Evaluation of Hematological and Biochemical Changes observed in HCV Patients with Different Level of Viremia
Evaluation of Hematological and Biochemical Changes observed in HCV Patients with Different Level of Viremia
Fadia M. Attia and Hanaa H. A. Gomaa
ABSTRACT
HCV viremic status is associated with many hematological and biochemical, immunological abnormalities in patients with chronic hepatitis C. Aim of the study: to describe different patterns of changes accompanying viremic status in HCV chronic liver diseases. 50 patients with chronic hepatitis C were enrolled in this study. Qualitative and quantitative PCR by real time PCR was done to determine the level of viremia before induction of therapy. In addition, complete blood count, prothrombin time and liver function tests were performed. The results showed that leucopenia and thrombocytopenia are more frequent in HCV patients with moderate degree of viremia than patients with mild viremia than those with no viremia (p<0.05). Moderate neutropenia (< 1000 /ul) and moderate lymphopenia (< 1000/ul) are observed in all patients with different levels of viremia in comparison with those patients with no viremia. Only 10 percent of patients with moderate viremia had mild anemia (Hb < 10 g/dl). Red cell indices are normal in different degree of viremia and in those with no viremic status. Platelets indices shows increased platelet distribution width in those with moderate viremia than patients with mild viremia than those with no viremia (p<0.05). ALT and AST are increased 3 fold normal range in patients with mild degree of viremia and more elevated than in patients with moderate viremia.
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