This paper observes the effect of pulmonary rehabilitation combined with tiotropium bromide on BODE index in clinical stable patients with chronic obstructive pulmonary (COPD) disease. For this purpose, a retrospective cohort was designed. In this work, 200 patients with COPD at stable stage were enrolled as research subjects. They were divided into the control group (n=100) given conventional treatment (bronchodilator, antioxidant, expectorant antitussive) and the research group (n=100) given pulmonary rehabilitation combined with tiotropium bromide treatment. The BODE indexes of two groups were compared and observed at 4 and 8 months of follow-up. After four months the research group showed significant improvement in dyspnea, 6MWD, FEVl% pred, BMI and BODE index, p<0.05. At eight months of treatment, the improvement was sustained for all outcomes at the research group, at p<0.05. Pulmonary rehabilitation combined with tiotropium bromide therapy for clinical stable patients with COPD can produce significant improvement in patients’ BODE index.
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