Rats Subchronically Exposed to Deltamethrin Nanoformulations Exhibited Less Genotoxicity Compared with those Exposed to Deltamethrin
Rats Subchronically Exposed to Deltamethrin Nanoformulations Exhibited Less Genotoxicity Compared with those Exposed to Deltamethrin
Ahlam G. Khalifa1*, Walaa A. Moselhy1, Hanaa M. Mohammed2 and Khaled Abdou1
ABSTRACT
The genotoxicological investigation of nanopesticides against a non-target model organism, the rat, will be a great way to learn more about how nanopesticides interact with the environmental and biological systems. Few studies on the genotoxicity of subchronic oral exposure to nano pesticides have been published. Male albino rats have been randomly divided into 4 identical groups. Group (I) had received only corn oil and acted as a control group. Group (II) had been given 3.855 mg/kg BW deltamethrin. Group (III) obtained deltamethrin loaded silica Nps at a dose of 8.795 mg/kg BW. The group (IV) obtained deltamethrin loaded chitosan Nps at a dose of 30.44 mg/kg BW. All remedies were administered by oral gavage 5 days a week for one month. The deltamethrin group showed a highly significant elevation in chromosome aberrations. Also, the ratio of polychromatic erythrocytes to normochromatic erythrocytes proved that deltamethrin had a stronger cytotoxic effect on the bone marrow cells than the CS/DM Nps and S/DM Nps groups. It was concluded that these innovative nanoformulations of DM were less toxic, which would lower health risks and boost application safety.
Keywords | Cytotoxic, Chromosome aberrations, Loaded, Nanopesticides, Safety
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