Neha Singh and Anjana Pandey
...tilized to differentiate cancerous cells from normal cells or even different types of cancerous cells, detect live pathogenic organisms, and to discover novel disease biomarkers to facilitate early detection of the disease and for therapeutic purposes....
Gökhan Kuş1,*, Hatice Mehtap Kutlu2, Djanan Vejselova2 and Emre Comlekci3
...amide and ceramidases on cancer therapy had become popular in recent years. Ceramide is a metabolite in sphingolipid pathway of the cells that has an ability to promote cell death in tumor cells when produced endogenously in the cells or applied exogenously. Ceramidases, which are main component of ceramide pathway catalyze metabolism of proapoptotic ceramide to anti-apoptotic sphingosine and other fatty acids. In this study we have evaluated the pro-apoptotic...
Pinar Oztopcu-Vatan1, Gokhan Kus2, Emine Inan3, Melek Gunindi Korkut3, Selda Kabadere4,* and Ruhi Uyar4
...he most common causes of cancer death. We tested whether licofelone, an inhibitor of both cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism, changes the survival rate and induces apoptosis in a hepatoma cell line (H4IIE). We determined in vitro survival rate with MTT assay, the morphological changes with an inverted microscope, apoptosis using flow cytometry and statistical significance with one way analysis of variance followed by...
Saba Irshad1,*, Ayesha Ashfaq1, Ammara Muazzam1 and Abida Yasmeen2
...l, antidiarrheal and anticancer activity of turmeric (Curcuma longa L.) and black pepper (Piper nigrum L.), used in Pakistani cuisine to enrich flavour and to treat infectious wounds. Their crude ethanol and methanol extracts were tested against five important bacterial and fungal strains. Both extracts showed maximum antibacterial activity against B. subtilis, E. coli and S. aureus. All alcoholic extracts were competent enou...
Sanjukta Chakrabarti1, Colin J. Barrow2, Rupinder K. Kanwar3, Venkata Ramana1*, Rakesh N. Veedu4,5 and Jagat R. Kanwar3*
...model of human A549 lung cancer. VEGF TrapR1R2 is a commercial anti-angiogenic fusion protein. Our earlier studies demonstrated the anti-angiogenic and anti-proliferative activities of VEGFR1(D1-D3)-Fc and RNV66 in in vitro functional assays. We compared the anti-tumorigenic properties of these three molecules for tumor volume reduction in xenotransplanted SCID mice and by histopathological and immunohistochemical analyses. Our results demonstrated that fusion...
Saba Manzoor1,*, Ali Raza Awan1, Abdul Wajid1, Sehrish Firyal1, Muhammad Tayyab1, Muhammad Mansha2, Asim Khalid Mahmood3, Abu Saeed Hashmi1 and Muhammad Wasim1,*
...ation study in different cancer types of animal origin has its pivotal role in diagnosis, prognosis and comparative studies. c-Myc gene was selected to study the mutation and expression profiling of different canine and feline tumors due to its predetermined role in tumor pathogenesis. A total of 52 tumor and normal samples were examined, among these, 40 canine and 12 feline samples were analyzed using Sanger sequencing method and RT-qPCR for the mutati...
Aqsa Gulzar1, Tariq Mahmud1,*, Rubina Munir2 and Asma Anjum3
...o 4a.
...
Kaori Sasaoka1, Takahiro Kataoka1, Norie Kanzaki1, Yusuke Kobashi1, Akihiro Sakoda2, Yuu Ishimori2 and Kiyonori Yamaoka1,*
... used for treating solid cancers; however, it induces nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m<...
Muhammad Shahbaz Aslam1, Iram Gull1, Zaigham Abbas2,* and Muhammad Amin Athar1
...h both antiviral and anticancer activities. Binding of IFNα-2 to its receptor on cell surface leads to activation of interferon stimulated genes which mediate its anti-proliferative and anti-angiogenic properties. Similarly, Thymosin alpha 1 (Tα-1) helps to fight against different infections such as cancer and hepatitis with its immune modulating properties as well as through its direct action on target cells. Th...
Riffat Mehboob1*, Shahida Perveen2, Naseer Ahmed3
...isk of developing breast cancer.
Objective: Purpose of the study was to analyze the spectrum of BBD in a tertiary care hospital of Lahore to understand the prevalence of inflammatory lesions, benign neoplasms and their age-wise comparison.
Methodology: The study was carried out at Pathology Department, King Edward Medical University, Lahore. Data of 368 cases of BBD during a time span of 3 years (2011-2014) was obtai...
Ayesha Noreen1, Dilara A. Bukhari2 and Abdul Rehman1,*
...lay an important role in cancer growth and metastasis. ROS and tumor cell interaction could activate the signalling pathways, promoting cell proliferation, invasion, inducing angiogenesis, inflammation and cellular transformation in cancer. A better understanding into the mechanism of ROS in cancer progression might be useful for the development of biomarkers and therapeutic strategies. Th...
Rafa Almeer1,*, A. Alqarni1,2, S. Alqattan3, S. Abdi4,*, S. Alarifi1, Z.Hassan5 and A. Semlali6
... agent.
...
Muhammad Khan1,*, Amara Maryam2, Hafiz Abdullah Shakir1, Javed Iqbal Qazi1 and Yongming Li3,*
...een shown to induce lung cancer metastasis. In the present study, we found for the first time that Baohuoside I (BHS-1), a natural flavonol glycoside inhibits BaP-induced A549 lung cancer metastasis by modulating the expressions of p-STAT3, COX-2, MMP-2, MMP-9, E-cadherin and N-cadherin. Moreover, we found that chronic BaP exposure promoted migration without enhancing the proliferation of cells and BHS-I was equally toxic to...
In-vitro Anticancer Activity of Copper (II) and Zinc (II) Complexes with Derived Schiff Base Ligands
Qaisar Jamal1,Salman Ahmad1, Nazma Habib Khan1, Sobia Wahid1, Muhammad Ikram2, Sadia Rehman2, Syed Basit Rasheed1 and Akram Shah1,*
...y screened for their anticancer potential. We aimed to investigate in-vitro anticancer activity of two transition metal compounds of derived Schiff bases; NM-3 (Tetrakis (2-{(E)-[(2- {[(Z)-(2-hydroxynapthyl) methylidene]amino} phenyl)imino] methyl}phenol) Copper(II) and NM-4 (Tetrakis (2-{(E)-[(2- {[(Z)-(2-hydroxynapthyl) methylidene] amino}phenyl)imino]methyl} phenol) zinc(II)), against human THP-1 leukemia cell line in-rel...
Asima Bano1, Hafiz Muhammad Tahir2, Hira Sherawat3, Muhammad Mutlib4, Muhammad Arshad5, Muhammad Akram Qazi6, Sajida Naseem5, Rabia Ishaq1, Iram Liaqat2
...transferases with breast cancer. For enzyme estimation plasma samples from the patients suffering from breast cancer and age matched healthy individuals (control) were collected. The results revealed decline in the level of these enzymes in breast cancer patients as compared to healthy individuals because of this decline the overall level of protein was also found to be decline. It is conc...
Muhammad Khan
... for discovering new anticancer drugs from non-cancer drugs. Drug repurposing has attracted the attention of scientific community involved in anticancer drug discovery because it is cost effective and less time consuming compared to the conventional drug discovery strategy involving de novo identification, characterization and validation of new bioactive molecules. Proscillaridin A ...
Saiqa Andleeb* , Shaukat Ali
RNA interference; A tool for treatment of human diseases
...y of human diseases like cancer, viral and neuromuscular has been controlled through RNAi. Some vectors and inducible systems are available now to treat numerous disorders. This review paper provides the basis for further development of RNAi technology as a drug therapy against various human disorders....
Shaukat Ali1,*, Sundas Nasreen1, Sobia Safeer1, Saiqa Andleeb1, Mubashir Ejaz1, Saira Bano2, Hafiz Abdullah Shakir3
Medicinal plants as therapeutic agents for cancer treatment
...time. Many
of anticancer lead bioactive molecules such as vinca alkaloid, vinblastine, vincristine, camptothecin, and taxanes
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and traditional pharmacology is reemerging
to caring good base as striking discovery train. The current declined in the nu...
of anticancer lead bioactive molecules such as vinca alkaloid, vinblastine, vincristine, camptothecin, and taxanes
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and traditional pharmacology is reemerging
to caring good base as striking discovery train. The current declined in the nu...
Muhammad Muddassir Ali1,2 and İbrahim Hakkı Ciğerci1,*
...al anti-oxidant and anti-cancerous activities are explored, but no study has been observed on liver cancerous cell line in term of its genotoxicty. So, genotoxic evaluation was carried out for the alcoholic and hexane extracts of T. turcica. Methanol extracts showed the highest DNA damage (20±1) at 200 µg/ml concentration and 11.67±2.52 at 50 µg/ml. Ethanol extracts showed the 2nd ...
Rahila Huma1,2, Tariq Mahmud1,*, Rubina Munir2, Sana Javaid Awan3,Kiran Iftikhar4 and Mufakkira-Tul-Islam5
...ture.
... 
Tahira Moeen Khan* and Amat ul Mateen
...al, anti-fungal and anti-cancer agents. In this work leaf extracts of Melia azedarach (commonly known as dharaik) a species of family Meliaceae and Morus nigra (commonly known as Shahtoot) family Moraceae were used for bio reduction of copper ions to CuO nanoparticles in place of harmful and expensive chemical/physical methods. A cheaper, simple to perform method giving high yield without by products is employed here. The leaf extract act bo...
Amna Younus1,3, Mariam Faiz2 and Abida Yasmeen1,*
...ures in Pakistani breast cancer patients. Newly diagnosed 300 breast cancer women from different areas of Punjab visiting Institute of Nuclear Medicine and Oncology Lahore were included in this study. Different clinico-pathological features were described. Vitamin D levels were determined and VDR FokI and TaqI SNPs were analyzed. Among different clinico-pathological features studied in breast
Jawaria Shaheen1, Samiah Shahid1, Sabahat Shahzadi2, M. Waheed Akhtar1,3 and Saima Sadaf1,*
...p;Triple negative breast cancer is the heterogeneous and most aggressive known subtype of breast cancer due to absence of estrogen, progesterone and HER2 receptors. We aimed to identify a panel of circulating miRNAs which can act as diagnostic and prognostic biomarkers specifically for TNBC. The blood samples were collected from 37 TNBC diagnosed patients and 34 age-matched non-TNBC controls to investigate the expression of ...
Saleha Gul1,2, Muhammad Khisroon2, Ajmal Khan2, Attaullah1, Saira Gul3 and Gul Nabi Khan1,4,*
...ucts and leading to lung cancer. However, the adverse effects of cigarette smoke on other tissues are largely unknown. We explored the genotoxic effects of tobacco smoke on peripheral lymphocytes of active and passive smokers. Blood samples were isolated from 100 males’ including 25 active-, 25 passive- and 50 non-smokers. Alkaline comet assay was done and classes were defined on the basis of comet tail length. Significant differences were found in total...
Muhammad Shahid Nadeem*, Maryam A. Al-Ghamdi and Jalaluddin Azam Khan
...quantitatively using non-cancerous human fibroblast cells (FB) and hepatocellular carcinoma cells (HepG2). A dose of 5U/ml of enzyme has shown an anti-proliferative effect up to 65 percent on HepG2 cells.
...
Rıfat Ertekin1*, Mete Ozkurt1, Gokhan Kus2 and Selda Kabadere1
...sure.
...
Asma Yousafzai1,*, Muhammad Luqman2, Nisar Ahmed1, Muneeza Arbab1,Muhammad Murad1, Naheed Sajjad3, Sara Naudhani1, Shakeela Daud1, Abdul Hameed Baloch4, Khushnaseeb5, Sana Zahoor6, Zahid Rauf7, Muhammad Mohsin Javed6 and Jamil Ahmad1
... both breast and ovarian cancer and account for 15-20% of all the hereditary breast cancer cases. Present study was aimed at identifying mutation in BRCA1/2 in breast cancer patients in Balochistan. Blood samples of 100 subjects including 50 breast cancer cases and 50 normal subjects were used to determine genetic variants in BRCA1 and B...
Farah Bilal*, Abdulmohsen Alhejaily, Shahida Husnain
...ys vital role in several cancers including lung cancer. Purpose of this study was to evaluate the prevalence of common nucleotide changes (E545K/E542K and H1047R/H1047L) occur in PIK3CA gene in non smoker patients of non-small cell lung cancer (NSCLC). Somatic mutational analysis was done by QMC-PCR following direct sequencing with sangers’ method. Only one sample detected p.E...
Zijuan Li1,2, Rong Ma2, Muhammad Khan3*, Chenchen Liu2, Xiaolin Cui2 and Yongming Li1,2*
...een shown to exhibit anticancer activity in various human cancer cells. However, the anticancer mechanism of piceatannol is not well studied. In the meantime, cisplatin (CDDP) is the first line treatment for some tumors. The present study was aimed to explore the cellular targets and anticancer mechanism of piceatannol in human osteosarcoma U2OS cells. C...
Shaukat Ali1,*, Sadia Batool2, Fatima Javed Butt2, Sundas Nasreen1, Hafiz Muhammad Tahir1
...agnosis and treatment of cancer; it is a second chief cause of deaths in the world. Advances in chemotherapeutic agents, various radiological techniques and bio-nanoparticles treatments (i.e., green synthesized metallic nanoparticles) attracted many researchers to conclude a novel cancer treatment strategy. Unluckily every strategy had some working limitations as a result of which cancer r...
Hafiza Sadaf Zahra1, Asia Iqbal2, Sayyeda Hira Hassan1, Hafiz Abdullah Shakir1*, Muhammad Khan1*, Muhammad Irfan3, Chaman Ara1, Shaukat Ali4
...The second most frequent cancer all over the world is breast cancer (BC). It is reported that only about 10% BC cases are attributed due to inherited genetic mutations while remaining 90% cancer cases are associated with environmental factors. Artificial light at night (ALAN) is considered one of the major environmental risk factors for breast cancer. It...
Bibi Nazia Murtaza1, Mazhar Saeed Chaudry2, Shamaila Inayat Nadeem1, Muhammad Shahid Nadeem3 and Abdul Rauf Shakoori4,*
...ead to induce or promote cancers. Number of somatic mutations in several genes, majority of which are involved in chromatin modification and transcriptional regulation, have been reported in NHL. G468R and G468A mutations in BRAF gene have been reported in NHL, BRAF is a member of RAS mediated MAPK pathway. In current study, hot spots of Kras gene were analysed in a 40 years old male patient, presented with NHL located in ascending colon wit...
Hong-mei Gao, Wen-long Su, Gui-bin Tao, Han-yang Li, Wen-zheng Cao and Zhi-dong Qiu*
...erapy drugs are toxic to cancer cells and normal healthy hematopoietic cells. Hemoglobin and red blood cell levels drop in cancer patients treated with chemotherapy. Geniposide can reduce the adverse radiation damage of bloosd tissue after high dose irradiation.We found that geniposide can recovery the red blood count after chemotherapy medications (5-Fluorouracil, 5-FU) treatment mice. The mechanism of action of genistein o...
Bo Gao1,2, Fengmei Yang3, Wei Chen2, Xiaojia Song4, Xiaobo Liu5 and Dongmin Li1*
...tumor, adjacent, and non-cancerous tissues. The tumor markers were detected with COBAS 6000. The prognostic value of relative MDR1 expression level in malignant tumors was investigated by univariate survival and Cox regression model analyses, and survival times were compared using the log-rank test. At the same time, through receiver operating characteristic (ROC) curve analysis, their diagnostic threshold values were calculated. MDR1 expression levels were th...
Mohammad Ejaz1, Salma Javed2, Muhammad Hamza1, Sadia Tabassum2, Muhammad Abubakar3, Irfan Ullah4*
...l, antibacterial and anticancer agents. Fungal endophytes like Taxomyces andreanae isolated from Yew plant have the potential to produce an anti-cancer compound called Paclitaxel. Other different fungal endophytic species produce various other types of anticancer compounds like camptothecin, podophyllotoxin, torreyanic acid, vincristine, and vinblastine. This review is organized to ...
Jie Yang
...mall;">Papillary thyroid cancer is one of the most common tumours subtype in thyroid cancers. Substantial amount of data have indicated that miR-16 is an important regulator of various tumours; however, the molecular functions of miR-16 in papillary thyroid cancer remained largely elusive. In order to investigate the regulation of miR-16, human papillary thyroid carcinoma cells are tr...
Hui-Ying Chen1,2*, Ping-Chuan Yin1,2, Ya-Nan Lu1,2, Hai-Yun Li1,2*and Yang Shan3
...rin in the prevention of cancer are yet to be fully elucidated. In the current study, the GSE115660 microarray dataset was downloaded from the Gene Expression Omnibus database to identify key genes in aspirin-damaged yeast cells following redox injury. Differentially expressed genes (DEGs) were subsequently identified and functionally enriched for analysis. Additionally, a protein-protein interaction network (PPI) was constructed and block analysis was perform...
Dil Afroza Khanom1, Amirun Nesa1, Muhammad Abu Sayed Jewel1, Muhammad Ayenuddin Haque1, Alok Kumar Paul1, Sonia Iqbal2, Usman Atique2,3*, Lubna Alam4
..., kidney tissue damages, cancerous cell growth, and even death in case of chronic exposure.
Kulsoom Iftikhar1, Shahzad Anwar1, Izhar Ul Haq1, Muhammad Tahir Khan1 and Sayed Riaz Akbar1
AN OPTIMAL NEURAL NETWORK BASED CLASSIFICATION TECHNIQUE FOR BREAST CANCER DETECTION
...ign and malignant breast cancer. The proposed method employs an optimal feature classification employing
artificial neural network. The proposed architecture has five input nodes, two hidden layers with eight neurons each
and one output node. Five features (cluster thickness, uniformity of {cell size, cell shape}, marginal attachment and
radius of circle enclosing the abnormality) are nominated as input features to the ANN to predict the b...
artificial neural network. The proposed architecture has five input nodes, two hidden layers with eight neurons each
and one output node. Five features (cluster thickness, uniformity of {cell size, cell shape}, marginal attachment and
radius of circle enclosing the abnormality) are nominated as input features to the ANN to predict the b...
Syeda Farzana Bibi* and Siraj-ud-Din
Fluorescence Analysis, Extractive Values and Cytotoxic Screening of Crataeva adansonii DC Leaf and Bark through Brine Shrimp Larvae Assay
...ugs can be used to treat cancer, multiple sclerosis and rheumatoid arthritis. During the present study ethanolic extracts of leaf and bark parts of C. adansonii were evaluated through cytotoxic activity. Brine shrimp larvae assay was conducted for this purpose. Extractive values of leaf and bark parts were estimated using n-hexane, chloroform, ethanol, methanol, water, and ether as a solvent. 10g of plant powder was dissolved in 200 ml solvent d...
Mahak Fatima1, Memoona Syed1, Rabia Zeeshan2, Farah Rauf Shakoori3, Naveed Shahzad4, Moazzam Ali1 and Zeeshan Mutahir1*
...itabine resistant breast cancer cells named MCF7-R. For this purpose, we transfected MCF7-R cells with MTH1 specific validated siRNA. Successful transfection of siRNA and consequent cytotoxicity in MCF7-R cells was confirmed by qRT-PCR, western blotting and cell viability assay. As a result of siRNA transfection, MTH1 protein was knockdown to approximately 77% in the transfected sample and resulted in a 1.75-fold increase in sensitivity of MCF7-R cells ...
Maryam Yousaf1, Naveed Shahzad2, Zeeshan Mutahir1 and Moazzam Ali1*
...ug resistance in various cancers. However, the role of Rab21, an endocytic Rab GTPase, in the emergence of drug resistance is not known. Therefore, we aimed to investigate the role of Rab21 in MRP-1, drug efflux pump, mediated resistance in prostate cancer cells. Drug sensitive (PC-3/Wt) and epirubicin resistant (PC-3/Res) prostate cancer cell lines were used in this study. Our data reveal...
Ghulam Akbar1*, Ali Ahmad2, Neha Arooj1, Muhammad Anjum Zia1, Aamna Rafique1, Sania Riasat1, Mohsin Raza1, Mahpara Qamar1, Shahneela Nusrat1 and Shakila Hanif1
Critical Update for the Treatment of Anemia by using Advanced Genome Editing Crispr Cas Technology
...rsistent kidney disease, cancer, ischemic heart ailment and inflammatory bowel disorder. However, with the development in generation at genome editing level have made feasible to accurate mutations in human genome. A site oriented specific break in double stranded DNA is induced by CRISPR/Cas9, whereas different oligonucleotides are provided to make accurate DNA template for genome correction. It is of importance to knowledge about types of CRISPR to treat ane...
MA Liman1, QI Yongxiao1, Wang Wenji2* and Zhong Qianyi3*
... focus in developing new cancer treatment strategies. Ginsenoside Rh2 (G-Rh2), a natural product derived from red ginseng, has been reported to have therapeutic effects on some tumors, but its antiangiogenic effects in zebrafish has not been evaluated. Here we investigated the antiangiogenic of G-Rh2 using the zebrafish angiogenesis model. Morphological observations of the G-Rh2-treated wild-type embryos were performed to evaluate the toxicity of the compound....
Yihong Tian, Yongmei Qi*, Sajid Naeem, Ke Gao and Yingmei Zhang*
...dine-induced autophay in cancer cell survival has not been fully elucidated yet. In the present study, we aim to investigate the effect and toxic mechanism of spermidine on cell survival using Hela cells, a cervical cancer cell line as a model. Cell viability was assessed by MTT assay. LDH leakage was determined using a LDH assay kit. Mitochondria membrane potential (MMP) was measured by flow cytometry. LC3 conversion and p6...
Yujun Zhao and Jianping Fan*
...3 and Caspase-8 in colon cancer SW480 cells were studied. Compared with the control group without medication, the proliferation inhibition rate of cells processed with Kanglaite injection (10, 20 and 40 μL/mL) significantly increased (p <0.05), the apoptosis rate increased (p <0.05), the expression of Bcl-2 protein decreased (p <0.05), the expression of Bax protein significantly increased (p <0.05), and the activity o...
Mehwish Saleem Khan
Evaluation of Changes in Zinc Levels in Patients Suffering from Cancer
...lled cell division. Some cancers may eventually spread into other tissues. There are more than 200 different types of cancer. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In t...
Humza Sami1, Mahnoor Sagheer1, Muhammad Amir Altaf1, Javaid Iqbal2 and Muhammad Zubair1,*
... the detection of breast cancer at early stages.
...
Canan Vejselova Sezer*
...s. Recently, the risk of cancer and its mortality rates have increased both in economically less and highly developed countries. Two of the leading causes of the death of cancer are lung and breast cancers among males and females, respectively. A variety of drugs are in use for cancer treatment but their recruiting properties are limited because of the d...
Muhammad Farooq1*, Allah Rakha2,Jawad Ul Hassan2, Iftikhar Ahmed Solangi1, A. Shakoor3, Muhammad Bakhtiar4, Muhammad Noman Khan5,Shoaib Khan5, Ibrar Ahmad6, Shabir Ahmed7 andWang Yunyang1*
...ral viral, bacterial and cancer diseases. Mushroom powder also used to reduce blood pressure and increase resistance of person against many diseases. Keeping in perspective the position of dietary and medicinal values of mushroom in this research mushroom powder was added into muffins to improve nutritious and dietetic status of muffin. To achieve desired objective mushroom powder was mixed with wheat flour to improve sensory attributes of muffins. The proxima...
Mehwish Saleem1*, Maria Tahir1, Maryam Ilyas2 and Aqsa Malik2
... body. The most frequent cancer type among males is blood cancer. Electrolytes are minerals carry vital charge. These are essential for maintaining or carrying vital body function. These carry out cell functions i.e hydration, muscle contraction, heart beating and conduction of nerve impulse. These include calcium, magnesium, sodium, potassium, chloride etc. Calcified body parts like teeth and bone contain calcium, which fir...
Hesham Saeed1*, Manal Abdel-Fattah1, Ahmad Eldoksh1, Farid S. Ataya2 and Manal Shalaby3
...pha; of the viability of cancer cell line was assessed by MTT assay. Morphological study showed that C. dromedarius IFNα protein inhibited cell survival of MDA-MB-231 triple negative breast cancer cells.
...
Jabeen Farheen1,2*, Simeen Mansoor1 and Maria Abid1
...ncare products can cause cancer in humans....
Mohammed Bashar Danlami1*, Basiru Aliyu1, Abbas Bazata Yusuf1, Bashar Gulumbe Haruna1 and Asmau Nono Mahe1
...he screening of cervical cancer. However, the routine test is known and prone to significant error rate. This study examines the prevalence of abnormal and unsatisfactory Pap smear among women attending Federal Medical Center Birnin Kebbi. The study was a retrospective review of all Conventional Papanicolaou smear registry data of women who underwent a cytological examination at the cytology unit of the FMC Birnin Kebbi spanning a period of 10 years (2009-2019...
Maha I. El Zaafarany1, WafaaM. Badawy2, Eman M. El Salakh3
...valence of HPV in breast cancer.Fifty four fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were sequenced. Findings were correlated with clinical and pathological characteristics.The HPV DNA prevalence in the breast cancer samples was 28 % (15/54). Sequence analysis in a subgroup of cases indicates the prevalence of high risk HPV16. In co...
Bingjie Zhou1, Hitesh Bhagavanbhai Mangukiya1, Siva Bharath Merugu1, Fakhar-un-Nisa Yunus1, Yuchen Fan1, Zhenghua Wu1,* and Dawei Li1,2,*
...esponsive gene in breast cancer cell lines, is a developmentally regulated gene belonging to the protein disulfide isomerase (PDI) gene family. AGR2 exists in both intracellular and secreted form, it is overexpressed in many types of cancer cells and also detected in extracellular space of solid tumor interstitial fluids. The intracellular AGR2 is critical in protein folding while secreted AGR2 function as a paracrine signal...
Khaliq Dad1, Muhammad Nawaz2*, Muhamamd Ibrahim3, Fengliang Zhao4, Rumsha Hassan2, Humaira Nawaz5, Muhammad Usman Saleem6, Kinat Javed2, Ayesha Komal2 and Hajra Naz2
...se, kidney failure, lung cancer, orthopedic disease, nervous system failure, low immunity level, mental retardation and growth retardation. Different environmental friendly and low cost biological remedies are used nowadays to control Cd toxicity such as phytoremediation phytostabilisation, rhizofilteration, phytoextraction. This review paper has summarized the impact of Cd on soil, plants and humans and strategies to remove or minimize its toxicity by applyin...
Muhammad Mansha1*, Sidra Yaqub1, Asma Abdul Latif2, Muhammad Wasim3 and Peter C. Thomson4
...ont-size: small;">Breast cancer is a leading cause of death in women. The objective of the present study was to evaluate diagnostic utility of HER2/neu test and the association of premature termination of pregnancy with breast cancer. Two hundred breast cancer patients from INMOL hospital, Lahore (Pakistan) were interviewed on reproductive factor...
Tabinda Urooj1,*, Bushra Wasim1, Shamim Mushtaq2, Syed Nudrat Nawaid Shah1, Lubna Faisal3, Moazzam Ali2, Nabeela Rasheed1 and Syed Faizan Ali Rizvi4
...n associated with breast cancer risk factors. This study has analyzed the data gathered from two-renowned tertiary health care centers targeting a large subpopulation of Karachi. This will greatly help in determining the most prevalent risk factors as well as the clinical findings of breast cancer lung metastatic females among the target population. This comparative cross-sectional study which is aimed to determine the risk ...
Dabeeran Zehra1, Zahida Memon1, Shumaila Usman2,*, Almas Jabeen3, Kauser Ismail1 and Rehan Ahmed Siddiqui2
...hers in the treatment of cancer owing to their proposed chemotherapeutic role, based on the concept of repurposing, as they are well tolerated, less toxic and inexpensive. In this study we evaluated the combine effects of low dose of Azithromycin with Sorafenib in HepG2 cell line. Co-treatment of Sorafenib and Azithromycin showed enhanced inhibition of cell growth and suppressed the MAPK pathway associated with cellular proliferation, however the effects on ce...
Neda Amani1, Mehrdad Shariati1, Rahim Ahmadi2,3*, Mokhtar Mokhtari1 and Saeed Khatamsaz1
...fects of testosterone on cancer cells have been reported in recent studies, however, the molecular pathway is unclear. This study aimed to investigate the effects of testosterone enanthate on expression level of iNOS, MMP9 and caspase-3, -8 and -9 in human colon (HCT) and gastric (AGS) cancer cells. Cell lines were divided into untreated (control) group and groups exposed to 0.001, 0.01, 0.1, 1 and 10 mg/ml of testosterone e...
Saydat Saad1, Doaa Abdel-Fattah1, Tarek Khamis2, Aya El-Sobky1*
...matory, antioxidant, anticancer, and antifungal properties. Low bioavailability, solubility, absorption, and untargeted control, the advantages of free form propolis are limited due to previous reasons. Nano-propolis is made using a variety of nanoencapsulation processes. Because of their smaller size, nano-propolis is more utilized by the body than the free one. This study focuses on some current research on the application of nanotechnology in animal health ...
Hanan Fathy Hammouda1, Mohammad Mahmoud Farag2*, Mervet M.F. El Deftar3, Mohamed Abdel-Gabbar4, Basant M. Mohamed4
...tem cells (rBM-MSCs) and cancer osteosarcoma cells. The non-cellular in vitro bioactivity test was performed in simulated body fluids for periods 1, 3, 10, 20 and 30 d by measuring the calcium and phosphate ion concentrations by SEM/EDX analysis. While, the bioactivity of expanded and differentiated osteoblast cells derived from isolated rBM-MSCs by flowcytometric analysis was studied by histochemical staining with Alizarin Red and von Kossa to confirm ...
Uzma Jabeen1, Asmat Salim2*, Irfan Khan2, Nadia Naeem3 and Rubina Mushtaq4
...n (DOX), a valuable anti-cancer drug can cause multi-organ toxicities. Among several suggested mechanisms, the role of oxidative stress remains obscure, though it is the most probable mechanism for its cardiotoxic effect. The main focus of this study is to analyze the mechanism of renal toxicity caused by this chemotherapeutic drug. As reactive oxygen species are significant regulators of transcription factors and gene expression, this study was aimed at analy...
Lin Lu
... on apoptosis of thyroid cancer cell line. TPC-1 cells were treated with HDP (final concentration 1 mg/mL, 2 mg/mL and 4 mg/mL), PI3K/AKT signal pathway inhibitor LY294002 (20 μmol/L) and LY294002 + HDP (4 mg/ml HDP and 20 μmol/L LY294002). Cell viability and apoptosis rate were detected by MTT and flow cytometry, respectively. The expression of Cyt-C, Bcl-2, Bax, cleaved Caspase-3, PI3K, AKT and p-AKT were detected by Western blotting. We found that act...
Xian Zhang1, Erjiang Lin1, Shizhe Hong1 and Zhengjie Zhu2*
...nd apoptosis of prostate cancer LNCaP cells under hypoxic conditions. Prostate cancer LNCaP cells were transfected with the eukaryotic expression plasmid pcDNA3.1 (D)/V5-His-SSAT, and cultured at 1% oxygen concentration. Western blotting was used to detect expression of SSAT, Akt, GSK-3β and β-catenin proteins; and flow cytometry was used to detect cell apoptosis rate and mortality rate. SSAT was successfully trans...
Seun Eui Kim1,2*, Myoung-Hoon Lee1, Hye Myoung Jang2, Garam Park2, Wan-Taek Im3, Gwang Joo Jeon2,4*
...s were in cases of other cancers. Although the anticancer activity of a rare ginsenoside compound K (CK) against various cancers has been reported, there are few studies on neuroblastoma. In this study, cell viability and cell migration assay were tested and the expression of 17 genes in related signaling pathways was analyzed to determine the potential of CK as an anti
Hye-myoung, Jang 1,3, Ju-Hyeun, Kim3, Garam Park1, Yoon Dong Choi4, Sun-Eui Kim1,5, Gwang Joo Jeon1,2*
... of todays as crucial as cancers. We have studied Agarwood (Aquiralia crassna) extract (AE) and its effects on prevention of dementia related diseases through ICR mice experiment. The mice were fed with 5 mg of AE per day for 16 weeks to see the effect of AE on inhibition of two major biomarkers of beta-amyloid (Aβ) and tau-protein (τ-protein) formed in the brain tissues. Under the hypothesis of obesity inducing potential dementia, mice were fed with ...
Ahmad Ali1, Zaib Ullah2, Muhammad Javaid Asad1*, Muhammad Rafi3, Muhammad Maqsood4 and Sajid Mahmood5,6
... and target sites of the cancer patients. It also the importance in medicines preparation of the specific target cells.
...
Sameena Gul1, Sayyeda Hira Hassan1, Amara Maryam1, Hafiz Abdullah Shakir1, Muhammad Khan*1, Muhammad Irfan2, Farah Rauf Shakoori1 and Javed Iqbal Qazi1
...sive in the treatment of cancer but due to continuous and repeated doses, cancer cells develop resistance against these chemotherapeutic drugs through multiple mechanisms including MDR1 gene expression. EGCG (Epigallocatechin-3-Gallate) is one of the major polyphenols present in the dry leaves of green tea plant (Camellia sinensis). It has been observed to potentiate the apoptosis and also inhibit ca...
Xinjun Zhang1,2, Pengyong Wang1,2, Huimin Ju1,2, Yanhong Wang1,2, Yang Yang1,2* and Guoqiang Zhu1,2*
...nd human urinary bladder cancer T24 cells, 7 canine UPEC strains were isolated from dogs in Yangzhou, China. The adhesion-encoding genes (iha, fimH, papA, papC, papG allele I, papG allele I’, papG allele II, papG allele III, focA, focG, sfaS), virulence-associated genes (sat, cdtI, cnf1, hlyD), iron uptake system encoding genes (iroN, iut, ireA) were investigated, and the ability of biofilm formation was examined. In addition, UPEC in invading T24 cells,...
Iqra Ejaz1, Saima Chaudhry2 and Sarah Ghafoor1*
...ted by injecting an anti-cancer drug Bleomycin (1mg/mL) into buccal mucosa of animals daily for 8 weeks. The 24 male Wistar rats were equally divided into two groups; six rats (group 1A) were injected with normal saline (control group) while 18 rats (groups 1B, 2A and 2B, experimental groups) were injected with bleomycin. The six rats of control group (1A) and the six rats of experimental group (1B) were sacrificed after week 4 and week 8. Of the remaining 12 ...
Mehroze Amin1, Afifa Yaqub1, Qindeel Fatima1, Rabail Hassan Toor1,3 and Abdul Rauf Shakoori1,2*
... known to favor p53 anti-cancer activity and promote apoptosis and cell senescence in cancer cells. It is also known to decrease the incidence of several cancers though it is not entirely true for breast cancer. In the present study, the effect of metformin has been studied on the expression of p53 and its interacting partners MDM-2, PIRH2 and ΔNp7...
Chemoprotective Effect of Daphnetin against Benzene Induced Leukemia Cancer via Alteration of CYP2E1
Junling Liu, Chen Sun, Qiao Yu, Yanzhi Liang, Shanshan Lin and Meng Tian*
...d as the 9th most common cancer in men and 12th in women. Available treatment for leukemia are chemotherapy, allogeneic cell transplantation and radiation therapy with side effects. Due to side effect linked with the treatment, medicinal herbs treatment having the more attraction to treat the leukemia. The current study was to scrutinize the anti-leukemic effect of daphnetin against benzene induced leukemia in rats and explores the underlying mechanism. Benzen...
Afifa Yaqub1, Mehroze Amin1, Qindeel Fatima1, Rabail Hassan Toor1,3, Saira Aftab1 and Abdul Rauf Shakoori1,2*
...or genes in a variety of cancerous cells. The present study explores the anti-cancer activity of UNC0642, a novel potent inhibitor of G9a in MCF-7 breast cancer cell line. Analysis of growth and proliferation parameters by various cell-based assays such as neutral red assay and BrdU cell proliferation assay showed that higher concentrations were lethal for the canc...
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...se, and several types of cancer has made obesity a challenge for world health. The current study’s objective was to assess the antioxidant capacity of cranberry extract in high-fat diet-induced obesity. For eight weeks, 36 white albino rats weighing 197±10 g were selected at random to five groups: Group I was administered a regular diet; Group II was fed a high-fat diet; Group III was given a high-fat diet plus cranberry extract (75 mg/kg); Group ...
Umar Farooq Gohar, Attia Majeed, Bushra Muneer* and Hamid Mukhtar
...cal synthesis of the anticancer drugs. In the present study, for the isolation of podophyllotoxin producing endophytic fungi 30 plant (Podophyllum hexandrum) samples were collected from different localities of Pakistan. About 261 fungal strains isolated, among them 22 strains had the ability to produce podophyllotoxin. Maximum podophyllotoxin production (88.14µg/ml) was shown by fungal strain P-18, which was later identified as Penicillium sp. through 18...
Qi Zhuo, Yuanchun Yao, Meisongzhu Yang*, Jinhua Chen and Miao Tian
...s and invasion of breast cancer cells. Tissue samples (28) were collected, and malignant and normal tissues were confirmed pathologically. The breast cancer cell line MDAMB-231 and the immortalized normal breast epithelial cell line MCF-10A were used in this study. Western blot analysis of miR-216b-5p and HDAC8 protein expression in tissue samples; reverse transcription quantitative PCR (RT-qPCR) real-time analysis of miR-21...
Alexander Tsybulsky1*, Eduard Kostetsky1, Anton Degtyarenko2, Michail Shchelkanov1,2,3
...ies of diagnosing animal cancers and improve the accuracy of differential diagnosis of benign and malignant neoplasms, in particular of the mammary gland (MG). Methods. Surgical material obtained after unilateral mastectomy with simultaneous hysterovariectomy, as well as peripheral blood samples of cats with MG tumours was used. Blood samples and surgical material obtained from healthy cats after a planned hysterovariectomy were used as control. In cats with e...
Muhammad Ismail1, Jabbar Khan1*, Zahid Rauf2, Khalid Khan3 and Muhammad Rafi1
...arly characterize breast cancer patients of district Bannu, KP, Pakistan for any possible polymorphism in the estrogen receptor (ESR1) gene. Blood samples in this regard were collected from clinically diagnosed eighteen breast cancer patients, all possessing invasive ductal carcinoma. DNA was amplified through PCR for 2 different sequences of ESR1 gene. Twelve normal individuals of different ages were also characterized. Amp...
Xiajun Zhang1, Jie Yang2, Wenjun Zhou1, Zhenshi Chen2, Weidong Wu3, Shaoru Zhang2 and Lihui Wang2*
...n: justify;">Endometrial cancer is the most common gynecological malignant tumor in many countries. TGF-β regulates cell proliferation, angiogenesis and metastasis, and is an inducer of epithelial-mesenchymal transformation. Tumor cells activate the TGF-β/Smad pathway, and inhibiting its signal transduction pathway is an important strategy for tumor therapy. First, we have found lncRNA CASC7 is a poor prognostic marker of endometrial
Jiangbo Shao1, Donglai Zhu2, Shengqiang Zou1, Guohong Ge1 and Ju Huang1*
...ical roles in increasing cancer stem cell expansion as well as decreasing sensitivity to the sorafenib therapy in hepatocellular carcinoma. In this study, the potential functions and mechanisms of SOX9 in promoting hepatocellular carcinoma progression were investigated through comprehensive bioinformatics analysis. We found that SOX9 mainly participated in heat stress response, protein folding as well as metabolism and biosynthesis of amino acid. SOX9 correlat...
Man Wang1 and Fengmei Yang2*
...the development of liver cancer based on bioinformatics analysis. GEPIA, UALCAN, cbioportal and other tools were used to analyze the correlation between TOP2A gene expression and methylation, prognosis and immune cell infiltration in databases. The expressions of TOP2A gene and protein in tumor tissues were higher than those in normal tissues, and the differences were statistically significant (P<0.05); TOP2A gene expression was positively correlated with i...
Samina Kausar1, Rana Badar Aziz2, Muhammad Waseem3, Muhammad Ahmad3, Hamza Shafiq4, Muhammad Asim5, Usama Zia6, Sobia Afzal7, Wanpeng Xi8*, Mansoor Hameed1* and Muhammad Usman Shoukat9
...diovascular illnesses or cancer. The tremendous results of carotenoids in human food have prompted numerous efforts in plant genetic engineering to supply products with greater carotenoid accumulation, which isn’t always only beneficial for agriculture but also has consequences for scientific research in terms of organic, chemical, and molecular or genetic regulation. Carotenoid metabolism and its regulatory network is not only increasing plant “de...
Monu Karki, Amit Kumar and Gnanavel Venkatesan*
...unity viz candidates for cancer biotherapy, immunomodulators, antivirals, viral vectors, and recombinant vaccines....
Dalia Zaafar1*, Heba M.A Khalil2, Soha Hassanin3, Mohamed R. Mousa4, Mona G. Khalil1
...ts frequently experience cancer metastasis, relapse, and therapeutic failure despite the use of advanced therapeutic strategies for cancer treatment. As a result, many scientists are currently looking for newly repositioned drugs that can either inhibit cancer proliferation or promote cancer cell apoptosis. Methods: This study examined the effectiveness ...
ASIMA BANO1, HAFIZ MUHAMMAD TAHIR*2, AROOSA RASHEED3, MUHAMMAD ARSHAD4, SHAFAAT YAR KHAN1 & RABIA YAQOOB5
...he association in breast cancer and plasma levels of non-specific esterases in breast cancer patients. For study blood samples were collected from various diagnostic laboratories of Sargodha city. Levels of non-specific esterases were determined in the normal and breast cancer patients. The levels of non-specific esterases were higher in healthy individuals than the breast
MUHAMMAD MUNEEB SOHAIL1, FATIMA AMEER2, GUR CHARN SINGH2, MUHAMMAD ZAID1*
...ovascular disease (CVD), cancer, or anemia were excluded from this study. Statistically significant and non-significant results were obtained for different lipoprotein fractions. Although, Body Mass Index (BMI) was a good classical indicator of obesity, other indicators like A Body Shape Index (ABSI) and Body Roundness Index (BRI), also proved significant in assessing the type and severity of dyslipidemia. Different lipoprotein fractions behaved differently wi...
ASMAT MEHMOOD, ZAEEMA KHAN AND NAILA MALKANI*
...ght: normal;"> Oral cancer is widely spreading throughout Asia. This study focused on the prevalence of oral cancer in Pakistan from 2010 to 2016. Data for oral cancer cases was collected from the country's numerous cancer registries and cancer treatment facilities. Age and gender factors were analyzed in the data...
Ubaida Hussain1,2*, Amtul Jamil Sami1*, Shazia Rafique3*, Muhammad Idrees khan3 and Ahmad Ali Shahid3
...hosis, fibrosis, hepatic cancer, and death. The goal of this work was to assess the cytotoxicity and in vitro inhibitory activities of local medicinal plant Azadirachta indica (A. indica) extracts on expression of NS3 and NS5A nonstructural proteins of HCV 3a genotype. Owing to the fact that HCV patients can develop HCC, plant extract has also been tested for cytotoxic activity. Colorimetric analysis was done to determine the vitality of HepG 2 cells for 24 h ...
Chenchen Liu1,2, Tong Wang1, Muhammad Khan3*, Xiaolin Cui2 and Yongming Li1,2*
...een shown to exhibit anticancer activity against a series of human cancers through multiple mechanism. However, the anticancer effects of ALT against ovarian cancer remains unknown. Here, we report that ALT inhibits growth and induces apoptosis in parental and cisplatin-resistant ovarian cancer cells. Growth inhibitory...
Lei Jiang, Yi Huang, Runfeng Yang, Xiaohui Jiang* and Hao Yan
...n sensitivity of ovarian cancer cells by regulating the expression of miR-455-5p /PAX2. The expressions of circ_0009910, miR-455-5p and PAX2 mRNA in HOSEPiCs and ovarian cancer cells SKOV3 and SKOV3/DDP were detected by qRT-PCR. SKOV3/DDP cells were grouped according to the transfection of different genes. The sensitivity of SKOV3/DDP cells to cisplatin was detected by CCK8 assay, and the apoptosis of SKOV3/DDP cells induced...
Yang Hu, Jingxin Ding, Beilei Xu, Xiangming Sun, Guoyu Li, Hui Song, Zheng Zong and Wenlan Li*
Fang Chen
...tance of small cell lung cancer (SCLC) to apatinib. Human SCLC cell line H69 was purchased from the American Type Culture Collection. Through stepwise screening, an apatinib-resistant SCLC cell line (H69/Apatinib) was established. All cell lines were stored in RPMI-1640 medium, which was supplemented with 10% fetal bovine serum, 100 µg/ml streptomycin and 100 U/ml penicillin and kept in humid air containing 5% CO2 at 37°C. The cell assay was performe...
Atena Azarniush1, Majid Moghbeli2*, Farshid Kafilzadeh1, Mohammad Kargar1 and Hooshang Jamali1
Xiaowei Huang1, Chao Ma1, He Lin1, Yuchen Wang1, Yan Xu1, Guangfu Lv2* and Zhe Lin1*
Zahra Abdulameer Al-Zayadi1, Hana Kadum Shanan1, Al Salihi Karima Akool2*
...ends to evaluate the anticancer effect of Sc- Root Extract (Sc-RE) against cancer induced by intraperitoneal injection of Polyvinyl pyrrolidone K-30 (PVP) in mice. 72 mice divided randomly into eight groups (G1, control group; G2, Sc-RE group; G3, chemotherapy alone; G4 cancer- group without treatment, G5, cancer-induced + chemotherapy; G6,
Lu Xie1,2,3,4,5, Ye Gu1,2,3,4, Qiang Liu1,2,3,4, Hongzhang Shen1,2,3,4, Yifeng Zhou1,2,3,4, Jiangfeng Yang1,2,3,4, Xiaofeng Zhang1,2,3,4* and Jinyu Huang1,5*
...7/9 and E2F1 in multiple cancer types. Survival curves and correlation analysis by GEPIA supported the significant roles of SET7/9 and E2F1 in the progression of HCC. Functional enrichment analysis suggested that the SET7/9-E2F1 axis is involved in the regulation of cell cycle, DNA repair and replication, and gene transcription. Our results implicated the potential of SET7/9 in combination with E2F1 as novel therapeutic targets and prognostic biomarkers in hep...
Yajuan Zheng, Qiuping Mo, Hongchao Tang, Qinghui Zheng and Dandan Guan*
...-align: justify;">Breast cancer is a phenomenon in which mammary epithelial cells proliferate out of control under the action of various carcinogenic factors. This study aimed to explore the role and regulatory mechanism of LGR5 in the occurrence and development of breast cancer. Fresh breast cancer case samples and normal breast cell samples were collected. Western blot was used to analyz...
Amina Rahat1, Zahin Anjum1*, Sehlina Zehra2, Fatima Umal Baneen3 and Rabia Chishti1
...etic; and it is also anticancerous. Nigela sativa is used for jaundice, paralysis, metabolic syndrome, insulin resistant syndrome, and high level of cholesterol, nerve tension problems; it stops hair fall and boost’s immune system. Based on the results of this study, it can be concluded that almost all the plant extracts showed potential antibacterial, insecticidal and antifungal activities against different. The research has focused on the potential the...
Muhammad Aijaz1, Nasir Mahmood2, Ghulam Mujtaba3 and Imran Riaz Malik1*
... women has become breast cancer patients. Genetic polymorphisms of the Interleukin-10 (IL-10) gene were studied at position -1082 (G/A) in breast cancer patients in the Pakistani population. Breast cancer patients (n= 200) were recruited from different local tertiary care hospitals along with healthy subjects (n=100) for molecular analysis of the human IL-10 gene mutation at the -1082 (G/A...
Qi Zhuo, Yuanchun Yao, Meisongzhu Yang* and Jinhua Chen and Miao Tian
...transgelin gene in colon cancer cells. HT29 cells were randomly divided into three groups: CON group, TGT group and DGT group. The transgelin gene was sub-cultured in the control (CON) group, transfected in the TGT (cells transfected with tranglin gene) group, and knocked out in the DGT (cells in which tranglin gene has been knowcked out) group. The protein expression and the gene expression were measured using Western blotting and RT-QPCR, respectively. We fo...
Arshad Javaid1*, Iqra Haider Khan1, Malik F. H. Ferdosi2, Aneela Anwar3 and Mujahid Manzoor4
...dant, antimicrobial, anticancer, anti-inflammatory, cytotoxicity, insecticidal and insect repellant properties as reported in the literature. ...
Dajun Su1, Tao Deng2* and Mingshui Xie2
...and apoptosis of ovarian cancer cells by targeting miR-761. Ovarian cancer cells SKOV-3 and normal ovarian cells FTE187 were divided into groups according to the experimental procedures, and were transfected negative, respectively. The expressions of lncRNALOXL1-AS1 and miR-761 in ovarian cancer cells were measured by qRT-PCR (quantitative real-time PCR). LncRNALOXL1-AS1 targeting miR-761 ...
Yakun Ge
...amic therapy to regulate cancer stem cells through reactive oxygen species (ROS). A2780 cell line was purchased from the American Type Culture Collection and cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum, 50μunits/mL penicillin and 50μg/mL streptomycin, maintained at 37°C and 5% CO2 in a humid incubator environment. Quantitative analysis of ROS was performed using flow cytometry and median fluorescence intensity detection. Cel...
Bing Yan1, Meng Meng Zhang2, Xi Chen2, Yongming Li2*, Muhammad Khan3* and Tonghui Ma1*
...nosis is associated with cancer stem cells (CSCs) which hold the potential of self-renewal, and differentiation into pathogenomic heterogeneous tumor formation leading to therapeutic resistance. Therefore, targeting CSCs and their associated signaling pathways is crucial for effective treatment of GBM. In this study, we showed that alantolactone (ALT) hold the capacity to suppress stem-cell-like phenotype (SCLP) of glioblastoma cells. ALT inhibited the growth,...
Hafiz Muhammad Arsalan1, Amina Arif1 and Muhammad Khalil Ahmad Khan2*
... a chronic proliferating cancer of bone marrow presently treated with BCR-ABL tyrosine kinase inhibitors (TKI). Within interacellular system, increased reactive oxygen species (ROS) production in response to antioxidant (AOX) defense systems lead to oxidative stress (OS). Our study aimed at biochemical profiling of CML patients in response to imatinib or nilotinib therapeutic drugs. Fresh venous blood sample (10 mL) of 170 CML diagnosed patients and 10 healthy...
Tahir Rasool Qamar1, Sanaullah Iqbal1*, Muhammad Nasir1 and Habib-ur- Rehman2
...t may prevent colorectal cancer (CRC) development. The present study was designed to explore the effects of chicory roots derived fructans, in raw form, against CRC in rats. After acclimatization period, forty male Wistar rats were randomly and equally divided into four groups. Chicory powder treatments were started to group G4 before administering carcinogenic injections. After one-month, groups G2-G4 received four subcutaneous injections of carcinogen 1,2-di...
Wei Wang1, Meifeng Zhou2, Yuebo Liang1, Fan Zhang1, Zhong Wu3, Shaowei Mo4* and Yi Qing Wang1*
... of HER2-positive breast cancer. However, effects of YAP/TAZ pathway on resistance of trastuzumab have not been explored. Tumor tissues were collected from 40 breast cancer patients for clinical studies. For in vitro studies, human breast cancer cell lines SK-BR-3-TS was obtained, and trastuzumab resistant model SK-BR-3-TR was constructed. Cell viability was determined using MTT assay. Cel...
Mahmoud Abdelhady Metwally1*, Mona Abdelftah Ali1, Farouk Abdelmohdy1, Mohamed Kassab1, Tarek Kamal Abouzed2 and Khalil Fathy Abou-Easa1
...lls (BMMSCs) can home to cancerous cells and suppress their growth. However, few studies have investigated the impact of conditioned medium harvested from BMMSCs on carcinogenesis. This study investigated the effect of BMMSCs-conditioned medium (BMMSCs-CM) on the hepatoma cell line HepG2 and described the underlying molecular mechanisms involved. We isolated BMMSCs and identified them using flowcytometry and culture characteristics, then prepared BMMSCs-CM. He...
Di Zhou1, Qingmeng Long1*, Rong Yang1, Xiaoshan Tan1, Jun Li1, Mingyan Tang1, Zhonghai Zhao3, Ye Ao2, Zhinan Zhou1 and Changxue Chen1
...em, endocrine system and cancer-related pathways and linked the cGMP-PKG, cAMP, TGFβ and mTOR signaling pathways to reproductive performance. We verified these results using qRT-PCR for 9 up-regulated (AMH, CYP19A1, FOXL2, FSHR, GATA4, INHBA, LHB, LHX9 and ZP3) and 9 down-regulated (CNOT1. DMRTA1, GHRHR, Hox-All, Oviductin, PCYT1B, SLC34A2, WDR19 andWnt-7A) genes. The results were consistent with the RNAseq results and we more specifically linked AMH, GAT...
Komal Mukhtar*, Saba Yasin, Husna Ahmad, Muhammad Amir Iqbal and Nabila Roohi
...esses such as anemia and cancer. ...
Sidra Mumtaz1, Sidra Arshad1, Rizwan Ullah Khan1, Muhammad Usman Rashid2 and Naila Malkani1*
...or expression and breast cancer risk (OR=3.185, 95% CI=2.161–4.69, p<0.001). In subgroup analysis, Ets-1 overexpression was found highly associated (OR=2.149, 95% CI=1.141–4.048, p= 0.018) with breast cancer as compared to other Ets factors. Funnel plots confirmed no publication bias. Our study suggested Ets overexpression (especially Ets-1) might indicate an increased progression rate of breast
Aamir Ali, Hafiz Muhammad Tahir*, Azizullah, Shaukat Ali, Muhammad Farooq Bhatti, Muhammad Summer and Ali Haidar Gormani
...dant, antibacterial, anticancer, anti-diabetic and antidepressant activities. Further studies should explore the mulberry leaves potentials as these plants have got the attention of both the pharmacological and commercial industries.
Novelty Statement | The mulberry leaves possess various therapeutic potentials. In this study, we have summarized all the therapeutic potentials of different mulberry lea...
Qi Jiayi1, Huang XuMiao2, Lin Wei3, Ao YaHui3, Zhao Wenting2* and Cao Chunhao3*
Qingsen Ran1,2, Manjing Li3, Jiayin Han3, Lifang Wang3, Han Wang3,4, Shaobo Liu5* and Yanping Wang1*
...n of core biomarkers for cancer prevention and treatment is crucial. Tumor glycolysis is an important metabolic phenotype and many natural compounds from medicinal plants exhibit anti-glycation effects. Therefore, it is of potential significant to find biomarkers based on glycolysis-related genes in predicting the prognosis of colon cancer (CC), a common invasive gastrointestinal tumor. In this study, clinical and gene data ...
Muhammad Javed Iqbal1, Farah Rauf Shakoori1*, Bushra Muneer2 and Abdul Rauf Shakoori3
...-align: justify;">Breast cancer is a growing cause of mortality in females across the world. Studies have shown that breast cancer incidence is variable depending upon various factors like ethnicity among others. For a better success rate in breast cancer treatment with minimum side effects, the world is now focusing on a precision medicine approach for breast canc...
Kanwal Nisa1, Sadia Roshan1, Shazia Shamas1,2*, Raheela Atta Mustafa3, Shamaila Irum1, Kalsoom Sughra4 and Memoona Iqbal1
...stosterone with prostate cancer patients by the evaluation of a tumor marker Prostate-specific antigen (PSA). Prevalence was recorded in Gujrat, Punjab, Pakistan. Blood samples of normal and prostate cancer males were taken from Gujrat, Punjab, Pakistan. Information including age, marital status, smoking, Prostate-specific antigen (PSA), testosterone, and any previous record was obtained with the patient’s consent. Exc...
Faisal Alzahani1* and Mohammed Abu El-Magd2*
...ster (CAPE) is a key anticancer component of honeybees propolis (bee glue), however, its anticancer effect is limited due to its rapid degradation into caffeic acid. To get rid of this disadvantage and increase the anticancer effect of CAPE, CAPE-loaded chitosan nanoparticles (CNPs) were used. The anti-tumor effects of CAPE and chitosan CNPs on cancer ce...
Wisnu Jaka Dewa1,2, Ekowati Handharyani3*, Sri Purwaningsih4, Silmi Mariya5
...f the characteristics of cancer is failure to regulate apoptosis process. Apoptosis is a programmed cell death that occur in every multicelluler organism. Bax and Bcl-2 are two proteins that are involved in controlling the apoptosis process. This research aimed to quantify the expression of bax and bcl-2 gene in colon cancer cell WiDr treated with red snail ethanol extract 125, 62.5 and 31.25 ppm concentration. mesenggerRNA ...
ASMA ZAFAR*, MONIBA KHAWAR, MAHNOOR CHAUDHRY, SAYYEDA SANA BATOOL, AMJAD HUSSAIN** & MUSHTAQ AHMAD SALEEM
... being used to eradicate cancer including chemotherapy, radiotherapy, immunotoxins, and drug therapy but these treatments cause various side effects to the cancer patients, as they not only target cancer cells but also cause harm to normal body cells. At present some live bacteria, bacterial products, and bacterial proteins are used to treat cancer. One ...
MARIAM ZAHEER*1, SYED SHAHID IMRAN BUKHARI2, MUDDA
...ulator, emulsifiers, anticancer and bioflocculants. They are widely used in food industry and bioremediation. This review article describes sources, synthesis, fermentation, extraction and applications of exopolysaccharides....
HAFIZ MUHAMMAD ARSALAN1,2*, SUMMARA TABASSUM1, MUHAMMAD SHERAZ YASIN3, FAROOQ SALEEM4, ZEEMAL SEEMAB AMIN1, MUNIB ASHFAQ1, UMAR FAROOQ GOHAR5 & RASHIDA BASHIR6
... diseases like diabetes, cancer, inflammatory responses, oxidant injuries etc. in the present study ethanolic extract of Piper betle leaf was used (300 mg/kg). Diabetes was induced in male albino rats by using Alloxan (150 mg/kg). Glutathione (GSH), Catalase (CAT), Malondialdehyde (MDA), Nitric oxide (NO), micronutrients (Vitamin A, Vitamin C and Vitamin E), serum glucose level and Advance glycation end products (AGE’s) were estimated. The results showed...
Aliya Irshad Sani1, Shumaila Usman2*, Zile Rubab1, Sufyan Ahmed3, Sana Iqbal3 and Zehra Ahmed4
...lts of OX40 and OX40L in cancer immunotherapy are still limited and most of the studies have evaluated their expression in tumor biopsies. In this study we aimed to find out gene expression of costimulatory molecules in naïve oral squamous cell carcinoma patients in saliva and blood as noninvasive biological samples by qPCR. The results revealed significant difference between the cycle threshold (Ct) values in the saliva and blood of OX40 (p value=<0.0...
Iqra Munir*, Farrah Iftikhar, Hira Fatima, Sunbal Khalil Chaudhari and Roha Ramash
...tive diseases, diarrhea, cancer, inflammation, stomachache and dysentery. About 30% plants used to cure cardiovascular diseases and ulcers. The purpose of this study is to recognize wild plants gathered for medicinal purposes by the local residents of Mandi Bahauddin and to document the common names and therapeutic uses associated with these plants....
Qurrat ul Ain Shafique1, Sana Batool2, Hanfa Ashfaq2, Asima Tayyab2, Roquyya Gul3 and Mahjabeen Saleem1*
...t is approved by FDA for cancer immunotherapy particularly kidney and skin cancer. Interleukin-2 (IL-2) is a 4-helix-bundle type I cytokine possessing a cytokine receptor chain essential for the immune response. The current study presents a vector/host combination (pET28a(+)/IL-2) and optimization of expression in LB,TB and M9 media with varying concentrations of inducers (IPTG and lactose) and post induction time. Maximum e...
Yan Wang1,2*, Lin Liu3, Na Li4, Yijun Zong1, Wei Liu1, Wenhua Xu1, Qi Wang1, Peijuan Zhang1 and Huiling Feng2,5*
... the development of lung cancer in naked mice were both noted. The effects of LY6K knockdown on glucose uptake rate, lactic acid and energy metabolism of A549 cells were determined by UV spectrophotometry. According to data analysis from GEPIA2, TCGA, and Kaplan Meier plotter, lung adenocarcinoma exhibits high levels of LY6K expression and is associated with a poor prognosis. The expression of LY6K was most significant in A549 cells. In A549 cells, LY6K knockd...
*Arshad Javaid1, Syeda Fakehha Naqvi1 and Iqra Haider Khan1
...terial, antioxidant, anticancer and antipsoriatic. However, this study concludes that
most of the compounds were antimicrobial in nature.
...
Shabnam Javed1 and Amna Shoaib2
...and water) against three cancer cell lines (lung A-549, hepatocellular HepG2and
urinary bladder EI-138). Cytotoxic assays were carried out with five concentrations (0.05,
0.01, 0.05, 0.1 and 0.5 mg mL-1) of methanolic extract and its subfractions through MTT
assay [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide]. Results revealed nhexane
and ethyl acetate fraction being the most potent against all ...
*Malik F. H. Ferdosi1, Iqra Haider Khan2, Arshad Javaid2 and Muhammad F. A. Fardosi3
..., antioxidant and/or anticancer activities....
*Malik F. H. Ferdosi1, Arshad Javaid2, Iqra Haider Khan2, Muhammad F. A. Fardosi3 and Ayesha Munir4,5
...ellant, antioxidant, anticancer, antimicrobial and/or anti-inflammatory....
Sheng Zhang, Rui Qiu, Zhiping Lv, Liying Yang and Wei He*
...n in non-small cell lung cancer patients (NSCLCP). This a retrospective observational study totally includes 40 participants, and these participants are divided into following two groups: control group (health participants), experimental group (NSCLCP), and then all these participants receive standardized bronchoalveolar lavage. Participants’ general data are collected and analyzed. EphA2 expression and PRMT1 expression in blood samples are determined by...
Hafiz Muhammad Farooq Yaqub1, Sehrish Firyal1, Ali Raza Awan1, Muhammad Tayyab1, Rashid Saif2, Muti ur Rehman3, Muhammad Wasim1*
...ing in tumor. Like human cancers, dogs have relatively high incidence of cancers, relatively large body size and responses to cytotoxic and other therapeutics. Small noncoding RNA having length of 22 base pair (bp) are called micro-RNA (miRNA), that are processed by Dicer from precursors with a characteristic hairpin secondary structure. miRNAs can regulate gene expression at the post-transcriptional level by binding to the ...
Hafiz Muhammad Farooq Yaqub1, Sehrish Firyal1, Ali Raza Awan1, Muhammad Tayyab1, Rashid Saif2, Muti ur Rehman3, Muhammad Wasim1*
...ing in tumor. Like human cancers, dogs have relatively high incidence of cancers, relatively large body size and responses to cytotoxic and other therapeutics. Small noncoding RNA having length of 22 base pair (bp) are called micro-RNA (miRNA), that are processed by Dicer from precursors with a characteristic hairpin secondary structure. miRNAs can regulate gene expression at the post-transcriptional level by binding to the ...
Malik F. H. Ferdosi1, Iqra Haider Khan2, *Arshad Javaid2, Muhammad Nadeem3 and
Ayesha Munir4
...luding ant-diabetic, anticancer, antihyperglycemic,
antioxidant, antimicrobial and anti-inflammatory.
...
*Arshad Javaid1, Iqra Haider Khan1 and Malik F. H. Ferdosi2
...oxidant,
anticancer, anti-inflammatory, antidiabetic, and analgesic.
...
Malik F. H. Ferdosi1, Iqra Haider Khan2, Arshad Javaid2*, Hafiz Muhammad Saeed1, Ifrayeem Butt2 and Ayesha Munir3
..., anti-inflammatory, anticancer and/or antidiabetic properties....
Arshad Javaid1*, Malik F. H. Ferdosi2, Iqra Haider Khan1, Amna Shoaib1, Hafiz Muhammad Saeed2, Muhammad Abrar Ul Hassan1
...tory, antimicrobial, anticancer, antimalarial, antioxidant, antidiabetic, antitumor, etc....
Riam Yousfe Muttair
...n the latest approach to cancer treatment, with checkpoint inhibitors substitute for the keys that open the immune system free against cancer cells. The paper covers the progress made in immunotherapy, highlighting next-stage checkpoint inhibitors as the vaccine which may turn today’s cancer treatment procedures into historical relics. The opening sentences describe historical backgr...
Lei Chu1, Jie Yang2, Zhenshi Chen2, Xiajun Zhang1, Weidong Wu3*, Shaoru Zhang2 and Lihui Wang2*
...lign: justify;">Cervical cancer (CC) is the most common malignant tumor in women, and its prognosis is poor. The key genes and pathways of CC need to be further discovered. GEO2R was used to identify differentially expressed genes (DEG), GO and KEGG enrichment were analyzed by DAVID. Then, the PPI network is constructed with strings. The HUB gene and module of DEGS were obtained by Cytoscape. Finally, GEPIA also analyzed the differential expression and surviva...
Xiaowei Zhang*
... trastuzumab, on gastric cancer with ascites. 225 patients with gastric cancer and ascites received by the Oncology Department and Gastrointestinal Department of the Central Hospital during October 2019-2021 were selected. They were subsequently assigned into apatinib group, trastuzumab group and combined treatment group. Compared with other treatment groups, the long-term and short-term survival rate of the apatinib treatme...
Tamara Natik Dawood*
..., anti-inflammatory, anticancer, and cardioprotective effects. The study aims to determine the influence of several levels of silymarin on the productive and biochemical parameters in local lambs. A total of 30 lambs are classified into three groups. G1 (ten lambs) received Silymarin (420 mg/kg) orally, G2 (ten lambs) received Silymarin (210 mg/kg) orally, while G3 (ten lambs) received distal water (control group). Several parameters are used in the current st...
Islam S Alani*, Huda Sadoon Al-Biaty
...rogression and spread of cancer cells, in addition to the advancement of tumors. The objective of this research was to evaluate the expression of PN in canine mammary gland tumors. The study material consists of 44 carcinomas and 6 benign tumors, together with 10 normal samples. Antibodies targeting the antigen POSTN have been used to conduct immunohistochemistry procedures. In normal biopsies, the expression of periostin was absent in the epithelial compartme...
Waqas Ahmad Shams1*, Gauhar Rehman2, Muhammad Ismail3, Rahmul Kabir4 and Abdul Qahar1
...seases such as diabetes, cancer, and inflammation. In this study, we investigated the antioxidant potential of extracts obtained from Crab Himalayapotamon emphysetum using various in vitro assays. Different solvents of varying polarities including ethanol, methanol, ethyl acetate, and water were employed for extraction. The results demonstrated significant antioxidant activity across different extracts in different in vitro assays. Particularly, the aqueous ex...
Quratulain Amjad1,2 and Abdul Rauf Shakoori1,2*
...or proliferation in lung cancer and glioblastoma cells whereas TGF-β is a well-described tumor inducer. The present study was aimed at deciphering the role of heparan sulphate in Slit2 mediated inhibition of cancer metastasis. Cancer proliferation was induced by TGF-β in lung cancer cells (H1650) and glioblastoma cells (SF767) and then the anti...
Nesreen Ahmed Nasser1, Anas H. Sadek2, Bayadir Abdulhussein Mahmeed3, Osama Akram Mohsein4*
...>...
Mehak Muhammad Ashfaq1*, Aqsa Naeem Chawla1, Muhammad Umaid Ali1 and Adnan Ahmed Bhutto2
...inked to a lower risk of cancer, cardiovascular disease (CVD), and other neurological conditions, including Alzheimer’s, Parkinson’s, and others. Nevertheless, due to research constraints and confounding variables such as study design, population size, and usage of various chocolate product types, dosages, and contents, additional large-scale human experiments are required to validate and advocate the chocolate diet. An increasing amount of researc...
Rawya Sh. Mohammed*, Baraa N. Al-Okaily
...ti-inflammatory, and anticancer properties. ...
Rehana Yasmin1,2, Rashda Abbasi2*, Tariq Saeed2, Madiha Sadiq2, Nuzhat Yasmeen3, Muhammad Iqbal4, A. Khuzaim Alzahrani5, Nadeem Kizilbash5, Ugur Bilge6, Nafees Ahmad2 and Sajid Malik1*
...ne of the most prevalent cancers among pediatric malignancies and causes huge economic burden. In this case-control study epidemiological, environmental, life-style related risk factors and phenotypic characteristics of leukemia subtypes were investigated in Pakistani population. A total of 1500 subjects, including 616 patients and 884 controls were recruited through a retrospective cross-sectional sampling design. Descriptive summaries were generated, and ris...
Rawya Shakir Mohammed*, Baraa Najim Al-Okaily
...ti-inflammatory, and anticancer activities.
Keywords | Curcumin, Doxorubicin, Ovarian follicles, Selenium nanoparticles, VEGF gene, Rats
...
Salim Saifullah1* and Achyut Adhikari2
... anti-inflammatory, anti-cancer, and anti-apoptotic properties. In this study, nepetin as yellowish powder was isolated from A. vulgaris extract through column chromatography. Structure of the compound was elucidated through various spectroscopic techniques such as Mass and NMR (1D and 2D)....
Nor Adila Zulkifli1, Nurul Zaizuliana Rois Anwar1*, Zalilawati Mat Rashid1, Zarinah Zakaria1, Norshazila Shahidan2, Lee-Hoon Ho1 and Faridah Yahya3
...mount of the potentially cancer-causing substance hydroxymethylfurfural (HMF) in honey and will reduce the physicochemical and nutritional attributes due to its heat sensitivity. Hence, ultrasound which is a non- thermal processing was chosen as an alternative method to minimize the quality loss during the processing of Kelulut honey. The purpose of this study was to investigate the effect of ultrasound processing on the quality of Kelulut honey. The ultrasoun...
Abrar ul Haq1, Shusheng Yin2, Amara Maryam1, Muhammad Khan1*, Hafiz Abdullah Shakir1, Muhammad Akhtar Ali3, Muhammad Irfan4, Muhammad Faisal Maqbool1 and Yongming Li2*
...induce apoptosis in lung cancer cells. However, the anticancer activity of lathyrol remains largely unknown in various human cancers. The present study was designed to evaluate lathyrol for its broad-spectrum anticancer activity and binding affinity with STAT3 DNA binding domain. Using CCK-8 assay kit, we showed that lathyrol reduced the cell viability o...
Sehar Aslam1, Muhammad Qasim1*, Mohsin Khurshid2*, Usman Ali Ashfaq1 and Muhammad Akhtar Ali3
...ococcus aureus. The anti-cancer activity of all isolates was also evaluated against the Human colorectal adenocarcinoma cell line (Caco-2), and all isolates showed significant anticancer activity. These findings validate the beneficial therapeutic values of novel probiotic strains isolated from dairy sources, specifically Dahi, and suggest that they could be used in food and drugs to treat various diseases....
N. M. Abed
... anti-inflammatory, anti-cancer, antibacterial and hepatoprotective properties. Propolis protects thyroid and gonadal function from NiCl2 and CCl4. In order to assess the protective impact of propolis extract against NiCl2 and CCl4, 80 adult male albino rats were divided into eight groups including control group, the propolis-treated group, the NiCl2-treated group, the CCl4-treated group, the NiCl2 and propolis-treated group and the CCl4 and propolis-treated g...
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