Behavioral and Biochemical Performance of Swiss and BalbC Mice Exposed to Multiple Concurrent Acute Stress
Behavioral and Biochemical Performance of Swiss and BalbC Mice Exposed to Multiple Concurrent Acute Stress
Rawda S. Mohamed1,2, Mohammed Y. Matoock2*, Abeer H. Abdelrazek2
ABSTRACT
Stress is involved in several neurological disorders of human beings. Mice are frequently used in biomedical research, including stress research. However, mice respond differently to stress. Therefore, we conducted this study to screen the behavioral and biochemical responsiveness of two different strains of mice, Balb/c (B) and Swiss (S). A total of fourteen adult males, each of (S) and (B) mice, were housed in either the control group or the multiple concurrent acute stress (MAS) group that was exposed to different physical and emotional stressors for 3-hours. Serum corticosterone level, brain levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), and glutathione (GSH) were measured. Mice were subjected to open field, plus maze, and dark light activity box tests. Swiss Multiple Acute concurrent Stress (SMAS) showed more responsiveness to MAS than Balb/c Multiple Acute concurrent Stress (BMAS) in most biochemical and behavioral parameters, with an elevated level of corticosterone and MDA IL-6, and TNF-α and reduced levels of GSH. In conclusion, SMAS showed a more effective response to MAS than BMAS, making them a selection model in stress research.
Keywords | Multiple concurrent acute stress, Balb/c, Swiss albino, Oxidative stress, Open field.
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