Nayle Maria Oliveira da Silva1*, Ricardo do Carmo Zanella2
...d the world. HCV induces chronic liver disease, which is characterized by a persistent hepatic parenchyma inflammatory process that may progress to cirrhosis and hepatocarcinoma. Viral clearance occurs in a minority of patients with viral hepatitis C, whereas chronic infection is established in 60 to 80% of all cases, 20 to 40% of which may evolve to cirrhosis and hepatocarcinoma. Genetic differences among infected hosts can...
Oladipo Elijah Kolawole*, Oloke Julius Kola, Awoyelu Elukunbi Hilda, Olasunmibo Oluwatobi Gabriel, Ogunyale Tolulope Temitope
E-mail | koladipo2k3@ yahoo.co.uk
... high risk of developing chronic hepatitis in immunocompromised individuals usually leading to liver cirrhosis. Individuals living with Human Immunodeficiency Virus have a greater risk to the virus due to their impaired immunity. The study was carried out to determine the sero- prevalence of Hepatitis E among people living with Human Immunodeficiency Virus in Ogbomoso. The blood sample of consented two hundred and seventy five (275) subjects were obtained and ...
Shagufta Jabeen1, Muhammad Saqlain Raja1, Sadia Saeed1, Muhammad Mobeen Zafar1, Rizwana Abdul Ghani1, Abid Mahmood1, Muhammad Fiaz2, Pakeeza Arzoo Shiaq1, Shahid Mahmood Baig3, S.M. Saqlan Naqvi1 and Ghazala Kaukab Raja1*
...other illicit drugs is a chronic, relapsing multifactorial disorder of brain and, if left untreated, major medical, social, and economic problems arise. Drug addiction is among major health issues faced by the World including Pakistan with an alarming annual increase in heroin addicts. The study was designed to identify the socio-demographic risk factors contributing to increasing susceptibility to heroin addiction in Pakistani populations. In this epidemiolog...
Muhammad Mansoor, Zaigham Abbas and Nageen Husssain*
...erythematosus (SLE) is a chronic autoimmune disease with characteristic organ involvement and autoantibodies production. The pathogenicity and etiology of the disease has yet to be elucidated. It is presently accepted that environmental factors trigger the disease in genetically sensitive individuals. Gluten, a protein fraction commonly found in wheat grains, associated with food related disorders and a number of autoimmune diseases. We hypothesized that glute...
Nasar Khan1,2, Fahad Ali3,7, Sulaiman Bahadar5,*, Khalil ur Rahman3, Abdul Aziz3, Noor ul Akbar4, Muhammad Daud6, Azam Hayat5 and Mujaddad ur Rehman5
...ain etiological agent of chronic hepatitis B, hepatocellular carcinoma and liver cirrhosis. A total of 659 HBsAg ELISA positive patients out of 16825 patients during July to October, 2013 were screened for HBV by real-time polymerase chain reaction. Out of 659, 522 (79.21%) were found positive for HBV, of which 318 (over all 4.4%) were male, while 341 (over all 3.55%) were female. The HBV PCR positivity rate was 80.18% (n=255) in males and 78.30% (n=267) in fe...
Zia-ur-Rehaman1, Naila Chand1, Sarzamin Khan1 and Rifat Ullah Khan2,*
...s, it was concluded that chronic high ambient temperature has negative effect on broiler immune and oxidative status. Ross and Arber Acer strains were more tolerant to summer high ambient temperature of tropical areas than Cobb and Hubbard.
...
Gut Microbe Analysis between Asthma Patients and Healthy Volunteers in Shaanxi Province, Xian, China
Hafiz Muhammad Ishaq1, Muhammad Shahzad2, Xiaokang Wu3, Chaofeng Ma4 and Jiru Xu1,*
...sthma is an allergic and chronic lung disease that causes inflammation and narrows the air passages. Present study aimed to characterize the gut microbiota of asthma patients and to investigate the alteration in similarity and diversity of gut microbial composition with comparison of healthy controls. Fecal samples from fifteen patients and five healthy individuals were collected. PCR-DGGE, by using universal primers focusing V3 region of 16S rRNA gene, was pe...
Rana Hanan1*, Muhammad Waqar Shafi1, Sumair Anwar2 and Numrah Nawaz1
...sion is a multifactorial chronic disease and a silent cause of high causalities around the globe. Both hyper and pre-hypertension affect all ages and professions, and are as common as flu infections by affecting 1 in every 5 persons. In order to determine frequency of hypertension and pre-hypertension among medical students and their association with various variable and fixed risk factors, this study was designed. The cross sectional study of 4 months was car...
Warda Fatima1 , Shahida Hasnain1 , Saqib Mahmood2
...ot;;">Schizophrenia is a chronic psychosis with a worldwide prevalence of 1%. It is diagnosed on the basis of psychiatricsymptoms and till now no biochemical test is available for its diagnosis. It is considered one of the most costlydisease in terms of diagnosis and treatment. Its heritability content is considered to be up to 80% but still it isunknown whether it’s a pure genetic disease. It is considered a polygenic multifactorial condition where both...
Gamalat Osman1, Mansour Galal1, Abbas Abul-Ezz2, Ahmad Mohammed1, Mohammed Abul-Ela3 and Asmaa Mostafa Hegazy2
...inants. L. carinatus was chronically exposed to crude oil at intervals of 24 hours, 15 days and 30 days. The LC50 of crude oil for L. carinatus was 700 ppm. HPLC analysis of 16 polycyclic aromatic hydrocarbons (PAHs) in the flesh demonstrated that PAHs accumulation in the treated snails was fluctuated with time. The accumulation is due to their biotransformation process during metabolism. The histopathological observations of the gills and mantle of L. carinat...
Tania Ahmed Shakoori1,*, Muhammad Saqib Saeed2, Asif Hanif2, Saima Mukhtar3 and Ayesha Ghauri4
...n the natural history of chronic obstructive pulmonary disease (COPD). Their frequency is directly related to the prognosis of the disease. The objective of this study was to identify the ‘frequent exacerbator’ phenotype and determine the risk factors for increased frequency of acute exacerbations in local chronic obstructive pulmonary disease (COPD) patients in a cross sectional analytical study design. For this...
Naheed Zahra*, Hassnain Shah*, M. Azeem Khan* and M. Zubair Anwar*
LIVELIHOOD ASSETS AND POVERTY NEXUS: A CASE STUDY FROM RAINFED POTHWAR AREA OF PAKISTAN
... sampled households were chronically poor, 5.0% transitory poor, 37.5% transitory vulnerable, 32.5% transitory non- poor and 22.5% was non-poor. Most of the sampled households fall along the transition line which implies their vulnerability to be trapped in poverty due to any shock. Beside other assets, even small scale irrigation was significant and an effective tool to improve income. Therefore along with improvement in irrigation practice through using high...
Anum Rafique, Sajid Abdullah, Khalid Abbas, Huma Naz* and Wardah Hassan
...ps. One group kept under chronic exposure of metals mixture (Pb+Cr) for 15 days and other group of fish was kept under controlled conditions. Partial purification of SOD was done by Ammonium sulphate precipitation. Ion-exchange column chromatography was used to purify enzyme for further partial characterization against different range of temperature and pH. As a result of ion exchange chromatography enzyme from kidney of control and Pb+Cr treated fish had high...
Anza Zahid*, Muhammad Ali Ayub, Mujtaba Saeed, Nasir Pasha, Abdul Jabbar Dar, Huzaifa Javed, Aimen Shakeel, Amna Nasir, Ana Akbar, Zainab Tarrar and Ayesha Humayun
... justify;">Diabetes is a chronic disease and non-compliance attitude of patients poses a great challenge to the success of therapy. Multiple factors influence compliance among diabetics and other chronic diseases and non-compliance results in avoidable consequences and complications. In order to determine the magnitude and factors of non-compliance to physicians’ advice in diabetics attending outpatients, a cross-secti...
Nasir Abbas1, Muhammad Suleman1, Nazir Ahmad Khan2,*, Ijaz Ali3, Mubashir Rauf1,5 and Sadeeq ur Rahman4,*
...cum (MG) in cases of chronic respiratory disease (CRD) in poultry and pheasantry birds of Northern Pakistan is underreported. In this study we report on the seroprevalence and isolation of MG from a total of 2341 poultry and 24 pheasantry birds. Overall, seropositivity of 46.56% (1090/2341) and 27.2% (6/24) against MG was observed among poultry- and pheasantry- birds, respectively. Broiler breeder and broiler showed 58.93% (264/448) and 37.23% (542/1456) s...
Hamza Khan1, Safdar Ali1, Ijaz Ahmad*2, Ihsanullah Khan3, Shujaat Hussain1, Bashir Ahmad Khan4 and Muhammad Suhaib5
...y;">Pakistan is facing a chronic deficiency of edible oil and imports around 75% of its edible oil from other countries which is a huge burden on our national economy. The situation thus requires for enhancing the indigenous oilseed production through different possible approaches. Development and promotion of local sunflower hybrids can be one of the options. Local sunflower hybrids with higher yield and wider adoptability can make Pakistan self sufficient in...
Niamatullah Kakar, Farhat Abbas, Muhammad Shafee and Tauseef Asmat*
...re involved in acute and chronic inflammatory disease. PCR proved to be more sensitive compared to the sputum smears or culture based tuberculosis diagnosis.
...
Kaleem Ullah1, Zafar Niaz2, Sami Ullah Mumtaz3, Sajid Abaidullah4*
...The relationship between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases strongly exists as diastolic dysfunction is commonly reported in COPD patients.
Objective: This study was conducted to determine the presence of left ventricular diastolic dysfunction in patients of COPD.
Material and Methods: A cross sectional study was conducted in Mayo Hospital Lahore for one year. A total of 50 confirmed c...
Komal Mushtaq1, Shoaib Waqas2*, Hafiz Muhammad Asim3
...ive treatment choice for chronic low back pain.
...
Masood Nizam Tabassum1*, Muhammad Ather Khan2, Saira Afzal3, Amir Gilani4, Abdul Wahab Gureja5, ShafaqTabassum6
...is (TB) is an infectious chronic bacterial disease caused by Mycobacterium tuberculosis (MTB). More than 95% of cases and deaths are reported in developing countries. Tuberculosis affects all age groups but adults are mostly affected in their most productive age. However, all age groups are at risks. In the world, TB is one of the major killer infectious diseases, which place it in one of the top 5 causes of death for females aged 15 to 44. The death ra...
Maaz Ahmad1*, Mussab Ahmad2 and Tehreem Munir3
...is a set of relapsing or chronic dyspeptic symptoms in the absence of structural organic lesions. Approximately 15-20% of the general population in many developed countries suffers from dyspeptic symptoms at any time in a year, whereas in Pakistan, 14-22 % of general population suffers from FD.
Objective: This study was designed to evaluate the effectiveness of carica papaya extract (CP) in preventing functional dyspepsia in human volu...
Farhat Ijaz1, Rana Khurram Aftab2*, Samia Jawed3
... are states of low-grade chronic inflammation, which result in increased levels of inflammatory markers such as C-reactive protein (CRP), interleukins 6 (1L-6) and tumor necrosis factor alpha (TNF-α). Relation of TNF-α with obesity induced IR and T2DM is unclear as results obtained from different studies are very controversial.
Objective: This study was designed to compare TNF-α levels and insulin resistance in obese and no...
Muhammad Nusrullah*1, Muhammad Younus2 and Yasir Nasir3
...ease is characterized by chronic airflow limitation which is not fully reversible and it can lead to respiratory failure.
Objective: To determine the correlation between arterial and venous blood gases in patients presenting with chronic obstructive pulmonary disease.
Material and Methods: This cross sectional study was conducted at Department of Chest Medicine, Mayo Hospital, Lahore, Pa...
Safia Rehman1, Nazish Mazhar Ali1,*, Gerald B. Pier2, Iram Liaqat1 and Bushra Mazhar1
... patients suffering from chronic and acute lung infections admitted to a local hospital in Lahore. Susceptibility of 134 isolates of P. aeruginosa was tested against selected antibiotics (meropenem, imipenem, piperacillin, amoxicillin, amikacin, gentamicin, tobramycin, kanamycin, clarithromycin, clarithromycin, cefepime, cefixime, levofloxacin, and ciprofloxacin), Lactobacillus strains and metal nanoparticles (copper, ferric and zinc). P. aeru...
Rida Zainab1, Sana Elahi1, Afshan Kaleem2,*, Daniel C. Hoessli3, Mehwish Iqtedar2, Roheena Abdullah2, Faiza Saleem2, Shanza Khan1, Anusha Ijaz1, Shagufta Naz2 and Abdul R. Shakoori4,5,*
...>...
Muhammad Khan1,*, Amara Maryam2, Hafiz Abdullah Shakir1, Javed Iqbal Qazi1 and Yongming Li3,*
... Moreover, we found that chronic BaP exposure promoted migration without enhancing the proliferation of cells and BHS-I was equally toxic to both BaP-treated and untreated A549 cells. Taken together, the data of present study indicate that BHS-I not only inhibits metastasis but also induces cell death in BaP-treated A549 cells. Therefore, BHS-I may become a potential lead compound for treatment of lung adenocarcinoma.
...
Jian Wang1,*, Zhi Liu2, Sheng Xu2, Mei-Fen Hu2, Xiao-Rui Liu1 and Wen-Jie Cai1
...ils of the patients with chronic renal failure (CRF). It was used to dynamically observe of Hemodialysis on the concentration of the CXCL8 in serum and the levels of CXCL8 mRNA in neutrophils were respectively measured by ELISA and PCR. The house keeping gene encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as the internal reference, the ratio of lgcDNA/lgGAPDH was regarded as the extreme level of CXCL8 mRNA. The serum level of CXCL8 and expression of...
Abid Hussain1,2, Farida Ahmed3, Shyamali C. Dharmage4, Shafiq ur Rehman1, Muhammad Shahbaz Aslam5 and Zaigham Abbas1,*
...nt allergens may lead to chronic clinical conditions like asthma and allergic rhinitis. Present study was conducted to investigate the prevalence of food and aero-allergen sensitization patterns. This retrospective study was designed to study allergy patients attending Allergy Centre, National Institute of Health, Islamabad. All enrolled patients were screened for set of allergens using skin prick test (SPT). Based on results of SPT, out of total 50550 allerge...
Yuyu Wang, Gangchun Xu*, Zhijuan Nie, Quanjie Li, Nailin Shao and Pao Xu*
...out depressed growth and chronic stress in commercial-scale in-pond raceway systems under this experimental conditions.
...
Fatima Tufail1, Sajid Abdullah1, Huma Naz2*, Khalid Abbas1, Laiba Shafique3
...des results in acute and chronic health effects. Fresh water fish species such as Channa striata serve as important bio-indicators for aquatic contamination to access the changes caused by human activities effectively and reliable monitoring bio-system to recognize and predict hazardous effects of pollutants. Therefore, this study was done to evaluate the toxicity of endosulfan (END),deltamethrin (DM) mixture on hepatic catalase (CAT) activity of f...
Shaikh Abdul Lateef, Zhou Lin, Wu Jian, Junjie Qian, Jonathan Hartanto Tan and Zheng Shusen*
...ests liver inflammation, chronic hepatitis and hepatocellular carcinoma. In this article, we present a comprehensive review characterizing the viral architecture, life cycle, infectivity mechanisms, immune escape strategies, disease epidemiology and preventive measures associated with HBV. The current antiviral therapeutics are not providing adequate protection against HBV. It is mandatory to characterize and devise novel antiviral therapies to control the spr...
Saeed Murtaza1,*, Nazir Ahmad2, Muhammad Asif Raza3, Muhammad Saleem Akhtar1, Muhammad Mazhar Ayaz4, Muhammad Ali5 and Rais Ahmed6
...testicular abscesses and chronic epididymitis. In early stages, sperm granuloma appeared as an anechoic mass with ill-defined border. In advanced stages, it exhibited a mixture of anechoic and hyperechoic areas, encircled by a thick hyperechoic border. In early cases of testicular degeneration, testicular parenchyma showed reduced echogenicity. However, in advanced cases, hyperechoic areas were scattered in affected parenchyma. Testicular abscesses showed anec...
De-Yong Zhang1, Xiao-Lu Xu1,*, Qin Ruan2, Xiu-Ying Shen3 and Yin Lu1
...
To determine the subchronic male reproductive toxicity of PFOS, male mice were administrated with a serial dosage of PFOS for 90 days for testicular observation and spermatogenesis evaluation. PFOS ≥ 11 mg/kg (accumulative dosage) resulted in visible histopathological changing in testis, including disorder and vacuolization of spermatogenic cells. Changed testicular organ coefficient (for dosage ≥ 55 mg/kg), decreased sperm concentration (for 110 mg...
Rais Ahmed1,2,*, Muhammad Khalid Mansoor1,2, Iftikhar Hussain1, Muhammad Saqib3, Muhammad Hammad Hussain4, Amjad Islam Aqib5, Haleema Sadia6, Javed Muhammad7, Asma Irshad8, Kashif Prince5, Muhammad Zain Saleem9 and Abdul Whab Manzoor10
...ne paratuberculosis is a chronic disease of cattle and buffaloes, causing progressive weight loss, persistent diarrhea and finally death. Due to zoonotic nature of the disease, workers in slaughterhouses are at a high risk of infection. In this study, the status of paratuberculosis was assessed in a slaughterhouse located in district Faisalabad, Pakistan. A total of 455 blood samples were collected from slaughtered cattle and buffaloes at random and then teste...
Muhammad Siddique1, Muhammad Shafique2,*,Abdul Mateen3, Naveed Shahzad4, Bilal Aslam2, Nasir Ahmad1 and Muhammad Usman Qamar2
...into four groups (acute, chronic, cirrhotic and hepatocellular carcinoma) on the basis of clinical reports and the patient’s history. HCV genotypes were determined by RFLP using amplified products and modified multiplex RT-PCR. Out of 3200 clinical samples, 5.37% (n=172) samples were HCV positive by ICT method. Among these, 96 (55.8%) were confirmed for HCV positive patients. Multiplex RT-PCR data showed that 75 (78%) patients had single HCV genotype inf...
Ahsan Anjum1, Asim Aslam1, Raheela Akhtar1, Tahir Yaqub2, Muti-ur-Rehman Khan1, Rizwana Sultan3, Saba Usman1, Aneela Zameer Durrani4 and Muhammad Usman4*
...69 percent lung samples, chronic type pleurisy in 97.96 percent, maximum aggregate pathological lesion score in 65.31%, while 48.98% lung samples had 6-10 numbers of sequestra. Besides, infiltration of inflammatory cells, congestion, hemorrhages, necrosis and other degenerative changes were observed in tissue samples of infected cattle. Significantly higher (P<0.05) micro-pathological lesion scores were given to lungs, kidney and lymph node samples from inf...
Ahmet Ozer Sehirli1,2, Serkan Sayiner3*, Ayliz Velioglu-Ogunc4, Nedime Serakinci5, Emel Eksioglu-Demiralp6, Berrak Yegen7, Feriha Ercan8 andGoksel Sener2
...ated in the treatment of chronic renal failure (CRF) with and without the presence of N-acetylcysteine (NAC). The renal mass of Wistar albino rats was reduced at a rate of 5/6. Captopril, Valsartan and NAC were applied intra-peritoneal alone or in combination. Blood pressure and heart rate were monitored at weekly intervals over a period of six weeks. Serum creatinine, blood urea nitrogen (BUN), lactate dehydrogenase (LDH) activity, cytokines (TNF-α, IL-...
Dil Afroza Khanom1, Amirun Nesa1, Muhammad Abu Sayed Jewel1, Muhammad Ayenuddin Haque1, Alok Kumar Paul1, Sonia Iqbal2, Usman Atique2,3*, Lubna Alam4
...nd even death in case of chronic exposure.
Joseph Anejo-Okopi1*, Ocheme Julius Okojokwu1 and Onyemocho Audu2
...akeholders. Treatment of chronic HCV infection has the potential to influence the 2030 elimination target due to the increasing availability of effective pangenotypic antiviral DAAs. Understanding the extent of HCV genetic diversity is important for treatment and development of vaccine. Among the routes of HCV transmission; intravenous drug addiction or injection drug use accounts for the majority of many cases apart from hemodialysis patients, unprotected sex...
Muhammad Raheel Faiz1, Ijaz Ashraf1, Haq Nawaz2, Muhammad Zubair3*, Muhammad Sajid Mahmood4, Sajid Hussain5 and Abdul Qadeer2
...immunity against various chronic diseases as they are rich source of minerals and vitamins. The annual vegetable production of Pakistan is about 10 million tons which adds almost $170 million in national economy. Unluckily, this production is far below than its required amount due to production, protection and marketing problems which are faced by the vegetable growers. Therefore, the present study was designed to identify and prioritize the production, protec...
M. Nafees*, Bushra Khan*, Robina Naz*
STUDY OF OCCUPATIONAL HEALTH SAFETY IN STEEL RE-ROLLING MILL WITH REFERENCE TO HIGH NOISE LEVEL AND TEMPERATURE
...workers exposed to these chronic conditions in the factory are suffering from post work irritability, headache, fatigue, eye infection and heat exhaustion. It was therefore, recommended that the Pakistan Environmental Protection Agency (PEPA) should strictly implement and follow-up on the occupational safety laws, adopt shift rotation and ensure reduction in the length of exposure of each worker i.e. 1.5 to 2 hours instead of 6 hours work in these working cond...
Parakriti Gupta1, Kapil Goyal2 and Mini Pritam Singh3*
Hepatitis E Virus and Zoonosis
...regnant women. Recently, chronic infections due HEV genotypes 3 and 4 have also been documented in immunosuppressed and transplant patients where prolonged virus shedding has been documented. The conventional diagnosis is established by detection of HEV antigen or anti-HEV IgM in acute sera. However, the detection of HEV RNA is important to establish the diagnosis in immunosuppressed patients. In transplant patients, decrease in immunosuppression is usually do...
Magbolah Salem Helal Alzahrani
...ek for 2 weeks to induce chronic liver damage. After injection of CCl4, blood samples were obtained using the retro-orbital method to confirm liver damage and estimate liver function. Rats given CCl4 prior to feeding M. chamomilla demonstrated decrease in serum lipoprotein HDL, LDL, VLDL fraction levels, indicating liver damage. Rats given CCl4 and fed on 5% M. chamomilla showed the most significant increase in or...
Yan Wen1, Liu Lian2, Zhuang Xun3, Murong Jiaying4, Cui Shuyi1, He Wanwen1, Mai Guanghuai5, Huang Wenzhu1, Chen Gang1,* and Wang Zhijun1,*
...y patients affected with chronic obstructive pulmonary disease (COPD). The elderly patients suffering from COPD were randomly divided into an observation group (n=30) and a treatment group (n=30). Accordingly, the patients in the observation group were given a medication-assisted treatment plan for stable COPD based on established guidelines and indoor rehabilitation training for pulmonary function. Outdoor-based rehabilitation therapy was also delivered to th...
Rida Younas1*, Tamseela Mumtaz1, Nabeela Roohi2 and Muhammad Amir Iqbal3
Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu*
...ize: small;">Asthma is a chronic inflammatory airway disease, characterized by reversible goblet cells, smooth muscle hyperplasia, airflow obstruction, hyperactivity enhanced, ultra-structural remodeling, and airway mucus production. The current experimental study was aimed at scrutinizing quercetin’s inhibitory effect on airway inflammation in mice and its possible mechanism of action. The mice received varying doses of quercetin from 22-30 days (1, 10 ...
Jia Shi
...ontrol in HBeAg negative chronic hepatitis patients is necessary as they are vulnerable to developing cirrhosis and hepatocellular carcinoma. The present study was aimed to evaluate the response rate of treatment by Peginterferon alfa-2a. In this systematic review and meta-analysis, a review of articles evaluating response rate to Peginterferon alfa-2a was done through the databases of Scopus, Google Scholar, Pubmed (inception - 2019). Fourteen studies reporti...
Joseph Anejo-Okopi1*, Jennifer Ifeoma Okpara1, James Mogoret Dabol1, Joshua Adetunji1, David Adeniyi2, David O. Amanyi3, Otobo I. Ujah4, Veronica David1, Patience Omaiye5 and Onyemocho Audu6
...) infected patients with chronic hepatitis B attending the hepatitis clinics of the two tertiary hospitals (Plateau State Teaching Hospital and HIV treatment center, at Jos University Teaching Hospital), Jos Metropolis from September to December 2018. The anti-HDV antibodies (IgM) were assayed using enzyme-linked immunosorbent assay HDV IgM ELISA Kit (MyBiosource, Inc, USA). The result was interpreted according to manufacturer’s instructions. Ninety HBsA...
Mai A. Kilany1; Hanaa H.A. Gomaa1; Yousry E. Abo El-magd2 and Nermin Raafat2.
...us that causes acute and chronic hepatitis in humans with a high propensity for chronicity. If untreated, chronic hepatitis C can progress to cirrhosis and hepatocellular carcinoma (HCC) in a subset of patients. HCC is a prevalent disease in many populations worldwide. It causes many financial problems in treatment modalities with high mortality rates. In develop-ing countries, the major c...
Ramazan Erdogan1*, Mikail Tel2, Vedat Cinar2 and Ragip Pala2
...ased with both acute and chronic exercises and FAS level decreased. It was determined that the biggest change in all parameters occurred in the zinc picolinate plus chronic exercise group. Regular exercise and zinc picolinate supplementation appear to have positive results on ATGL, ZAG and GLUT-4, which are markers of glucose metabolism.Besides, it has been determined that regular exercise and zinc picolinate supplementation...
...cal stable patients with chronic obstructive pulmonary (COPD) disease. For this purpose, a retrospective cohort was designed. In this work, 200 patients with COPD at stable stage were enrolled as research subjects. They were divided into the control group (n=100) given conventional treatment (bronchodilator, antioxidant, expectorant antitussive) and the research group (n=100) given pulmonary rehabilitation combined with tiotropium bromide treatment. The...
Mona Mohammed EL-Derbawy1, Eman Naser Hafez2*,
Mona Abdel Daym Abd Rabbo1, Nagwa Ibrahim Toaleb3,
Saedia Abdel Hady Sayed El-Ahl1 and Bahaa Eldkeen Wade EL-Aswad4
... a tool for diagnosis of chronic schistosomiasis.
...
Zhiyuan Sun1, 3, Xuhui Zhang2,*, Xian Li3, Yanping Huang3, Shiyan Sui3, Weifeng Liu3, Guochao Ni3, Xiaozhou Xu1, Jianbo Yang1, Xue Lian1 and Hui Jia1
... remains elusive whether chronic stress affects lipopolysaccharide (LPS) -induced inflammation via the crosstalk. Pigs were administered LPS injection with or without continuous adrenocorticotropine hormone (ACTH) pretreatment. Twenty-four 30-day-old Duroc × Landrace × Large White crossbred piglets (12 ± 0.5 kg) were randomly assigned to 4 treatments: control, LPS, ACTH, and ACTH+LPS groups. Each group consisted of 6 male piglets. All ACTH p...
Asad Ullah1*, Umar Sadique2, Ibadullah Jan2, Imad Khan1, Raheela Taj3, Mumtaz Ali Khan4, Salah-ud-din4, Naimat Ullah Khan1
...B) is a communicable and chronic infection triggered by Mycobacterium tuberculosis (MTB). Bovine tuberculosis (bTB) is one amongst neglected zoonotic disease (NZD) caused by Mycobacterium bovis; has an economic importance with public health significance and life-threatening infection at the human-animal-ecosystem interface in low-resource settings and developing countries globally. Our study aimed to investigate the incidence of pulmonic tuberculosis caused by...
Mohammad Hussain Haidary1, Rozanaliza Radzi1*, Muhammad Waseem Aslam1, Seng Fong Lau1, Farina Mustaffa Kamal2, Ahmad Rasul Radzali1
... extraction...
Xiaoli Cai1,2, Saeed Ahmed3, Zhixin Lei1,*, Jianping Wu1,* and Taolei Sun1,2,*
...athogenic bacteria cause chronic, persistent and latent infections. The treatment for intracellular infection faces many challenges, such as targeting bacteria with antimicrobial drugs and resistance to multidrug (MDR). The present study delivers a possible elucidation to this problem via Nano Drug Delivery. Nanomaterials are relatively small as compared to ordinary antibiotics. The nanoparticle has unique physical and chemical properties, a large surface area...
Yuan Zhang1, Qingyue Han1, Peiquan Du1, Yi Lu1, Lianmei Hu1, Sadaqat Ali2, Khalid Mehmood2, Sajid Hameed2, Zhaoxin Tang1, Hui Zhang1* and Ying Li1*
...og have pancreatitis and chronic compensatory alkalosis. The X-ray examination revealed pleural effusion of the dog; B-ultrasound showed nodular lesions in the spleen and enlarged lymph nodes in the abdominal cavity. Subsequent cytological examination of smear made from lymph node FNA and peritoneal fluid revealed a large number of lymphoblasts. The above symptoms could be combined to make a preliminary diagnosis of lymphoma in dogs. To further determine the t...
Yuan Zhang1, Qingyue Han1, Peiquan Du1, Yi Lu1, Lianmei Hu1, Sadaqat Ali2, Khalid Mehmood2, Sajid Hameed2, Zhaoxin Tang1, Hui Zhang1* and Ying Li1*
...og have pancreatitis and chronic compensatory alkalosis. The X-ray examination revealed pleural effusion of the dog; B-ultrasound showed nodular lesions in the spleen and enlarged lymph nodes in the abdominal cavity. Subsequent cytological examination of smear made from lymph node FNA and peritoneal fluid revealed a large number of lymphoblasts. The above symptoms could be combined to make a preliminary diagnosis of lymphoma in dogs. To further determine the t...
Alexander Tsybulsky1*, Tatyana Tabakaeva1, Anna Klimovich2, Michail Shchelkanov1, Eduard Kostetsky1, Maksim Aliev1, Anton Degtyarenko3
...laquo;FeLV-infection and chronic leukaemia» (n = 10) and healthy control cats (n = 6), we examined the following: 1) Haematological parameters of the blood; 2) Biochemical blood indicators of the physiological characteristics of the kidneys and liver, whose disorders are most critical in the progression of the leukaemic process; 3) Replicative and expressive activity of provirus FeLV in blood white cells (WBC); 4) Concentration of the IFNs and viral p27-...
Saima Parveen1, Altaf Mahmood2*, Ayesha Azad3, Sajid Umar4, Nosheen Shoukat6, Mirza Muhammad Arsalan Azam5, Qurat-Ul-Ain5 and Nausheen Akhtar Malik1
... body hepatitis (7.79%), chronic respiratory disease (7.67%), necrotic enteritis (6.48%), coccidiosis (6.09%), mycotoxicosis 5.43%), fowl cholera (4.74%), infectious coryza (4.41%), fowl typhoid (4.22%), omphalitis (3.71%) and hydropericardium syndrome (0.05%). Maximum share in crude morbidity was contributed by bacterial diseases with highest proportional morbidity of 48.68% followed by viral (40.32%), parasitic (5.80%) and fungal (5.20%) diseases. This epide...
Heba El-Zahar*, Zeinab Abd El-Rahman, Abbas El-Naggar
...disease characterized by chronic gastrointestinal inflammation. Due to the continuous rise in incidence, simple and cost-effective methods of diagnostic and clinical assessment are urgently required. The goal of this study was to look at the hematobiochemical alterations in association with the evaluation of C-reactive proteins (CRP), haptoglobin and fecal calprotectin concentration as prognostic markers in dogs with IBD. After a detailed clinical, labora...
Noora Hassan Hezam Al-Aqmer1*, Zain Aamir2, Muhammad Farooq Hanif3, Soumble Zulfiqar4, Sibgha Zulfiqar1, Mateen Izhar5 and Abdul Rauf Shakoori4*
Ahlam G. Khalifa1*, Walaa A. Moselhy1, Hanaa M. Mohammed2 and Khaled Abdou1
...n the genotoxicity of subchronic oral exposure to nano pesticides have been published. Male albino rats have been randomly divided into 4 identical groups. Group (I) had received only corn oil and acted as a control group. Group (II) had been given 3.855 mg/kg BW deltamethrin. Group (III) obtained deltamethrin loaded silica Nps at a dose of 8.795 mg/kg BW. The group (IV) obtained deltamethrin loaded chitosan Nps at a dose of 30.44 mg/kg BW. All remedies were a...
Chinar Mustafa Mohammed1*, Thamer M. Bashir1, Omar A.M. Al-Habib2, Farhad Ramadhan1, Mohammed Bassam1
...heart disease, including chronic heart failure. This study investigated the potential protective effects of taurine, on behavior and cardiovascular function in the male rat following arrhythmia induced by the social stressor. Here, we studied levels of heart electrical activity following experimental conditions: Cage control, social isolation in standard rat housing for 14 days, and pharmacokinetics effect of intravenous administration of different doses of ta...
Peyman Mohammadzadeh1*, Aida Rasuli2, Bahman Noroozi Gorgani2, Sajjad Mohammadi3
...ngaroo with a history of chronic neuro-ocular toxoplasmosis had an extensive mixed fracture of the posterior and base of the skull. Direct deep and countercoup brain bruises, independent fractures of the top and roof of both orbits, subdural hemorrhage with edema and shifting of the mid-line to the left, frontal lobe with severe hemorrhagic discharge in the ventricles, diffuse subarachnoid hemorrhage and exclusion of berry aneurysm in vertebral arteries, traum...
Khaliq Dad1, Fenliang Zhao2, Rumsha Hassan3, Kainat Javed3, Humaira Nawaz4, Muhammad Usman Saleem5, Tahreem Fatima6 and Muhamad Nawaz3*
...stem by causing acute or chronic disorders in the people of all ages. Similarly these pesticides cause serious threats to the aquatic ecosystem after their release by comprising different toxic substances, heavy metals and contaminants. This review paper has focused on the toxic nature of different pesticides, impacts and their possible refinement strategies from the environment as well as ways to minimize their impacts on plants and animals as adverse impacts...
Abdulaziz A. Alaqil1*, Mohammed I. Buhaya2
...dividuals suffering from chronic diseases. The current study aimed to investigate the effect of dietary linseed oil (LO) inclusion, as enriched-source of omega-3 polyunsaturated fatty acids, on egg production performance and egg yolk cholesterol content, blood hematology and biochemical composition of commercial laying hens. A total of 180 Hy-Line brown laying hens 36-week-old were randomly divided into four groups (9 replicates x 5 birds each). The four group...
Andi Hiroyuki1,2,*, Refina Sastya Qomariyuti1, Najmah Nur Islami3, Vanessa Ayu Sumirat4, Neni Anggraeni5, Mas Rizky A.A Syamsunarno2,6
Farheen Shaikh*, Saima Naz and Nadir Ali Birmani
...hip. They cause acute to chronic infestation to hosts directly. These parasitic insects are the source of various diseases, like flue, and also serve as a vector of some bacteria and helminthes parasites. Presently only one type of host, guinea fowl Numida meleagris (Linnaeus, 1758) was selected and examined for parasites examination, investigation, identification, population density, means and rate of infestation of from different urban and rural localities o...
Muhammad Said1, Amjad Hussain Mirani1, Abdul Kabir*1,2, Muhammad Haris Raza Farhan3, Abdul Latif Bhutto1, Ghulam Shabbir Barham1, Khaleeq Ur Rahman Bhutto4, Muhammad Uzair1, Maaz Khan1
S. M. Ashraful Karim1, Md. Shohel Al Faruk2*
Muhammad Izhar ul Haque1, Farhan Anwar Khan1*, Umar Sadique1, Hamayun Khan1, Zia ur Rehman1, Salman Khan1, Hayatullah Khan1,2, Faisal Ahmad1,3, Mumtazur Rahman1, Faiz Ur Rehman1, Muhammad Saeed1, Mehboob Ali1 and Saqib Nawaz1
...quo;s disease (JD), is a chronic infectious disease of animals caused by Mycobacterium avium subsp. paratuberculosis (MAP). It is also a serious public health concern as MAP is responsible for Crohn’s disease in human beings. This infectious disease is so far unexplored in animals in Khyber Pakhtunkhwa (KP) province of Pakistan. Therefore, this study was proposed to investigate the presence of MAP by indirect ELISA (iELISA), associated histopathological ...
Mingqing Wang1 and Xiaojuan Chen2,*
...th acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and many studies have tried to specify an effective treatment. Objective of this study was to observe and analyze the therapeutic effect of glucocorticoid combined with respiratory stimulant on patients with AECOPD along with the optimal nursing care required for these patients. Also, tumor necrosis factor-alpha (TNF-a) was assessed as an inflammatory factor to see the response to treatmen...
Shahid Iqbal1,2, Zulha Javed1, Mushtaq Hussain Zahid3, Qurat ul Ane Gillani4 and Furhan Iqbal1,*
Maria Al Mazed1*, Md. Ashikur Rahman1 and Sk. Istiaque Ahmed2
S. Feroza 1, A. G. Arijo1†, F. M. Bilqees2* and M. S. Phulan1
...tion. Severe congestion, chronic pneumonia, exuded in one lobe of the lung were seen, whereas, necrosis and atrophy in infected heart were notable observations....
Aamir Mushtaq1*, Fatima Habib2, Umar Farooq Gohar3, Abdul Malik4 and Mobasher Ahmad2
...to explore its acute and chronic toxicity. The dried fruits/seeds of P. anisum were powdered and its methanolic extract (with 19 % yield) was prepared by cold extraction technique. Acute toxicity studies were performed in female albino mice by administration of single oral doses (4, 5, 6, 7 and 8 g/Kg/po) respectively, to individual groups (n=5) and after that the behavioral changes were observed. To find the chronic toxicit...
Muhammad Shahid1*, Muhammad Idrees1, Afza Rasul2, Iram Amin1 and Samia Afzal1
...is playing a key role in chronic liver disease all around the globe. Currently, in Pakistan, it is a huge burden on health and the economy, affecting about 6 to 8% of the overall population. HCV is dependent on the lipid metabolism of the patient to replicate and then disturb the blood cell count and liver enzymes to ultimately damage the liver. To distinguish the potential HCV patients from healthy individuals at an early stage is quite important for its cont...
Ghulam Jelani1, Muhammad Haris Raza Farhan2, Rida Asrar3, Muhammad Ahmad1,4*, Chanda Naseem5, Zafar Ali Khoso6, Majid Hussain Soomro7*
...analysis to identify the chronic respiratory poultry disease, method of prevention, their seasonal incidences, and the treatment by the use of good antibiotics and supportive therapy.
...
...
Ubaida Hussain1,2*, Amtul Jamil Sami1*, Shazia Rafique3*, Muhammad Idrees khan3 and Ahmad Ali Shahid3
...ected people and forms a chronic infection which can progress to liver cirrhosis, fibrosis, hepatic cancer, and death. The goal of this work was to assess the cytotoxicity and in vitro inhibitory activities of local medicinal plant Azadirachta indica (A. indica) extracts on expression of NS3 and NS5A nonstructural proteins of HCV 3a genotype. Owing to the fact that HCV patients can develop HCC, plant extract has also been tested for cytotoxic activity. Colorim...
Soedarmanto Indarjulianto1*, Alfarisa Nururrozi1, Yanuartono1, Sitarina Widyarini2, Dhasia Ramandani3
...osis in a cat exhibiting chronic submandibular lymphadenopathy. A five-year-old female cat showed lethargy, partial anorexia, weight loss, and intermittent sneezing for several months before being examined. Clinical examination demonstrated mucopurulent discharge from both nostrils, swollen on the nasal bridge and maxillary sinus. Subsequently, the cat was diagnosed infected by cryptococcosis based on cytology, fungal culture, serology, and hematology. Lymphad...
Yisi Chen*, Jun Zhang and Fayin Li
...uropathic pain caused by chronic contraction injury. Forty-five rats were randomly divided into three groups: blank group (untreated, 3 groups, n=15), isoflurane group (general anesthesia of plantar incision, inhalation of 2.5% isoflurane, 3 groups, n=15), propofol group (general anesthesia of plantar incision, intravenous infusion of propofol to the lateral tail vein through the implanted catheter with the infusion rate of 1.5 mg kg-1 min-1, 3 groups, n = 15)...
Xiaowei Huang1, Chao Ma1, He Lin1, Yuchen Wang1, Yan Xu1, Guangfu Lv2* and Zhe Lin1*
...re divided into control, chronic unpredictable mild stress (CUMS), fluoxetine (3 mg/kg), OR800 (OR 800 mg/kg) and OR400 (OR 400 mg/kg) dose groups. After the last administration, the content of corticotropin-releasing hormone (CRH), adrenocorticotrophic hormone (ACTH) and corticosterone (CORT) in serum were detected. Hematoxylin and Eosin (H&E) staining was used to observe the hippocampal histomorphological changes. The protein levels of glucocorticoid rec...
Seyi Olalekan Olawuyi1*, Adedotun Oluwagbenga Anjorin2, Oluwagbenga Titus Alao3, Tosin Dolapo Olawuyi3, Rachael Ajibola Ayinla3 and Rasheed Ayodele Ayinla3
...erable to transitory and chronic food insecurity status. The odds ratio estimates of the ordinal logistic regression model also indicated that gender of the farmers (p<0.05), years of formal education (p<0.1), dependency ratio (p<0.01), farm size (p<0.05), adoption of bio-security (p<0.1), land ownership (p<0.1), and access to bio-security information (p<0.1) have significant influence on the levels of farmers’ food security status i...
Sumbal Nazir1*, Farkhanda Manzoor2, Ishrat Perveen3, Anum Rana2, Irum Naureen1, Abad Ali Nadeem3 and Hafiza Najma Naeem2
...queen cell virus (BQCV), chronic bee paralysis virus (CBV) and Israeli acute paralysis virus (IAPV). For the pathogen screening, collection of guts from the diseased honeybee colonies was followed by RNA isolation. The RNAs were quantified on spectrophotometer. Results have shown the occurrence of fungus and/or pathogen infestation which was caused by microsporidium Nosema apis with 277bp. It has been observed that the honeybee colonies were badly affected due...
Aamir Ali, Hafiz Muhammad Tahir*, Azizullah, Shaukat Ali, Muhammad Summer, Ali Haidar Gormani, Saira Nawaz and Ayesha Muzamil
...ctor involved in various chronic diseases. This research study was conducted to evaluate anti-inflammatory and analgesic potentials of hot water extracts of mulberry leaves (mulberry tea) of two species i.e., Morus alba and Morus nigra. Mice were fed orally with mulberry leaves extract (200mg/kg, 100mg/kg and 50mg/kg) mixed in distilled water. Mice paw edema was induced by carrageenan injection while formalin was injected to mice paw for induction of pain. The...
Umara Amir ud Din1, Waqas Ahmed Khan1*, Khurrum Shahzad1,2, Basharat Ali3, Misbah Hussain1,4 and Fazli Rabbi Awan4
...ich remains uncontrolled chronically. Renin angiotensin aldosterone system (RAAS) is a major regulator of the blood pressure, electrolytes and fluid homeostasis. RAAS plays a key role in modulating the sodium metabolism, vasoconstriction, vascular tone and renal hemodynamics. Angiotensin converting enzyme (ACE) is a key member of RAAS pathway and target for anti-hypertensive drugs. ACE (I/D) polymorphism studies for its association with kidney function and ris...
Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1
...public health concern is chronic renal disease (CRD). Thus, it is necessary to search for beneficial and helpful medications that can stop CRD from progressing to end-stage renal failure. Aims: The purpose of this study was to evaluate how erlotinib and garcinia cambogia alleviate the harmful effects of adenine on the rat’s kidneys. Methods: Forty animals were divided into four groups: Control group: received normal vehicle, adenine group: received orall...
Selvaraj Thanga Malathi¹, Venkatraman Anuradha1*, Mohamed Yacoob Syed Ali2, Muhameed Sajjad Sarwar3, Nagarajan Yogananth2
...n of Lithium [30%] for a chronic period of 60 days. The levels of FT3, FT4 and TSH tested were significantly decreased in treated groups when compared to the normal. Thus, it is evident that determination of thyroid hormone secretion and histological studies (FESEM – field emission scanning electron microscopy) were useful in determining the effect of trace metal pollution and its effect in freshwater fish species.
Lianci He1, Dingxi Bai2, Chenxi Wu2, Yizhu Zhong2, Shi Chen2, Xinru Bao2, Jing Gao2*, Chaoming Hou2*
...ongee (SXC) in rats with chronic fatigue syndrome (CFS) on NF-κB signalling pathway and the expression of related factors. To reveal the relevant signal transduction mechanism in the treatment of CFS. Seventy two male SD rats were randomly divided into 6 groups with 12 rats in each group. Namely: control group (CON), low dose Shenxian Congee group (SXC-L), medium dose Shenxian Congee group (SXC-M), high dose Shenxian Congee group (SXC-M), fluoxetine hydr...
Hafiz Muhammad Arsalan1, Amina Arif1 and Muhammad Khalil Ahmad Khan2*
...loid leukemia (CML) is a chronic proliferating cancer of bone marrow presently treated with BCR-ABL tyrosine kinase inhibitors (TKI). Within interacellular system, increased reactive oxygen species (ROS) production in response to antioxidant (AOX) defense systems lead to oxidative stress (OS). Our study aimed at biochemical profiling of CML patients in response to imatinib or nilotinib therapeutic drugs. Fresh venous blood sample (10 mL) of 170 CML diagnosed p...
Abdullah Alsrhani1*, Aisha Farhana1, Shahid Hussain2 and Muhammad Ikram Ullah1
...;s thyroiditis (HT) is a chronic devastating autoimmune disorder of the thyroid gland, which develops due to environmental and genetic predispositions. Various studies have explored the role of 25(OH)-D deficiency in HT. Although vitamin D supplementation is suggested to improve thyroid functions, the mechanism of action of vitamin D on thyroid hormones remains unclear. The objective of the present study was to determine serum concentrations of thyroid hormone...
Samia Afzal1*, Jahanzaib Ahmad1, Iram Amin1, Liaqat Ali2, Muhammad Shahid1, Mohsin Ahmad Khan1 and Muhammad Idrees1
...replication, both in HBV chronic active and inactive state patients from four different a Pakistani provinces. Blood samples along with patient history and demographic data were collected from 100 (n=100) patients, all of these were positive for HBsAg (further characterized as acute or chronic hepatitis B). Viral titer was quantified from the HBsAg positive samples by real time-PCR, HBeAg by ELISA, and HDV RNA was detected b...
Akram Ali Baloch1*, Adeel Ahmad2, Kaleem U. Kakar3, Sara Naudhani1, Samiullah Khan1, Agha Muhammad Raza3, Imrana Niaz Sultan1, Humaira Zahid4, Saadullah3 and Shakeela Daud1*
...zed as third most common chronic brain disorder. It is regarded as an enduring tendency to produce seizures. A type of epilepsy known as lafora disease is autosomal recessive progressive myoclonus epilepsy (PME) with onset in teenage years of a progressively stubborn seizure disorder which brings declining mental function, dementia and finally death within ten years after the first symptoms. Lafora disease is defective in two well-known genes EPM2A and EPM2B. ...
Salma Jameel Askar
...amine the effects of sub-chronic exposure to meloxicam, nonsteroidal anti-inflammatory drug, on hematological alterations and liver functions parameters in albino male rats and to determine the effects of Beetroots ethanolic extract in alleviation these alterations. Eighteen male albino rats were used, and they were divided into three groups of six animals each: G1, which received a dose of distilled water as a negative control; G2, which received a dose of me...
Komal Mukhtar*, Saba Yasin, Husna Ahmad, Muhammad Amir Iqbal and Nabila Roohi
...painters. In conclusion, chronic paint exposure predicts future illnesses such as anemia and cancer. ...
SHEIKH AJAZ RASOOL1*, MUNAZZA DANISH AJAZ2, MUHAMMAD SALMAN RASOOL3, AHSAN SATTAR SHEIKH4 & FIRDAUS KOUSAR BUKHARI5
...with diarrhoea. Acute or chronic or persistent campylobacteriosis are dealt with antibiotics and proton-pump inhibitors. However, an ever increasing problem of antibiotic resistance evolution has been there and that is alarming. Thus, urgency exists for finding out non-classical therapies as reduction factors against Campylobacter nuisance in humans and poultry. In addition, a few probiotics have been instrumental to cut down the adverse effects rendered due t...
Shafi Muhammad1, Bibi Nazia Murtaza2, Aftab Ahmad1, Muhammad Shafiq3, Nurul Kabir4 and Hamid Ali1*
...A distinctive feature of chronic hepatitis C infection is the presence of persistent liver inflammation characterized by the expression of different inflammatory molecules including Interleukin-17 (IL-17). The progression of chronic liver ailments (fibrosis, cirrhosis) towards hepatocellular carcinoma (HCC) is determined by the distortion produced in the normal structure of liver. Pakistan bears the second highest numbers of...
Milena Vlahovic*, Dragana Matic, Marija Mrdakovic, Larisa Ilijin, Anja Grcic, Aleksandra Filipovic, Jelica Lazarevic and Vesna Peric-Mataruga
...ere exposed to acute and chronic effects of two cadmium concentrations, 10 and 30 μg Cd/g dry food, as well as a three-day recovery from chronic treatments. PMM is also an indirect indicator of food consumption and was found to be significantly reduced compared to control in both acute effects and chronic treatment at 30 μg and its three-day recovery. The PMM reduction during acute t...
Rana Mahmood Ahmad*, Orooba Mohammed Maeed Ibrahim
...creasing inflammation in chronic inflammatory models were evaluated using the cotton pellet-induced granuloma method. Decreasing granuloma weight suggests that the proliferative phase has been successfully suppressed. In the current study, treatment with clove oil extract on infected rats significantly decreased levels of the pro-inflammatory cytokine TNF-α value after nine days of treatment, which are central inflammatory cytokines involved in the patho...
Fadia M. Attia and Hanaa H. A. Gomaa
...alities in patients with chronic hepatitis C. Aim of the study: to describe different patterns of changes accompanying viremic status in HCV chronic liver diseases. 50 patients with chronic hepatitis C were enrolled in this study. Qualitative and quantitative PCR by real time PCR was done to determine the level of viremia before induction of therapy. In addition, complete blood count, prot...
Sarah G. Yousef1*, Ahmed Shehta2, Hend M. El Damaty1 and Hussein A. Elsheikh3
...ne’s disease (JD), chronic granulomatous disease caused by Mycobacterium avium subsp. paratuberculosis (MAP), is regarded as a potential public health issue and a significant threat to the dairy and agricultural food businesses. This study was conducted for the molecular investigation of MAP in cattle reared for small-scale dairy production in Sharkia Governorate, Egypt. Seventy-five fecal samples were collected from diarrheic and healthy dairy cows that...
Afrasyab Khan1,3, Ali Raza Jahejo1,3, Meng-li Qiao1,3, Xin-yu Han1,3, Raza Ali Mangi1,3, Ding Zhang1,3, Yu-hai Bi2, George F Gao1,3* and Wen-xia Tian1,3*
...ten causes diseases of a chronic and persistent nature. However, there is limited data available on Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway genes expression in chicken erythrocytes infected with Mycoplasma synoviae (M. synoviae). Therefore, the aim of the current in-vitro study was to determine the interaction between chicken erythrocytes and M. synoviae using Transmission electron microscope (TEM) and fur...
Ghaith Z. Hasan Al-Askari *, Eman H. Yousif Al-Taee
...verity of acute upper or chronic vitamin D intoxication (VDI) through the study of cytogenetic effects in addition to histopathological changes in the tissues of female rats. The methods included in the first experiment, the female rats were orally administered the following lethal doses: 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16 mg/kg b.w. of vitamin D. Survival and mortality numbers were observed following 24 hours of intoxicat...
NAILA MALKANI*, IRFAN ISHAQUE, KHALID SHAHBAZ, RIZWAN ULLAH KHAN, ARIFA SHABBIR & ATIF YAQUB
...issues revealed signs of chronic damage in the wild captured fish as characterized by lymphocyte infiltration and altered morphology of functional units. It is concluded from findings of the present study that farm-raised Labeo rohita were healthier and safer to consume compared to the wild-caught fish....
ADEEBA SYED1, DILAWAR HUSSAIN2, UZMA RAFI1 & SUMAIRA MAZHAR1*
...to examine the acute and chronic exposure of pesticide, chlorpyrifos (CPF) to the fresh water fish Labeo rohita. During acute exposure, fish were exposed to different concentrations of CPF ranging from 0, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04 and 0.05 mg/L for 96 hrs in glass aquaria. The 96 hrs LC50 value of CPF for Labeo rohita was found to be 0.01 mg/L. During chronic exposure fish were subjected to 1/...
Wasan Ali Hasan1*, Manal Abdulkhaliq Ibrahim2
...rs, including asthma and chronic obstructive pulmonary disease, are prevalent conditions affecting the airways. Current study aimed to investigate the impact of famotidine on respiratory inflammation in rats. Thirty adult male albino rats were segmented into five distinct groups, each group comprising six rats (n=6). A_group (Negative Control) rats received distilled water only, without any drug; B_group (Positive Control) rats underwent ovalbumin sensitizatio...
Shahabaz Ul Haq1, Khurram Ashfaq1, Arsalan Khan2*, Adeel Khalid1, Shahrood Ahmed Siddiqui3,4, Raheela Taj5, Asad Ullah6, Hidayatullah Soomro7 and Muhammad Wasim Usmani8*
Bushra AL-Khaqani, Amira Mohammed*
...dwide. Asthma defined as chronic airway inflammation. A natural substance called resveratrol, which is present in several plants, red wine, and grapes, has been researched for its potential anti-inflammatory, and antioxidant qualities, and to induce relaxation of airway smooth muscle. The current study investigated whether Resveratrol (RES) could lessen allergic asthma that ovalbumin (OVA) causes in rats. Current results revealed that RES improved significantl...
Abdelghafour El-Hamzaoui*, Mouloud Lamtai, Laila Ibouzine‑Dine, Sofia Azirar, Mohamed Yassine El-Brouzi, Ayoub Rezqaoui, Aboubaker El-Hessni, Abdelhalem Mesfioui
...d 100 mg/kg following subchronic GBH exposure. Notably, markers of OS exhibited discernible alterations solely at 75 and 100 mg/kg, with no significant variation observed at lower doses (25 and 50 mg/kg). Our study confirms the dose-dependent effect of subchronic exposure to GBH, implicating markers of OS in the hippocampus as potential contributors to the observed neurobehavioral changes. Thus, our findings underscore OS as...
Md. Khayrul Basher1, Sumon Sarkar2,3, Md. Samiul Haque1, Sourav Sarker4, Md. Rashedul Islam1*
...cern across the world is chronic arsenic exposure from contaminated water, which is linked to hematological, biochemical, and many other significant systemic illnesses. The current study on adult female mice assessed the protective effects of Na-selenite against arsenic-mediated hematological, biochemical, and organ development toxicities. In this study, adult female mice (Swiss Albino) were categorized into four groups namely control, NaAsO2, NaAsO2+Na2SeO3, ...
Kingsley O. Omeje1, Juliet N. Ozioko2, Amaechi L. Ogara2, Benjamin O. Ezema2* and Dilibe C. Urama3
...city after the acute and chronic toxicity tests after 24 hr. Some hematological indices (red blood, white blood cells, packed cell volume, lymphocytes, neutrophil, mean cell volume) increased after the 28-day treatment regime. There was increase in the plasma concentration of high-density lipoprotein and triacylglycerides, with a decrease in the plasma concentration of low-density lipoprotein, with non-significant increase (p>0.05) in the activities of anti...
Mahmood Iqbal Sheikh
...stan is suffering from a chronic shortage of wood.
Most of the indigenous species are rather slow growing
and take a long time to mature. The existing
deficiencies can only be met through planting of local
and exotic fast growing tree species such as poplars and
willows in climatically suitable areas. Exotic poplars
were, therefore, introduced in late fifties. Over a
period of time techniques of scientific production of
nursery stock and field planting...
Miss Munawar Sultana and Anwar Ahmad Khan
...aves are used in asthma, chronic bronchitis and all kinds of coughs. The powdered
leaves are used in malarial fevers, dysentery and diarrhoea. The boijed leaves infusion
is useful for tuberculosis and rheumatic joints (1).
Adhatoda vasica locally known as Berg-e-Bansa is extensively used in Unani and Ayurvedic systems of medicines from time immemorial. Recent survey carried out by the Medicinal Plant Branch, Pakistan Forest Institute Peshawa...
Adhatoda vasica locally known as Berg-e-Bansa is extensively used in Unani and Ayurvedic systems of medicines from time immemorial. Recent survey carried out by the Medicinal Plant Branch, Pakistan Forest Institute Peshawa...
Mahmood Iqbal Sheikh
...he sides. In view of the chronic shortage of raw material to feed the pulp and paper industry in Pakistan, planting of fast growing species in irrigated forest plantations, extensive practice of agro-forestry and involvement of private enterprise in such projects of national importance has been recommended....
Dunia Tahseen Nema Al-Aridhi
... examined the link among chronic kidney disease (CKD) and hyperuricemia, although the precise relationship is unknown. The present study aimed to discover whether they were directionally connected or not.
This study followed adults aged 18 and above with CKD stages (1-4) over a period of 12 months. It has been conducted in Al-Kindi Teaching Hospital- Baghdad / Iraq, during the period (2022-2023). Data, on demographics, clinical information and lab resu...
This study followed adults aged 18 and above with CKD stages (1-4) over a period of 12 months. It has been conducted in Al-Kindi Teaching Hospital- Baghdad / Iraq, during the period (2022-2023). Data, on demographics, clinical information and lab resu...
Ali D. Nashmi1*, Jawad K. Hasan1, Manal A. Ibrahim2
... lung conditions such as chronic bronchitis or asthma. An inhibitor of phosphodiesterase enzymes 3 and 5, dipyridamole is a conventional antiplatelet drug that increases adenosine. The purpose of this study was to investigate whether dipyridamole plays a role as an anti-inflammatory to improve airway inflammation. A total of 24 healthy rats (albino, male), were weighted (150-300 g), were divided into four groups, each group consisting of six rats; Group A rats...
Hala Harifi*, Mouloud Lamtai*, Siham Ait Salhi, Fatima-Zahra Azzaoui, Omar Akhouayri, Abdelhalem Mesfioui, Leila Bikjdaouene
... evaluate the effects of chronic exposure to Mn, specifically its impact on the general condition of male Wistar rats, by recording all clinical symptoms associated with this intoxication. Different doses ranging from the lowest to the highest (6 mg/kg, 25 mg/kg, 30 mg/kg, and 40 mg/kg i.p.) were administered intraperitoneally over a period of 12 weeks. The objective of the study was to identify the lethal dose and the tolerated toxic dose in order to establis...
Hind A.Norii1, Adel M.Hassen ALZobidy2*
...hich is characterized by chronic anovulation, polycystic ovaries, biochemical and clinical manifestations of hyperandrogenism. This study aims to evaluate the effects of the alcoholic extract Vitex agnus-castus on body weight gain and possible alteration of reproductive hormones in letrozole-induced PCOS induced by letrozole in adult female rats. The negative control received 1 ml of 0.5% carboxymethyl cellulose (CMC) whereas positive control animals received ...
Baraa Najim Al-Okaily
Dalia M.A. Elmasry1*, Dalia M. El-Husseini1, Asmaa A. Eissa1, Zakaria R. Elkanawati2, Momtaz A. Shahein3, Amany Adel4
Idrissi Ouedrhiri Housna1, Bikri Samir1,2*, Benloughmari Douae1, Aboussaleh Youssef1
... in T2DM mice exposed to chronic immobilization stress (CIS).Mice were divided into four groups: normal-control (NC), diabetic treated with MET (D-Met), stressed diabetic treated with MET (D-Ims-Met), and stressed diabetic treated with a combination of MET and MEL (D-Ims-Met-Mel). T2DM was induced experimentally by exposing mice to fructose for 14 days followed by a single intraperitoneal injection of streptozotocin (STZ). Stress symptoms were induced using th...
Mohammad Moneruzzaman Khandaker1*,Nuratiqah Emran1, Nurul Elyni Mat Shaari1, Arba Aleem2, Zanariah Mohd Nor1 and Ali Majrashi3
...eptible to its acute and chronic toxicity through plant food. Similarly, Cd hinders the growth of plants by causing the loss of chlorophyll, which in turn negatively impacts the activities of photosynthesis. Therefore, this current study aims to evaluate the effects of Cd on the germination behaviour, morphology, growth and development of Pak Choi plants. The sterilized Pak Choi seeds were germinated on a soaked filter paper of a petri dish. The petri dish inc...
Jian Bai1, Xiyuan Dong1, Longjie Gu2, Jianhua Wang3 and Chen Gong3*
...c prostatitis/chronic pelvic pain syndrome (CP/CPPS) patients with lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) eventually show increased sympathetic tension. Therefore, this study aimed to assess the effects of serum Immunoglobulin G (IgG) on secreted norepinephrine (NE) amounts and norepinephrine transporter (NET) expression in sympathetic neurons. The purified serum IgG from the patient group Control, CP/CPPS+ED, CP/CPPS and ...
Mayada Sahib Hassan1*, Hayder Talib Mahdi1, Sajaa R. Al-Saedi1, Ali Farid Shakir1, Ali J. Al-Nuaimi1, Marwa Sabah Majed1, Ridha Adel Fahad1, Karar Ali Kadhim1, Mustafa Ali Noor1, Ameer Hameed Kadhim1, Hussein Ali Mohammed Hadi1, Zainab Amori Oribi2, Mazin Talib Abbas3, Mahdi S. Hassan4
...very sensitive organs to chronic Pb toxicity. Lead produces free radicals and causes oxidative stress, both of which are linked to renal damage. Tribulus terrestris (TT) has anti-inflammatory and antioxidant effects. The hydroalcoholic extract of TT has been investigated against lead acetate-induced nephrotoxicity. In experimental animals, forty adult male albino rats were utilized. Four groups of animals were used in the study. Ten male rats each group are us...
Batool S. Hamza1*, T.S. Al-Amery2
...ndometritis (18 %; 9/50) chronic endometritis (30 %; 15/50), and while metritis cases (16 %; 8/50) were of the chronic type of inflammation. In all six cases of perimetritis (1.5% of the total) (1.5%; 6/50), the uterine serosa was found to be thicker than usual, and pus of a yellowish hue was observed to accumulate. The pathological changes of acute endometritis includes stromal edema and severe engorgement of a few endometr...
