Effects of the selenium nanoparticles on the biomarkers of oxidative status in the Wistar rats spleen following the experimental cadmium toxicity
Effects of the selenium nanoparticles on the biomarkers of oxidative status in the Wistar rats spleen following the experimental cadmium toxicity
Soraya Khosravian Dehordi*, Abdolnaser Mohebbi and Kahin Shahanipour
ABSTRACT
Exposures to heavy metals in environment produce several armful health effects. The generation of oxidative stress creates by the common mechanism their carcinogenicity and toxicity. The present study was planned to determine whether an oral administration of nano-selenium (nano-Se) influencing on biomarkers of oxidative status in the rats spleen exposed to the cadmium (Cd) metal. For this purpose, thirty male rats equally divided into six groups, group I received nano-Se (0.1mg/kg) alone as dose, group II selenite odium (0.1mg Se/kg) alone, group III Cd chloride (300mg/250cc), group IV Cd along with nano-Se, group V Cd along with selenite sodium and group VI (control) given (1 ml) saline. All doses was orally (gavage) given to rates.Protein carbonyls (PC) andthiobarbituric acid reactive substances (TBARS),superoxide dismutase (SOD) glutathione peroxidase (GPx) and catalase (CAT) values in spleen were measured. An increase in TBARS and PC levels was obtained in rats' spleen of the Cd-group than controls and nano-Se decreased this effect close to the control. The CAT values of all groups did not differ significantly. The values of SOD and GPx were reduced in splenic tissue of Cd-intoxicated rats, but the nano-Se was able improve these undesirable effects. However, these findings imply that the nano-Se could be an efficient material in cases of Cd-intoxication.
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