Raw Chicory Roots Powder has Impact on Various Biomarkers of Colorectal Cancer in Male Wistar Rats
Raw Chicory Roots Powder has Impact on Various Biomarkers of Colorectal Cancer in Male Wistar Rats
Tahir Rasool Qamar1, Sanaullah Iqbal1*, Muhammad Nasir1 and Habib-ur- Rehman2
ABSTRACT
Prebiotics modulate metabolism and ensure a healthy gastrointestinal tract that may prevent colorectal cancer (CRC) development. The present study was designed to explore the effects of chicory roots derived fructans, in raw form, against CRC in rats. After acclimatization period, forty male Wistar rats were randomly and equally divided into four groups. Chicory powder treatments were started to group G4 before administering carcinogenic injections. After one-month, groups G2-G4 received four subcutaneous injections of carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) at dose of 40 mg/kg body weight, twice a week for 2 weeks. After DHM injections, chicory powder treatments were started to group G3 as well and group G2 was DHM control group receiving only basal diet while G1 was normal control group. The amount of chicory roots powder given was 5% w/w mixed in basal diet. It was observed that group G4 showed better results overall. Enzymatic activities of pathogenic bacteria were lowest in this group and were significant (p≤0.05) when compared to group G2. Percentage of total aberrant crypt foci (ACF) inhibition was also higher (30.14%) in group G4 as compared to group G3 (18.55%). Elevated levels of short chain fatty acids were observed in chicory root powder groups particularly in G4 which having significant higher levels of acetate and butyrate compared to group G2. Group G4 also hindered body weight loss due to carcinogenesis effect. It can be concluded that chicory root powder has protective impact against CRC biomarkers particularly if it is taken as preventive measure.
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