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Detection of Hepatitis E Virus among HIV Infected Individuals in Ogbomoso, South-western Nigeria

Detection of Hepatitis E Virus among HIV Infected Individuals in Ogbomoso, South-western Nigeria

Oladipo Elijah Kolawole*, Oloke Julius Kola, Awoyelu Elukunbi Hilda, Olasunmibo Oluwatobi Gabriel, Ogunyale Tolulope Temitope

E-mail | koladipo2k3@ yahoo.co.uk

Department of Pure and Applied Biology (Microbiology/Virology Unit), Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, Nigeria.

ABSTRACT

Hepatitis E virus is a foodborne and waterborne virus commonly transmitted faecal-orally and through the transplacenta. Hepatitis E virus is one of the viruses that causes acute and self-limiting infection with a high risk of developing chronic hepatitis in immunocompromised individuals usually leading to liver cirrhosis. Individuals living with Human Immunodeficiency Virus have a greater risk to the virus due to their impaired immunity. The study was carried out to determine the sero- prevalence of Hepatitis E among people living with Human Immunodeficiency Virus in Ogbomoso. The blood sample of consented two hundred and seventy five (275) subjects were obtained and their sera were screened for antibodies to HEV using Enzyme Linked Immunosorbent Assay. Samples were collected over a period of 4 months (September – December, 2014). The mean age and mean CD4+ count of the subjects were 40.14±0.47 years and 387.28±18.91 cells/mm3 respectively. Out of 275 subjects tested, 15(5.45%; 95% confidence interval) were positive for anti-HEV IgM. Anti- HEV IgM was highest among the age group 11-20 (9.09%), female (7.83%), civil servant (7.37%), > 500 CD4/ mm3 (7.89%). The multivariate analysis between age and CD4 count shows highest prevalence in the age range 31-40 years with CD4+ count less than 200cells/μl. The seroprevalence shows there is a significant difference between age and CD4+ cell count. The result provides the evidence that Hepatitis E virus is present among HIV individuals in Ogbomoso and they are more susceptible to the virus.

 

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Hosts and Viruses

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Vol. 8, Iss. 1, Pages 1-22

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