan1, Maria Altaf1, Zeemal Seemab Amin1, Muhammad Khalil Ahmad Khan2, Anum Shahzadi1, Hina Mudasser1, Iqra Maqsood1, Nazia Gulshan1, Saira Naseem3
...sm which cause potential oxidative injury to tissues and lead to cartilage degradation in RA patients.
...
Fariha Latif1*, Muhammad Javed2, Hammad Ahmad Khan2 and Khalil-Ur-Rehman3
...b on bioaccumulation and oxidative stress in the liver, kidney, gills, muscles and brain of Cirrhina mrigala. The 120-days old fish were exposed to 1/4th (11.81mgL-1) and 2/3rd (31.49mgL-1) of 96-h LC50 of water-borne Pb for three fortnights (42 days) in glass aquaria at pH 7.5, temperature 30°C and total hardness 250mgL-1. After each fortnight, fish were sampled from each treatment a...
Saman Muhsin Abdulkareem* and Nadir Mustafa Nanakali
...re studied on indices of oxidative stress, liver enzymes activity and the expression of cytochrome P450 1A1 (CYP1A1) against hepatotoxicity induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in male rat. Thirty adult male Wistar rats randomly divided into five equal groups. TCDD and QCT were orally administered at the dose of 10µg/kg /day and 20 mg/kg/day, respectively by gavage dissolved in corn oil for 90 days. At the end of the study, ani...
Dilara Abbas Bukhari*, Mehwish Faheem, Shamoona Arshad and Khalid P. Lone
...e determined to evaluate oxidative stress while urea and creatinine, was used to evaluate kidney function. It was found that there was an increase in weight (p<0.05) of both males and female mice fed with diet containing ghee. Kidney LPO and CAT were significantly increased in both male and female mice. GSH level showed decreasing trend in female while increase was observed for male kidney. Creatinine level increased in both male and female experimental gro...
Elmas UlutaÅŸ1,*, Abdullah Eryavuz2, Aziz Bülbül2, Abdur Rahman3,*, Ä°smail Küçükkurt4 and Cangir Uyarlar5
...ameters, live weight and oxidative status in goats. In this study, twenty four male Angora goats each of 12 months of age, and weighing approximately 35 kg were divided into four groups as: control group (C) fed with basal diet containing 31.76 ppm Zn, experimental group 1 fed with basal diet supplemented with 500 ppm Zn, experimental group 2 fed with basal diet supplemented with 750 ppm Zn and experimental group 3 fed with basal diet supplemented with 1000 pp...
Fatima Hashim Abbas1,2* and Alaa Tareq Shakir Al-Hassnawi1
...eased the level of serum oxidative stress (MDA) and this elevation may be driving the detrimental effects induced by parasitic or vial infections.
...
Ahmet Ozer Sehirli1,2, Serkan Sayiner3*, Ayliz Velioglu-Ogunc4, Nedime Serakinci5, Emel Eksioglu-Demiralp6, Berrak Yegen7, Feriha Ercan8 andGoksel Sener2
...d to decrease indicating oxidative damage. These results indicate that oxidative mechanisms induce tissue damage in CRF, and the angiotensin receptor blocker, Valsartan, improved oxidative tissue damage when used in combination with the ACE inhibitor, Captopril or NAC, yielded better results and could be a novel approach for the treatment of CRF when used in combination with anti-oxidants....
Aamir Mushtaq1,2, Rukhsana Anwar1 and Mobasher Ahmad1,2,*
...dried seeds to check the oxidative neuronal decay in brain parts. Methanolic extract of Pimpinella anisum (meP.a) dried seeds was explored qualitatively and quantitatively for analysis of phytoconstituents along with anti-oxidant activity. Anti-amnesic activity was found by behavioral and biochemical studies for which male albino mice were grouped into seven groups. Mice were subjected to elevated plus maze, hole board and light dark paradigm on (day 7<...
Alicja Kowalczyk1, Marian Kuczaj2, Anna Szul3 and Ewa Czerniawska-PiÄ…tkowska4*
Yuhong Li1, Dongxue Wu1, Xue Wang1, Mi Zhang1, Hanyu Zhu1, Zhe Shi1 and Fumin Feng1,2*
...creased, suggesting that oxidative stress reaction occurred in all drug groups. Compared with the baseline group, the mRNA and protein levels of NF-κB and TNF-α in the H group showed an increasing trend, and p-NF-κB and p-IκB also showed an increasing trend. However, these indicators increased first and then slightly decreased in the R, Z and HRZ groups. Among them, the significant changes in the indicators of the HRZ group were earlier...
Haiyan Yang1, Hongxia Liu1, Wenlong Wu1*, Weilin Li2 and Lianfei Lyu1
Mazhar Abbas1*, Kishwar Jam1, Rashid Iqbal Khan1, Muhammad Zafar-ul-Hye2, Tariq Rafique3 and Zahid Mahmood4
...on growth, yield and antioxidative behaviour of bottle gourd cv. Aakash F1. Three level of Quantis (6 ml, 8 ml, 10 ml) and Acevit-C (100 ppm, 150 ppm and 200 ppm) were applied as foliar treatment following RCBD design. Results showed that impact of foliar application of both Quantis and Acevit-C on bottle gourd growth and reproductivity were significant. Moreover, application of 100 ppm Acevit-C and 10 ml/L-1 Quantis exhibited 6.5 and 11.5 fold increment in yi...
Mahak Fatima1, Memoona Syed1, Rabia Zeeshan2, Farah Rauf Shakoori3, Naveed Shahzad4, Moazzam Ali1 and Zeeshan Mutahir1*
... DNA and subsequently to oxidative damage. The present study explores the relationship between MTH1 gene silencing and its outcome on the growth of gemcitabine resistant breast cancer cells named MCF7-R. For this purpose, we transfected MCF7-R cells with MTH1 specific validated siRNA. Successful transfection of siRNA and consequent cytotoxicity in MCF7-R cells was confirmed by qRT-PCR, western blotting and cell viability assay. As a result of siR...
Rubina Munir1,2*, Muhammad Zia-ur-Rehman3, Muhammad Makshoof Athar1, Noman Javid1,4, Ayesha Roohi2 and Syeda Fatima Razavi2
Yaqiu Liu1, Zhijian Wang 2, Xinhui Li 1*, Jianrong Zhao2 and Weitao Chen 1
...e: small;">The effect of oxidative stress on gill and gut enzyme activity in Paramisgurnus dabryanus was studied under different breathing restraint treatments. A total of 150 healthy mature individuals (mean initial body weight = 16.1 ± 3.7 g and mean initial total fork length = 13.1 ± 1.2 cm) were selected for the experiment. The experimental specimens were separated into three modes: control group (n = 50) without any stress treatments;...
Adnan Khan1, Rifat Ullah Khan1, Muhammad Subhan Qureshi2, Muhammad Mobashar3, Ali Gohar4, Shakoor Ahmad1, Kamran Khan5, Hamayun Khan1 and Shabana Naz6*
...T1 due to cryo shock and oxidative stress respectively. Sperm DNA integrity and pH were increased linearly from T1 to T3. The dead sperm percentage was significantly (P<0.01) low in groups with semen sample treated with T2 compared to other groups. Significantly (P<0.01) high sperm individual motility percentage was observed for T2 than T3 and T1. Sperm acrosomal integrity percentage showed significantly ((P<0.01) high value in T2. It is concluded tha...
Naveed Akhtar1*, Muhammad Fiaz Khan1*, Sadia Tabassum1,
Munawar Saleem Ahmad2 and Khan Dil Badshah3
...and muscles related with oxidative stress damage was observed. Genotoxicity increased with increase in time and concentration of cypermethrin. Cypermethrin is therefore extremly harmful to aquatic life.
...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...ncrease the incidence of oxidative stress. Caffeic acid is a powerful free radical scavenger and possesses antioxidant effect against the various diseases. Previous study suggests that the caffeic acid have potent anti-inflammatory activity. The aim of the current study was to scrutinize the protective effect of caffeic acid against the streptozotocin induced GDM in rats and explores the possible mechanism of action. A total 36 female rats were caged into the ...
Eman A. Al-Shahari1,2, Abdelhalim A. Alkhazendar3, Eman R. ElBealy4 and Abeer A. Alm-Eldeen3*
...tions via increasing the oxidative stress. Quercetin, a polyphenolic, that has antioxidant activity. Therefore, this study was performed to examine the possible role of quercetin in modulating aging-induced testicular damage. Samples from 30-months old rats’ testis were examined before and after 200 mg of quercetin/Kg administration. Before quercetin administration, they showed an increase in the lipid peroxidation and 8-hydroxy-2’-deoxyguanosine w...
Memoona Tehseen1, Sajila Hina2*, Alim-un-Nisa2 and Naseem Zahra2
...ificant effectiveness in oxidative stabilization of the sunflower oil. ...
Alamaary Mohaammed Saad1,3, Abd Wahid Haron1*, Mohamed Ali2,
Mark Wen Han Hiew1 and Lawan Adamu1
...a are susceptible to the oxidative stress OS during cryopreservation. The excessive reactive oxygen species (ROS) and the capacity of the antioxidants could affect the OS level in the frozen semen. This study was to determine the addition of different concentrations of antioxidants to evaluate oxidative stress and fertility of frozen semen in horses. Seven stallion were used for semen collection in this study. A total of twe...
Yawang Sun, Yongjiang Wu, Jingbo Chen, Zili Wang, Juncai Chen, You Yang and Guozhong Dong*
...>This study investigated oxidative stress and the consequent DNA damage induced by lipopolysaccharide (LPS) in bovine mammary epithelial cell line MAC-T cells. Cells were cultured for 48 h with different LPS levels (0, 0.1, 0.5, 2.5, 12.5, and 100 ng/mL). The results showed that cell viability was negatively correlated with LPS concentrations. The production of reactive oxygen species increased in a dose-depend manner. Cellular concentrations of
Nashwa M. Helmy1, Ahmed S. Ahmed2, and Zeinab3 Y. Mohamed
...th LSD exposed to strong oxidative stress so recommended to use antioxidants in infected animals during treatment....
Aliya Munir1, Sajid Abdullah1*, Huma Naz2*, Khalid Abbas1, Tanveer Ahmed3 and Zahid Farooq2
Wenjuan Yan1, Qunlan Zhou2, Bo Liu2,3*, Cunxin Sun2, Huimin Zhang3 and Changyou Song2
...wn, reduce the damage of oxidative stress.
...
Miloudi Hilali1*, Hanae El Monfalouti1, Larbi El Hammari2, Farid Amar3, Zakaria Mennane4, Malika Haddam5, Nadia Maata6 and Badr Eddine Kartah1
Mengke Wang1, Shucheng Huang2, Cai Zhang1*, Haizhou Gong1,
Shunan Cuan1, Shuaishuai Wang1, Qi Shao1, Wenhao Xu1, Sudan Meng1,
Pengfei Li1, Yuqin Wang1 and Zijun Yang1
...ing free radical-induced oxidative stress, which can cause considerable injury to commercial laying hens. However, the effects of monoammonium-glycyrrhizinate in improving liver lipid metabolism and antioxidant capacity of laying hens is unclear. The current study examined the ameliorative effects of monoammonium-glycyrrhizinate (MAG) on liver lipid metabolism and antioxidant capacity in laying hens. One hundred eighty 320-day-old Hy-Line brown laying hens wer...
Li Ma1 *, Xu Han1, Bo Yang2 and Chunhua Zhou3
...n profoundly protect the oxidative damage in HUVECs. However, compared to the oxidation-treated cells, the apoptosis rate was significantly decreased in drug-treated cells. Mechanistically, the percentage of G1 phase and S phase cells in vitamin C and drug groups was decreased, and the percentage of G2 phase cells was increased significantly. Intriguingly, the number of CD105/CD62E-marked HUVECs cells was markedly observed. In comparison to the oxide-treated c...
Muhammad Aftab1*, Aneela Riaz2, Ghulam Sarwar3, Muhammad Arif1, Qudsia Nazir1, Ifra Saleem1, Sarfraz Hussain1, Abid Ali4, Abid Niaz1, Fakhar Mujeeb4, Khalid Mahmood5 and Sarfraz Nawaz6
...s of (B and Salt) causes oxidative stress in plants due to increase in production of the reactive oxygen species (ROS) including hydroxyl radicals (OH-), hydrogen peroxide (H2O2) and superoxide (O2-). However, on their side, efficient antioxidant defense system developed in plants, which having lower molecular weight of antioxidants. It also reduces (ROS) enzymatic activities including catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD). Under comb...
Muhammad Shahbaz1,2, Sajid Abdullah1*, Huma Naz3*, Khalid Abbas1, Tanveer Ahmed4, Sana Mehmood1, Muhammad Adeel Hussan5
...e impact of Vitamin E on oxidative stress enzyme (catalase) of fish. Vitamin E has proven beneficial in protecting cellular membranes against oxidation and increases the resistance to stress.
Amr N. El-Shahat1, Refaat G. Hamza1,*, Ashraf M. Mounir1 and Madeha N. Al-Seeni2
...gainst radiation induced oxidative stress and biochemical alterations in the liver and kidney of male albino rats.In the present study, gamma- irradiation (2 Gy every 3 days up to 8 Gy total doses) induced biochemical and oxidative damage in rats when compared to control group. In GFJ (10ml/Kg B Wt. /day) treated irradiated group, there were noticeable decreases recorded in lipid contents, concentration of serum urea, creati...
Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
...cations, blood pressure, oxidative stress and haematological disorders. This study was done in the investigation of antihyperlipidemic effects of methanol extract of seeds of this plant in hyperlipidaemia Wistar albino rats induced by Triton X-100. There were 4 groups of rats: Group A served as normal; Group B, C and D were given high cholesterol diet and administered with intraperitoneal injection of Triton X-100 to induce hyperlipidaemia. Group B was adminis...
Noor Bad Shah Khattak1, Hamayun Khan1, Muhammad Tarique Tunio2, Shakoor Ahmad1, Nazir Ahmad3, Syed Murtaza Hassan Andrabi4, Obaidullah5, Ihsan Ali1,5,* and Nan-Zhu Fang5,*
...This study describes antioxidative activity of green tea (GT) extract on standard post-thawed quality indicators of frozen buffalo bull’s spermatozoa. Semen samples were obtained from the bulls for three weeks through artificial vagina. Egg yolk was used as an extender, in which different concentrations of GT extract (0.0%, 0.50%, 1.0%, 1.5%, 2.0% and 2.5%) were added. Semen quality indicators studied were the percentage of motility, survivability, plasm...
Faryal Malik, Mudassar Nawaz Khan* and Israr-ud-Din
...wheat varieties suffered oxidative stress due to flooding but showed a recovery trend due to increased activities of antioxidant enzymes that scavenged the oxidative radicles, thus helping the wheat to recover. Atta Habib reflected higher recovering ability than Siran and Ghanimat-e-IBGE. The findings of the current study will surely help in contributing efforts to develop flood-tolerant cultivars....
Elfadil Elfadul Babiker1, Khalid Ahmed Abdoun2*, Fahad AL Juhaimi1, Kashif Ghafoor1, Riyadh Salih Aljumaah2 and Ahmed Abrahim Al-Haidary2
... examined changes in the oxidative state and the concentrations of vitamin C, glucose, and cholesterol in the serum of ewes and goats fed on alfalfa hay-based diet (AHD) supplemented with 25% Moringa oleifera (MOD) or Moringa peregrine (MPD) leaves. Thirty ewes (2 years old and 50-60 kg BW) and 30 goats (2 years old and 35-40 kg BW) were randomly allocated to 3 experimental groups, consisting of 10 ewes and 10 goats each. The 3 experimental groups of either ew...
Syukriah Syukriah1, Ulinnuha Nur Faizah2, Hendry T.S. Saragih3*, Rizki Fitrawan Yuneldi4, Soenarwan Hery Poerwanto5, Raden Roro Upiek Ngesti Wibawaning Astuti5, Stephan Immenschuh6
... examined differences in oxidative stress-mediated effects in pregnant and offspring mice in Plasmodium berghei infection. A Complete randomized design was used in this study, in which 25 mice were divided into five groups. Group 1 as a control group, consisted of non-pregnant and Plasmodium-uninfected mice, group 2 comprised pregnant and uninfected mice, group 3 to 5 were pregnant mice and were infected with 1 x 101iRBCs, 1 x 102 iRBCs, and 1 x 103 iRBCs resp...
Hong Yin*, Dan Yang, Ji-Jie Liu, Jing-Wei Ding and Dan-Dan Cui
... through controlling the oxidative stress and balancing the level between FAS and acetyl-CoA carboxylase (ACC)....
Muhammad Tariq1, Imtiaz Rabbani2, Muhammad Shahbaz Yousaf2, Imdad Ullah Khan1*, Hafsa Zaneb2, Sajid Iqbal3, Alam Zeb Khan1, Shakirullah1, Muhammad Shuaib Khan1, Atta Ur Rehman1 and Mumtaz Ali Khan2
...ous stresses there is an oxidative stress which damages the spermatozoa endogenously. These stresses can be controlled with the inclusion of antioxidants in semen extender at the time of cryopreservation. In the current study, semen from four (n=4) healthy Nili Ravi buffalo bulls was collected through artificial vagina and Gallic acid was added to the semen at 1 µM, 15 µM, 30 µM, 45 µM, 60 µM, and 100 µM. A total of six grou...
Doaa Sh. Mohamed1, Nema S. Shaban2 , Mai M. Labib3, Olfat Shehata4
Semra Okur Gumusova1, Gul Fatma Yarim2, Cuneyt Tamer1,*, Ayris Salt2 and Gokhan Inat3
...the relationship between oxidative stress and cell damage may provide important insight into infection treatment. Previous studies have shown that many viruses induce oxidative cell damage during their replication in mamalian cell culture, but fish viruses has not been well-studied. Infectious pancreatic necrosis (IPN) is caused by infectious pancreatic necrosis virus (IPNV) and it is a viral, fatal and contagious disease of...
Min Li1, Shiwu Deng2*, Yiqian Peng3 and Hong Li2
...ugh mitochondrial and ER oxidative stress pathways. Left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd) and left ventricular end-systolic diameter (LVESd) of SD rats were measured by echocardiography, and the mRNA expression level of peroxisome proliferator-activated receptor gamma co-activator 1-a (PGC1 a), superoxide dismutase (SOD2) and citrate synthase (Cs) were detected by real-time PCR. Ultrastructural changes of my...
Uzma Jabeen1, Asmat Salim2*, Irfan Khan2, Nadia Naeem3 and Rubina Mushtaq4
... mechanisms, the role of oxidative stress remains obscure, though it is the most probable mechanism for its cardiotoxic effect. The main focus of this study is to analyze the mechanism of renal toxicity caused by this chemotherapeutic drug. As reactive oxygen species are significant regulators of transcription factors and gene expression, this study was aimed at analyzing the expression levels of genes that are induced in response to o...
Jabbar Khan1, Mehwish Jehan1, Zeeshan Mutahir2, Muhammad Rafi1, Muhammad Ismail1, Aamer Abbas1 and Jabbar Tanveer3
...n control group and that oxidative stress, induced by heat stress, may have a negative effect on the availability of Se, which accordingly resulted in reduced synthesis of thyroid hormones. Beside that the concentrations of total protein, cholesterol, albumin and glucose were found significantly higher in Damani breed than control group, indicating that Damani breed had comparatively better adaptive capabilities in preparing the internal physiology and metabol...
Ibrahim Samir Abd El-Hamid1*, Wafaa Adel Abd Fouda1, Hesham Attia Shedeed1, Safaa Ali Mostafa1, Ahmed Mohamed Elbaz2, Salah Abo Bakr2, Baliegh Hamdy Mosa1, Ali Saber Morsy1, Amal Mohamed Hasan1, Khamis Refaay Emam3
...oductive performance and oxidative status of Hi- Plus doe rabbits.
Keywords | Rabbits, microalgae Nanochloropsis oculata sp., Reproductive performance, Productivity, Blood constituents.
...
Yuechen Li1, Yumo Li1, Xuefeng Zhuang1, Guangfu Lv2, Xiaowei Huang1, Zhe Lin1, Yuchen Wang1* and He Lin1*
Feng Xu, Weijing Fan and Guobin Liu*
...vity, apoptosis rate and oxidative stress level of HUVECs. The low concentrations (25, 50, 100 μmol/L) of rutin had no toxic effect on HUVECs, and the activity of HUVECs was significantly reduced after intervention with high concentrations (200, 400 μmol/L) of rutin. ox-LDL treatment significantly reduced HUVECs activity, CAT and SOD levels,NEXN-AS1 expression (P<0.05), and increased apoptosis rate, MDA level, and miR-410-3p expression (P<0.05). Ru...
Emtenan M. Hanafi1*, Fouad M. Tawfeek2, Walid S. El Nattat1, Moetazza M. Alshafei3, Seham S. Kassem3, Kawkab A. Ahmed4, Enas N. Danial5, Hagar Elbakry3, Hoda S. El-Sayed2
...d lipid profile, leptin, oxidative markers and low level of testosterone and the epididymal Spermatozoa had low sperm viability and higher abnormalities than control group. Feeding the microcapsules (G2,G3) improved the animals’ health condition. Animals in G2 showed good spermatozoa profile while, those fed SP (G3) showed low sperm count and motility. Histopathological examination declared testicular degeneration in G1 and G3 and a high spermatogenesis ...
Iram Liaqat1*, Umaima Bibi2, Muhammad Arshad3 and Najma Arshad2*
...tural sources, to reduce oxidative injury to the cells and overcome oxidative deterioration of foods affecting human life. The study was designed to assess the antioxidant capability of six selected medically principal plants; Hyssopus officinalis, Origanum vulgare, Thymus vulgaris, Glycyrrhiza glabra, Cordia latifolia and Zizyphus jujuba. Antioxidant activity was determined by total phenolic content determination, Pyrogallo...
Marwa Ragab Saeed Abdallah, Hussein Mohamed Hussein Mohamed, Mohamed Mohamed Talaat Emara, Mai Atef Mohamed
...ackaging showed the most oxidative stability (low TBARS, peroxide values, met-myoglobin, and carbonyl contents, high scavenging activity) and the highest sensory quality among the different treatments. The composite treatments extended the wholesomeness of pastirma to 16 weeks at 5 °C in comparison with 12, 8, and 4 weeks for uncoated vacuum-packed, aerobically packed WPI/BW, and untreated control samples, respectively. Therefore, the application of WBI/BW...
Rawda S. Mohamed1,2, Mohammed Y. Matoock2*, Abeer H. Abdelrazek2
Xing Lu1, Mahmoud A.O. Dawood2, Fan Wu1, Hua Wen1, Wei Liu1, Juan Tian1, Ming Jiang1, Li-Juan Yu1, Xiang Li3, Ning Xu3 and Hong-Wei Liang1*
Muhammad Kashif Iqbal1*, Khalid Mehmood2,4, Shakeel Ahmed3, Fazul Nabi4, Muhammad Arif Rizwan1, Muhammad Kaleem1, Mushtaq Ahmed1, Abdul Waheed1 and Jiakui Li5
...l through rectifying the oxidative imbalance and liver damage....
Muhammad Akram1*, Muhammad Imtiaz Shafiq2, Amber Malik3, Farmanullah Khan4, Munir Ahmad Bhinder5 and Muhammad Sajjad6
...of CVDs. To counter this oxidative stress, the most important natural antioxidant defense mechanisms include endogenous glutathione concentration, superoxide dismutase, catalase, and glutathione S-transferase (GST). GST neutralizes reactive oxygen species to regulate physical homeostasis in the body. The target of this study was to evaluate the molecular role of GST genotypic polymorphism involved in the development of CVD. For this case-control study, a total...
Eman A. Al-Shahari1,2, Eman R. ElBealy3, Abdelhalim A. Alkhazendar4 and Abeer A. Alm-Eldeen4*
...res and functions due to oxidative stress and the reduction in the oxidative damage’s tolerance. Quercetin, a flavonoid has the ability to face the oxidative injury through its antioxidant activity. Therefore, the present study was designed to investigate the possible role of quercetin in modulating liver’s function and structure in aged male rats. Forty eight male albino rats ...
Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5
Florence N. Nworah*, Nene O. Uchendu, Ifeoma F. Chukwuma*, Emmanuel C. Ossai and Emmanuel C. Ezeako
...udy investigated the antioxidative and haematopoietic potency of the blood of Pelusios sinuatus (turtle) on cyclophosphamide induced myelosuppression in rats. Blood constituents were determined to identify the presence of vitamins and minerals. Thirty albino rats used were grouped into six comprising of five rats each and each group except group A was induced with cyclophosphamide. Group A received normal saline, group B remained untreated, group C, D, E and F...
Hemat A. Abdel Magied*, Heba H. Habib, Amany H. Waly, Ahmed Fadl, Sayed M. Shalash
... PE and PEP enhance meat oxidative by decreased malondialdehyde (MDA) by 28.15 and 19.87 %, respectively and improve meat quality by decreased low density lipoprotein (LDL) by 7.69 and 4.73 %, respectively. The EXP2 observed chicks fed on low ME and low CP diet significantly decreased total body weight gain (BWG) with increased in total feed intake and FCR. Chicken treated by PEP had significant increased on final body weight, BWG and improved FCR for control ...
Noha M. Abd El-Azeem*, Hemat A. Abdel Magied, Mervat N. Ghazal, Nehad A. Ramadan, Enayat H. Abo El-Azayem, Y. S. Hussein, Heba H. Habib
...m, by protecting against oxidative stress factors caused by pregnancy and lactation in female rabbits under heat stress.
Keywords | Antioxidant; Turmeric; MOS; Biostrong; stress; Rabbit does
...
K. H. El-Kholy1*, Enayat Hassan Abo El-Azayem2, Safaa Ataya Barakat2, Mona Gamel Mohamed3, Sara H. M. Hassab1
...ty by protecting against oxidative stress which in turn increasing the production yield. This study hypothesized that using Aloe vera (AV) leaves powder may provide protection against stress and enhance animal physiological responses. Thus, this study aimed to investigate the effect of dietary AV addition on growth traits, caecal ecosystem and some physiological and biochemical responses in growing rabbits. APRI rabbits (age = 6 weeks, n = 60) were split equal...
Rezqita Putri Pitaloka1, Kartiawati Alipin1, Mas Rizky A.A Syamsunarno2, Gemilang Lara Utama3, Ramdan Panigoro2, Ratu Safitri1*
...ation in the body causes oxidative stress, which can lead to cell death. Iron chelating agents such as deferoxamine, deferiprone, and deferasirox have been used to treat iron overload, but their uses are inconvenient caused by their side effects. Therefore, the invention of an alternative chelating agent with a more efficient effect, convenient uses, and affordable is essential, which can be done with natural plants. Sappan wood (Caesalpinia sappan L.) contain...
Shahrokh Mojarradgandoukmolla* and Hasan Akan
...enal function tests, and oxidative biomarkers were measured. Histological evaluation was also performed. Among the hematological parameters in the treated groups, only lymphocytes showed a significant change in the treated group with T. uncinata. The levels of liver enzymes, lipid profile and glucose in the ethanol group increased significantly compared to the control, while these parameters were significantly improved in the groups treated with these t...
Marwa S. Khattab1*, Ahmed H. Osman1, Huda O. AbuBakr2, Rehab A. Azouz3, Asmaa A. Azouz4, Heba S. Farag5
Dong-Min Hou1, Ting Jia2, Hui-Juan Wang1, Zheng-Kun Wang1 and Wan-Long Zhu1*
...ignificantly enriched in oxidative phosphorylation, steroid biosynthesis, glycerophospholipid and fatty acid metabolism pathways related to energy metabolism and lipid metabolism. Differentially expressed genes ND3, ND4, ND5, ND6, ND4L, CYTB, ATP8 and ATP6 in oxidative phosphorylation pathway were significantly up-regulated. Key genes related to lipid metabolism were identified as ELOVL6, ACACA, HSD17B12, SQLE, LSS, DHCR7, D...
Shaolin Zeng, Shuai Yuan* and Kai Liu
...ion content on levels of oxidative stress indicators of myocardial tissue of rats in the sevoflurane group was detected by ELISA. We found that the inhibition expressed by content of miR-26a-5p in rats after post-ischemic treatment with sevoflurane inhibited the anti-inflammatory effect of post-ischemic treatment with sevoflurane. The post-ischemic treatment with sevoflurane promoted the activity of SOD, CAT as well as GSH-Px, and inhibited MDA and ROS levels,...
Serkan Özkaya1*, Oktay Özkan2, Sabri Erbas3, Isa Gökhan Yalçın4, Dariusz Piwczynski5 and Wojciech Neja5
...re suppressed due to the oxidative stress to which they are also exposed. In the present study, it was investigated whether Oreganum onites L. aromatic water (OW) could serve as an agent of reducing the effects of oxidative stress while improving the growth performance of suckling Holstein calves. Twenty-eight newborn calves (n=7, in each group) were randomly selected and assigned to the following four treatments: Control, 4...
Doaa H. Assar1, Rasha A. Al Wakeel2, Mahmoud M. El-Maghraby3, Mohammed M. El-Badawy3, Adel A. El-Badawy3, Wael M. Nagy3, Mustafa S. Atta2, Abdel-Khalek E. Abdel Khalek4*
...>Keywords | Allicin, Antioxidative enzymes, Healthy status, Immunity, milk, Lambing rat. ...
Ibrahim Samir Abd El-Hamid1, Alaa Emara Rabee2, Moustafa Mohamed M. A. Ghandour2, Rasha Salah Mohammed3, Ahmed Mohamed. Sallam4
...ality, blood metabolism, oxidative status and testicular structures. Three groups of fourteen Damascus bucks were formed. The first group (control, n=4) served as the control group. The second group (n=5) supplemented with 10 g/head/day of plant herb mixtures (PHM), along with turmeric (Curcuma longa), ginger (Zingiber officinaleor), and garlic (Allium sativum). The third group (n=5) supplemented with 5 g/head/day of commercial Quebracho tannins extract (QT). ...
Nadia A Eltablawy1, Ibrahim El Tantawy El Sayed2, Hamed Mohamed Abdel Barry2, Marwa A. Ibrahim3*, Maha Nageib Ahmed Serag ElDein2
..., iron accumulation, and oxidative stress as evidenced by the increased MDA, and NO in association with significant reduction of GSH content in cardiac tissue. Furthermore, mRNA expression of iNOS was significantly upregulated and eNOS and Top 2 ß mRNA expression levels were downregulated. The pre and concomitant administration of TME with DOX as well as the post-administration of TME at 100 and 200 mg /kg suppress the harmful effect of DOX on heart tiss...
Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Mengli Jiang and Jicang Wang*
...d down the occurrence of oxidative stress induced by Cd. Therefore, as an effective antioxidant, Nar has a certain protective effect on oxidative stress and kidney injury induced by Cd....
Mohsin Shad1, Muhammad Usman2 and Qurratulann Afza Gardner1*
..., resulting in defective oxidative phosphorylation and consequently effects other metabolic pathways. In the present article, we comprehensively compare the biodiversity of cyt b in bc1 and b6f complexes using in silico structural analysis tools, emphasizing that despite vast knowledge available in this field, still there are so much to explore about cyt b....
Rukhsana Anwar1*, Ammara Abd-Us-Sattar1, Afifa Noor2, Kanwal Ashiq1,3 and Shah Jahan4
...zyme activity and reduce oxidative stress....
Asmatullah Kaka1*, Wahid Haron2, Nurhusien Yimer3, Abdullah Channo1, Ali Raza Jahejo2, Mahdi Ebrahimi3, Dildar Hussain Kalhoro4
...s) content were used for oxidative stress evaluation. Frozen-thawed results showed significant (p < 0.05) enhancement in all sperm parameters with 10 ng/ml of DHA supplementation. DHA improved (p < 0.05) SOD levels in all supplemented groups compared with the control group. Level of TBARS was higher (p < 0.05) at 15 ng/ml as compared to other DHA supplemented and control groups. A dose-dependent increase (P<0.05) was found in C22:6n-3, DHA and n-3P...
Makruf Arif1*, Claude Mona Airin1, Dwi Sunu Datrianto2, Dinda Anggun Roro Sejati3
... justify;">Damage due to oxidative stress during semen preservation can cause a decrease in motility, viability, and damage to plasma membranes that can reduce fertility rates. The use of antioxidants in semen preservation is very important to suppress lipid peroxidation so it can maintain the quality of the sperm. This study aimed to determine additional honey to the quality of KUB rooster sperm during cold storage. The semen with superior quality was diluted...
Owolabi Olutunmise Victoria1*, Saka Olusola Stephen2, Olashinde Oluwaseun Ruth1, Alli Smith Yemisi Rufina3
...the antidiabetic and antioxidative properties of young Cola acuminata leaves aqueous extract. Diabetes was induced using alloxan monohydrate.5 ml of normal saline was given to group I , group 2 received 5 mg/kg/ body weight of the standard drug glibenclamide, group 3 was given 140 mg/kg of alloxan while groups Young C. acuminata leaves aqueous extract was administered orally in graded doses to the diabetic animals (50mg/kg, 100mg/kg, 200mg/kg and 400mg/kg body...
Asmaa A. Darwish*, Mona A. Mahmoud, Adel M. El-Kattan
...dney function tests, and oxidative stress than the diseased does. Total antioxidant capacity (TAC) and Zn had the highest likelihood ratios among the suggested markers with acceptable sensitivity, specificity, PPV, NPV, and accuracy rates, and their combination yielded better values. The study concluded that the clinicopathological alterations associated with ovine and caprine brucellosis are a mirror for the immune response against the disease. Most of these ...
Bin Hu1*, Jianchang Qu2, Tenglong Han3 and Jun Leng1
...in inflammatory factors, oxidative stress molecules, and blood glucose control related indicators were detected in each patient. There was no statistical difference in gender distribution, age distribution, BMI and HbA1c between the control group and the study group before treatment (P>0.05). After treatment, the PI (P=0.000), GI (P=0.000), PPD (P=0.031), and CAL (P=0.022) of the study group with diabetes and periodontitis were significantly different from ...
Alsaied Alnaimy Habeeb*, Amaal M. Kamal, Mostafa Abbas A. Atta, Ahmed K. Sharaf
Dalia Zaafar1*, Heba M.A Khalil2, Soha Hassanin3, Mohamed R. Mousa4, Mona G. Khalil1
Jianli Xiong1,2,*, Hongtao Ren2, Guanglu Li2, Xiaochan Gao2, Yong Huang2 and Shiyang Gao2
...e function, and decrease oxidative damage of growing swan geese....
Anhar Ibrahim Elhanafy*, Amr Mohamed Mousa, Amaal Mohamed Kamal
...s, hematology, immunity, oxidative stress and thyroid hormones in doe rabbits at high ambient temperature. Forty mature female New Zealand White rabbits (6 months age) were divided into four groups. Three of them (0.1, 0.2 and 0.3 mg/doe) represent different concentrations of BV, while the fourth group was control. Twice weekly injections of does were carried out along 12-weeks. Results revealed that BV treated does were significantly improved RBCs count, WBCs...
Oussama Zghari*, Mouloud Lamtai, Sofia Azirar, Mohamed Yassine El-Brouzi, Hajar Benmhammed, Aboubaker El-Hessni, Ali Ouichou, Abdelhalem Mesfioui
...abnormalities as well as oxidative stress (OS). Conversely, melatonin (MEL) has been considered as an antidepressant, anxiolytic substance and protects neurons from OS. The present study was designed to evaluate the neuroprotection effect of MEL against Al neurotoxicity and OS in male Wistar rats. Rats received an intraperitoneal and/or a single intrahippocampal injection of NaCl, MEL or AlCl3. Before two weeks of intrahippocampal surgery period, MEL (4 mg/kg)...
Hasanain Jihad Neamah
... sperms are sensitive to oxidative stress during cooling storage. The purpose of this study was the evaluation of adding an aqueous prickly pear extract (PPE) in ram semen on sperm parameters during cooling storage. Three levels of PPE were added to the diluted ram semen (PPE1=5mg +Tris extender, PPE2=10 mg +Tris extender, and PPE3=30 mg +Tris extender), and compared with control group (Tris extender without addition of PPE). Motility of sperm, hypo osmotic sw...
Mansoor Ayoob1, Atta Hussain Shah1, Zaheer Ahmed Nizamani2, Muhammad Faisal Ayoob2,3*, Deepesh Kumar Bhuptani1,5 and Abdul Sattar Baloch4
...ts antimicrobial and antioxidative attributes. Hence, it prolongs the shelf life of beef meat without having any adverse effects on its quality....
Rahma Boukarine*, Leila Hamdi and Kamel Khelili
...hich aid protect against oxidative stress. This study was conducted on Albino Wistar rats to investigate the antioxidant effect of Eruca sativa on the hepatic and renal profile damaged by xylene. Seventy rats were divided into seven equal groups and treated by gavage for 30 days as follows: Control group (C), group (CO), positive control group (RE) was received 350 mg / Kg bw of Eruca sativa aqueous extract (ESAE), 2 toxic groups X1 and X2 were treated with xy...
Nawfal Hammadi Jasim1, Yasmeen Jassim Mohammed2 , Jala Amir Salman Alahmed1, Majdy Faisal Majeed3*
...ed free radical-mediated oxidative stress, through an increase of antioxidant enzymes and histological alterations in the liver. ...
Sarwat Yousuf1, Shaista Emad2 , Mohammad Misbah ur Rehman3, Zehra Batool4, Sara Qadeer5, Yousra Sarfaraz1, Sheeza Sheikh1, Sana Sadaf6 and Tahira Perveen1,*
...obehavioral function and oxidative stress. Rats were treated with lemon peel oil at a dose of 0.7, 1.4, 2.1, 2.7, 3.5 g/kg for 14 days. Results showed that lemon peel oil at low doses has antidepressant and anxiolytic activity. Muscular strength was also improved at low doses. The brain antioxidant defense enzymes were also enhanced whereas plasma corticosterone levels were significantly decreased following the administration of a low dose of lemon peel oil. H...
Antonius Agung Wiono1, Maria Elizabeth Nana Wijayanti1, Dhika Yonika Primacitra1, Trioso Purnawarman2, Andriyanto3, Aulia Andi Mustika3, Amaq Fadholly3*
... factor that can induces oxidative stress then releasing the number of free radicals, which can damage cells and disturb the hormonal system directly affect livestock productivity. This research expected the effect of PhytoceeTM on mitigating the risk induced by heat stress and its productivity of broiler chicken.Materials and Methods:Broiler chicken were divided to six groups (normal control, negative control, heat stress treated vitamin C 200 g/ton and 400 ...
Mahroze Fatima1*, Syed Zakir Hussain Shah2, Muhammad Afzal3, Muhammad Bilal4 and Ayesha Khizar1
...vitamin E showed the pro-oxidative effect that favored lipid peroxidation, resulting in a decreased growth rate....
Muhammad Rizwan1, Hamid Akbar1*, Aftab Ahmad Anjum1, Muhammad Arif Khan1, Aneela Zameer Durrani2, Muhammad Abid Hayat3, Anjum Masood4, Muhammad Talha Sajjad1 and Nadeem Raza2
...as aimed to evaluate the oxidative stress status (malondialdehyde, MDA; catalase, CAT), metabolic status (beta hydroxybutyric acid, BHBA; nonesterified fatty acid NEFA) and hematological changes (hemoglobin, total leucocytes, red blood cells, neutrophils, platelets, lymphocytes) in serum of dairy cows before and after the surgical correction of left displacement abomasum. Twenty-six cows were divided into two groups as control (Group-A) and treatment (Group-B)...
Vui Van Nguyen1, Samorn Ponchunchoovong2, Sajeera Kupittayanant3, Pakanit Kupittayanant2*
...p>During chilled storage oxidative stress is the primary cause for the reduction in the longevity of canine sperm. To prolong the chilled canine sperm quality, the study investigated the effects of the adding antioxidants to semen extender on canine sperm during 12 days of chilling storage. Twenty ejaculates from five American Bully dogs were used. The sperm quality was determined by system automatic sperm analyser for sperm motility parameters, and by confoca...
Maryam Beheshti1, Mohammad Reza Taheriyan2*, Sikander Shahzad3, Memoona Siddique4, He Tianwei5, Muhammad Farooq5*, Huzaifa Kashif6 and Naila Ilyas7*
... the fatty acid profile, oxidative stability, and their effect on hematological and cholesterol tests in the rat diet of soybean, hemp, and palm olein. In this study, oxidative stability and the peroxide and iodine index were done as chemical tests, and the components of each were then identified and measured using a gas chromatography-mass spectrometer. Rats were separated into 5 groups of 8 and given treatments of hemp, pa...
Jie Wang1, Di Fang1, Jianqing Zhao1, Fei Huang2, Bo Liu2, Weikun Tao2, Baoshan Cui2 and Qinghua Gao1,2,3*
...t abundant pathways were oxidative phosphorylation and Wnt signaling pathway”,”MAPK signaling pathway “,” Regulation of actin cytoskeleton “and VEGF signaling pathway”. To conclude, these RNA-Seq results confirmed the differential expression of several genes in embryos of different genders during embryonic development. These DEGs partcipate in the transcriptional regulation of bovine embryonic development of different gender...
Vui Van Nguyen1, Samorn Ponchunchoovong2, Sajeera Kupittayanant3, Pakanit Kupittayanant2*
... dog sperm is impeded by oxidative stress, leading researchers to investigate the impact of incorporating essential oils derived from Ocimum gratissimum leaves in order to prolong the viability of chilled dog sperm. The sperm’s characteristics were assessed using an automated sperm analyzer and a confocal microscope to analyze motility and membrane properties, respectively. Additionally, malondialdehyde production was measured to evaluate lipid peroxidat...
Weijun Chen1*, Shiyang Gao1, Ping Sun1, Xiaohui Sun2, Yongbin Wei1, Jingyang Chen1 and Jialong Chen1
...cantly increased hepatic oxidative stress by increasing malondialdehyde (MDA) content, decreasing activity levels of antioxidant enzymes and contents of reduced glutathione (GSH). Furthermoure, diet HF significantly decreased the mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), and simultaneously increased the mRNA expression of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and ...
Hafiz Muhammad Arsalan1, Amina Arif1 and Muhammad Khalil Ahmad Khan2*
... defense systems lead to oxidative stress (OS). Our study aimed at biochemical profiling of CML patients in response to imatinib or nilotinib therapeutic drugs. Fresh venous blood sample (10 mL) of 170 CML diagnosed patients and 10 healthy individuals was collected in heparin vial from oncology department, Mayo hospital and Jinnah hospital Lahore, Pakistan. Biochemical profiling of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione ...
Mohammad Bani Ismail
... saw increased levels of oxidative stress-related proteins NRF2, HO-1, and NQO-1. SPN protects against oxidative stress and inflammation-induced cardiomyopathies, according to our study....
Chen Zhao, Lulu Ding, Ying Ye, Congying Kou, Haoran Xiao, Jing Zhu and Jicang Wang*
...athological observation, oxidative stress index and autophagy-related gene expression level were detected of rat kidneys. The results showed that Cd caused the pathological changes of kidneys. And Cd also increased the content of glutathione and malondialdehyde and decreased the content of catalase and total superoxide dismutase. Instead, Nar significantly attenuated these Cd-induced toxic activities. Furthermore, the protein expression levels of Beclin1 and P...
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...es, elevation of hepatic oxidative stress (a significant increase in lipid peroxidation concomitant with a significant decrease in glutathione content and antioxidant enzyme activities), tumor necrotic factor-α (TNF-α) and apoptotic marker Caspase-3 compared to the control group. Rats received BPA along with SeNPs-CP showed significantly less severe damage and remarkable improvement in all the measured parameters when compared to BPA-rats. In this ...
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...es, elevation of hepatic oxidative stress (a significant increase in lipid peroxidation concomitant with a significant decrease in glutathione content and antioxidant enzyme activities), tumor necrotic factor-α (TNF-α) and apoptotic marker Caspase-3 compared to the control group. Rats received BPA along with SeNPs-CP showed significantly less severe damage and remarkable improvement in all the measured parameters when compared to BPA-rats. In this ...
Azza M. El-Kattawy1, Tarek Abou Zed1, Randa Megahed1 and Mohammed El-Magd2*
...educed the levels of the oxidative markers [lipid peroxide marker malondialdehyde (MDA) and nitric oxide (NO)], 6) increased the levels of antioxidant markers [reduced glutathione (GSH) and superoxide dismutase (SOD)]. These findings conclude that administration of Sim relieved pristane-induced arthritis, with best improvement in the Sim co-treated (prevention) group. Thus, Sim could be used as a protective drug against rheumatoid arthritis based on its immuno...
Nida Sadaqat1, Sheheyar Ahmed Khan1, Amna Bibi1, Sadaf Zahra1, Muhammad faisal Salamt1, Noreen Latief2 and Fatima Ali1*
... healing by reducing the oxidative stress, improving wound closure, reducing tissue inflammation with no significant change in blood parameters. There were no significant differences in weekly and final body weights and no significant changes observed in hematological and biochemical markers. A significant increase in collagen synthesis was observed in the NAC treated group with up-regulation of VEGF, IGF-1, PCNA, SDF-1 and CXCR-4 and down regulation of caspas...
Fatima Ali1*, Rimsha Tahir1 and Tahir Rehman Samiullah2
Wei Fang1,2,3, Jiawei Hong1,2,3,4, Zhengyi Fu1,2,3, Jing Hu1,2,3, Gang Yu1,2,3, Zhenhua Ma1,2,3* and Humin Zong5*
...aling in cardiomyocytes, oxidative phosphorylation; The distribution types of SSR sites and their characteristic analysis results showed that the most important repeat type was mononucleotide repeats (7,840, accounting for 51.31%), followed by dinucleotide repeats (4,007, accounting for 26.22%), while the number of tetranucleotide, pentanucleotide and hexanucleotide repeat was relatively small. Through the above analysis, it could be concluded that the differe...
Fariha Qahar and Muhammad Sayyar Khan*
...or, and atrazine-induced oxidative stress. The overexpression of the NtSAT4 gene from Nicotiana tobacco under 35S promoters in various compartments of the cell, which includes cytosol, plastids, and mitochondria in transgenic lines, resulted in enhanced tolerance in terms of lesser wilting and pigment discoloration to induced stress compared to non-transformed plants. In terms of approximate percentage damage, under 14% H2O2stress,30-60% of the leaf area turne...
Mustafa M. Khalaf*, Rana A. Salih
...r damage associated with oxidative stress, its therapeutic usage is restricted. The most potent antioxidant among flavonoid chemicals is quercetin, the aim of this study was to evaluate the protective effect of quercetin against cyclophosphamide. An explanation of quercetin’s hepatoprotective effects against cyclophosphamide-induced hepatotoxicity. Twenty-eight male Westar rats (that weighed 200–250 g) were chosen at random and divided into four eq...
Zainab Sattar Ali* , Safa Azhar Razzaq , Layla Hammody Hashem
...ence revealed SeNPs have oxidative stress on reproductive system at high concentration, as well as the propolis and L-Arginine and has prophylactic effects on testes against the effect of SeNPs, regarded to his the antioxidant impact.
...
...
Jyotsana Shakkarpude1*, Aditya Mishra2, Deepika D. Caesar2, R.K. Sharma3, Anand Kumar Jain2, Sanju Mandal2, Rajesh Kumar Vandre4, Danveer S. Yadav5, Bhavna Ahirwar6 and C.P. Solanki6
...ce (NEBAL) and increases oxidative stress in animals. Betaine is a growth promoting nutritional additive used in livestock. Betaine contains three methyl groups and thus acts as a methyl donor for metabolic reactions. Betaine acts as molecular chaperone, as it repairs heat shock proteins. The present study was aimed to investigate the effect of dietary betaine on heat and metabolic stress during lactation in Murrah buffaloes (Bubalus bubalis). For this purpose...
Shafqat Ullah1, Asad Ullah2*, Imad Khan2, Rafiq Ullah1, Raheela Taj3, Fatima Syed3, Shumaila Gul4, Faiza Khan5, Ibad Ullah Jan6, Muneeb Islam7 and Sumaira8
...ne of the hurdles is the oxidative stress, which is responsible for the reduction of gut morphology and growth performance in the poultry birds. The present study was performed to explore the impact of inorganic selenium (sodium selenite). Day old chicks were kept in a control environment. At day 7, five groups were made with four replicas in each group based on the diet being offered. Group A, the positive control group fed with normal basal diet group B was ...
Wisit Ketpanyapong1, Kulisara Marupanthorn2*
Afshan1, Asad Ullah2*, Imad Khan2, Rafiq Ullah1, Tahira Tayyab1, Fatima Syed3, Raheela Taj3, Shumaila Gul4, Faiza Khan5, Ibad Ullah Jan6, Syed Weqas Ali7 and Assad Ullah8
...of the major problems is oxidative stress which causes free radical damage and imbalance of thyroid functions. The research experiment was performed to check the effect of orally inorganic selenium on the redox status and thyroid hormones of broilers under dexamethasone induce stress. Day old 100 chicks were purchased from trading hatchery and divided randomly into five different groups having four replicates (n=5) in each group. Broiler chickens feed with sta...
Ying Chen1, Chao-Zheng Li2, Zhun Yu3, Jia Zhou4, Yan Xu4, Zhe Lin4, He Lin4* and Xiao-Wei Huang4*
...f myocardial, and reduce oxidative stress injury. The relevant mechanism may be related to the regulation of Nrf2/ARE signaling pathway in rat myocardial tissue by VAP....
Dan Song1,2, Ming-Juan Ge3, Jie Li1,2, Yi Jiang1, Xiu-Mei Kong1, Jiao-Jiao Xu1, Xu Ji1,2, Rui-Xin Shi1 and Qin Zhao1,2*
...m in humans and animals, oxidative stress and energy metabolism during hypoxia may be related to hypoxia-related diseases. Gentiana straminea Maxim (G. straminea), a natural Tibetan herb with exerts several biological effects, was used to study the anti-hypoxia effects of its ethanol extract. Three extract methods were employed to evaluate the best extraction methods. Male Kunming specific pathogen-free (SPF) mice were randomly divided into blank control, mode...
Hanaa H.A. Gomaa1*, Dalia Y.A. Amin1, Mona A. Ismail1, Basma Hamdy2, Khaled A. El-Dougdoug3
...c acid, phenol, proline, oxidative enzyme activities (polyphenol oxidase and superoxide dismutase) and virological assessments were assayed. Reduction in the disease severity of treated foliar ChNPs and BM fig plants was recorded. Systemic acquired resistance was detected related to Chlorophyll a and b and carotenoid, Phenol, Proline, salicylic acid and oxidative enzymes contents. ...
Rasema Majeed, Alaa Kamil Mahmood*
...ssociated with increased oxidative stress and DNA damage. Natural products such as ginger ethanolic extract (GEE) have antioxidant and anti-inflammatory properties that may help in mitigate these effects. Chitosan nanoparticles (CNPs) can improve delivery and bioavailability of encapsulated agents such as GEE. The aims of this study to evaluate the protective effects of ginger ethanolic extract, chitosan nanoparticles, and ginger ethanolic extract loaded with ...
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
...ety of cell lines due to oxidative stress. Curcumin Phytosome has antioxidant effects. We aimed to determine how silicon dioxide nanoparticle (SiO2NPs) exposure to female rats affected the oxidative state. Ultraviolet-visible (UV-VIS), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy were used to investigate SiO2NPs and Curcumin Phytosome nanoparticles (CPNPs). Intense surface plasmon re...
Estabraq Hayder Khayoon, Ammar Ahmed Abdulwahid*
...e how the brain effected oxidatively by Acrylamide exposure and the ability of Curcumin to ameliorate the neurotoxicity. For this investigation, thirty mature male albino rats be used, (10/group), the control group (CC), animals were intubated with distilled water for 40 days, Group G1, rats received Acrylamide 5 mg/kg B.W. every day for 40 days by gavage needle, and Group G2, in this group animals got Acrylamide 5 mg/kg B.W. and Curcumin 100 mg/kg B.W. for 4...
Rehan Ahmed Siddiqui1,2*, Shabana Usman Simjee2,3, Nurul Kabir4, Muhammad Ateeq3,5, Kevin Joseph Jerome Borges6, Muhammad Raza Shah3 and Rahman M. Hafizur2
Abdeljabbar Nassiri1, Mouloud Lamtai1*, Inssaf Berkiks1,2, Hajar Benmhammed1, Sidi Mohamed Coulibaly1,3, Miloud Chakit1, Laila Ibouzine-dine1, Abdelhalem Mesfioui1, Aboubaker El-Hessni1
...ssion-like behaviors and oxidative stress (OS) in the prefrontal cortex (PFC) of rats across different ages (adolescence, emerging adulthood, and middle adulthood) and the possible existence of sexual dimorphisms. Rat pups were maternally deprived on postnatal day 9 for 24 hours. The rats of both genders were then tested in the open field and the elevated plus-maze tests for anxiety, and in the forced swimming test for depression at different time points. Addi...
Suhad Mohmmed Alrobyrai1 , Falah Muosa Al-Rekabi2*
...against various forms of oxidative stress and inflammation. This study explored the hepatoprotective effects of Alpha Lipoic Acid (ALA) and Tempol against subacutely repeated acetaminophen (APAP) exposure in a murine model. Fifty male Balb-c mice were divided into five groups. Groups received 700 mg/kg.BW of APAP and oral treatments: G1 (distilled water, negative control), G2 (no treatment, positive control), G3 (Par+Tempol, 20 mg/kg.BW), G4 (Par+ALA, 20 mg/kg...
Sara Brikat, Mouloud Lamtai*, Miloud Chakit, Laila Ibouzine-Dine, Ilhame Fitah, Oumaima Abouyaala, Abdelhalem Mesfioui, Aboubaker El Hessni
...ognition (OR) tests. The oxidative stress (OS) was assessed by measuring the levels of Thiobarbituric acid reactive substances (TBARS), nitric oxide (NO) and catalase activity (CAT) in the hippocampus. The administration of Curc and/or Los increased significantly the recognition index (p < 0.01) as compared with the HFD group, and were able to prevent this effect on the memory induced by the HFD (p < 0.01). Additionally, the levels of TBARS and NO in HFD...
Tayfun Karatas1*, Betul Apaydın Yıldırım2 and Serkan Yıldırım3
...chemistry (AST and ALT), oxidative stress, immunity, apoptosis, histopathology and DNA damage caused by CMN....
Taghreed Jabbar Humadai*, Bushra Ibrahim AL-Kaisei
...n rats that reflected on oxidative stress and increase IL1 and TNF alpha expression also induce hypospermatogenisis in testes and sperm stasis in epididymis. So, the objective of the present study was to evaluate the toxic effect of tetrodotoxin on the histological structure of male reproductive system and oxidative stress induction in male albino rats. The methods included sixty male albino rats at age 8-9 weeks and weighte...
HAFIZ MUHAMMAD ARSALAN1,2*, SUMMARA TABASSUM1, MUHAMMAD SHERAZ YASIN3, FAROOQ SALEEM4, ZEEMAL SEEMAB AMIN1, MUNIB ASHFAQ1, UMAR FAROOQ GOHAR5 & RASHIDA BASHIR6
Youfang Li1, Xu Li2, Shaik Althaf Hussain3, Jayasimha Rayalu Daddam4 and Zhigang Chen5*
... oxalate induced induced oxidative stress, alteration in the serum as well as urinary biochemical alterations as well as spiked expression of miR-21. The alterations were reversed in all the treatment group especially EGCG and EGCG-Quercetin. The reversal potentials of combinational therapy were found to be more effective than the standard drug, Allopurinol. The histopathological analysis also confirmed the same. Although, EGCG has a potent inhibitory effect o...
Nurcholis1*, Syetiel M. Salamony1, Abdullah Baharun2
...e cooling process causes oxidative stress and affects sperm motility. Antioxidants in the diluent can maintain the motility of bull sperm during the cooling process until after thawing. This research examines the effect of Myrmecodia extract (MYE) supplementation, which has high antioxidants, on semen diluent during the cooling to cryopreservation process. Specifically, five PO bulls aged four years were collected using an artificial vagina (AV) twice we...
Taghreed Jabbar Humadai*, Bushra Ibrahim Al-Kaisei
...tochemical analyses. The oxidative stress result showed elevation in Malon Di-Aldehyde concentration in liver tissue treated with tetrodotoxin. The pathological lesion in liver of animals exposed to toxic dose of tetrodotoxin was characterized by dilation and congestion of portal vein, Focal aggregation of mononuclear cells formation granulomatous like lesion, Various form of nuclear necrosis with number apoptotic hepatocyte, nuclear pyknosis with evidence of ...
Mehwish Zafar1, Muhammad Shahzad1*, Muhammad Zubair Akram2, Quratulain3, Mehak Shehzad4 and Samreen Nazeer5*
... mechanisms i.e., ionic, oxidative and osmotic stress. One possible and climate resilient strategy is to introduce new crops that can bear high level salinity and allow irrigation with saline water. Quinoa has great potential to grow under saline conditions having outstanding nutritious value. Pot based complete block design was conducted in COMSATS University Abbottabad, Pakistan during winter season. Five quinoa lines (L30, L81, L11, L9, and L24) were grown ...
Abeer Alahmari1,2*
...s myrrh extract (AME) on oxidative stress-dependent nephrotoxicity caused by ethanol in rats. Male Sprague‒Dawley rats orally received 40% ethanol (3 g kg-1) and were then orally treated with (500 mg kg-1) AME daily for 30 days. Kidney function, oxidant and antioxidant status, and histopathology alterations in renal tissue were measured. Animals that received ethanol displayed nephrotoxicity, as confirmed by markedly increased serum creatinine, urea, and u...
Abdelghafour El-Hamzaoui*, Mouloud Lamtai, Laila Ibouzine‑Dine, Sofia Azirar, Mohamed Yassine El-Brouzi, Ayoub Rezqaoui, Aboubaker El-Hessni, Abdelhalem Mesfioui
...ultaneously, hippocampal oxidative stress markers (catalase, nitric oxide, and lipid peroxidation) were assessed to elucidate the involvement of oxidative stress (OS) in the observed effects. Our results delineate a clear dose-dependent effect of GBH, revealing escalated anxiety and depression-like behaviors at doses of 75 and 100 mg/kg following subchronic GBH exposure. Notably, markers of OS exhibited discernible alteratio...
Noura K. Al-Suwailem1, Nancy N. Kamel2, Ahmed O. Abbas1,3*, Farid S. Nassar1,3 , Dalia A.A. Elsayed4, Gouda F. Gouda1,5, Hosam M. Safaa6
... Stress exposure induces oxidative stress, which affects the general metabolism of heat-stressed birds and impairs carcass yield and meat quality. We investigated the impact of Moringa oleifera leaf meal (MLM) supplementation in heat-stressed (HS) broilers on their blood metabolites, antioxidant bio-indicators, carcass yield, and meat quality. We used three hundred one-day-old Cobb chickens and were randomly divided into three groups, each with five replicates...
Eman Ali Hussein1*, Majdy Faisal Majeed2
...eptozotocin (SZ)-induced oxidative stress damages pancreatic beta cells and results in hyperglycemia in rats, which leads to diabetic nephropathy. The goal of this investigation was to see if Trigonella foenum-graecum (TFG) flavonoid extract could protect the kidneys from the effects of (SZ). The goal of the current study was to determine if the ethanolic extract of (TFG) exhibited antioxidant activity against nephropathy resulting from the effects of diabetes...
Kang Cheng1*, Zhihua Song2, Jingyi Niu1, Jin Huang1, Laiting Liu1, Jinrong Wang1 and Yong Zhang1*
...tress-induced intestinal oxidative stress and inflammation, and explore the possible mechanisms at transcriptional levels. Twenty-four male Sprague-Dawley rats aged 8 weeks were randomized to 3 groups, namely, control, heat stress, and heat stress + fisetin (HS-FIS). The experiment lasted for 3 days with daily 1.5 h of heat treatment (40°C) for the heat stress and HS-FIS groups. Rats of the HS-FIS group were orally given 100 mg fisetin /kg bo...
Asad Sultan1, Ziaul Islam2*, Faiza Shahzadi3, Sarzamin Khan1, Rafiullah Khan1 and Ihsan Ali4
... utilization, liver anti-oxidative function, and welfare indices of commercial broilers. A total of 320 one-day-old Cobb 500 chicks were divided into four treatment groups (80 chicks/group). The first control group (G1) was fed with the basal diet without supplementation of Y. schidigera extract. The second, third and fourth groups (G2, G3, and G4) were fed with Y. schidigera extract supplementation rate of 5, 10, and 15ml/200L to drinking water, respectively....
Amal Mohammed Ali Alah Al-Marmadhi*, Saadeya Ali lefelef Al-Gnami
... effectiveness combating oxidative stress associated with hyperthyroidism.
Keywords | Allicin nanoparticles, Methimazole, Hyperthyroidism, T3, T4 and TSH, Iodine levels, Thyroid gland, Female rats, Herbal medicine, Garlic and biochemical
... 
Wadood Shah* and Sanam Zarif Satti
...anisms by producing anti-oxidative enzymes and accumulating osmoprotectants. Changes in photosynthetic pigments are one of several factors that affect how much water is accessible to plants under scarce water situation. Photosynthetic pigments, antioxidant enzymes and phenolic compounds play a vital role in a plant’s capacity to endure drought stress conditions. ...
Rhuan Chaves1, Diego Leal2, Ygor de Paula³, Andreia Vilas Boas4, Ana Toledo4, Sígfrid López-Ferrer5, Vinicius Cantarelli3, Cesar Garbossa2*
...city to absorb moisture, oxidative loss of vitamins in feed and its metabolism generates a compound that can taint animal-origin products. The aim of this study was to evaluate the effects of feeding diets containing natural choline (Kolin plus™ FC) as a replacement of choline chloride on performance and blood variables of weaned piglets. A total of 360 piglets with an average initial body weight of 6.33 ± 0.20 kg were utilized in a 41-day experim...
Hawraa F.H. Alowaid1*, Afrah Adil Hassan1, Majdy Faisal Majeed2
...otential contribution of oxidative stress dysfunction to the etiology of renal and hepatic injury brought on by TML. For this purpose, male adult rats were treated with TML (15 and 30 mg/kg/day oral administration) 30 days in a row. A significant decrease in liver and kidney tissue SOD, CAT, NO, and MAD was detected in TML groups, while, hepatic and Renal histopathological alterations included inflammation, necrosis, hemorrhage, and congestion, in TML-treated ...
Abdul Ghaffar1*, Kashfa Akram1, Habiba Jamil1, Riaz Hussain2, Ghulam Abbas3, Fozia Afzal4, Ahrar Khan5,6, Rabia Tahir7, Muhammad Ahmad Chishti1 and Shahnaz Rashid3
...sticide exposure induces oxidative stress, evidenced by elevated production of free radicals and alterations in antioxidant defense enzymes. Comet assay analysis detected DNA damage in pesticide-exposed workers, correlated with increased age and duration of exposure. In conclusion, pesticides elicit oxidative stress and lead to hematological, serological, and genetic abnormalities in exposed agricultural workers....
Shumaila Usman1,2, Irfan Khan2, Kanwal Haneef3 and Asmat Salim2*
... weak acid that uncouple oxidative phosphorylation by decreasing ATP production. Cells treated with DNP were analyzed for the morphological changes and islet specific markers (MafA, Ngn3, Nkx 6.1, Pdx-1, insulin, glucagon, somatostatin and Sca-1) at gene and protein levels. In the presence of DNP, NIH3T3 cells appeared round, small and contracted while after reoxygenation they regained the normal fibroblast like spindle shaped morphology. The strategy to induc...
Waqas Ahmad Shams1*, Gauhar Rehman2, Muhammad Ismail3, Rahmul Kabir4 and Abdul Qahar1
...in protecting cells from oxidative damage, which is implicated in various diseases such as diabetes, cancer, and inflammation. In this study, we investigated the antioxidant potential of extracts obtained from Crab Himalayapotamon emphysetum using various in vitro assays. Different solvents of varying polarities including ethanol, methanol, ethyl acetate, and water were employed for extraction. The results demonstrated significant antioxidant activity across d...
Saadeya Ali Lefelef Al-Gnami1, Fatima Ibrahim Mohammad2, Huda Jassim Mohammed Al-Helali3
Sher Afgan1, Muhammad Asif2, Iqra Yaqoob3, Muhammad Latif4, Zureesha Sajid2, Kainat Akram3, Ghulam Mujtaba5, Manzoor Hussain6, Muhammad Farooq1, Mourad Ben Said7,8* and Furhan Iqbal3*
...provided by them against oxidative stress which may influence disease progression in RA....
Roy Sukbir Singh1, Jekson Martiar Siahaan2,3*, Endy Juli Anto4, Syafruddin Ilyas5, Putri Eyanoer6, Hendrika Andriani7,8
...endothelial dysfunction, oxidative stress, and inflammation. Aloe vera, renowned for its secondary metabolites, is suggested as a potential treatment because of its hypolipidemic, antioxidant, and anti-inflammatory qualities. This study employed both in-silico and in-vivo approaches to explore these effects. The in-silico analysis involved molecular docking simulations to evaluate the interactions of Aloe vera compounds with inflammatory mediators such as TNF-...
Mohammed Haider Asker1*, Yahya Fawzi Hashim2, Huda Hamid Mohsen3
...10 (G4). Serum levels of oxidative stress markers (e.g. MDA), cardiac injury markers (CPK and troponin), inflammation markers (e.g. CRP), and thyroid function (e.g TSH) were assessed. Additionally, histological examination was performed post-H andE staining to for pathological lesions. The group G2 exhibited elevated levels of MDA (4.22 ± 0.16 mmol/L), CPK (317.40 ± 0.24 U/L), and troponin (1.19 ± 0.004 mg/dL), which collectively indicated...
Baraa Najim Al-Okaily
...nvestigate the impact of oxidative stress on the liver, kidneys, and other organs. Achieving a full understanding of the fundamental concept of stress is crucial as it facilitates an intimate understanding of the causes of stress. Oxidative stress refers to an imbalance between the levels of oxidants and antioxidants, resulting in a disturbance of regulation and potential damage to molecules and cells. Thus, this review is d...
Mehak Muhammad Ashfaq1*, Aqsa Naeem Chawla1, Muhammad Umaid Ali1 and Adnan Ahmed Bhutto2
...ion, insulin resistance, oxidative stress, inflammation, and platelet functions through many mechanisms. Eating dark chocolate lowers blood pressure, both diastolic and systolic, increases the bioactivity of nitric acid, and strengthens endothelial function. However, due to the amount of sugar it contains, it adversely impacts our health, resulting in weight gain....
Idrissi Ouedrhiri Housna1, Bikri Samir1,2*, Benloughmari Douae1, Aboussaleh Youssef1
...n (LPO), a key marker of oxidative stress (OS), in T2DM mice exposed to chronic immobilization stress (CIS).Mice were divided into four groups: normal-control (NC), diabetic treated with MET (D-Met), stressed diabetic treated with MET (D-Ims-Met), and stressed diabetic treated with a combination of MET and MEL (D-Ims-Met-Mel). T2DM was induced experimentally by exposing mice to fructose for 14 days followed by a single intraperitoneal injection of streptozotoc...
Rawya Sh. Mohammed*, Baraa N. Al-Okaily
...ups effectively improved oxidative stress-related factors, hormonal profiles, inflammatory criteria, and reduced expression of the PTEN gene. The present investigation has shown that CurSeNPs exhibit preventive actions against doxorubicin toxicity in adult female rats, possibly through their antioxidant, anti-inflammatory, and anticancer properties. ...
Sumaya Loay Mohamed Shams Al-Dean1*, Sura Shakir Hammoud2, Mohammedali J. Ghafil3
...preservation by reducing oxidative stress caused by thawing. Nonetheless, there aren’t any appreciable variations in normal acrosome % between the treatment and control groups. This study concludes that the quality of ram semen improves on treating with ascorbic acid and tocopherol in egg-yolk citrate extender. The addition of vitamin C and Vitamin E to the sample improves the motility, viability, and membrane integrity of poor semen quality.
Ngele Blessing Alfred, Agba Mary-Ibenreh Ogaboh*, Bassey Rosemary Anietie and Egeh Ajah Egwu
...cal processes, including oxidative stress enzymes activities and chlorophyll content. A mixture of sawdust and sand (1:1) was utilized as the growth medium. Detergent solutions with concentrations of 1g/l, 2.5g/l, and 5.0g/l were prepared, with deionized water as the control (0g/l). Maize seeds were sown in germination trays and irrigated with these solutions to assess the effects on germination, growth performance, oxidative
Dwi Walid Retnawati1,2, Mohamad Agus Setiadi3*, Iman Supriatna3, Ligaya Ita Tumbelaka3
...re capable of triggering oxidative stress leading to placental retention (RP). The production of cows is often affected by RP, resulting in economic losses for the local community in dairy farm. Therefore, this research aimed to measure selenium (Se) and Malondialdehyde (MDA) levels as a candidate for RP parameters in dairy farm. The measurement started with preliminary research of plasma MDA levels in 20 cows comprising 5 RP and 15 non-placental retention (NR...
