Protective Effect of Selenium Against Arsenic-Induced Hematological, Biochemical Alteration, and Organ Development Anomalies in Adult Female Mice
Protective Effect of Selenium Against Arsenic-Induced Hematological, Biochemical Alteration, and Organ Development Anomalies in Adult Female Mice
Md. Khayrul Basher1, Sumon Sarkar2,3, Md. Samiul Haque1, Sourav Sarker4, Md. Rashedul Islam1*
ABSTRACT
A major environmental health concern across the world is chronic arsenic exposure from contaminated water, which is linked to hematological, biochemical, and many other significant systemic illnesses. The current study on adult female mice assessed the protective effects of Na-selenite against arsenic-mediated hematological, biochemical, and organ development toxicities. In this study, adult female mice (Swiss Albino) were categorized into four groups namely control, NaAsO2, NaAsO2+Na2SeO3, and Na2SeO3 (10 µm NaAsO2 and 10 µm Na2SeO3, respectively) were orally administrated via drinking water up to 60 days of the treatment period. Then the hematological, biochemical parameters, organ-to-body weight ratio, and morphology of the Liver and Lung were assessed. Na-arsenite exposure caused significant (p<0.05, respectively) increases in WBC count, RBC count, platelet count, hemoglobin, ESR, TCE, and RDW SD. The result also showed that serum RBS, ALT (SGPT), Alkaline phosphatase, Total cholesterol, Triglyceride, and Uric acid levels were significantly (p<0.01) higher in the NaAsO2 exposed group. Arsenic exposure also led to a significant (p<0.02) decrease in the organ-to-body weight ratio in the spleen and slight discoloration and consistency of the liver and lung than the control group. It’s interesting to note that co-administration of sodium selenite markedly mitigated all the changes caused by arsenic-induced alteration of hematological parameters, serum biochemical parameters, organ to body weight ratio (p<0.05, p<0.01, p<0.05, respectively). The current study provides compelling evidence for the protective effectiveness of the co-administration of Na-selenite against hematotoxicity, biochemical change, and organ toxicity in adult female mice carried on by exposure to Na-arsenite.
Keywords | Sodium arsenite, Sodium selenite, Mice, Hematological and serum biochemical parameters, Lung, Liver
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