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Identification of Immune-Related LncRNA for Predicting Survival in Skin Cutaneous Melanoma

Identification of Immune-Related LncRNA for Predicting Survival in Skin Cutaneous Melanoma

Qi Jiayi1, Huang XuMiao2, Lin Wei3, Ao YaHui3, Zhao Wenting2* and Cao Chunhao3*

1Chongqing Medical University, Chongqing, 400016, China
2Hubei University of Chinese Medicine
3Department of Integrated Traditional Chinese and Western Medicine, The First Affiliate Hospital of Chongqing Medical University, Chongqing, 400016, China
 
Qi Jiayi and Huang XuMiao contributed equally to this work.
 
* Corresponding author: fanquli88@gmail.com, 1932709377@stmail.hbtcm.edu.cn

ABSTRACT

Immune-related lncRNAs (LncRNA) play an essential role in tumorigenesis and progression, and sought to develop an immune-related lncRNA signature to assess the value of immune-related lncRNAs to discover their prognostic values. RNA-seq and clinical information were obtained from the Cancer Genome Atlas (TCGA) database, which aims to screen for immune-associated lncRNAs based on constructing a risk scoring formula. Besides, in virtue of univariate and multivariate Cox regression, immune-associated lncRNA signatures formed its structure. In addition, in virtue of gene ontology (GO) and KEGG pathway enrichment analysis genes were given functional identification. In total, there were 102 differentially expressed immune-related lncRNAs which were identified, and there were four genes (USP30-AS1, U62317.1, ZEB1-AS1 and MIR205HR) which were screened from the gene signature to form a prognostic signature model. Based on the survival analysis results, patients with high-risk scores had poor survival outcomes. To conclude, we constructed a predictive signature of four immune-related lncRNAs, which can provide assistance for prognosis prediction and immunotherapy of SKCM.

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Pakistan Journal of Zoology

February

Pakistan J. Zool., Vol. 56, Iss. 1, pp. 01-501

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