Effect of Vitex Agnus-Castus Ethanolic Extract and Ciprofene Citrate on Reproductive Hormones in Polycystic Ovary Syndrome in Female Rats
Effect of Vitex Agnus-Castus Ethanolic Extract and Ciprofene Citrate on Reproductive Hormones in Polycystic Ovary Syndrome in Female Rats
Hind A.Norii1, Adel M.Hassen ALZobidy2*
ABSTRACT
Polycystic ovary syndrome (PCOS) is a complex genetic, endocrine, and metabolic disorder which is characterized by chronic anovulation, polycystic ovaries, biochemical and clinical manifestations of hyperandrogenism. This study aims to evaluate the effects of the alcoholic extract Vitex agnus-castus on body weight gain and possible alteration of reproductive hormones in letrozole-induced PCOS induced by letrozole in adult female rats. The negative control received 1 ml of 0.5% carboxymethyl cellulose (CMC) whereas positive control animals received 1 mL of 0.5% CMC (carboxymethylcellulose). Three treatment groups were treated with either the VAC vitex agnus castus extract (150 mg/kg bw or 250 mg/kg bw or 1 mg/kg bw) orally. The result showed an increased in body weight gain in the control group and animals suffering from PCOS. Also, an increase in serum LH was observed in the PCO group and decreased in estrogen and progesterone was noticed. Additionally, an increased in the hormone testosterone and prolactin was noticed in the group of PCO. The ameliorative effect of extract of VAC was clearly observed at doses of 150 and 250 mg/kg bw on the release of estrogen and progesterone. Taken together, our findings illustrate that Vitex agnus-castus alcoholic extract impact the physiological parameters of female rats.
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