Wound Healing Effectiveness Test of Dermal Patch Formulated with Green Synthesized Silver Nanoparticles from Plantago major L. Extract
Wound Healing Effectiveness Test of Dermal Patch Formulated with Green Synthesized Silver Nanoparticles from Plantago major L. Extract
Johan Sukweenadhi1*, Stefan Pratama Chandra1, Finna Setiawan2, Christina Avanti2, Kartini Kartini2, Arief Koeswanto3 and Deok-Chun Yang4
ABSTRACT
Skin is the largest organ in the body and has a very important role. A wound is an injury in which the skin is torn, cut, punctured, or traumatized. Wounds in diabetic patients are difficult to heal. Green synthesis is one of many methods that can be used to synthesize silver nanoparticles. Based on a statistical analysis of the average wound area, epidermal reconstruction, and TIME-H scores, significant differences began to occur from day 12 to day 14. The average wound area, epidermal reconstruction, and TIME-H scores in the diabetic mice group that were given a dermal patch formulated with silver nanoparticles synthesized using Plantago major L. extract were not significantly different from the normal group and the ACA and ACA Ag groups. Based on these results, it can be concluded that the dermal patch formulated with silver nanoparticles synthesized using Plantago major L. extract helps wound healing in diabetic mice and is not significantly different from wound dressings and silver dressings on the market (p-value < 0.05). In addition, the best concentration that can be formulated into the dermal patch is 0.005% (p-value <0.05).
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July 2023
Vol.39, Sp. Iss. 1
