Amtul Jamil Sami1,*, Madeeha Khalid1, Rehman Shehzad1, Sana Mughal1 and A.R. Shakoori2
...was administered to male albino mice for up to eight weeks for growth promoting activity. Increased mammary growth was observed in test female non lactating mice, as compared to controls when placental lactogen was applied. Increase weight gain for visceral tissues like kidney, liver, muscle and lungs was also observed, as compared to control subjects. It was also recorded that the exogenous supply of bubaline PL reduces fat cells in the hypodermal layer of sk...
Rabia Qurashi, Qurat ul Ane Gillani* and Furhan Iqbal*
...ofile of 6 week old male albino mice. Blood samples from male albino mice (CGP55845 treated N = 14 and saline treated N = 16) were collected directly by cardiac puncture and used for estimation of hematological and some serum biochemical parameters. The hematological parameters did not show any significant variation between the two groups. From amongst serum biochemical parameters triglycerides (P = 0.02) in CGP55845 treated...
Muhammad Nazar Aftab1, Ahmed Ali1, Muhammad Asad1, Sadia Fatima2 and Furhan Iqbal2,*
...chemical profile of male albino mice. Eight week old male albino mice were used as experimental animals and were divided into two groups. First group was treated with 80mg/Kg body weight of AlCl3 for 16 days while control group was treated with saline solution for the same period of time. Complete blood count were determined in both experimental treatments at the end of dose supplementation. Our results revealed t...
Tahir Abbas*1, Khawaja Raees Ahmad2, Asmatullah3, Khalid Pervaiz Lone4, Muhammad Ali Kanwal2, Sadia Suleman2
Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice
...-hepatic anomalies. Male albino mice (Mus musculus) were equally divided (n=10) as C; control, Cr-treatedandCr-JgroupsreceivingCr+6 in the form of potassium dichromate (K2Cr2O7) 50ppm for 10days ad-libitum while Cr-J group additionally given 0.25ml/12h Jambul Fruit Extract (JFE) for next 5days by oral gavage. On the 16th day blood, liver and kidney were collected for biochemical and histopathological analysis.Cr+6 treated group showed severe histological chang...
Muhammad Babar Khawar1, Muddasir Hassan Abbasi1, 2, Sana Fatima3, Khawaja Abdul Mujeeb2, Nadeem Sheikh1
Alterations in proteins and transaminases activity induced by thioacetamide in albino rats
...of TAA administration in albino
rats. Rats were randomly divided into three groups (n=3) namely control group, 12h group and 24h group. Each
experimental group (12h and 24h) was administered 300 mg/ kg TAA intraperitoneally (i.p) while control received
same volume of normal saline solution. Rats of 12h and 24h group were killed after 12 and 24h of TAA administration
respectively. Blood was obtained; livers were excised and processed...
rats. Rats were randomly divided into three groups (n=3) namely control group, 12h group and 24h group. Each
experimental group (12h and 24h) was administered 300 mg/ kg TAA intraperitoneally (i.p) while control received
same volume of normal saline solution. Rats of 12h and 24h group were killed after 12 and 24h of TAA administration
respectively. Blood was obtained; livers were excised and processed...
Atiq-ur-Rehman1,2,*, Abida Latif1,*, Rukhsana Anwar1, Nasir Abbas1, Sajid Nawaz2 and Hamid Turab Mirza3
...as carried out in Wistar albino rat models. Changes in postprandial levels of blood glucose in rat models (normal and diabetic) were examined after starch load with or without chloroform fraction. Chloroform fractions (250 mg/kg and 500 mg/kg b.w.) dose levels were administered to the rats and the samples of blood were taken at 0 h, 0.5 h, 1 h, 2 h and 3 h intervals. In vitro results showed that chloroform fraction at concentration of 100 µg/ml sh...
Aiguo Zhou1,3,4, Shaolin Xie1,4, Zhenlu Wang1, Lanfen Fan1, Yanfeng Chen2, QiaoYe1, Fang Zeng1 and Jixing Zou1,*
...> should be regard as an albino of biocolor type.
...
Abd El-Nasser Ahmed Mohammed1,2,*
...anesthesia. Seventy-five albino female mice (21.74 ± 0.19) were distributed into three groups; control (G1; N=25; not receive N. sativa oil) and two N. sativa oil groups supplemented with either 1.0% (G2; N=25) or 2.0% (G3; N=25) for 30 days. Changes of body temperature, heart rate, blood parameters (RBCs, WBCs, hematocrit, hemoglobin, glucose and total protein), oocyte quality after ovarian transplantation (cumlus enclosed, brilliant cres...
Chaman Ara1*, Asmatullah1, Zainab Riaz1, Memoona1, Asma Chaudhary2, Shagufta Andleeb2
... induced by BP in female albino mice.
Novelty Statement | Curcumin, an active component of turmeric along with its proven anti-fungal and antimicrobial activities also detoxify Paraben (suspected car-cinogen and endocrine disruptor) instigated damages.
...
Sameh S. Tawfik, Ahmed A. Elkady* and Ehab T. Mohamed
... was investigated. Forty albino-rats were divided into four groups: Control, rats were orally administered the vehicle for 6weeks, TSE-treated (each rat received 230mg TSE; once daily, for 6weeks), irradiated (animals subjected to whole body γ-rays (8Gy), and TSE-treated and irradiated (each rat received 230mg TSE; once daily for 6week, then one-hour later after last-treatment, rats were exposed to whole body γ-rays (8Gy). The results revealed that...
Saara Ahmad1,*, Iftikhar Ahmed2, Saida Haider3, Zehra Batool4, Laraib Liaquat3, Fatima Ahmed5, Asra Khan1, Tahira Perveen3, Mirza Jawad ul Hasnain6, Saima Khaliq7 and Saad Bilal Ahmed8
Ahmet Ozer Sehirli1,2, Serkan Sayiner3*, Ayliz Velioglu-Ogunc4, Nedime Serakinci5, Emel Eksioglu-Demiralp6, Berrak Yegen7, Feriha Ercan8 andGoksel Sener2
...The renal mass of Wistar albino rats was reduced at a rate of 5/6. Captopril, Valsartan and NAC were applied intra-peritoneal alone or in combination. Blood pressure and heart rate were monitored at weekly intervals over a period of six weeks. Serum creatinine, blood urea nitrogen (BUN), lactate dehydrogenase (LDH) activity, cytokines (TNF-α, IL-1β, IL-6) concentrations, urinary volume, creatinine, and both serum and urinary electrolyte levels were ...
Aamir Mushtaq1,2, Rukhsana Anwar1 and Mobasher Ahmad1,2,*
...l studies for which male albino mice were grouped into seven groups. Mice were subjected to elevated plus maze, hole board and light dark paradigm on (day 7th and 8th), for behavioral studies after which their brain were removed by decapitation for biochemical assessment. Results indicated the existence of total phenols (170.14 ± 1.16 mg of GAE/g of extract), flavonoids (87.67 ± 0.67 mg of RE/g of extract), tannins (194.04 &...
Magbolah Salem Helal Alzahrani
...totoxin. Thirty-six male albino rats were treated with subcutaneous injection of CCl4 in paraffin oil 50% V/V (2ml/kg b. wt.) twice a week for 2 weeks to induce chronic liver damage. After injection of CCl4, blood samples were obtained using the retro-orbital method to confirm liver damage and estimate liver function. Rats given CCl4 prior to feeding M. chamomilla demonstrated decrease in serum lipoprotein HDL, LDL, VLDL...
Gregory Ejikeme Odo1,*, Juliana Ekenma Agwu1, Nkechi Nweze2, Clara Ikegbunam2,Felicia Ekeh N1, Vincent Ejere1, Ngozi Ezenwaji1, Reginald Njokuocha2, Godwin Ngwu1 and Fabian Okafor1
...nta erecta (L) in 48 albino wistar rats, Rattus norvegicususingbiochemical and haematological indicesof toxicit
Asmat Ullah1,2, Shahid Iqbal1,2 and Furhan Iqbal2*
... on selective aspects of albino mice behavior in a gender specific manner. Seven week old female and male albino mice were used as experimental animals. Mice were orally supplemented either with 300 mg/ml solvent/Kg of body weight Bauhinia variegata’s leaf extract or with saline solution (0.9% NaCl) for 17 days. Behavioral observations were made by applying a series of neurological tests (Rota rod, Elevated plus...
Tafail Akbar Mughal1, Shaukat Ali1*, Hafiz Muhammad Tahir1, Shumaila Mumtaz1, Samaira Mumtaz1, Ali Hassan1 and Syed Akif Raza Kazmi2
... lipid profiles of Swiss albino mice in which diabetic phenotype was induced by alloxan. A single injection of Alloxan (150 mg/kg) was applied intravenously to induce diabetic phenotype. Alloxan induction raised the overall level of triglycerides, low density- lipids (LDLs), and cholesterol and reduced the level of high density lipids (HDLs). Oral administration of 200 mg/kg aqueous extract of B. lycium Royleroot bark for 28 days rescued all these chang...
Hagar E. Mohammed1, Ranwa A. Elrayess2 and Heba N. Gad El-Hak2*
Chaman Ara1*, Asmatullah1, Saima Hanif1, Shagufta Andleeb2, Beenish Zahid3 and Madeeha Arshad4
...induced toxicity in male albino mice, Mus musculus. Eighty, 8-9 week old mice were divided randomly into eight groups, each containing 10 mice and exposed to three sub-lethal concentrations (37.5µg/g; 18.7µg/g; 9.37µg/g B.W) of aluminum, with and without onion extract. Control and antidote groups were treated with distilled water and onion equous extract, respectively. Doses were administered orally by gavage for 30 consecutive days, o...
Ramazan Erdogan1*, Mikail Tel2, Vedat Cinar2 and Ragip Pala2
...2 male 8-week-old Wistar albino rats were randomly divided into 6 groups, each of seven; Control (C), Zinc picolinate (ZP), Chronic exercise (CE), Chronic exercise+Zin picolinate (CE+ZP), Acute exercise (AE), Acute exercise+Zinc picolinate (AE+ZP). Rats were subjected to a 30-min running test 5 days a week for 6 weeks after dietary zinc picolinate (6 mg Zn / kg) was started.An exhaustion exercise was performed on the last day for acute exercise. It was observe...
Sajida Batool1, Saira Batool1, Sitara Shameem1, Fatima Khalid1, Tahira Batool2, Summera Yasmeen1, Saima Batool3*
... changes in the liver of albino laboratory mice, 20 adult male mice were equally distributed (n=10) into two groups. Atrazine was given at the dose of 200 mg/kg body weight through gavages for 28 days while the control (Cnt) group remains untreated. On the 29th day, all animals were sacrificed to recover liver for histological preparations. Atrazine (ATZ) caused various hepatic implications in the treated animals. ATZ exposure caused a significant decline in m...
Syed Shahid Imran Bukhari1*, Nusrat Jahan2, Muhammad Khalil Ahmed Khan3, Mariam Zaheer1, Sabir Javed1
...ract in diabetic induced albino mice. Male albino mice, weighing (25±5g) were divided into three groups; Group 1: normal (non diabetic nontreated), Group 2: diabetic non treated (DNT), Group 3: diabetic treated (DT) mice. Group 3 was treated with three doses of A. barbadensis (200 mg/kg, 300 mg/kg and 400 mg/kg) per day for 14 days were assigned as DT1, DT2 and DT3 respectively. Aloe vera given orally produced signifi...
Amr N. El-Shahat1, Refaat G. Hamza1,*, Ashraf M. Mounir1 and Madeha N. Al-Seeni2
...liver and kidney of male albino rats.In the present study, gamma- irradiation (2 Gy every 3 days up to 8 Gy total doses) induced biochemical and oxidative damage in rats when compared to control group. In GFJ (10ml/Kg B Wt. /day) treated irradiated group, there were noticeable decreases recorded in lipid contents, concentration of serum urea, creatinine and uric acid, glucose level, activity of some liver enzymes and liver and kidney TBARS levels with remarkab...
Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
...n hyperlipidaemia Wistar albino rats induced by Triton X-100. There were 4 groups of rats: Group A served as normal; Group B, C and D were given high cholesterol diet and administered with intraperitoneal injection of Triton X-100 to induce hyperlipidaemia. Group B was administered with distilled water and high cholesterol diet on daily basis during the whole treatment and served as hyperlipidaemia control group. Group C was kept as a standard group and receiv...
Juliet N. Ozioko1, Obinna V. Ayogu2, Benjamin O. Ezema1, Dilibe C. Uramah3 and Kingsley O. Omeje*,1
...and hepatocyte of wistar albino rat. Twenty-five rats that weighed 98-168g were separated into five groups. Phytochemicals were quantified using standard methods. Alkaloids, flavonoids, tannins, saponnins and terpernoids were detected. The leaf extract had 0.415 % of alkaloids, 0.102 mg/TAEq of tannins, 0.211 mg/QEq of flavonoids and 0.360 mg/GAEq of phenolics. Phytol, oleic acids, hexadecanoic acids and octadecanoic acids were detected in the leaf extract by ...
Jocelín Selene Sánchez Cisneros1, Braulio Alejandro Fuantos Gámez1, Martin Herrik Ramón Kane1, Laura Miranda Contreras2, Camilo Romero Núñez2*
...s case describes a young albino Burmese python that presented with dry-looking skin, multiple folds and wounds. Skin samples were taken for histopathology and compared with a healthy specimen of the same species and colour characteristics. The diagnosis was cutaneous collagen dysplasia suggestive of cutaneous asthenia. This is the first report of cutaneous asthenia in a baby albino Burmese python in Latin America.
Ke...
Safaa M. Barghash1*, Amani A. Hafez2
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
...rk was carried out on 40 albino rats, and equally divided into 4 groups, (10 rats/group) as following: Group 1, animals served as control. Group 2, animals received STZ. Group3, animals received laser. Group 4, animals received STZ+ laser. After the experiment, blood samples were collected for biochemical analysis. Also, the pancreas was dissected for histopathology. Results: biochemically, there was a significant increase in hepato-renal enzymes, cholesterol...
Ishrat Younus1,2 and Afshan Siddiq1*
...sativus var. caudatus in albino mice. The analgesic and antipyretic activities were determined at three different doses (50, 100 and 200 mg/kg) using different pain models (writhing induced, tail flick) and yeast induced pyrexia tests, respectively. The extract exhibited significant (p < 0.05) in vivo analgesic and antipyretic potential in term of % writhes inhibition, increased latency time and reduced rectal temperature when compared with control. The ext...
Ahmed Alazzouni1, Ashraf Al-Brakati2,*, Sherif Rabie1, Mohamed Gabry1 and Basmaa Hassan1
Ahlam G. Khalifa1*, Walaa A. Moselhy1, Hanaa M. Mohammed2 and Khaled Abdou1
...ave been published. Male albino rats have been randomly divided into 4 identical groups. Group (I) had received only corn oil and acted as a control group. Group (II) had been given 3.855 mg/kg BW deltamethrin. Group (III) obtained deltamethrin loaded silica Nps at a dose of 8.795 mg/kg BW. The group (IV) obtained deltamethrin loaded chitosan Nps at a dose of 30.44 mg/kg BW. All remedies were administered by oral gavage 5 days a week for one month. The deltame...
Emtenan M. Hanafi1*, Fouad M. Tawfeek2, Walid S. El Nattat1, Moetazza M. Alshafei3, Seham S. Kassem3, Kawkab A. Ahmed4, Enas N. Danial5, Hagar Elbakry3, Hoda S. El-Sayed2
...tive performance of male albino rat. Total flavonoids, total phenolics, DPPH, HPLC and antimicrobial test against different types of bacteria were done for SP extract. BL has been microencapsulated in association with SP. Twentiy eight. adult male rats were divided into 4 equal groups. G1 received high fat diet (HFD), G2 received HFD and microencapsulated BL, G3 was supplemented by HFD plus encapsulated SP and BL. While G4 received basic diet as a control. Aft...
Asmaa Khamis1, Osama Abdalla1, Mohamed Hashem2, Noha Abdelnaeim1*
...Cl4). A total of 60 male albino rats were equally distributed in six groups. The first group received purified water and was kept as a control. The second and third groups were given oral PN and PM (500 mg/kg/day) for 31 days, respectively. The fourth group was intraperitoneally injected with CCl4 (2 ml/kg/day) on days 15 and 16 of the experiment. The fifth and sixth groups received oral PN and PM (500 mg/kg/day), respectively, for 31 days and were injected wi...
Rawda S. Mohamed1,2, Mohammed Y. Matoock2*, Abeer H. Abdelrazek2
...te stress, Balb/c, Swiss albino, Oxidative stress, Open field. ...
Mohammed A. Almujtaba1, Turky Omar Asar2, Salma Naqvi3, Vikas Kumar4, Fahad A. Al-Abbasi1, Abdulbasit I. Al-Sieni1 and Firoz Anwar1*
...ing in rats. Male Wistar albino rats were divided into 4 groups (n=6) for 28 days of experimental protocol. Group-1 served as normal control (NC), group 2 as doxorubicin control (DC), group 3 as doxorubicin+ Zamzam treatment (DZ) and group 4 as Zamzam control (ZZ). Doxorubicin (1mg/ kg bw) was injected i.p. in DC and DZ groups on first day of study. NC and DC groups were at normal bottled water p.o., while DZ and ZZ groups received Zamzam water p.o. for 28 day...
Eman A. Al-Shahari1,2, Eman R. ElBealy3, Abdelhalim A. Alkhazendar4 and Abeer A. Alm-Eldeen4*
...e rats. Forty eight male albino rats (3 and 30 months old) were used. Half of the rats at each age received 200 mg quercetin/Kg every other day for 2 weeks. Thirty months old rats showed a decrease in the liver AST, albumin, SOD, CAT and GPx while showed an increase in the liver ALT, plasma cholesterol and MDA comparing with 3 months old rats. The percentages of p53 and bax positive areas/ field were 26.04% and 24.9%, respectively. After quercetin administrati...
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...or eight weeks, 36 white albino rats weighing 197±10 g were selected at random to five groups: Group I was administered a regular diet; Group II was fed a high-fat diet; Group III was given a high-fat diet plus cranberry extract (75 mg/kg); Group IV was fed a high-fat diet with cranberry extract (150 mg/kg); and Group V was fed a high-fat diet plus metformin (500 mg/kg). The lipid profile was determined using blood samples, and liver tissue samples were...
Malik Fiaz Hussain1, Atif Akbar2, Muhammad Asif1, Laraib Nisar3, Muhammad Naeem Ashiq3 and Furhan Iqbal1*
...f NiO NPs on behavior of albino mice in a sex specific manner. Five weeks old albino mice (N = 48) of both sex were intraperitoneally injected with either low dose (20 mg) or high dose (50mg/ ml saline/ Kg body weight) of NiO NPs (average particle size 43 nm) for 14 days. Control groups were treated with saline solution. A series of behavioral tests were conducted in all subjects. Both low and high dose of NiO NPs treated ma...
Abdulkhaliq A. Al-Janabi1*, Mohammad S. Alsalami1, Arkan B. Mohammed1, Abdulkhaliq A.R. Al-Douri2
...profiles in New Zealand (albino) rabbits. Twelve male rabbits aged 6-7 months with an average initial weight of 1308.00±39.97 g were used in this study. The rabbits were divided into three groups; the control group was treated orally with distilled water, and the second and third groups were treated orally with 150 or 300 µl Omega-3, respectively. The rabbits’ body weight significantly increased in both Omega-3 treated groups, as well as red...
Florence N. Nworah*, Nene O. Uchendu, Ifeoma F. Chukwuma*, Emmanuel C. Ossai and Emmanuel C. Ezeako
...ins and minerals. Thirty albino rats used were grouped into six comprising of five rats each and each group except group A was induced with cyclophosphamide. Group A received normal saline, group B remained untreated, group C, D, E and F were respectively treated with standard haematopoietic drug, Ginovera (5 mg/kg body weight), 50 and 100 mg/kg body weight of raw blood and 100 mg/kg body weight of cooked blood respectively. Determination o...
Shahid Iqbal1,2, Zulha Javed1, Mushtaq Hussain Zahid3, Qurat ul Ane Gillani4 and Furhan Iqbal1,*
...s of blood serum of male albino mice. The extracts were administrated orally (100 mg/ ml solvent/ Kg body weight) for 15 days and it was observed that the complete blood count (CBC) remained unaffected while cholesterol (P = 0.03) and triglyceride (P = 0.008) levels in serum were significantly elevated in P. pinnata leaf extract treated mice. Mice treated with E. camaldulensis leaf extract had significantly reduced white blood cells (P = 0.05), platelets (P = ...
Maha Mostafa1, Sohail Soliman1, Reham I. Mohamed2 and Wael M. El-Sayed1*
...ale (20) and female (40) albino mice were orally administered testosterone at 25 mg/kg for 35 days. The males were allowed to mate with females to estimate the fertility index. After the end of treatment, mice were sacrificed, blood was collected for biochemical analysis, and sex organs were dissected out for histological preparations. Administration of testosterone has significantly increased the body weight and decreased the gonad weight in both sexes. It dr...
Mohamed M. Bahr1, Mohamed S. Amer1*, Khaled Abo-EL-Sooud2, Shaimaa M. Kamel3, Marwa A. Fouly4, Ahmed N. Abdallah5, Ashraf A. Shamaa1, Omar S. El-Tookhy1
...ogy: 24 male New Zealand albino rabbits were used in this study, divided randomly into 4 groups (6 rabbits per group), induction of corneal ulcers centrally in groups (I, II) and peripherally in (III, IV). Treated groups are (I, III) using topical lyophilized canine Mesenchymal Stem Cells derived EVs & control groups are (II, IV) using topical normal saline. Result: both treated groups appeared fluorescein negative at the 5th day and are characterized by r...
Owolabi Olutunmise Victoria1*, Saka Olusola Stephen2, Olashinde Oluwaseun Ruth1, Alli Smith Yemisi Rufina3
Magda A. Eldomiaty1,2, Manal E. Elsawaf2, Soad S. Ali3, Heba El-Sayed Mostafa4,5*
Aamir Mushtaq1*, Fatima Habib2, Umar Farooq Gohar3, Abdul Malik4 and Mobasher Ahmad2
...were performed in female albino mice by administration of single oral doses (4, 5, 6, 7 and 8 g/Kg/po) respectively, to individual groups (n=5) and after that the behavioral changes were observed. To find the chronic toxicity, the animals were divided in three groups (n=6) which were orally administered with normal saline, P. anisum methanolic extract 400 mg/Kg, and 800 mg/Kg respectively for three months. The results of acute toxicity study represented the LD...
Ali I. Al-Ameedi1, Zahraa M. Ayad2*, Wed Abbas Mohammed3, Salim K. Hajwal4
...urea in Mice. Forty male albino mice were randomly divided into 4 groups of ten animals. The first group received hydroxyurea (80mg/kg B. W) orally daily for 30 days, while second and third group received Ginkgo Biloba (100 mg/ kg.BW) and omega3 (150 mg/kg.BW) orally daily for two weeks of HU administration as protective and 4th group (C-ve) were considered as control negative group was given distilled water orally. After therapy by removing the bone marrow fr...
Waheed Khan1, Muhammad Ajmal Khan2, Bakhtawar Khan1*, Aftab Amin3, Muhsin Ali4, Awais Farid, Ali Hazrat5 and Muhammad Yahya5
Muhammad Akram¹,²*, Rashid Mahmood³, Fahim Arshad4 and Umer Farooq Gohar5
...15 days. Invigoration of albino shoots with fresh MS basal medium resulted in multiple green buds, which successfully transformed into 54.60 and 652.78 healthy shoots in 30 and 120 days, respectively. These shoots were rooted, acclimatized, and transferred in field conditions. The present study thus establishes a simple in vitro liquid culture system for the mass propagation of P. minima, providing a strategy for the long-term conservation of multiple endanger...
Shaimaa A.Tawfik2,3, EL S.T. Awad1*, Hoda O.Abu Bakr1, Amira M.Gamal-Eldeen4, Esmat Ashour2, Ismail M.Ahmed1
...status. Methods: 40 male albino rats weighing 150-200g were divided equally into four groups 10/each. CSO (5% w/w) were administrated oral daily for 30 consecutive days. DOX treated groups were injected IP at a dose of 2.5 mg/kg trice weekly to be totally 15 mg/kg for two weeks. G1 Control, G2 CSO, G3 Doxorubicin, G4 CSO/DOX. Antioxidant activity, histopathological examination, immunohistochemical analysis of CYP3A4, MRP-1, and c-MYC proteins and expression o...
Rahma Boukarine*, Leila Hamdi and Kamel Khelili
Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1
Ni Putu Sarini1*, I Gde Suranjaya1, I Gusti Agung Arta Putra1, I Wayan Suarna1, Lindawati Doloksaribu1, I Ketut Puja2, I Ketut Gde Natakesuma3, I Gusti Ngurah Bagus Rai Mulyawan4
...d some irregularities in albino, injin, gading, bang, poleng, mores, panjut, and cundang. The MC1R (Melanocortin 1 Receptor) gene plays an important role in the pigmentation process and its variations are associated with differences in the skin and coat colors. The purpose of this study was to analyze the genetic variations of the MC1R gene in 10 Bali cattle reared in Bali Province which have aberrant color patterns. Blood samples were taken from the 10 Ba...
Khalid M. Al-Syaad1,2
...ts. A total of 24 Wistar albino rats were included in this study, divided into four groups; each group containing 6 rats and administered the treatment doses orally by gavage for 28 days. Control, treated with a physiological solution (5.0 ml/rat). CC-treated group, treated with CC 15 mg/kg/bw. CC+propolis, treated with CC 15 mg/kg/bw + 30 mg/kg/bw propolis. Propolis-treated group, treated with 30 mg/kg/bw propolis. Blood samples were collected for biochemical...
Azza M. El-Kattawy1, Tarek Abou Zed1, Randa Megahed1 and Mohammed El-Magd2*
... arthritis. Female Swiss albino mice (20-30g) were randomly divided into 5 groups (n= 10/group): control, Sim control, pristane-induced arthritis, Sim co-treated, and Sim post-treated group. Sim treatment significantly 1) downregulated the expression of immunomodulatory genes [interferon gamma (IFNγ) and lactoferrin (LF)], 2) decreased the expression of inflammation-related genes [tumor necrosis factor alpha (TNFα) and interleukin 1 beta (IL1β...
Salma Jameel Askar
... functions parameters in albino male rats and to determine the effects of Beetroots ethanolic extract in alleviation these alterations. Eighteen male albino rats were used, and they were divided into three groups of six animals each: G1, which received a dose of distilled water as a negative control; G2, which received a dose of meloxicam at 1.3 mg/kg.BW was a positive control, and G3 received a dose of meloxicam and beetroo...
Ali Mosa Rashid Al-Yasari1, Zahid I. Mohammed2, Haider S. Almnehlawi3,4, Ali F Bargooth5, Nawar Jasim Alsalih1, Huda F. Hasan6*, Mohenned A Alsaadawi1
Haneen Imad Al-Sultani1*, Ahmed Obaid Hussain1, Hazar Shakir Saleh2
... of rosuvastatin in male albino rats. Thirty-two adult albino rats were used in the study. After acclimatization, the rats were randomly divided into four groups (8 rats in each group) as follows: The first control group was given normal saline solution, the second group 10 mg/kg rosuvastatin, the third group was given 20 mg/kg rosuvastatin, while the fourth group was given 40 mg/kg rosuvastatin. The dose was continued ...
Rana Mahmood Ahmad*, Orooba Mohammed Maeed Ibrahim
...hteen adults male Wistar albino rats, six months, weighing 200–250g, were used and randomly grouped as follows: Group 1 was kept as a positive control group without treatment. At the same time, Group 2 received clove oil extract orally (10 mg/kg B.W.). Group 3 received Piroxicam (5mg/kg B.W) orally. The anti-inflammatory activity of clove oil extracts and their efficacy in decreasing inflammation in chronic inflammatory models were evaluated using the co...
Estabraq Hayder Khayoon, Ammar Ahmed Abdulwahid*
...tion, thirty mature male albino rats be used, (10/group), the control group (CC), animals were intubated with distilled water for 40 days, Group G1, rats received Acrylamide 5 mg/kg B.W. every day for 40 days by gavage needle, and Group G2, in this group animals got Acrylamide 5 mg/kg B.W. and Curcumin 100 mg/kg B.W. for 40 days by gavage needle as well. At the zero and the end times of the experiment, blood samples were taken using the heart puncture techniq...
Salema Lafta Hassan1*, Taghred Jabbar Humadai1, Sabrin Ibraheem Mohsin2
Ahmed K. Fahd*, Ali H. Saliem
...n the beginning, 84 male albino mice were selected, acclimated, and categorized into four equal groups: The 1st tested by the hot plate, the 2nd treated with acetic acid, the 3rd examined by application 10 μl of 2% formalin solution and the 4th was examined by the tail-flick test. Within each experiment, the study mice were subdivided equally into three subgroups; the 1st was administered only distilled water (control), the 2nd was drenched with apigenin (5...
Ghaith Z. Hasan Al-Askari *, Eman H. Yousif Al-Taee
...e (LD50) of VD in female albino rats and to assess the effects of vitamin D (VD) on the severity of acute upper or chronic vitamin D intoxication (VDI) through the study of cytogenetic effects in addition to histopathological changes in the tissues of female rats. The methods included in the first experiment, the female rats were orally administered the following lethal doses: 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16 mg/kg b.w. ...
Taghreed Jabbar Humadai*, Bushra Ibrahim AL-Kaisei
...stress induction in male albino rats. The methods included sixty male albino rats at age 8-9 weeks and weighted 190-200 gm were divided into three groups: The first group: Consisted of 20 rats control were given distilled water and normal rat pellet, the second group: Consisted of 20 rats injected weekly 0.5µg /kg. b.w. by I/P route which represented 1/20 LD50 of tetrodotoxin, the third group: It also consisted of 20 r...
SYED SHAHID IMRAN BUKHARI1*, IQRA AZAM1, MUDDASIR HASSAN ABBASI1, MEERAB DAUD1, NADEEM SHEIKH2, ANDLEEB BATOOL3, RABIA MAHMOOD2 & MARYAM MUKHTAR2
...its and cakes etc. Swiss albino mice of six weeks were divided into control group and experimental group. Experimental group was administered with Alloxan monohydrate (200 mg/kg) intraperitoneally and then livers were extracted after 3, 6 and 12 hours. All the samples were processed for gel run and thermo cycler program, which revealed alterations in the expression of hepatic mRNA (IL-6) in all loads equally confirmed by the results of housekeeping gene β...
HAFIZ MUHAMMAD ARSALAN1,2*, SUMMARA TABASSUM1, MUHAMMAD SHERAZ YASIN3, FAROOQ SALEEM4, ZEEMAL SEEMAB AMIN1, MUNIB ASHFAQ1, UMAR FAROOQ GOHAR5 & RASHIDA BASHIR6
...etes was induced in male albino rats by using Alloxan (150 mg/kg). Glutathione (GSH), Catalase (CAT), Malondialdehyde (MDA), Nitric oxide (NO), micronutrients (Vitamin A, Vitamin C and Vitamin E), serum glucose level and Advance glycation end products (AGE’s) were estimated. The results showed that levels of the Malondialdehyde (0.087, 0.151 and 0.104 respectively), Advance glycation end products (0.026, 0.053, 0.025) and Nitric oxide (0.07, 0.438, 0.190...
Wasan Ali Hasan1*, Manal Abdulkhaliq Ibrahim2
... rats. Thirty adult male albino rats were segmented into five distinct groups, each group comprising six rats (n=6). A_group (Negative Control) rats received distilled water only, without any drug; B_group (Positive Control) rats underwent ovalbumin sensitization and challenge of the airways; C_group rats were treated orally with a dose of prednisolone (4.12 mg/kg/d) and subjected to ovalbumin sensitization of the airways; D_group rats received oral famotidine...
Taghreed Jabbar Humadai*, Bushra Ibrahim Al-Kaisei
...n (TTX) on liver of male albino rats. At the age of 8–9 weeks and weighing 190–200 gm, 60 male albino rats were separated into 3 groups: First group of 20 rats received distilled water and regular pellets. Second group of 20 rats received weekly injections of 0.5 µg/kg b.w. by I/P route, which was equivalent to 1/20 LD50 of tetrodotoxin. Third group of 20 rats received weekly injections of 1 µg/kg b.w...
Md. Khayrul Basher1, Sumon Sarkar2,3, Md. Samiul Haque1, Sourav Sarker4, Md. Rashedul Islam1*
Sura Ayed Radam*, Inam Badr Falih
Ali D. Nashmi1*, Jawad K. Hasan1, Manal A. Ibrahim2
...otal of 24 healthy rats (albino, male), were weighted (150-300 g), were divided into four groups, each group consisting of six rats; Group A rats were given oral distal water and was considered a negative control group. Group B rats received distal water orally with ovalbumin (ova) sensitization, which was considered a positive control group. Group C rats were given dipyridamole (26.4 mg / kg) orally with sensitization to the ova. Group D rats received prednis...
Tahani Ahmad Al-Matrafi1, Zuhair M. Mohammedsaleh2, Mamdoh S. Moawadh2, Waheeb S. Aggad3, Rawabi Mohamed almuhimed4, Zamzam Alhuwaymil5, Aishah E Albalawi6, Ifat Alsharif7, Hailah M. Almohaimeed8, Fatima S. Alaryani9 and Mona H. Soliman10,11*
...icity. In this study, 36 albino mice were randomly grouped into six groups, each consisting of six mice: Group I (normal control), Group II (paracetamol-toxified), Group III (positive control with Silymarin @ 200 mg/Kg), Group IV (aqueous T. dioica extract @ 400 mg/Kg), Group V (methanolic T. dioica extract @ 400 mg/Kg), and Group VI (ethanolic T. dioica extract @ 400 mg/Kg). Hepatoprotective potential was assessed through liver function indicators (ALT, AST, ...
Hasan Ali Al-Sailawi1, Araa Ali Hadi1, Hussein A. Raheem2, Mustafa Mudhafar3,4, Sahi J Dhahi5, Qais R. Lahhob6*
... grafting of the skin of albino male rabbits by N-acetyl cysteine (NAC) and Serratiopeptidase and then compare their effect on the skin grafting of rabbits. Nine rabbits were divided into three groups. Each group had three animals: Group 1 (G1) was used as a control (skin grafting without any drug), and the skin was taken from the shoulder to the femoral area. In group 2 (G2), the skin graft was taken from the same area in the G1 using Serratiopeptidase, while...
Emad M. Gad1, Haidy G. Abdel-Rahman2, Mohy Eldin Abd-El-Fattah1, Merna M. Kamal1, Ahmed Shaker Eltahan3, Amina A. Dessouki3*
...r the whole night. Sixty albino rats were separated into six equivalent groups. Group I control rats administrated 0.5ml distilled water by gavage for six weeks, group II untreated diabetic rats, group III–VI are diabetic groups; received dapagliflozin (1 mg/Kg daily) by gavage for 6 weeks, mulberry fruit extract (300mg/kg b.wt) by gavage, mulberry leaves extract (250 mg/kg b.wt) by gavage and combination of DAPA, MFE and MLE, respectively for 6 weeks. U...
Saher Mahmood Jwad1, Tamadhur Hani Hussein2, Tahreer Mohammed Al-Thuwaini2*
Hina Abrar1*, Hina Yasin1, Hira Naeem2, Rabia Bushra1, Shaukat Mahmood2 and Kaneez Fatima3
Aamir Khan Awan1, Nighat Sultana1*, Rahmat Ali Khan2, Rifhat Sultana3,
Umm-e-Kalsoom1, Fayaz Ahmed Sahibzada4, Rifat Ullah Khan5, Naimat Ullah Khan6, Nazir Ahmad Khan7, Syed Haider Zaman8, Mir Sadiq Shah9 and Assar Ali Shah10*
...alloxan-induced diabetic albino rats. The diabetes was induced in albino rats using alloxan at the concentration of 150 mg kg-1 body weight. After 15 days, the treated groups with glabinclemide and different varieties of methanolic and aqueous extracts showed a significant (P<0.05) decrease in the blood glucose level as compared to diabetic control while slight differences were seen in body weight. The total cholesterol, ...
Adham Omar Mohamad Sallam1*, Ashraf Abd El-Hakem Ahmed El-Komy1, Enas Abdulrahman Hasan Farag2, Samar Saber Ibrahim3
...uced by Meloxicam. Fifty albino rats were divided into five groups: A control, vehicle control, Meloxicam-treated, GSE-treated, and a combination treatment group. The study evaluated biochemical parameters, oxidative stress markers, and histological changes in liver and kidney tissues. This study addresses a significant gap in understanding how GSE can counteract NSAID toxicity, with potential clinical implications for safer long-term NSAID use. GSE administra...
Amal Mahmood Alwan1*, Thekra Atta Ibrahim1, Ghalib Idrees Atiya Ali2
Nbaa Mutea Abid AL-Alh1, Nuha Hatem Khalaf1, Nagam Khudhair1*, Ahmed Khalid2
...s carried out on 30 male albino rats, 12-14 weeks old. The Rats were divided into 5 groups, G1 control negative received distilled water 2 ml. CPZ was administered orally at dose 2 mg/kg of body weight. The rats dosed CPZ were divided as follows: G2 a positive control group, received CPZ alone. G3 was given an ethanolic extract of costus at a dose of 1.5 mg/kg, and G4 was administered an ethanolic extract of costus at a dose of 3 mg/kg. G5 was administered an ...
Shaza N. Alkhatib1, Rasha M. Ghoneim2, Hend M. Tag2,3, Hekmat M. Tantawy2, Heba M.A. Abdelrazek4*
Mariam Ismail Ali1*, Rania Helmi Abdou1, Mary Ayad Sargious2, Omnia Mohamed Khattab2, Kawthar Abdelwahed Elhady1
Sherine Abbas1, Heba M.A. Abdelrazek2*, Eman M. Abouelhassan3, Nayrouz A. Attia4, Haneen M. Abdelnabi4, Seif El-Eslam E. Salah4, Abdelrahman M. Zaki4, Mohamed A. Abo- Zaid4, Nadia A. El-Fahla5
... exposure on male Wistar albino rats’ offspring. In this experiment, 18 adult female and 6 male Wistar rats were used. All experimental animals were kept in the same environment which was suitable, away from stresses and of adequate hygiene was provided. They were alienated into two groups. Control and treated with neem leaves extract groups; they were allowed to mate. Neem extract was administered from gestation day 1 (GD1) till full term. The weight of...
Bassant Mahmoud Emam1, Jehan Abd Elrazek Hassanen1, Abeer Gaffer Ali Hassan3, Azza Mahmoud Abdullah1, Hadeer Said Aboelnaga2, Amina Ali Dessouki2*
...arried out using 50 male albino rats allocated into 5 groups (n = 10/group): Control, diabetic non-treated, and diabetic groups treated by DAPA (1 mg/Kg b.wt), FSE (250 mg/kg, b.wt) and FSP (100mg/kg, b.wt). All doses were daily administered by stomach tube for 8 weeks. Serum biochemical analyses of insulin, glucose, lipid profile, and liver function tests, besides histopathological analyses for the liver and pancreas, were performed. The FSE or FSP and DAPA t...
N. M. Abed
... and CCl4, 80 adult male albino rats were divided into eight groups including control group, the propolis-treated group, the NiCl2-treated group, the CCl4-treated group, the NiCl2 and propolis-treated group and the CCl4 and propolis-treated group. Blood-based ELISA kits were applied to determine T3, T4, TSH, LH, FSH and testosterone in the rats after four weeks of medication. Results analysis indicated a significant increase (P≤ 0.05) in TSH and lower T3 an...
