Correction of Hemorrhagic Anemia by Nano Hemosome Carrying Nano Cobalt Ferrite in Rabbits
Correction of Hemorrhagic Anemia by Nano Hemosome Carrying Nano Cobalt Ferrite in Rabbits
Huda S.J1*, Nasr T.M1, Mohanad A. Al-Bayati2
ABSTRACT
The objective of this research was to treat Hemorrhagic anemia which is artificially induced in rabbits using Nano hemosome encapsulated Nano Cobalt Ferrite. Additionally, investigated the Hematological correction profile after the blood samples treated period. Hemorrhagic Anemia was artificially induced in rabbits through a process of bloodletting depending on the body weight. Nano Cobalt Ferrite was prepared and encapsulated by Nano hemosome via the Bangosome method. Anemic rabbit dosed with Nano hemosomal Cobalt-Ferrite 1/40of LD50% dose 75mg/kg Bw. Hematological parameters were analyzed in the blood samples that were collected from a rabbit. The outcomes of the hematological profile before and after hemorrhagic corrections were Hemorrhagic group RBC 5.96±0.11 x 106/mm³, WBC 6.35±1.04 x 103/mm³, PCV 33.02±6.28%, Hb 11.19 ± 0.88 g/dl and Platelet count were295.11±10.73 x 103/mm³, corrected as compared with treated group RBC 6.61± 0.54 /mm3, WBC6.53±1.33 /mm3, PCV33.23±5.21 %, HB11.2±1.31 g/dl and Platelet count 292.71± 14.92 x103/mm³. This study investigated the efficacy of Nanohemosomes loaded with cobalt ferrite nanoparticles (CoFe2O4 NPs) in treating hemorrhagic anemia in a rabbit model. The results provide promising evidence for this nanomedicine platform’s potential to accelerate red blood cell (RBC) recovery and improve hematological parameters following blood loss. Rapid recovery: the Nanohemosome-CoFe2O4 NP complex significantly improved RBC count, WBC count, PCV, and Hb levels within four days, bringing them closer to pre-anemia levels in control rabbits. The preferential uptake of CoFe2O4 NPs by the targeted delivery Nanohemosome. As well as leading to improved cell health and increased RBC production.
Keywords | Hemorrhagic anemia, Cobalt ferrite nanoparticles, Nanohemosomes, nano-medicine, Toxicity, Rabbit
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April 2024
Vol. 12, Iss. 4, pp. 586-801
