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HER2/neu Levels, Premature Termination of Pregnancy and Breast Cancer Risk: A Hospital-Based Study from Lahore, Pakistan

HER2/neu Levels, Premature Termination of Pregnancy and Breast Cancer Risk: A Hospital-Based Study from Lahore, Pakistan

Muhammad Mansha1*, Sidra Yaqub1, Asma Abdul Latif2, Muhammad Wasim3 and Peter C. Thomson4

1Department of Zoology, University of Education, Lahore, Pakistan.
2Department of Zoology Lahore College for Women University, Lahore
3Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore
4School of Life and Environmental Sciences, University of Sydney, Australia.

*      Corresponding author: dr.mansha@ue.edu.pk

ABSTRACT

Breast cancer is a leading cause of death in women. The objective of the present study was to evaluate diagnostic utility of HER2/neu test and the association of premature termination of pregnancy with breast cancer. Two hundred breast cancer patients from INMOL hospital, Lahore (Pakistan) were interviewed on reproductive factors. HER2/neu levels were determined by ELISA from 52 patients and 37 age-matched control women. The results of survey study showed that “premature termination of pregnancy” emerges as a potential risk factor of breast cancer. Number of pregnancies has significant association with premature termination of pregnancies (P = 6 × 10–11). The regression coefficient for number of pregnancies is 0.220 ± 0.029= 1.25× i.e. a 25% increase for each additional pregnancy. There is a significant positive association between premature termination of pregnancies and number of children (P = 0.024): the regression coefficient is 0.108±0.048=1.11× i.e. 11% increase for each additional child. The analysis of Her2/neu showed that its levels were higher in younger patients (≤ 42 years) than in older patients (0.884 vs 0.614 units, P= 0.049). The ROC curve indicated that the optimal test (maximum Se + Sp) occurred at HER-2 Neu values of = 0.615, where Se= 0.73 and Sp= 0.49. The AUC value for this test was 0.57, with 1 being a perfect test, and 0.5 being equivalent to random allocation. In brief, premature termination of pregnancy/ miscarriage is a potential risk factor and HER2/neu cannot be used as a suitable diagnostic test.
 

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Pakistan Journal of Zoology

December

Vol. 53, Iss. 6, Pages 2001-2521

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