Johanna Lindahl 1, 2
British Journal of Virology
...l-over of the virus into humans results in more than 60 000 clinical cases of Japanese encephalitis annually, with high case fatality rates. The main vectors preferably feed on livestock and breed in rice fields, and the majority of cases subsequently occur in rural areas. This review lists the risks of emergence of diseases due to the on-going urbanization, with especial focus on vector-borne diseases, particularly Japanese encephalitis. It is concluded, tha...
El-Sayed M. Abdelwhab, Jutta Veits and Thomas C. Mettenleiter
Avian Influenza H5N1 in Egypt: What we Know and What we have to Know?
...d mammals. Infections of humans were accompanied by mutations in the hemagglutinin (HA) protein which improved the binding affinity to human receptors but simultaneously retained its specificity for avian-receptors. Vaccines were applied nationwide to control the disease in poultry. Meanwhile, the viruses accumulated several point mutations in the HA immunogenic epitopes resulting in antigenic drift and the establishment of infections in vaccinated poultry. Th...
Xingdong Yang and Lijuan Yuan
...arities between pigs and humans in terms of genetics, physiology, intestinal anatomy, and immune system, pig is particularly a suitable animal species for the modeling of human enteric pathogen infections, immune responses and for vaccine evaluations. These are the basis for the successful establishment of the infection and disease models for human rotavirus, human norovirus and human enterovirus 71 using neonatal gnotobiotic pigs. The differences between germ...
Josef D. Jarhult1, 2
... problem both in treated humans and in the environment. The use of oseltamivir for treatment of uncomplicated influenza in otherwise healthy patients should be questioned....
Benjamin Beit-Hallahmi
..., and are shared by most humans. Academic research, or science, is the product of counter-intuitive, unnatural psychological processes, and the resulting concepts are beyond the reach of most. It is not surprising that religion has been around for possibly more than 100,000 years, while academic research is a recent historical development. Over the past century, individuals who make academic research their life’s work have been themselves the subject of ...
Jonas Johansson Wensman1*a, Karl-Johan Leuchowius2,3 a, Jiting Yan1, Anna-Lena Berg4, Liv Bode5, Hanns Ludwig5, Sandor Belak6, Ulf Landegren2, Ola Soderberg2, Mikael Berg6
...mals, possibly including humans. Viral persistence in the brain has been frequently observed, however, the exact mechanisms behind BDV’s ability to establish persistence despite a prominent immune response are not known. Here we have used in situ proximity ligation assay (in situ PLA), a selective tool for studying virus-host protein-protein interactions. BDV P (phosphoprotein) and N (nucleoprotein) have previously been reported to interact with several ...
Behzad Hussain1, 2, Abdullah Iqbal2, Muhammad Abubakar2*
...ransmitted mainly to the humans through hard tick bite and direct contact with blood of the infected animal. The occurrence of CCHF outbreak in Pakistan is increased quite significantly near Eid-ul-Adha. Haemorrhages are the major signs of this fatal disease. No treatment of CCHF is available currently but Ribavirin antiviral drug is used to cure this disease. There is currently no commercially available vaccine for this disease. It is recommended that the dis...
Haq Aman Ullah1*, Aneela Zameer Durrani2, Muhammad Ijaz2 and Aqeel Javeed3
...abolite highly toxic for humans and animals. In the present study contamination status of aflatoxin B1 in cotton seed cake, wanda, wheat bran and homemade concentrate mixture of dairy goats was investigated in district Lahore of Pakistan. A total of Twenty 20 goat farms were randomly selected and out of that 40 feed samples 2 from each farm were collected in the month of April. All the samples were analysed for the determination of aflatoxin B1 by using revers...
Moustafa Kardjadj1, Pam Dachung Luka2
...PR and increasing global humans and animals movements,the virus has continued to be reported in previously PPR-free countries and thereby considered as an emerging pathogen.. However, the increased detection of the virus in the light of rinderpest eradication and the lack of awareness of the disease in areas where the virus has been detected for the first time in recent years given the educational status of farmers contributed to this emergence....
Inamullah Khan, Muhammad Subhan Qureshi, Rajwali Khan, Syed Muhammad Sohail, Ijaz Ahmad, Muhammad Shoaib and Asim Ijaz
...ollected from cattle and humans respectively. Total 40 samples of subsistence farms and 30 nomadic herds were analysed. Forty eight farm workers, 40 farm owner 36 abattoirs workers, 15 veterinary assistants, 15 veterinarian and 40 butchers were also screen out. Overall sero-prevalence in cattle was 15.36% on SPAT, 14.39% by i-ELISA and 14.14% through PCR. Higher prevalence was recorded in abattoir shops (31.01%) followed by private farms (11%) and animal selli...
Oladipo Elijah Kolawole, Oloke Julius Kola and Awoyelu Hilda Elukunbi
...e most common viruses in humans. It is the best known cause of infectious mononucleosis. In acquired immuno-deficient Syndrome patients, several distinct and additional EBV-associated diseases may occur and some forms of malignancies. This study was designed to determine the incidence of EBV in Human immune-deficient virus (HIV)-infected individuals in Ogbomoso, Oyo State, Nigeria. Two hundred and seventy eight HIV-infected individuals were screened for EBV an...
Bin Wang, Bo Zhang, Nan Yang, Liang Dou and Jianghong Ran*
... supplemental feeding by humans. The social structure and demography of this species, however, have not been examined in natural populations. To determine if cooperative breeding occurs in populations unassociated with humans, we surveyed two natural populations in the Ganzi Tibetan Autonomous Prefecture in western China. We compared the demography of the natural populations with that of the habituated population. The result...
Muhammad Luqman Sohail1,*, Muhammad Sarwar Khan1, Muhammad Ijaz1, Muhammad Avais1, Muhammad Yasir Zahoor2, Omer Naseer1 and Muhammad Usman Saleem3
...ge of animal species and humans. 18 Leptospira positive horses based on ELISA and 9 healthy horses were included in the study. Blood profile, serum biochemistry and mineral profile were analyzed at day 0, 7 and 21 of infection. Results showed significant decrease (P<0.05) in red blood cells (RBC), packed cell volume (PCV), hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC) and platelets while total leucocytes count (TLC), neutrophils, ...
Idowu Fagbamila1*, Adaobi Okeke2, Micheal Dashen2, Patricia Lar2, Sati Ngulukun1, Benshak Audu1, David Ehizibolo1, Paul Ankeli1, Pam Luka1, Maryam Muhammad1
...a spread from poultry to humans....
Shahzad Ali1,*, Heinrich Neubauer2, Falk Melzer2, Iahtasham Khan1, Shamim Akhter3,Tariq Jamil2 and Sajid Umar3
Muhammad Shahid1, Iram Amin1,*, Samia Afzal1, Zareen Fatima1, Sadia Zahid1, Usman Ashraf1 and Muhammad Idrees2
... Virus is transmitted to humans by Aedes aegypti and Aedes albopictus having five serotypes 1-5 and infecting about 100 million people each year. To address dengue outbreak 2013 in Pakistan we aimed to conduct a comprehensive study at molecular level to determine the main causative serotype of 2013 DENV outbreak in Pakistan. Overall 703 serologically positive suspected patients from different major health centers of Pakistan were re...
Uzma Farid Durrani1,*,Sagar Mal Goyal2, Asim Khalid Mahmood1,Cathleen Hanlon3, Susan Moore3, Muhammad Waqas1 and Raheela Akhtar4
...g incidence of rabies in humans and dogs living in Lahore, Pakistan.
... 
John G. Bruno
...f rickettsia exposure in humans who have seroconverted. Such anti-idiotypic aptamer antigens might also serve as rickettsial vaccines, if fully developed. The top five highest affinity R. rickettsii and top five R. typhi anti-Fab aptamers as assessed by enzyme-linked aptamer sorbent assay (ELASA) screening were shown to specifically bind their cognate antibodies when captured by their Fc tails on the surface of Protein A-conjugated magnetic beads. While no cle...
Sogolo L. Lebelo1,* and Gerhard van der Horst2
...mpared to other mammals, humans and nonhuman primates, however, there also seem to be species differences among the mammalian group. The association of these cells with developing cells, and Sertoli cells was established. However, the association of Leydig cells with spermatogenic cells at different stages of spermatogenesis needs further investigation.
...
Rais Ahmed1,*, Khushi Muhammad1, Masood Rabbani1 and Muhammad Sarwar Khan2
...onversion in animals and humans.
...
Jawad Anwar* and Zafar Iqbal
...e prevalent in crops and humans, therefore, the need for novel and effective antibacterial compounds to treat, prevent and resist is highly demanded. Luckily fungi are potential producer of antibacterial natural products. The present study was initiated to investigate the antibacterial activity of Trichoderma harzianum against phyto and human pathogenic bacterial strains. T. harzianum was grown under different conditions and their extracts were evaluated, usin...
Sanjukta Chakrabarti1, Colin J. Barrow2, Rupinder K. Kanwar3, Venkata Ramana1*, Rakesh N. Veedu4,5 and Jagat R. Kanwar3*
... aberrant vasculature in humans, may lead to various pathological conditions including tumor development. The most important factor implicated in the angiogenic processes is vascular endothelial growth factor (VEGF) protein and its family of ligands and receptors (VEGFRs). Survival, proliferation, migration and invasion of endothelial cells which give rise to the vascular network, is mediated through VEGF/VEGFR activation of the signal transduction pathways. T...
Pan Hong, Ruonan Li, Yumeng Li, Hainan Lan* and Xin Zheng*
...growth hormone (GH) from humans and rats have been extensively reported. However, to date, there are no descriptions of the cell behaviour of porcine GH in domestic animals. Thus, freshly isolated porcine hepatocytes were used as a somatic cell model to study the internalization and subcellular localization of porcine growth hormone (pGH), and the results showed that pGH could be internalized into porcine hepatocytes in a time-dependent manner. The results als...
Ann Milliken Pederson
...deed, Peters claims that humans have an “ontological thirst” for the ultimate and this book attempts to satisfy the thirst or at least provide the water to drink. In a world where fragmentation, brutality, and chaos mark the lives of so many, it is no wonder that people long for wholeness, healing, transformation, and an encounter with the ultimate. Ted Peters’ new book locates the vocation of humankind within their cosmic home, brings togeth...
Ali Haider Saleem1,*, Khalid Javed2, Masroor Ellahi Babar3, Tanveer Hussain3, Asad Ali2, Afzal Ali2, Nisar Ahmad2, Muhammad Zahid Farooq1 and Muhammad Dawood2
...tion in both animals and humans. The sequence variations have been studied, reported and associated with many growth traits like weaning weight, six month body weight and nine-month body weight etc. in cattle, buffalo, goat and sheep worldwide. LEP gene polymorphism and associations have not been extensively reported in Lohi sheep of Pakistan, so this study aimed to find any variations in gene sequence and possible association with growth rate to explore meat ...
Hongwei Liang1,2,*, Miaomiao Tong1, Lihuan Cao1,2, Xiang Li3, Zhong Li1 and Guiwei Zou1,*
...a healthy food source to humans.
...
Grace Chinenye Onyishi, Ifeanyi Oscar Aguzie, Joseph O. Okoro, Christopher Didigwu Nwani*, Ngozi Ezenwaji, Ndubisi Stanley Oluah and Fabian C. Okafor
...these parasites endanger humans as well. This study was conducted to determine the terrestrial snail species and associated helminth parasites in Ugwueme agricultural zone of Enugu State, Nigeria. The snails were collected from two communities. Light and teasing methods were used for recovery of parasites from the snails. A total of 618 snails belonging to 7 species (Achatina achatina, A. belteata, A. degneri, Limicolaria aurora, L. flammea, Lamellaxis grac...
Syeda Madiha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Tahira Perveen and Saida Haider*
...ed to induce toxicity in humans and as well as in animals. The present study evaluated the protective role of curcumin against rotenone-induced motor deficits, biochemical and neurochemical alterations. Rotenone was injected subcutaneously at the dose of 1.5 mg/kg for 8 days. Supplementation of curcumin (100 mg/kg/day, p.o.) was started before 15 days of rotenone injection. The effects of curcumin pre-treatment were evaluated by different motor behavioral para...
Evolutionary Analysis and Phylodynamics of Avian Influenza Virus H5N1 between 2015 and 2016 in Egypt
Osama Elshazly1, AbdelSatar Arafa1, Mohammed A. Rohaim2, Ismaeil M. Reda2 and Hussein A. Hussein2*
...de 2.2.1.1 isolates from humans and chickens. Our results revealed that linking the epidemiological and sequence data is important to understand the prevalence, transmission, persistence and evolution of the virus, and to monitor the circulating AIV strains and emergence of new AIV subtypes in Egypt. The wide circulation of the 2.2.1.2 subclade, carrying triple mutations (120, 129∆, I151T) associated with increased binding affinity to human receptors, is...
Ali Zaman1,*, Abdul Haleem1, Sajjad Ur Rahman2, Adnan Amin3 Asma Saeed1, Sana Ullah4 and Naimat Ullah4
...tion of birds as well as humans which is zoonotic of significant economic and public health concern. From total 650 broilers sera were taken, around the five geographically distinct districts and analyzed through hemagglutination inhibition (HI) test for detection of H5 antibodies. Highest sero-prevalence of Avian Influenza (H5) was recorded in district Abbottabad 36.15% (47/130) followed by Dera Ismail Khan 33.08% (43/130), Tank 26.92% (35/130), Peshawar 21.5...
G. Venkatesan* and Amit Kumar
...r small pox infection in humans. This virus causes contagious form of disease, mainly but not limited to sheep and goats, which lead to high economic impact in developing countries including India. The causative agent, Orf virus (ORFV) belong to the genus Parapoxvirus (PPV) of the family poxviridae produces a typical papillomatous, cauliflower like external growth around mouth regions and rarely the lesions are found in other parts of the body and internal org...
Safina Naz1, Muhammad Akbar Anjum1, Saeed Akhtar2, Syed Atif Hasan Naqvi3* and Muhammad Asif Zulfiqar4
...ious health risks to the humans. In the present study, edible portions of five vegetables viz., okra, tomato, spinach, carrot and cauliflower, grown with canal, tubewell and sewage irrigation water, were assessed for their proximate (moisture, ash, protein and fiber) and heavy metal (Pb, Ni, Cu, Cd, Fe and Cr) contents. Significant differences were found for proximate composition of canal, tubewell and sewage water irrigated vegetables. The vegetables grown wi...
Zain ul Abidin1, Aisha Khatoon2, Abdul Whab Manzoor1,*, Nida Arooj1, Sajjad Ali1 and Muhammad Numan1
...ffecting all mammals and humans. This infection spreads through biting of infected and/or carrier animals to healthy ones including humans. Incubation period of this infection is quite variable ranging from a few days which can last up to one year in few cases. This case report presents the diagnosis and screening of suspected rabies samples of cow and mule. Clear behavioral changes along with paralysis of tail and hind legs...
Asad Ullah1, Umar Sadique Khattak2, Sultan Ayaz1, Muhammad Subhan Qureshi2, Imad Khan1, Ibad Ullah Jan2, Irfan Khattak1, Raheela Taj3, Sahar Nigar4, Naimat Ullah Khan1,Mumtaz Ali Khan5 and Muhammad Luqman Sohail6,*
...ol among the animals and humans of the study area, and highlight the need for farmer education regarding bovine tuberculosis.
... 
