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Effect of Chysophyllum albidum Ethanol Leaf Extract on Haematological and Platelet Indices of Apparently Healthy Wistar Rat

Effect of Chysophyllum albidum Ethanol Leaf Extract on Haematological and Platelet Indices of Apparently Healthy Wistar Rat

Juliet N. Ozioko1, Obinna V. Ayogu2, Benjamin O. Ezema1, Dilibe C. Uramah3 and Kingsley O. Omeje*,1

1Department of Biochemistry, University of Nigeria
2Department of Zoology and Environmental Biology, University of Nigeria
3Department of Plant Science and Biotechnology, University of Nigeria
 
* Corresponding author: kingsley.omeje@unn.edu.ng

ABSTRACT

Chysophyllum albidum ethanol leaf extract was studied to ascertain it potentials on hematological indices and hepatocyte of wistar albino rat. Twenty-five rats that weighed 98-168g were separated into five groups. Phytochemicals were quantified using standard methods. Alkaloids, flavonoids, tannins, saponnins and terpernoids were detected. The leaf extract had 0.415 % of alkaloids, 0.102 mg/TAEq of tannins, 0.211 mg/QEq of flavonoids and 0.360 mg/GAEq of phenolics. Phytol, oleic acids, hexadecanoic acids and octadecanoic acids were detected in the leaf extract by Gas Chomatography-Mass Spectroscopy. White blood cells, hemoglobin and platelets were some of the hematological indices increased after the oral administration of the extract. Red cell distribution width (RDW), a platelet index implicated in cardiovascular ailments was lowered after consumption of the leaf extract of C. albidum. The liver marker enzymes aspartate transaminase and alanine transaminase showed no significant changes in their serum activity. Similarly, superoxide dismutase and catalase showed no significant increase after the period of study.

 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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