Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice
Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice
Ahmed K. Fahd*, Ali H. Saliem
ABSTRACT
This article aims to determine the analgesic impact of Apigenin and Diclofenac in mice model. In the beginning, 84 male albino mice were selected, acclimated, and categorized into four equal groups: The 1st tested by the hot plate, the 2nd treated with acetic acid, the 3rd examined by application 10 μl of 2% formalin solution and the 4th was examined by the tail-flick test. Within each experiment, the study mice were subdivided equally into three subgroups; the 1st was administered only distilled water (control), the 2nd was drenched with apigenin (50 mg/Kg B.W.) orally, and the 3rd was drenched only diclofenac (0.71 mg/kg B.W). The hot plate’s outcomes showed that the animals treated with apigenin significantly increased in time than with diclofenac. The number of writhes in both apigenin and diclofenac-treated groups has been significantly reduced in the acetic acid test when compared to the control. The formalin test revealed that both apigenin and diclofenac-treated groups reported significantly lower flinches and licks than the control. For the tail-flick test, the results have significantly increased in withdrawal time in apigenin and diclofenac-treated groups than with the control; with the ability of apigenin to relieve the pain when compared with diclofenac.
Keywords | Herbal therapy, Hot plate, Acetic acid, Formalin solution, Tail-flick test, Iraq
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April 2024
Vol. 12, Iss. 4, pp. 586-801
