Cansu Akbulut1,*, Tuğba Kotil2, Burcu Öztürk1 and Nazan Deniz Yön1
...>2) is widely used nanoparticle all over the world. In this study, we have investigated the histopathological effect on zebrafish ovaries after exposure to TiO2 nanoparticles. Adult zebrafish individuals were exposed to 1, 2 and 4 mg/L TiO2 for 5 days, and then their ovaries were evaluated using light and transmission electron microscopy. Numerous degenerated follicles with cytoplasmic vacuolizati...
Obaidullah1, Zafar Ali Shah1* and Sami Ullah2
...ze its copper and silver nanoparticles followed by their antibacterial assessment. Lapachol was isolated from stem heartwood of heterophragma adenophyllum seem through column chromatographic technique. Characterization of Lapachol was carried through melting point assessment and running its comparative TLC against standard, added with structure elucidation by FT-IR spectrum. Silver nanoparticles of Lapachol were synthe...
Sanjukta Chakrabarti1, Colin J. Barrow2, Rupinder K. Kanwar3, Venkata Ramana1*, Rakesh N. Veedu4,5 and Jagat R. Kanwar3*
...multiple doses, chitosan nanoparticle conjugated aptamer inline with the previous report on RNV66, and an approved VEGF inhibitor Avastin. Overall, the findings highlight that VEGFR1(D1-D3)-Fc can also serve as a potential anti-angiogenic molecule. ...
Soraya Khosravian Dehordi*, Abdolnaser Mohebbi and Kahin Shahanipour
Promy Virk
...perty of gold and silver nanoparticles respectively. The green gold and silver (Au/Ag) nanocomposite showed a profound antihyperglycemic effect which was significantly better than all other treated groups. The results on serum ALT, creatinine levels and blood urea also showed a comparable ameliorative effect of both the bulk Trigonella seed extract (TBN) and the green nanocomposite (TN), being more efficacious than metformin. Thus, the green synthesis a...
Safdar Ali1*, Obaidullah Shafique1, Tariq Mahmood2, Muhammad Amir Hanif1, Ijaz Ahmed3 and Bashir Ahmad Khan4
...ransfer in the plants or nanoparticle-mediated gene. Biofuel production from biomass is estimated to speed up using nanotechnology. Researchers and manufacturers have to demonstrate that the application of nanotechnologies have no harmful effect on the atmosphere against the anomaly based only on small amounts of toxicological research and concerns about the safety of nanomaterials....
Safia Rehman1, Nazish Mazhar Ali1,*, Gerald B. Pier2, Iram Liaqat1 and Bushra Mazhar1
...us strains and metal nanoparticles (copper, ferric and zinc). P. aeruginosa isolates showed in vitro resistance against 11 of 14 antibodies tested. The isolates were highly susceptible to meropenem, piperacillin, and amoxicillin. It was also observed that the growth of these resistant P. aeruginosa strains was significantly inhibited in the presence of Lactobacilli spp. and nanoparticles of si...
Khurram Shahzad1*, Muhammad Naeem Khan1, Farhat Jabeen2, Nasreen Kosour3, Muhammad Sohail1, Muhammad Khalil Ahmad Khan1, Munir Ahmad1
Bioaccumulation of manufactured titanium dioxide
... The use of various nanoparticles in industry and domestic practices enviably end
into the aquatic environment. Nanoparticles have the potential accumulative and
toxic influence in the water environments. There is a need to exploremore likely
accumulation of nanoparticles in the aquatic organisms. This study was designed
to investigate the possible bioaccum...
into the aquatic environment. Nanoparticles have the potential accumulative and
toxic influence in the water environments. There is a need to exploremore likely
accumulation of nanoparticles in the aquatic organisms. This study was designed
to investigate the possible bioaccum...
Tahira Moeen Khan* and Amat ul Mateen
...on of copper ions to CuO nanoparticles in place of harmful and expensive chemical/physical methods. A cheaper, simple to perform method giving high yield without by products is employed here. The leaf extract act both as reducing and capping agent. The atomic absorption shows a linear curve between concentration and absorbance. The uv-vis spectrum revealed the shift of absorption towards longer wavelength with the increasing concentration of plant extract. XRD...
Syed Makhdoom Hussain1*, Nisar Ahmad1, Azhar Rasul1, Muhammad Mudassar Shahzad2, Muhammad Latif3, Muhammad Zubair Ul Hassan Arsalan1, Muhammad Umair1 and Hafiza Hina Shafqat1
...stimate the impact of Cr nanoparticles on growth performance, nutrient digestibility and hematological parameters of C. catla fingerlings fed nano- Cr particles supplemented sunflower meal based diets. The experiment was consisted on seven test diets on the basis of supplementation of nano Cr graded levels (0, 0.5, 1, 1.5, 2, 2.5 and 3 mg Kg-1). Chromic oxide was used as an inert marker. Fingerlings were fed at the rate of 5% of their live we...
Khansa Nazir1,*, Tariq Mukhtar1 and Humayun Javed2
...arasitic nematodes using nanoparticles can be one of the important alternatives. In the present study, the nematicidal activity of silver nanoparticles (AgNP) was investigated against the most destructive root-knot nematode (Meloidogyne incognita). The maximum mortality of juveniles was recorded at a concentration of 100 mg/ml followed by 75 mg/ml of AgNP. The minimum mortality was recorded with 25 mg/ml of AgNP. With...
Shaukat Ali1,*, Sadia Batool2, Fatima Javed Butt2, Sundas Nasreen1, Hafiz Muhammad Tahir1
...gical techniques and bio-nanoparticles treatments (i.e., green synthesized metallic nanoparticles) attracted many researchers to conclude a novel cancer treatment strategy. Unluckily every strategy had some working limitations as a result of which cancer remained a catastrophe for humanity. The present review article devised the modern cancer treatment paradigm which proposed directions towards probiotics or biotics-cancer t...
Muhammad Javaid1*, Unsar Naeem-Ullah1, Waheed S. Khan2, Shafqat Saeed1, Mirza Abdul Qayyum1 and Muhammad Arslan Khan1
Role of Nanotechnology in Crop Protection and Production: A Review
...ess seed treatments with nanoparticles, to improve the crop yield use of smart gene delivery system. This technology can also be useful for sustainable water use and irrigation water filtration. It also plays an important role in pollution reduction. Green revolution of any developing countries can be achieved by adopting nanotechnology....
Ayesha Talib1,2, Khanzadi Nazneen Manzoor1, Wajahat Ali1, Maria Saeed1, Muhammad Asif Gondal1, Malik Badshah3 and Abid Ali Khan1*
...to fight them is through nanoparticles. Green synthesis is an easy way to synthesize nanoparticles by using biological resources as it is cost effective, eco-friendly and large-scale production possibilities exist. Copper nanoparticles (CuNPs) have been synthesized from the aqueous fruit extracts of Ficus sycomorus and their physico-chemical properties as well as antimicrobial activ...
Ahmed Weli Hussein Osman1,2, Rakibul Islam1, Md. Bazlar Rashid1, Abdiaziz Idiris Mohamud2,3* and Pravin Mishra4
Nanoparticle Tactics for the Oral Delivery of Insulin in Alloxan-Induced Hyperglycemia in Rat (Rattus norvegicus domestica) Model
...at challenges. Polymeric nanoparticles are suitable colloidal carriers for insulin delivery. The current study was carried out to evaluate nanoparticle tactics for the oral delivery of insulin in the alloxan-induced hyperglycemia in rat model. Twenty male rats of age four months were randomly allocated into four different groups (T0, T1, T2, and T3). After acclimatization diabetes was induced in three groups of rats (T1; pos...
Muhammad Shahid1*, Unsar Naeem-Ullah1, Waheed S. Khan2, Shafqat Saeed1 and Kashif Razzaq3
Application of Nanotechnology for Insect Pests Management: A Review
...rious size and shapes of nanoparticles to be synthesized by using the naturally occurring biomolecules. These biomolecules acting as a driving force for the designing of greener, safe and environmentally benign protocols for the synthesis of nanoparticles. Insect pests are main density dependent factors that deteriorate the quality and production of various crops i.e. vegetables, fruits, ornamental and field crops. In past d...
Canan Vejselova Sezer*
...marin-loaded solid lipid nanoparticles and investigation of its effectiveness on treatment of lung and breast cancers. In this respect, these nanoparticles and silymarin were elucidated by using MTT assay for cytotoxicity, annexin-V analyses for cell death mechanism and confocal and transmission electron microscopies for morphological and ultrastructural changes. Based upon our findings, it can be concluded that silymarin-lo...
Hassan Shahzad Khan1, Muhammad Tariq1*, Tariq Mukhtar2 and Asim Gulzar1
... their green synthesized nanoparticles was evaluated against A. albopictus. The maximum mortality of 88% of 3rd instar larvae of A. albopictus was caused by datura extract followed by neem and clove. On the other hand, neem and clove extracts caused the maximum mortality (80%) of 4th instar larvae followed by datura extract (78%). Similarly, the minimum mortalities of 3rd and 4th instar larvae we...
Tajnees Pirzada1*, Weenghar Ali Chandio1, Mansoor Ali Kalhoro2, Mir Munsif Ali Talpur1, Waheed Ali Mirbahar1, Abdul Ghafar Solangi1, Zulfiquar Ali Jumani1 and Rehana Kerio1
...he effect of, zinc oxide nanoparticles and humic acid (HA) coated nanoparticles were evaluated for Brassica campestris seed germination. A simple one-pot method was used to synthesize HA/ZnO NPs involving zinc oxide nanoparticles (ZnO) core (20-35 nm in diameter) and humic acid shell. HA/ZnO NPs were used to investigate the effect on the germination profile of Brassica campestris. Germinat...
Xiaoli Cai1,2, Saeed Ahmed3, Zhixin Lei1,*, Jianping Wu1,* and Taolei Sun1,2,*
...rdinary antibiotics. The nanoparticle has unique physical and chemical properties, a large surface area, and an electric charge. Additionally, its antibacterial drug encapsulation can make it easier to enter the cell and improve the concentration in the target tissue. In the current review, the purpose is to find a more effective nanometer system to fight against intracellular bacterial infection. Current observation describes the drug resistance mechanism of ...
Nisar Ahmad1, Syed Makhdoom Hussain2,*, Azhar Rasul2, M. Mudassar Shahzad3, Arshad Javid4, Hamda Azmat5, M. Zubair ul Hassan Arsalan2, Sadia Tabassum2 and Bilal Ahmad2
...imate the efficacy of Se nanoparticles on mineral absorption and carcass composition of C. mrigala fingerlings fed nano-Se particles supplemented sunflower meal based diets. The experiment was consisted on seven test diets on the basis of supplementation of nano Se graded levels (0, 0.5, 1, 1.5, 2, 2.5 and 3 mg/kg). Chromic oxide was added as an inert marker. Fingerlings were fed at the rate of 5% of their live wet weight. Maximum improvement in mineral absorp...
Saydat Saad1, Doaa Abdel-Fattah1, Tarek Khamis2, Aya El-Sobky1*
Lethal and Sub Lethal Effects of Plant Extracts and Green Silver Nanoparticles against Culex pipiens
Abdul Jabbar1, Muhammad Tariq1*, Asim Gulzar1, Tariq Mukhtar2 and Tayyaba Zainab3
...green synthesized silver nanoparticles (AgNPs) were evaluated against 3rd and 4th instar larvae of C. pipiens. The green synthesized AgNPs of these plants were characterized by UV-Multiskaner. LC20 and LC50 values were calculated through Probit and Logit analysis (POLO) software. All the plant extracts and their green synthesized AgNPs caused the maximum mortalities of 3rd and 4th larval instars of C. pipiens after 96 hours. With the increase in time intervals...
Fan Xu1,2*, Cheng Wu3 and Su Zeng1
...eter, Malvern zeta sizer nanoparticle size analyzer, accusizer APS 780 particle size analyzer and Agilent 6460 LC-MS/MS mass spectrometer. From the experimental results, 5 μg:50ml group kept good targeting within 6 h. The encapsulation rate of 5 μg:100ml group decreased significantly after 6 h, and the percentage of fat globules > 5 μ m (PFAT5) in 10 μg:10ml group was relatively high. The risk of embolism was easily caused by injection or small ...
Mohamed A. Hussein1, Bahgat A. Abd El-Rehman2, Kareem A. Eldin2, Mohamed Fouad Mansour1*
...us vaccine with chitosan nanoparticles and aluminum phosphate nanoparticles as adjuvants and evaluate their impact on biochemical, cellular and humoral immune response in sheep, The prepared vaccines were sterile, safe, emulsion is stable and validity within acceptable limit 0.02 EDF50/ml up till 15th month with AlP-NPsV and AlHV except Ch-NPsV that was valid up to 16th month. Lymphocyte count increased from the 1st week pos...
Sara Mohamed Hemeda1, R.H. Sayed2, Hani Hassan1, Sheima A.E.2, Hassan Aboul-Ella3, R. Soliman3*
...gated with gold chloride nanoparticles and used in the development of competitive lateral flow kits for the detection of β-lactams antibiotic residues in dairy milk. The concentration of the gold chloride-antibody conjugate in the conjugation pad was adjusted to detect β-lactam antibiotics in milk samples that exceed the permissible limit. In the newly developed kits, each involved β-lactam antibiotic conjugated with KLH was placed in the test l...
Malik Fiaz Hussain1, Atif Akbar2, Muhammad Asif1, Laraib Nisar3, Muhammad Naeem Ashiq3 and Furhan Iqbal1*
...lign: justify;">Ni oxide nanoparticles (NiO NPs) are extensively used in industries dealing with welding, electroplating and in production of alloys but despite of their large scale uses, it is expected that they might have lot more drawbacks than their bulky counter parts. Present investigation was aimed to document the effect of two different doses of NiO NPs on behavior of albino mice in a sex specific manner. Five weeks old albino mice (N = 48) of both sex...
Reem M. Ramadan1, Fady Sayed Youssef2, Gehad Genidy Mohamed3, Sameh Hamed Ismail4, M.M. El-Bahy1, Shimaa Abdel-Radi1*
...sent study. The produced nanoparticles are spherical with 63 nm zeta size and high stability in the aqueous media. The coccidiocidal efficacy of the C-Oo.Nc was evaluated versus five chicken Eimeria species oocysts. The immature oocysts were exposed to 5, 10, 20, and 40 ppm, each for 1, 3, 6, 9, 12, 24, and 36 h. Percentage of sporulation inhibition in oocysts and comet assay were used to investigate the C-Oo.Nc destructive effects. The infectivity of sporulat...
Dhiya Altememy1, Mohammad Darvishi2*, Samira Shokri3, Saber Abbaszadeh4
...fect of titanium dioxide nanoparticles (TiO2NPs) synthesized with Origanum vulgare, carvacrol, Hypericum perforatum, and calcium alginate scaffold-loadable calcium alginate on infected wounds with Staphylococcus aureus was investigated in diabetic rats. Eight groups of 12 rats in any group were diabetic by intraperitoneal injection of alloxan. After the rats were anesthetized, 2cm2 wounds were created and inoculated with bacterial suspension of S. aureus (ATCC...
Farzana Bashir2, Aysha Saleem1, Khalid Iqbal Khichi2, Rubina Nelofer3* and Rauf Ahmad Khan2
...dy was to prepare copper nanoparticles (Cu-NP) embedded on rice husk and to use them as a cost effective approach for the removal of microbial contaminant from drinking water. The copper nanoparticles (Cu-NP) were prepared by using copper sulphate, sodium hydroxide and ascorbic acid and then embedded on rice husk for the removal of bacterial contaminants from drinking water. The Cu-NP embedded rice husk then characterized by...
Saydat Saad Abd El-Megeed1, Walaa Yehia El-Sayed1*, Tarek Khamis2
...activities of zinc oxide nanoparticles (ZnO NPs) were assessed in rats. ZnO NPs were characterized by transmission electron microscopy (TEM). Diabetes was induced by streptozotocin (STZ) -nicotinamide in rats, and some biochemical and molecular parameters were determined. The results revealed that ZnO NPs in combination with Empagliflozin suggestively declined the blood glucose levels, lipid profile, and liver and kidney functions. A reduction was recorded in ...
Mehwish Saleem1* and Amina Atiq2
...-align: justify;">Garlic nanoparticles are inexpensive, harmless, easy to use and eco-friendly. In this study, silver nanoparticles based on inexpensive garlic clove extract were created, and their all-around antibacterial effectiveness was assessed. To create garlic clove extract-based silver nanoparticles, 100 ml of distilled water was combined with 0.01g, 0.025g, and 0.05g extracts of b...
Heavy metals (HMs) are harmful and lethal at negligible levels and non-biodegradable in the typical ecosystem and constitutes animal, human and environmental hazards. They are divided into toxic metals like Lead, Cadmium, Arsenic, etc. and essential elements like copper, zinc, manganese, iron, nickel and chromium. Additionally, could be categorized into two groups based on the natural and anthropogenic sources releasing origins. Population and industrial expansion led to food contamination with HMs. Poisonous metals can be transferred from irrigation water to agricultural soils, agricultural operations, air pollution, animal feed, and packaging materials. Toxic metals are non-biodegradable, non-thermos degradable, and exceedingly stable in the ecosystem; as a result, they quickly build in various foods. Metal pollution of many foods, including agricultural commodities, and animal protein sources such as fish, milk, meat, and eggs, poses a hazard to food safety and security. Toxic metal pollution of irrigation water, agricultural soils, plants, and animals result in their integration into the food chain, posing a health hazard to humans. Most metals are harmful to animals and humans and accumulate in several organs like the skeleton, hepatic tissue, spleen, and renal tissues. Metals have a deleterious impact on the production of plants and animals. As a result, several remediation strategies have become necessary to limit the hazardous HMs pathway into the food chain and the human body. Metal nanoparticles are employed in beneficial applications, although they are associated with specific hazards.
Keywords | Food contamination, Heavy metals, Nanoparticles, Pollution sources, Remedy, Soil contamination
...nd the human body. Metal nanoparticles are employed in beneficial applications, although they are associated with specific hazards.
Keywords | Food contamination, Heavy metals, Nanoparticles, Pollution sources, Remedy, Soil contamination
...
Maria Azam1, Tahir Mahmood Qureshi1, Saddam Hussain2, Amjad Islam Aqib3*, Shanza Rauf Khan4, Kashif Akram1, Misbah Ijaz5, Maheen Murtaza6, Afshan Muneer6 and Sammina Mahmood7
...>s particularly metallic nanoparticles are a wise approach to modulating drug resistance. The current study thus focuses on the replacement of antibiotics with ZnO, MgO, and Fe2O3 nanoparticles. To achieve this goal, 200 cattle milk samples were collected aseptically and screened for subclinical mastitis using the purposive sampling technique. Following Bergey’s manual of determinative bacteriology, S.aureus was identi...
Eman M. Abdelhady1, Nader Y. Mostafa1, Mohammed A. El-Magd2* and Ghada A. Kirrella1
...chitosan powder (CP) and nanoparticles (CNPs) on the microbiological quality and shelf life of beef minced meat during its refrigerated storage for 9 days. The size of CNPs ranged from 150 to 350 nm as determined by transmission electron microscopy. Comparing the effect of the two chitosan products, CNPs exhibited higher antibacterial properties against S. aureus and E. coli, as revealed by lower minimal inhibition concentrations than the CP. Among...
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...s to synthesize selenium nanoparticles from Citrus paradise peels extract (SeNPs-CP), their general characterization, and their assessment for antioxidant activities against liver injury induced by bisphenol A (BPA) in male rats. In this work, Citrus paradise peels extract used for reduction of sodium selenite (Na2SeO3) to reduce Se ions to Se0 confirmed by changing the colour of the solution from light yellow to red. The synthesized SeNPs were characterized b...
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...s to synthesize selenium nanoparticles from Citrus paradise peels extract (SeNPs-CP), their general characterization, and their assessment for antioxidant activities against liver injury induced by bisphenol A (BPA) in male rats. In this work, Citrus paradise peels extract used for reduction of sodium selenite (Na2SeO3) to reduce Se ions to Se0 confirmed by changing the colour of the solution from light yellow to red. The synthesized SeNPs were characterized b...
Mohamed I. El-Katcha1, Mosaad A. Soltan1, Seham M. El-Kassas2*, Mahmoud M. Arafa3, El-Sayed R. Kawarei 3, Karima M. El-Naggar1*
...group received the Cu as nanoparticles (CuO-NPs) at the same levels of the organic form, respectively. Birds fed the experimental diets for 10 weeks at 110 g/hen/day. Organic Cu failed to compensate body weight losses (P > 0.05), and the CuO-NPs significantly increased it (P < 0.05). Both organic and CuO-NPs non-significantly increased average egg production, shell composition of calcium and phosphorus % and yolk Cu contents (P > 0.05). In contrast, t...
Zainab Sattar Ali* , Safa Azhar Razzaq , Layla Hammody Hashem
...owth of uses of selenium nanoparticles (SeNPs) in our environment made the evaluation of its toxicity an urgent requirement. This study designed to investigate the impact of Green synthesized of SeNps and prophylactic effects of L-Arginine and propolis for male reproductive system. The animals evenly partitioned to four groups; (G1) group: were received distilled water. (G2) group: were intubated 200mg/kg B.W of Black Tea Selenium Nan...
Fariha Javaid1*, Zahoor Qadir Samra1, Madeeha Shahzad Lodhi1,2, Aroosha Hussain1 and Gulnaz Pervaiz1
...fy BRM by using magnetic nanoparticles. After purification, BRM enzyme was characterized and utilized in the detergent industry due to its stability at a wide range of pH and temperature; results showed that stem BRM has the highest enzyme activity at 23.5 U/ml as compared to crown leaf (11.7 U/ml) and peel (19.5 U/ml). The specific activity of leaf, peel, and stem BRM was determined 0.8, 1.2, and 1.4 U/mg, respectively. Total protein content was 660 mg, 810 m...
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
...city of silicon dioxide nanoparticles (SiO2NPs) effect the immune system and lipid profile, Curcumin Phytosome nanoparticles (CPNPs) possess several biological activities including anti-inflammatory, and hypolipidemic effects. We determined dyslipidemia and inflammatory state induced by exposure to silicon dioxide nanoparticles (SiO2NPs) in female rats could be ameliorated by the administ...
Sabi Ur Rehman1*, Laiba Arshad1, Saman Ali1, Shazma Massey2, Safeer Khan3, Abdul Samad4 and Fazal-Ur-Rehman5
...ient production of metal nanoparticles utilizing botanical extracts. Silver nanoparticles are particularly noteworthy due to their potent antibacterial properties and relevance in nanomedicine. This study presents a green synthesis method using Sarcococca saligna leaf extracts to successfully produce both silver and gold nanoparticles. The formation and stability of the
Rana Mahmood Ahmad*, Orooba M.S. Ibrahim
...to synthesize zinc oxide nanoparticles (ZnONPs) biologically by using Syzagium aromaticam extract and evaluate the effect against Polyarthritis produced by complete Freund’s Adjuvants injected (S.c.) into the hind paw. The confirmation of the synthesis and characterization of ZnONPs was achieved through the utilization of a UV-spectrophotometer and SEM. For this purpose, eighteen adult male rats 200 ± 50 g at six months of age will be ra...
Rasema Majeed, Alaa Kamil Mahmood*
... these effects. Chitosan nanoparticles (CNPs) can improve delivery and bioavailability of encapsulated agents such as GEE. The aims of this study to evaluate the protective effects of ginger ethanolic extract, chitosan nanoparticles, and ginger ethanolic extract loaded with chitosan nanoparticles (GEE-CNPs) against DNA damage and pancreatic histological changes in dogs with alloxan-nicotin...
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
...nent. ...
Johan Sukweenadhi1*, Stefan Pratama Chandra1, Finna Setiawan2, Christina Avanti2, Kartini Kartini2, Arief Koeswanto3 and Deok-Chun Yang4
...sed to synthesize silver nanoparticles. Based on a statistical analysis of the average wound area, epidermal reconstruction, and TIME-H scores, significant differences began to occur from day 12 to day 14. The average wound area, epidermal reconstruction, and TIME-H scores in the diabetic mice group that were given a dermal patch formulated with silver nanoparticles synthesized using Plantago major L. extract were not...
Faisal Alzahani1* and Mohammed Abu El-Magd2*
...PE, CAPE-loaded chitosan nanoparticles (CNPs) were used. The anti-tumor effects of CAPE and chitosan CNPs on cancer cells have been separately studied but the precise epigenetic molecular mechanisms for the combined therapy are still unclear. This study aimed to investigate the epigenetic mechanism of CAPE and/or CNPs on human HepG2 cells. The results revealed a significantly higher cytotoxic effect for CAPE on HepG2 cells than CNPs. The combined therapy with ...
Ahmed Kadhim Munahi1* , Hameed A. Al-Timmemi2
... aimed to apply chitosan nanoparticles on spinal cord regeneration in dogs. For this objective, sixteen healthy mongrel dogs were used. They were divided into two equal groups (n=8) at random. All dogs underwent dorsal laminectomy and left lateral hemisection at the level of the second lumbar vertebra. In the control group, the hemisections were treated with 0.2 mL of phosphate buffer saline. Chitosan nanoparticles were appl...
Saddam Hummadi1, Nadia Al-Falahi2*
Rehan Ahmed Siddiqui1,2*, Shabana Usman Simjee2,3, Nurul Kabir4, Muhammad Ateeq3,5, Kevin Joseph Jerome Borges6, Muhammad Raza Shah3 and Rahman M. Hafizur2
...) and CA-conjugated gold nanoparticles (CA-AuNPs) against rhabdomyolysis-induced AKI induced in mice. CA (50 mg/Kg) and CA-AuNPs (30 mg/Kg) were given to the animals for four days. On the fourth day and after 24 h of water deprivation, 50% glycerol intra-muscular was administered. Blood urea and creatinine were tested. Kidney histopathology was done and damaged kidney areas were measured. Immunohistochemistry for actin and cyclooxygenase-2 (COX-2) were also ca...
Noor A. Namaa*, Hayder A.N. Al-Zamely
...seng extract and Ginseng nanoparticles on the level of total protein in testicular tissues utilizing the two assays of Western blotting and Bicinchonic Acid. A total of 60 Wister rats were chosen, prepared, and divided equally into three groups: T1, T2, and negative control, which received only distilled water daily and no other treatment. T1 was given a daily dose of (500 mg/kg) of Ginseng extract, while T2 received a daily dose of 250 mg/kg of Ginseng NPs. A...
Aalaa S. Saad1*, Amira A. Elokle2, Dalia Y. Youssef2, Neven M. Omara2, Samr Kassem3
...lign: justify;">Chitosan nanoparticles loaded with lysozyme (CS-LZ-NPs) are gaining popularity as an alternative approach for inhibiting foodborne pathogens. This study aimed to evaluate the antibacterial activity of synthesized Chitosan nanoparticles (CS-NPs) and CS-LZ-NPs against E. coli O157 in chilled chicken fillets and relative eaeA (Intimin), stx2 (Shiga toxin) expression. The average particle size was 250 nm and 281....
Huda S.J1*, Nasr T.M1, Mohanad A. Al-Bayati2
...aded with cobalt ferrite nanoparticles (CoFe2O4 NPs) in treating hemorrhagic anemia in a rabbit model. The results provide promising evidence for this nanomedicine platform’s potential to accelerate red blood cell (RBC) recovery and improve hematological parameters following blood loss. Rapid recovery: the Nanohemosome-CoFe2O4 NP complex significantly improved RBC count, WBC count, PCV, and Hb levels within four days, bringing them closer to pre-anemia l...
Wafa’a Mohammad Abduwhab1*, Waseem Ali Hasan2, Mohanad Abdulsataar AL-Bayati3*
...ting in the formation of nanoparticles. This modification was undertaken to enhance both the physical stability of the oil and the therapeutic properties of pumpkin seed oil, while simultaneously mitigating the potential side effects associated with Lidocaine. Evaluation of the therapeutic effect of Nano phytosome pumpkin-lidocaine gel on the healing of third burn wounds. Twenty-five,10 to 18-week- old ,white male and female adult rabbits weighting 2.5-3 kg di...
Kashif Abdaal, Aneeza Batool, Muhammad Tariq Navid*, Saeed Ahmed, Asma Saleem Qazi, Waseem Safdar, Haidar Ali, Mobeen Ur Rashid, Somia Rafaqat
... infectious pathogen(s), nanoparticle-based and plant-based delivery mechanisms have proven as more targeted and adaptable approaches to boost immune responses. Hence, it proves the vaccines as a big breakthrough in preventive and therapeutic medicine over 200 years and named “Future Medicine”. To assess vaccine safety and efficacy, scientists are now using various model animals like mice, ferrets, pigs, and nonhuman primates before using them for ...
Muhammad Atif Raza1, Muhammad Tariq Javed2, Muhammad Fiaz1*, Muhammad Shakeel3, Muhammad Shahbaz Ul Haq2, Amna Kanwal2, Syeda Maryam Hussain1 and Muhammad Zubair Siddiqi4
...e given concentration of nanoparticles zinc oxide and copper oxide at different rate; 25+10, 37.5+15 and 50+20 mg/kg/d, respectively. Collected data were analyzed using complete randomized design through ANOVA technique. Mortality percent was found minimum 13.3% in birds under T3 group. Effect of all nanoparticle levels was not different (P>0.05) to that of antibiotic in terms of total serum protein and lipid profile; tot...
Abdur Rahman Khan1*, Mansoor Ali Khan1, Abdur Rehman1 and Muhammad Umair Khan1
...Due to the vast scope of nanoparticle, it paves a way to use nano-structure in wood composite products for better industrial products manufacturing. The article aim is to review the current state of research regarding the use of nanomaterials in wood composite products.
...
Amal Mohammed Ali Alah Al-Marmadhi*, Saadeya Ali lefelef Al-Gnami
...tigate impact of allicin nanoparticles on female rats with induction of the hyperthyroidism. Fifty mature female rats (aged 90 days and weighted 150±10 g) have been randomly assigned to 5 equal groups (10 each),control (C) group , T1,T2,T3 and T4 groups were drenched with thyroxine (300mg/kg of B.W for 28 days ) for hyperthyroidism induction, T2 was drenched with methimazole (2.5 mg/kg of B.W for 30 days), T3 was drenched with allicin
Javairia Mehboob1, Syeda Hafsa Ali1*, Fahima Ashraf Kasi1, Syeda Ayesha Ali2, Safa
Farooqi3, Muneeza Arbab4,
...n biosynthesis of silver nanoparticles. Green Silver
nanoparticles (AgNPs) were synthesized from 1mM Silver Nitrate (AgNO3) solution incubated
with leaf extracts of Cynara scolymus (Artichoke), Alkanna tinctoria (Alkanet), and
Lavandula angustifolia (Lavender), respectively. The synthesized nanoparticles were
characterized visually, UV-Vis sp...
Humam T. Hadi1*, Orooba M. S. Ibrahim2
...ques for generating gold nanoparticles. This study evaluated the potential of Syzygium aromaticum gold nanoparticles (SaAuNPs) in treating psoriasis in mice. The study had two parts. The first part involved the extraction of clove oil and the synthesis of SaAuNPs using a green synthesis method. The second part involved the induction of psoriasis in mice using 5% imiquimod cream, followed by topical application of different ...
Riam Yousfe Muttair
... bi-specific antibodies, nanoparticle delivery systems, etc. The novel humanized next-generation checkpoint inhibitors demonstrate various antagonistic activity against multiple immune checkpoints as well as resistance mechanisms at the same time. It follows from here that these can offer a promising prospect of outcomes improvement as well minimization of off-target effects. These studies deliver the information about a growth of immunotherapy, and the produc...
Saadeya Ali Lefelef Al-Gnami1, Fatima Ibrahim Mohammad2, Huda Jassim Mohammed Al-Helali3
...tive impacts of piperine nanoparticles and vitamin C on several blood parameters and liver tissue in male rats treated with dexamethasone. The forty-eight male rats were randomly divided into six groups. Nanopiperine (15 mg/Kg.B.W) was given orally to the T1 group. Vitamin C (25 mg/Kg.B.W) was given orally to the T2 group. The T3 group received orally dexamethasone (2 mg/Kg.B.W). Nanopiperine and dexamethasone were given orally to the T4 group at the same dose...
Essa D Alhtheal1*, Sufian S Salman2, Salah M AL-Kubaisi3
...losporine-laden chitosan nanoparticles in treating induced aplastic anemia was evaluated and the effect of cyclosporine loaded with chitosan nanoparticles with their doses alone was compared. The investigation of possible side effects of treatment regimens used. This study aimed to prepare chitosan nanoparticle and cyclosporine loaded on nanochitosan and pure chitosan. Pure chitosan was pr...
Al-Sadik Y. Saleem1, Mohamed Y.I. Youssef1, Fayza A. Ahmed1*, Shereen El. Abdel-Hamid1, Enas N. Said1, 2, Heba S.A. Gharib1, Asmaa I. Abdelaty1
...y synthesized zinc oxide nanoparticles (ZnONPs) and control groups. While surfacing, body care, resting and aggressive behaviours with all their patterns were the lowest in the extracted oils treated groups than the other groups. Crossing test showed that fish raised at the extracted oils treated groups were more active and could had the highest values of growth rate than those raised at ZnONPs groups. It was concluded that the addition of extracted oils from ...
Rawya Sh. Mohammed*, Baraa N. Al-Okaily
...esized curcumin selenium nanoparticles (CurSeNPs), using a hydroalcoholic extract of Curcuma longa rhizomes, in reducing disruption to hormonal profiles, redox homeostasis, inflammatory parameters, and ovarian tissue PTEN gene expressions in rats treated with doxorubicin. CurSeNPs were synthesized using sodium hydrogen selenite and a hydroalcoholic extract derived from Curcuma longa. The in vivo study utilized thirty-two mature female rats divided into four ex...
Kremlin Mark B. Ampode1,2,3*, Ramanathan Solaiyappan1, Baskaralingam Vaseeharan1
...is the use of zinc oxide nanoparticles (ZnONPs) synthesized from probiotics like Bacillus subtilis. This study explored the potential effects of ZnONPs synthesized using Bacillus subtilis on the performance, antioxidant activity, and neurotoxicity of tilapia (Oreochromis mossambicus). A total of 96 fish were divided into four groups: T1 (Control), T2 (3 mg ZnONPs /g diet), T3 (6 mg ZnONPs /g diet), and T4 (9 mg ZnONPs /g diet), with four replicates per group a...
Mohamed Ahmed Abaza1, Amany O. Selim2, Mona Abdallah3, Shimaa A.E. Atwa4, Hala El Daous5, Mona Abd-Allah Abd-Elrehim6, Mohamed M.S. Gaballa7, Reda R. Fathy1*
Mustofa Hilmi1,4, Zuprizal2, Nanung Danar Dono2, Bambang Ariyadi3*
... concentration of silver nanoparticles that can inhibit gram-positive and negative bacteria. It was done so that the silver nanoparticles could be evaluated as an antimicrobial agent, and there was also the possibility that they could be used as a feed additive. This study assesses microbial inhibition and the minimum inhibitory concentration (MIC) in a laboratory setting. The substances utilized included silver
Rawya Shakir Mohammed*, Baraa Najim Al-Okaily
...esized curcumin-selenium nanoparticles (CurSeNPs) by combining sodium hydrogen selenite with a hydroalcoholic extract obtained from Curcuma longa rhizomes in alleviating the disturbance of vascular endothelial growth factor (VEGF) mRNA expression, histomorphometric and histological alterations of ovaries in healthy rats that administered doxorubicin.Thirty-two fully grown female rats were randomly divided into four equal groups and were treated for two weeks a...
Khaled A. El-Dougdoug1, Wael S. El-Araby2* and Rehab, A. Dawoud3
Shaymaa Jabbar Hassoon1*, Hiba Ibrahim Ali2, Ayat Jasim Mohammed3, Oras Salman4
...ial properties of silver nanoparticles synthesized from cinnamon extract against bacteria isolated from fresh sheep meat. Silver nanoparticles were synthesized by mixing 1ml of Cinnamon extract (0.025) % with (50ml) of silver nitrate solution (1.25)% and the ratio was (1:50) (v:v) at room temperature for (8hrs.) with pH(6.5-7) , later 8hrs, A higher pigment amount was seen. The physical features of AgNPs were pro...
Abeer S. Hafez1, Shereen M. Aly1, Dalia M. A. Elmasry2*, H. A. Hussein3, Marwa A. Abdelmagid4
...easily applied. Propolis nanoparticles are easily absorbed and have better antibacterial and antifungal effects than ordinary propolis. The present study aimed to compare propolis ethanolic extract (PEE) and propolis nanoemulsion (PN) as a feed additive in poultry farms by evaluating their influences on growth, immune status, and pathological conditions in chickens. The size, uniformity, and spherical shape of PN were measured at 4.065 ±1.12nm, with a p...
Jalal Ahmed Khan1, Ishfaq Ahmed Hafiz1, Ayesha Maryam2, Sher Muhammad2 and Rashid Iqbal Khan1,3*
...ate the impact of silver nanoparticles (30 and 40 ppm) on growth and productivity of five different gloxinia cultivars i.e., Kaiser Wilhelm, Violaciea, Blenche de Meru, Mont Blance and Tigrina Red. The experiment was conducted following complete randomized design under controlled conditions. The results concluded that Blenche de Meru and Mont Blance were best among cultivars and exhibited the ameliorated vegetative and reproductive parameters. The maximum no. ...
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