Protective Effects of Broccoli Aqueous Extract on Hypothyroidism and Retrogression of Liver Functions Induced by Paracetamol (Acetaminophen) in Albino Male Rats
Protective Effects of Broccoli Aqueous Extract on Hypothyroidism and Retrogression of Liver Functions Induced by Paracetamol (Acetaminophen) in Albino Male Rats
Saher Mahmood Jwad1, Tamadhur Hani Hussein2, Tahreer Mohammed Al-Thuwaini2*
ABSTRACT
To evaluate the possible ameliorative impacts of broccoli aqueous extract on the regression of thyroid and hepatic tissues, as well as on oxidative stress markers induced by paracetamol (acetaminophen), a study was conducted on sixty male laboratory rats. The animals were equally divided into four experimental groups. The control group was orally treated with 0.9% normal saline solution. The second group was orally administered 1g/kg of paracetamol. The third study group was orally given 200 mg/kg of broccoli aqueous extract along with 1 g/kg of paracetamol. Lastly, the fourth experimental group was orally administered 200 g/kg of broccoli aqueous extract only. Furthermore, all treatments related to this study were administered for forty-five days, once daily. In this study, there was a noticeable increase in the activities of liver enzymes, malondialdehyde, lipid peroxide, and thyroid-stimulating hormone levels in the paracetamol treatment group compared to the other study groups. Conversely, glutathione reductase, glutathione peroxidase, triiodothyronine, and thyroxin levels were desirably decreased in the paracetamol treatment group compared to the other study groups. Otherwise, the two experimental groups that orally received broccoli aqueous extract + paracetamol, and broccoli extract only, showed no remarkable alterations in these biomarkers when compared with the control group. According to the findings of the current study, broccoli aqueous extract exerted potent protective activities on the thyroid and hepatic tissues, as well as ameliorated their functions. Furthermore, it inhibited or reduced the oxidative damage induced by paracetamol probably due to its biologically effective ingredients, particularly the strong antioxidants.
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