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Biochemical Effect Of The Protective Effect Of Quercetin After Induced Hepatotoxicity By Cyclophosphamide In Male Rats

Biochemical Effect Of The Protective Effect Of Quercetin After Induced Hepatotoxicity By Cyclophosphamide In Male Rats

Mustafa M. Khalaf*, Rana A. Salih 

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq.

*Correspondence | Rana A Salih Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq; Email: rana.a@covm.uobaghdad.edu.iq  

ABSTRACT

Malignant diseases and autoimmune disorders are treated with cyclophosphamide (CPA). However, as a result of its serious negative consequences, including liver damage associated with oxidative stress, its therapeutic usage is restricted. The most potent antioxidant among flavonoid chemicals is quercetin, the aim of this study was to evaluate the protective effect of quercetin against cyclophosphamide. An explanation of quercetin’s hepatoprotective effects against cyclophosphamide-induced hepatotoxicity. Twenty-eight male Westar rats (that weighed 200–250 g) were chosen at random and divided into four equal groups for this investigation. During the initial periods of acute exposure, the animals had treatment with quercetin (50 mg/kg) for 30 days on consecutive days. Cyclophosphamide (100 mg/kg) was administered intraperitoneally only on 10 and 30 days six hours after the final dosage of quercetin. After 24 hours, all of the animals were led into sacrificed and their blood and livers were collected identically for analysis of the liver enzymes and hepatic oxidative stress indicators. Cyclophosphamide significantly increased malondialdehyde (MDA), liver biomarkers (ALT, AST, ALP, and TP), and prothrombin time. Otherwise, glutathione (GSH), and total protein (TP) level was substantially reduced in the control group. Studies have demonstrated quercetin’s capacity to decrease cyclophosphamide’s effects on (MDA, ALT, ALP, TP, and AST) while increasing GSH. Also, quercetin significantly affects body weight for their group and mixed group with cyclophosphamide. The results demonstrated quercetin’s capacity to lessen the cyclophosphamide-induced changes in MDA, ALT, ALP, TP, and AST while enhancing the changes in GSH. Moreover, quercetin notably impacts body weight for both the quercetin and cyclophosphamide mix groups. Conclusion: The hepatoprotective efficacy of quercetin against cyclophosphamide’s cytotoxic effects was investigated in this study after showing the results concluded when used quercetin as protective.  

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Advances in Animal and Veterinary Sciences

June

Vol. 12, Iss. 6, pp. 994-1205

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