Bioinformatic Analysis of the Possible Mechanism of TOP2A Expression in the Development of Liver Cancer
Bioinformatic Analysis of the Possible Mechanism of TOP2A Expression in the Development of Liver Cancer
Man Wang1 and Fengmei Yang2*
ABSTRACT
The expression and significance of topoisomerase IIA in liver hepatocelluar carcinoma (LIHC) were analyzed to explore the possible mechanism of topoisomerase IIA in the development of liver cancer based on bioinformatics analysis. GEPIA, UALCAN, cbioportal and other tools were used to analyze the correlation between TOP2A gene expression and methylation, prognosis and immune cell infiltration in databases. The expressions of TOP2A gene and protein in tumor tissues were higher than those in normal tissues, and the differences were statistically significant (P<0.05); TOP2A gene expression was positively correlated with immune cells infiltration (P<0.05); the overall survival, disease-free survival and survival probability of patients with high expression of TOP2A gene were lower than those with low expression of TOP2A gene (P<0.05). In clinical specimens, the expression of TOP2A in cancer tissues were significantly higher than that in the normal tissues, and were related to Edmondson grade. To conclude, the methylation of TOP2A gene and the infiltration of tumor-associated immune cells may play an important role in the pathogenesis of liver cancer, and the expression of TOP2A gene can be used as a prognostic indicator of liver cancer.
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