Muhammad Arif Zafar1*, Arfan Yousaf1, Murtaz-ul-Hasan1, Faisal Ayub Kiayani1, Matee ul Islam2 and Muhammad Farooq Iqbal1
...iotics and non-steroidal anti-inflammatory drug, good outcome in the calf was obtained. There was no postoperative complication suggesting that modified two-layer hand-sewn anastomosis technique was a successful technique. It was concluded that traumatic hernia may lead to septic shock and modified two-layer hand-sewn anastomosis technique may be recommended in calves with no postoperative complications and there is a good chance for long-term survival....
Aqsa Gulzar1, Tariq Mahmud1,*, Rubina Munir2 and Asma Anjum3
...v>The anti-cancerous and anti-inflammatory potential of two novel Schiff bases was carried out by MTT - colorimetric protocol on HeLa cells (cervical disease) and Luminol-improved chemiluminescence assay, respectively. The novel Schiff bases 4a and 4b have been synthesized by the reaction of 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide with 3-nitro and 4-nitrobenzaldehyde. Characterization of the synthesized compounds was...
Ashraf M. Mounir, A.N. El shahat* and A.M. Abdul Azeem
...gum resin that possesses anti-inflammatory and antioxidant activity. Gamma-irradiation is used for decontamination of Boswellia tears to achieve satisfactory microbiological quality and public health safety. Hence, examining the effect of gamma-irradiation on the contents of Boswellia oleo-gum resin and also investigating the role of gamma-irradiate frankincense aqueous extract (GFAE) against ISO-induced MI in rats were the two aims of this study...
Rıfat Ertekin1*, Mete Ozkurt1, Gokhan Kus2 and Selda Kabadere1
...d (TA) is a nonsteroidal anti-inflammatory medicine stimulating apoptosis in cancer cells like pancreas, oesophagus and lungs. This study aims to determine the role of TA in cell viability and apoptosis in glioma cells (T-98G) and androgen-sensitive human prostate cancer cell line (LNCaP). In our study, 1, 5, 10, 25, 50, and 100 μM doses of TA were applied to T-98G and LNCaP cell lines for periods of 24 and 48 h. Subsequent cell vitality was tested with MTT...
Sameh S. Tawfik, Ahmed A. Elkady* and Ehab T. Mohamed
...a potent antioxidant and anti-inflammatory drug to prevent and/ or ameliorates the hazardous-effects of γ-rays
...
Hui-Ying Chen1,2*, Ping-Chuan Yin1,2, Ya-Nan Lu1,2, Hai-Yun Li1,2*and Yang Shan3
...Aspirin is a widely used anti-inflammatory and antithrombotic drug that exhibits chemopreventive anti-tumor properties. Aspirin is considered to be partially mediated by the induction of apoptosis in cells. However, the underlying molecular mechanisms of aspirin in the prevention of cancer are yet to be fully elucidated. In the current study, the GSE115660 microarray dataset was downloaded from the Gene Expression Omnibus database to identify key genes in aspi...
Anurag Sharma*, Naresh Kumar, Geetanjali Singh and Anika Sharma
...tive, anti-carcinogenic, anti-inflammatory, antibacterial, antifungal and galactagogue activity. The commercially available drugs pose health threats and prove detrimental to both human and animal health. The traditional use of herbal preparations suggests that they are safe and effective, however, scientific validation is still required for many of them especially for animal use. The phyto-pharmacological research on these two natural products show a ray of h...
Magbolah Salem Helal Alzahrani
...ociated with calming and anti-inflammatory properties. The plant’s healing properties come from its flowers, which contain volatile oils including bisabolol, bisabolol oxides A and B, and matricin as well as flavonoids. This study aims to elucidate the possible therapeutic applications of different levels of M. chamomilla on the functional status of liver, in rats injected with carbon tetrachloride (CCl4), a known hepatotoxin. Thirty-si...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...caffeic acid have potent anti-inflammatory activity. The aim of the current study was to scrutinize the protective effect of caffeic acid against the streptozotocin induced GDM in rats and explores the possible mechanism of action. A total 36 female rats were caged into the male rats for the pregnancy, and 33 female pregnant rats were collected and weight. The female rats were group into following groups and each group contains 6 rats. Once the pregnancy was v...
Waseem Khalid1, Ali Ikram1*, Muhammad Rehan2, Farukh Adeem Afzal1, Saadia Ambreen1, Marryam Ahmad3, Afifa Aziz1 and Anam Sadiq1
...by melon seed, including anti-inflammatory agents, hypoglycemic agent, antimicrobial, anti-genic and antioxidant potential.
... 
Ibadullah Jan1*, Iqbal Munir2, Inamullah Khan3, Syed Muhammad Suhail4 and Aqib Iqbal2
... Dodonaea viscosa, as an anti-inflammatory, antipyretic, and analgesic along with in vivo acute toxicity in the animal model. Different techniques such as xylene induced ear edema model, Carrageenan induced paw edema model, Hot plate pain model, Ethanoic acid-induced pain model, Yeast instigated pyrexia model acute toxicity model was used to investigate Dosiflavone. Dosiflavone showed significant (p<0.05) reduction of the ear edema at a high dose. However, ...
Fahrauk Faramayuda1,2*, Totik Sri Mariani3, Elfahmi1,4 and Sukrasno1
...abetic, antihypertensive anti-inflammatory. The country of Indonesia has three varieties of O. aristatus, namely purple, white-purple and white. The purple and white-purple population has started to decline. Efforts are needed to maintain the two varieties’ population, one of which is plant tissue culture. It is hoped that in vitro cultured plants contain the same secondary metabolites as the wild type. This study aims to identify the chemical content of...
Zhengyi Fu1,2,3,4, Rui Yang1,2,3, Shengjie Zhou1,2,3, Zhenhua Ma1,2,3* and Gang Yu1,2,3*
...s were up-regulated, but anti-inflammatory cytokines were down-regulated and inflammatory markers were up-regulated, indicating an obvious inflammatory response. The expression levels of S and M grade anti-inflammatory and proinflammatory cytokines was more balanced. This study provides the basis for finding the relationship between size heterogeneity and gene expression level of barramundi juveniles, and may provide insight...
Roheela Yasmeen1*, Laiba Asif1 and Samia Djeffal2
...use of the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been linked to this rapid decline in vulture populations. Diclofenac has been in use since 1974 to treat several problems in cattle such as pain during calving, lameness, mastitis, and swelling. The drug was also used to treat diverse problems such as dysmenorrhea, ocular inflammation, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and actinic keratosis etc. Although, it is g...
Zahid Beg Mirza1,*, Naveed Ali Soomro2 and Farwah Shariff1
...n the use of non-steroid anti-inflammatory drugs, that is diclofenac and other drugs known to be harmful to vultures, were gathered through interviews. This paper suggests that the vultures and other raptors in the mountainous eco-region of Sindh are in relatively larger populations compared to the Eastern side of Sindh due to the abundance of wild ungulates in protected areas such as the Khirthar National Park. ...
Ayesha Muzamil, Hafiz Muhammad Tahir, Shaukat Ali, Iram Liaqat, Aamir Ali, Muhammad Summer
...oteins that act pro- and anti-inflammatory cytokines. The main component of immunity is IL-1. IL-6 cytokine play its role in regulation of metabolic reactions. The activity of various leukocytes is suppressed by IL-4 and IL-10 (anti-inflammatory cytokines) that triggers the production of pro-inflammatory cytokines. This review paper provides an overview of inflammation, its associated factors, causes and treatment and role o...
Amr N. El-Shahat1, Refaat G. Hamza1,*, Ashraf M. Mounir1 and Madeha N. Al-Seeni2
... possess antioxidant and anti-inflammatory activities. The present study was designed to determine the possible protective effects of graviola fruit juice (GFJ) against radiation induced oxidative stress and biochemical alterations in the liver and kidney of male albino rats.In the present study, gamma- irradiation (2 Gy every 3 days up to 8 Gy total doses) induced biochemical and oxidative damage in rats when compared to control group. In GFJ (10ml/Kg B Wt. /...
Fujun Miao1, Chunlan Shan2, Wei Yang3, Hao Wang3, Shuxiang Geng1 and Delu Ning1*
.... Walnut oil exerted the anti-inflammatory effects in the liver of ALD by decreasing the liver index, malondialdehyde (MDA) contents, and the expression levels of F4/80. The expression levels of key factors in the toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling pathway reduced significantly after feeding with walnut oil to the ALD mice. Walnut oil may exert a protective effect on ethanol-induced ALD in mice by inhibiting the TLR4/NF...
Saydat Saad1, Doaa Abdel-Fattah1, Tarek Khamis2, Aya El-Sobky1*
...rous benefits, including anti-inflammatory, antioxidant, anticancer, and antifungal properties. Low bioavailability, solubility, absorption, and untargeted control, the advantages of free form propolis are limited due to previous reasons. Nano-propolis is made using a variety of nanoencapsulation processes. Because of their smaller size, nano-propolis is more utilized by the body than the free one. This study focuses on some current research on the application...
Hafiz Adnan Ahmad1,2*, Muhammad Aslam2, Salman Gul2, Tariq Mehmood2 and Munawar Ali Munawar2
...in search of more potent anti-inflammatory agents. Title compounds were synthesized by chlorosulfonation of 3,4-diphenyl-1,2,5-oxadiazole (3) followed by condensation with amines and all derivatives were obtained in moderate to good yield. All synthesized hybrids were characterized with spectroscopic techniques and further evaluated for anti-inflammatory potential. The synthesized hybrids were screened in vivo by employing c...
Mian Abdul Hafeez1*, Adeel Sattar2, Faiza Aslam3, Muhammad Imran3, Kamran Ashraf1, Rashid Zia2 and M. Muntazir Mehdi1
...buprofen, a nonsteroidal anti-inflammatory drug and coccidiostat (Clopidol) alone and in combination against coccidiosis in broiler birds. Chicks were randomly allocated to five treatment groups of 25 broilers in each pen on 5th day of age. Birds in groups A, B, C and D were challenged by 60,000-70,000 sporulated oocysts of mixed species local isolates at 21st day of age. Groups A and B were medicated with Ibuprofen (100mg/kg body weight) orally and Ibuprofen ...
Doaa Sh. Mohamed1, Nema S. Shaban2 , Mai M. Labib3, Olfat Shehata4
...issue in mice due to its anti-inflammatory and antioxidant properties.
Keywords | Doxorubicin, Medicinal plant, Transmembrane receptors, Heart toxicity, Oxidative stress, Cytokines
...
Ni Putu Vidia Tiara Timur1*, Maria Maliga Vernandes Sasadara2, Purwanta1, Anak Agung Jayawardhita3
... using an antibiotic, an anti-inflammatory agent and supportive therapy. Regular monitoring was conducted for two months before it was confirmed that no saliva was re-accumulated.
Keywords | Salivary mucocele, Surgery, Treatment, Local dog, Bali
...
Uzma Jabeen1, Asmat Salim2*, Irfan Khan2, Nadia Naeem3 and Rubina Mushtaq4
... terms of changes in the anti-inflammatory cytokine, interleukin-10 (IL10). Of the oxidative stress induced genes analyzed, the expression of Gpx1 was found to be increased significantly. Significant increase was also observed in case of IL10 gene, while kidney injury biomarker level was not increased in response to DOX. It is concluded from this study that DOX treatment can modulate the expression levels of Gpx1 and IL10, while injury markers may have differe...
Asmaa Khamis1, Osama Abdalla1, Mohamed Hashem2, Noha Abdelnaeim1*
... PM have antioxidant and anti-inflammatory effects, especially PM, which showed better improvement than PN against CCl4 hepatotoxicity in rats.
Keywords | Phyllanthus niruri, Plantago major, carbon tetrachloride, hepatotoxicity, histopathology, apoptotic markers
...
Gamalat Y. Osman1, Elham M. Hassan1*, Tarek A. Salem2, Azza H. Mohamed1
...ed anti-schistosomal and anti-inflammatory effects on infected mice.
Keywords | Schistosoma mansoni, Trigonella foenum, Fenugreek water extract, Praziquantel, Rutin, P-cumaric
...
Md. Sabuj Rahman and Md. Mahmudul Alam*
...iotics and non-steroidal anti-inflammatory drugs, a good prognosis in the calf was noticed. After 1 month, a mild skin problem occurred which was minimized simultaneously....
Dhiya Altememy1, Mohammad Darvishi2*, Samira Shokri3, Saber Abbaszadeh4
...due to antimicrobial and anti-inflammatory activities. They can therefore be used as an effective remedy for healing wound infections in diabetics.
Keywords | Nanoparticle, Herbal plants, Diabetes, Staphylococcus aureus, Treatment
...
Farah Abid1,2, Mohammad Saleem1,3*, Tahir Maqbool4, Tania Ahmed Shakoori5, Faheem Hadi4, Tahir Muhammad4, Saira Aftab4, Yasir Hassan7 and Shabana Akhtar4,6*
...ave potential to perform anti-inflammatory and anti-arthritic activity which could have beneficial impact for the patients associated with arthritis....
Shaolin Zeng, Shuai Yuan* and Kai Liu
...evoflurane inhibited the anti-inflammatory effect of post-ischemic treatment with sevoflurane. The post-ischemic treatment with sevoflurane promoted the activity of SOD, CAT as well as GSH-Px, and inhibited MDA and ROS levels, while miR-26a-5p inhibition expression content inhibited the increase in activity of SOD. To conclude, the post-ischemic treatment with sevoflurane is able to inhibit PTEN expression to promote the activation of PI3K/Akt signaling pathwa...
Saima Rubab1,3*, Ghazala H Rizwani2, Arjumand Iqbal Durrani3, Iram Liaqat4*, Urooj Zafar5, Mahjabeen6, Farah Batool7, Noor-E- Seher3, Naveera Younas3 and Ayesha Sadiqa8
...ated for the comparative anti-inflammatory and analgesic potential using different parameters like licking - biting response, inflammation of hind paw and writhing effect. The results showed that different pharmacological activities were due to the presences of various phytochemicals like tannins, resin and flavonoids, observed maximally in ethanolic extract with minor quantity of alkaloids and glycosides. Fourier transform infrared spectroscopy (FTIR) of drie...
Samiya Rehman*, Eman Mustafa, Ali Ahmad Faiz, Maheen Kanwal, Farkhanda Yasmin and Arooj Fatima
... extent through usage of anti-inflammatory drugs, exercise and deactivation of microglial pathways. Plants are proved to be promising source of recovering drug addiction side effects. This article also focuses on psychological and emotional regulations, caused by drug addiction involve depression, schizophrenia, family problems and involvement in various criminal activities. Support of local community, use of preventive measures and public policies are require...
Ahmed Ali Chandio1, Asghar Ali Kamboh1*, Nazar Ali Korejo2, Riaz Ahmed Leghari3 and Muhammad Ali Chandio4
... traditional use, having anti-inflammatory, anti-pyretic, anti-nociceptive, anti-oxidant, anti-ulcer, antihyperglycaemic and anti-microbial activities. The current investigation aimed to explore the immunomodulatory and gut microflora modulatory effects of dietary P. pinnata in broilers. Day old broiler chicks (n=125) were purchased from local hatchery and equally divided into the five groups, i.e., C (control) that offered basal diet, while, T1, T2, T3 and T4...
Anhar Ibrahim Elhanafy*, Amr Mohamed Mousa, Amaal Mohamed Kamal
...istic immune stimulator, anti-inflammatory and antioxidant substitute to pharmaceuticals to be applied in rabbit farms. Furthermore, rabbit wellbeing was significantly influenced by injecting < 0.3 mg BV/rabbit twice weekly. ...
Sahar Ezeldien1,2, Foromo Dramou2, Fatma M. Yousseff3*, Alexander A. Nikishov2, Sergy B Seleznev2
...n for its antibacterial, anti-inflammatory, and antioxidant properties. This study was conducted to determine the effect of chamomile aqueous extract on the productivity, egg quality, and serum biochemical parameters of laying Japanese quail. A total of 42 Japanese quail were separated into two groups of 21 birds each, with three replicates per group (7 birds) at random; the control group without any additives and the supplemented group with chamomile aqueous ...
Aamir Ali, Hafiz Muhammad Tahir*, Azizullah, Shaukat Ali, Muhammad Summer, Ali Haidar Gormani, Saira Nawaz and Ayesha Muzamil
...as conducted to evaluate anti-inflammatory and analgesic potentials of hot water extracts of mulberry leaves (mulberry tea) of two species i.e., Morus alba and Morus nigra. Mice were fed orally with mulberry leaves extract (200mg/kg, 100mg/kg and 50mg/kg) mixed in distilled water. Mice paw edema was induced by carrageenan injection while formalin was injected to mice paw for induction of pain. These extracts significantly decreased edema in mice paw. The level...
Asmaa A. Darwish*, Adel M. El-Kattan, Mona A. Mahmoud, Mohamed T. Ragab, Amani A. Hafez
...(P˂0.05) decline in the anti-inflammatory cytokine, anti-oxidants, insulin, T3, and T4 levels. The iron profile of infected animals was characterized by a significant (P˂0.05) hypoferremia, hyperferritinemia, and hypotransferrinemia. The estimated pro-inflammatory cytokines and APPs yielded high sensitivity and specificity values in both infected species, but IL-1β, IL-6, and Fb had the highest likelihood ratios in infected sheep and IL-1β and IL-1...
Amr N. El-Shahat1*, A.M. Abdul Azeem1 and Mohamed H.M. Abd el Megid2
...as antioxidant activity, anti-inflammatory activity and prevention of cardiovascular diseases. The present study aims to investigate the effectiveness of bay leaf extract (BLE) in protection against high cholesterol diet (HCD) induced hypercholesterolemia. About thirteen compounds of essential oils were identified by GC/MS analysis including 1.8-cineole, Linalool and sabinene which represent the main volatile oils of bay leaf. Supplementation of BLE with HCD f...
Sarwat Yousuf1, Shaista Emad2 , Mohammad Misbah ur Rehman3, Zehra Batool4, Sara Qadeer5, Yousra Sarfaraz1, Sheeza Sheikh1, Sana Sadaf6 and Tahira Perveen1,*
...idant, antibacterial and anti-inflammatory agent. This study intended to determine the potential role of lemon peel oil in neurobehavioral function and oxidative stress. Rats were treated with lemon peel oil at a dose of 0.7, 1.4, 2.1, 2.7, 3.5 g/kg for 14 days. Results showed that lemon peel oil at low doses has antidepressant and anxiolytic activity. Muscular strength was also improved at low doses. The brain antioxidant defense enzymes were also enhanced wh...
Arshad Javaid1*, Iqra Haider Khan1, Malik F. H. Ferdosi2, Aneela Anwar3 and Mujahid Manzoor4
...timicrobial, anticancer, anti-inflammatory, cytotoxicity, insecticidal and insect repellant properties as reported in the literature. ...
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...ning the antioxidant and anti-inflammatory properties of both the flavonoids present in grapefruit and selenium and increasing the efficiency of the selenium nanoparticles....
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...ning the antioxidant and anti-inflammatory properties of both the flavonoids present in grapefruit and selenium and increasing the efficiency of the selenium nanoparticles....
Azza M. El-Kattawy1, Tarek Abou Zed1, Randa Megahed1 and Mohammed El-Magd2*
...ed the expression of the anti-inflammatory gene IL10, 5) reduced the levels of the oxidative markers [lipid peroxide marker malondialdehyde (MDA) and nitric oxide (NO)], 6) increased the levels of antioxidant markers [reduced glutathione (GSH) and superoxide dismutase (SOD)]. These findings conclude that administration of Sim relieved pristane-induced arthritis, with best improvement in the Sim co-treated (prevention) group. Thus, Sim could be used as a protec...
Sajida Batool, Iqra Ashraf, Shafaat Yar Khan, Sitara Shameem* and Breha Kazmi
...and 24 h while levels of anti-inflammatory cytokines (Interleukin-10) were measured after 4 and 48-h via enzyme-linked immunosorbent assay (ELISA). C. procera treatment exhibited a significant decline in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines on PHA stimulated T-cells in time-dependent and dose-dependent manner. These findings are suggesting the immunomodulatory potential of methanolic leaf...
Salma Jameel Askar
...ive pain is nonsteroidal anti-inflammatory drugs, suppression of cyclooxygenase (COX-1) activity by these drugs has been associated with substantial side effects, beetroots act as a medicinal herb in the treatment of hematological disorders, and act as antioxidant. The aim of this study was to examine the effects of sub-chronic exposure to meloxicam, nonsteroidal anti-inflammatory drug, on hematological alterations and liver...
Aamir Ali, Hafiz Muhammad Tahir*, Azizullah, Shaukat Ali, Muhammad Farooq Bhatti, Muhammad Summer and Ali Haidar Gormani
...cal activities including anti-inflammatory, antioxidant, antibacterial, anticancer, anti-diabetic and antidepressant activities. Further studies should explore the mulberry leaves potentials as these plants have got the attention of both the pharmacological and commercial industries.
Novelty Statement | The mulberry leaves possess various therapeutic potentials. In this study, we have summarized all t...
Raed Hussein Salih Rabee1, Yahya Sabah Abdulameer1, Walla Farhan Obed1, Noor R Abady1, Adnan Mansour Jasim1*, Firas Hussein Albawi1, Mohammed Jasim Jawad2, Ahmed Samir Abukhomra3
...inst E. coli, as well as anti-inflammatory and antioxidant properties. Furthermore, histopathological examination of the intestinal broiler received BBR showed improvements and restore tissue near to normal.
Keywords | Enerofloxacin, Berberine, E. coli, Antibiotic residues, CYP450, Antioxidant, Drug docking
... 
