Epithelial Periostin Expression in Canine Mammary Tumors
Epithelial Periostin Expression in Canine Mammary Tumors
Islam S Alani*, Huda Sadoon Al-Biaty
ABSTRACT
Mammary neoplasms are a prevalent form of malignancy found in canines female . Periostin (POSTN) is a protein that performs crucial functions in the progression and spread of cancer cells, in addition to the advancement of tumors. The objective of this research was to evaluate the expression of PN in canine mammary gland tumors. The study material consists of 44 carcinomas and 6 benign tumors, together with 10 normal samples. Antibodies targeting the antigen POSTN have been used to conduct immunohistochemistry procedures. In normal biopsies, the expression of periostin was absent in the epithelial compartment. High levels of POSTN expression was detected in 93.2% of cancerous biopsies as well as in 16.7% of benignly diagnosed biopsies. With a noticeable difference between these two groups (P≤0.01). PN was found to be highly expressed in 92.1% of the newly diagnosed cases and 100% of the recurring cases. PN exhibited a higher level of expression in females (95%) compared to males (75%), with a statistically significant difference (P≤0.01). Additionally, PN expression was shown to be significantly higher in the advanced age group (10–15 years), with a 100% expression rate. Furthermore, there was a significant variation in periostin expression among different breeds (P≤0.05). The statistical analysis indicates that there is no significant variation in periostin expression across different cancer groups based on type (P≤0.01), stage (P≤0.01), and grade (P≤0.01) of cancer.In conclusion, periostin expression can be used to evaluate the existence of malignancies in dogs with mammary tumors.
Keywords | Periostin, Mammary tumors, Immunohistochemistry, Female canines, Cancerous biopsies, Neoplasms
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