Association of GSTT1, GSTM1 and SNP rs1695 in GSTP1 with the Incidence of Rheumatoid Arthritis in Southern Punjab, Pakistan: A Case-Control Study
Association of GSTT1, GSTM1 and SNP rs1695 in GSTP1 with the Incidence of Rheumatoid Arthritis in Southern Punjab, Pakistan: A Case-Control Study
Sher Afgan1, Muhammad Asif2, Iqra Yaqoob3, Muhammad Latif4, Zureesha Sajid2, Kainat Akram3, Ghulam Mujtaba5, Manzoor Hussain6, Muhammad Farooq1, Mourad Ben Said7,8* and Furhan Iqbal3*
ABSTRACT
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases in the world causing painful and swollen joints. RA is a progressive disease that can lead to various physical disabilities. The current study aimed to assess the association of the presence/absence of GSTM1, GSTT1 and single nucleotide polymorphism [SNP] (rs1695) in GSTP1 gene with RA. A cross-sectional study was conducted at Institute of Zoology, Bahauddin Zakariya University Multan from May 2020 to March 2021 and included RA patients (cases; N = 100) and controls (N = 100) enrolled from Multan district in Pakistan. A T-ARMS PCR protocol was applied to report the genotype at studied GSTs. The association of rs1695 in GSTP1 with RA was studied either individually or in various combinations with GATM1 and T1. A significant association of absence of GSTT1 and heterozygous genotype (AG) at rs1695 in GSTP1 was found to be associated with RA in the present study. Subjects whose age varied between 41 and 55 years and women suffered more from RA. It is concluded that polymorphisms in GSTs may disturb the protection provided by them against oxidative stress which may influence disease progression in RA.
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