Muhammad Mushtaq, Umer Sadique, Naila Chand, Iftikhar Ahmed, Said Sajjad Ali Shah, Ijaz Ahmad, Imran Ullah and Muqadar Shah
...ated with development of diabetes, high blood pressure and kidney failure. Hypercholesterolemia is mainly caused by high fat diet, obesity and diabetes.Hypolipidemic and hypoglycemic effect of water based infusion of Withania somnifera was investigated in broiler chicks. One hundred and twenty (120) day-old broiler’s chicks were alienated into four treatment groups namely WST-0, WST-I, WST-II and WST-III with three rep...
Tasnim Farasat*, Saima Sharif, Farkhanda Manzoor, Muneeza Zafar and Shagufta Naz
...otential risk factors of diabetes on their first visit to a local hospital. Among the newly diagnosed diabetic subjects 33% (n=66) were with retinopathy. Out of which 30% (n=18) were male and 70% (n=48) were female. High density lipoprotein (HDL), both systolic and diastolic blood pressure, cholesterol level and serum insulin were significantly higher (p< 0.05) in proliferative group of diabetic retinopathy, while triglyceride level, HbA1c (%), and low dens...
Shabana1,*, Farah Ehsan1 and Shahida Hasnain1,2
...PARGC1α) gene with diabetes in Pakistani population. A total of 900 blood samples (diabetic=451, controls=449) were genotyped by PCR-RFLP. A significant difference in genotype distribution was observed between cases (Gly/Gly, 66.9%; Gly/Ser, 20.17%; Ser/Ser, 12.8%) and controls (Gly/Gly, 67.4%; Gly/Ser, 28.5%; Ser/Ser, 4.00%) (p = 0.013). The cases showed significantly higher frequency of the Ser allele compared to the controls (22.9% vs. 18.3%; O...
Ambreen Butt1, Uzma Malik2, Khadija Waheed3, Amna Khanum3, Samar Firdous4, Sara Ejaz5 and Fawad Randhawa2, Tania Shakoori6*
...12 levels are reduced in diabetes including gestational diabetes. We sought to compare serum cobalamin between pregnant females diagnosed with gestational diabetes mellitus (GDM) and healthy controls and to propose a cut off value for serum B12 levels as a predictive biomarker for GDM. Study design was Quantitative cross-sectional study. This study was carried out at Lady Atchison Hospital...
Rehana Shahida1, Tasnim Farasat1, Shagufta Naz1,* and Shahjahan2
...er in IGT p< 0.01 and diabetes subjects (p<0.01). It was2.44 fold higher in IGT group and 4.5 fold higher in diabetic group. Expression levels significantly correlated with serum values of TNF-α (p< 0.01). Thrombomodulin showed a strong relationship with insulin and insulin resistance in diabetic group (p<0.05).
...
Muhammad Saqlain1, Humaira Kalsoom1, Muhammad Fiaz1,2, Abid Mahmood1, Rizwan Aziz Qazi4 ,Waseem Safdar5, Pakeeza Arzoo Shaiq1,Bernard M.Y. Cheung3 and Ghazala Kaukab Raja1,*
...lin resistance, obesity, diabetes, and metabolic syndrome (MetS). In this study the association of Ala54Thr polymorphism with MetS and its risk components was studied in a local Pakistani population. MetS subjects and controls were recruited from out-patient departments of Pakistani hospitals. Ala54Thr genotyping of 200 MetS patients and 200 healthy controls was performed using a PCR-RFLP. Genotype and allele frequencies were calculated and computed for geneti...
Faiza Hassan1, Mubshara Saadia1,*, Muhammad Sher1, Mian Anjum Murtaza2, Muhammad Arshad3,Asam Riaz4 and Mahmood Ahmad Khan5
...>Life time management of diabetes by synthetic drugs has been found cost effective with severe side effects as well. Herbal remedies are gaining popularity. Black cumin and garlic are found effective against hypoglycemia, hyperlipidemia, and hypercholesterolemia. Present study was designed to evaluate the relative antidiabetic potential of garlic aqueous (AGE) and petroleum ether (EGE) extracts compared to black cumin (Nigella sativa oil; NSO) and insul...
Mian Sajjad Ahmad1, Somia Iqtadar1, Sami Ullah Mumtaz1*, Zafar Niaz1, Iqra Waheed2 and Sajid Abaidullah1
...sk factor for developing diabetes Mellitus & is associated with hyperglycemia and insulin resistance. To determine the frequency of impaired glucose tolerance in obese patients. This Cross Sectional study was carried out in North Medical Ward, King Edward Medical University/ Mayo Hospital Lahore for 6 months i.e. January to June 2014. Total 160 obese patients visiting outpatient department of North Medical Ward, Mayo Hospital Lahore for 6 months were inclu...
Promy Virk
...oach in nanomedicine for diabetes management.
...
Anza Zahid*, Muhammad Ali Ayub, Mujtaba Saeed, Nasir Pasha, Abdul Jabbar Dar, Huzaifa Javed, Aimen Shakeel, Amna Nasir, Ana Akbar, Zainab Tarrar and Ayesha Humayun
Farhat Ijaz1, Rana Khurram Aftab2*, Samia Jawed3
...Abstract | Type 2 diabetes mellitus (T2DM) and insulin resistance (IR) are linked to each other. Obesity and T2DM are states of low-grade chronic inflammation, which result in increased levels of inflammatory markers such as C-reactive protein (CRP), interleukins 6 (1L-6) and tumor necrosis factor alpha (TNF-α). Relation of TNF-α with obesity induced IR and T2DM is unclear as results obtained from different studies are very controversial.
Iqra Arooj1,* and Shahida Hasnain2
...rs are smoking, obesity, diabetes, family history, high blood pressure etc. Previous genome wide association studies have identified association of large number of loci with risk of CHD in different populations. The purpose of this study was to determine the association of 6q25.1/rs6922269 and 9p21.3/rs1333049 loci with risk of CHD in a population of Punjab province of Pakistan. A total of 645 subjects were included in this study of which 435 were patients vis...
Riffat Mehboob1*, Sami Ullah Mumtaz2, Zoya Manzoor3, Sajid Abaidullah2, Fridoon Jawad Ahmad1
Deranged biochemical and hematological profile of septicemia patients in Mayo hospital, Lahore
...According to this study, diabetes (45.56%) was the main comorbidity of septicemia. Most of the patients were between 51-70 years while septicemia occurred equally in both genders. Major predictors for diagnosis were WBCs, hemoglobin, AST, ALT, ALP, urea and creatinine. Other biomarkers gave no information regarding septicemia diagnosis. This demands the use of improved diagnostic biomarkers in developing countries....
Atiq-ur-Rehman1,2,*, Abida Latif1,*, Rukhsana Anwar1, Nasir Abbas1, Sajid Nawaz2 and Hamid Turab Mirza3
...lklore medicine to treat diabetes. No study has been conducted so for to determine α-amylase inhibition for the evaluation of hypoglycemic potential of the plant. So, the aim of this study was for the investigation of in vitro, in vivo anti-diabetic potential and mode of action of various fractions of methanolic extract of the aerial parts of this plant. Various fractions (n-hexane, chloroform, ethyl acetate and n-butanol) from the most act...
Rabia Khalid1, Saleema Bashir Shams1, Bibi Nazia Murtaza1,*, Gaitee Joshua1, Saira Mushtaq1, Hassan Al-Talhi2 and Abdulaziz Al-Amri2
...for MetS leading to CVD, diabetes type-II, atherosclerosis and hypertension.
...
Salma Javed1, Muhammad Fiaz Khan1, Irfan Ullah2, Sadia Tabassum1,*
...a high burden of type II diabetes, with approximately 8 million (6.72%) people suffering from it. The present study was carried out to assess the prevalence and the possible risk factors of type II diabetes in Hazara region Khyber Pakhtunkhwa, Pakistan. The total area was divided into six clusters, and the data was collected randomly from different hospitals, clinics, and different localities of Hazara region.The report incl...
Tanveer Ahmad1, Tariq Mehmood1, Muhammad Shahid1, Adnan Ahmad1,2, Muhammad Asim Raza Basra1, Muhammad Zia-ur-Rehman3* and Munawar Ali Munawar1
... to alarming increase of diabetes mellitus around the world, there is a need to discover new molecules to tackle with the problem. In this work, sulfonamides and sulfonylurea-sulfonamide hybrids were synthesized from simple molecule of 4-aminobenzenesulfonamide by its reaction with aryl sulfonyl chlorides. Anti-diabetic activities of these pharmacophores were studied by oral glucose tolerance test (OGTT) percentage analysis on Sprague Dawley (SD) rats at the d...
Ahsan Numan1,4, Khadija Irfan Khawaja2, Abdul Basit Qureshi3, Muhammad Shahbaz Yousaf4, Imtiaz Rabbani4, Hafsa Zaneb5 and Habib Rehman4*
... to be 31.48% when 2,290 diabetes mellitus Type-2 subjects were screened. The patients with DSP were older (p < 0.05), had longer duration of DMT2 (p<0.01), elevated systolic blood pressure (p<0.05), blood sugar (p < 0.05), HbA1c (p<0.001), cholesterol (p<0.01), LDL (p<0.001), triglycerides (p<0.05) and more obese (p<0.01) when compared with the diabetic patients without clinical DSP. Occurrence of fatty liver was more (p&...
Xuya Zhou1, Ying Liu1, Deqin Xu1, Jie Bao1, Yaru Cao2 and Yong Jin3*
... (BNP) in blood serum of diabetes complicating arthritis rats. Blood pressure was measured by a noninvasive caudal artery blood pressure meter. Western blot analysis showed that unification of two drugs caused protein expression levels of COX-2 to reduce obviously and increased protein expression levels of CYP4A1. Immunohistochemistry showed the increased expression of CYP4A1. Elisa indicated that the decreased production of PGE-2 and the increased production ...
Ahmed Weli Hussein Osman1,2, Rakibul Islam1, Md. Bazlar Rashid1, Abdiaziz Idiris Mohamud2,3* and Pravin Mishra4
Nanoparticle Tactics for the Oral Delivery of Insulin in Alloxan-Induced Hyperglycemia in Rat (Rattus norvegicus domestica) Model
...). After acclimatization diabetes was induced in three groups of rats (T1; positive control, T2: insulin only insulin, and T3; insulin with nano particles) by administered alloxan injection at dose of 120mg/kg body weight intraperitoneally. Group T0 was kept for negative control while T1 was kept positive control. T2 were considered as insulin treated group at 21IU/kg and T3 as insulin with nano particles of same dose as insulin. Over the sequence of the exper...
Mohsin Ali1, Nargis Haider Kakar2, Rida Dawood3,4, Qurat-ul-ain Fatima5, Zunera Tanveer2, Shoaib Ahmad Malik6, Tauseef Muhammad Asmat1, Asadullah1, Muhammad Masood Tariq Kiani1 and Mohammad Zahid Mustafa1*
...ters of age, duration of diabetes and type of treatment were measured. Venous blood was taken to investigate the thyroid profiles. Out of 224 patients examined, 67.85% showed the normal thyroid profile and thyroid abnormalities were seen in 32.15% of subjects. There were 10 patients with clinical hypothyroidism, 54 patients had subclinical hypothyroidism, and 8 patients had clinical hyperthyroidism. No case with subclinical hyperthyroidism was investigated. Th...
Ahmad Sadiq1, Muzafar Shah2*, Habib Ullah1, Irfan Ali1, Amir Alam3,
Navid Jalil1 and Muhammad Khan3
...es and 52 female) type 2 diabetes (T2DM) subjects were diagnosed at Hayatabad Medical Complex (HMC) Peshawar and private diabetic clinic “Khattak Medical Centre” (KMC), Dabgari Garden Peshawar, Khyber Pakhtunkhwa, Pakistan. The normal or control group consists of twenty (9 females and 11 males) people having no history of diabetes mellitus, hypertension and cardiovascular disease. Glycated hemoglobin HbA1c, rando...
Eslam Moradi-Asl1*, Behnam Mohammadi Ghalehbin2, Kamran Akbarzadeh3, Jafar Mohammad-Shahi4, Hajar Afshin4
...i>, who had a history of diabetes and also blind that reefed to hospital in 13 September and was admitted to date 18 September 2019.Larvea extracted manually from thumb finger of left foot and sent to Medical Entomology Laboratory of the School of Public Health, Ardabil University of medical Sciences for identification. This case is a first time was reported from Ardabil province, northwest of Iran and the Diabetics, Blindness and Physical inability to protect...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...ize: small;">Gestational diabetes mellitus (GDM) is an atypical condition of pregnancy outcome that affect the maternity and infant. Pregnant women are a high risk to develop the GDM suffering from the diabetes, it showed the effect on the development and growth of the fetus. During the GDM increase the incidence of oxidative stress. Caffeic acid is a powerful free radical scavenger and possesses antioxidant effect against t...
Ahsan Numan1,4, Abdul Basit Qureshi2, Fehmeda Farrukh Khan3,Faisal Masud3,Ijaz Ahmad4, Kamran Ashraf5, Nisar Ahmad5, Muhammad Shahbaz Yousaf 4, Imtiaz Rabbani4, Hafsa Zaneb6 and Habib Rehman4*
...he effect of duration of diabetes mellitus type-2 on the electrophysiological characteristics of sensorimotor nerves in patients with clinical diabetic polyneuropathy (DSP). Clinical diagnosis of DSP was assessed with the Michigan Neuropathy Screening Instrument. The diagnosed patients with DMT2 were randomly distributed into 2 groups. Group-I (n= 79) included the patients with DSP having <10 years of duration of DMT2, called short duration, while DSP patie...
Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
...treatment, for combating diabetes complications, blood pressure, oxidative stress and haematological disorders. This study was done in the investigation of antihyperlipidemic effects of methanol extract of seeds of this plant in hyperlipidaemia Wistar albino rats induced by Triton X-100. There were 4 groups of rats: Group A served as normal; Group B, C and D were given high cholesterol diet and administered with intraperitoneal injection of Triton X-100 to ind...
A.M. Abdul Azeem, Ashraf M. Mounir and Amr N. El-Shahat*
...rapy in the treatment of diabetes. This research was aimed to explore the influence of gamma (γ)-irradiation on the total phenolic compounds and total flavonoid contents of dried pumpkin seeds as well to determine the hypoglycemic influence of γ-irradiated pumpkin seeds dried powder (GPSDP) on diabetic rats. In this work, the level of total phenolic and total flavonoid contents of raw dried pumpkin seeds was significantly increase under the effect ...
Ying Feng1 and Xuqun Pei2,*
...d glucose regulation and diabetes was higher than that of the normal glycemic group at the beginning and 3 months after the onset. The proportion of LAA and SAO in the two groups, other than the normal blood glucose group, reached 61.90%, 52.00%, 33.30%, and 40.00%, respectively. Compared with the other two groups, the MMSE and Mattis dementia scale scores and their attention were different in the impaired glucose regulation group; animal experiments found tha...
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
...mental animals to induce diabetes. Nowadays, efforts have been directed and focused on complementary medicine. Aim: Our study was designed to assess the hypoglycemic activity of the laser on diabetic experimental animals. Methods: The present work was carried out on 40 albino rats, and equally divided into 4 groups, (10 rats/group) as following: Group 1, animals served as control. Group 2, animals received STZ. Group3, animals received laser. Group 4, animals ...
Wei Cui1, Yanwei Du1, Lijuan Jiang1, Yan Wei1, Yuguo Li1, Wenfeng Zhang1* and Ling Zhang2*
... of the complications of diabetes, closely related to the degeneration and apoptosis of hippocampal neurons. Buyang Huanwu Decoction (BHD) is a classic traditional Chinese medicine prescription, which has the functions of benefit qi, activing blood circulation and dredging collaterals. To investigate the protective effect and mechanism of BHD on hippocampal neurons in diabetes, a high glucose (HG) induced PC12 cell injury mo...
Bibi Hajira*, Imran Khan and Zia-ud-Din
...wards the development of diabetes mellitus because of its high starch digestibility. Previous studies suggested that the addition of other grains, legumes and medicinal herbs to bread might reduce its starch digestibility. However, the incorporation of these non-wheat materials into bread is challenging from consumer acceptability perspective. Therefore, the current study investigated the effect of incorporating red sorghum and barley flours in white bread on ...
Jiacheng Du and Yuping Cao*
...tension, and gestational diabetes of patients in Group A is significantly lower (P<0.05). AMH level showed high specificity (77.52%) and sensitivity (81.46%) in predicting IVF-ET clinical pregnancy in PCOS patients. PCOS patients with lower AMH levels showed better sex hormone levels and clinical pregnancy outcomes in IVF-ET. Serum AMH level is valuable (of good value) in predicting IVF-ET clinical pregnancy in PCOS patients. In clinical practice, intervent...
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...ic disorders like Type 2 diabetes, cardiovascular disease, and several types of cancer has made obesity a challenge for world health. The current study’s objective was to assess the antioxidant capacity of cranberry extract in high-fat diet-induced obesity. For eight weeks, 36 white albino rats weighing 197±10 g were selected at random to five groups: Group I was administered a regular diet; Group II was fed a high-fat diet; Group III was given a ...
Dhiya Altememy1, Mohammad Darvishi2*, Samira Shokri3, Saber Abbaszadeh4
Saydat Saad Abd El-Megeed1, Walaa Yehia El-Sayed1*, Tarek Khamis2
...viate the progression of diabetes.
Keywords | ZnO nanoparticles; Diabetes mellitus; Glucagon-like peptide-1; Gene expression; Hedgehog signaling pathway.
...
Amber Khalid1*, Farah Ashfaq1, Shahzadi Farah1, Amna Akbar1, Farkhanda Manzoor1, Muhammad Babar Khawar2, Saira Riaz3 and Safina Ashfaq3
...ilments including type 2 diabetes, renal diseases and hypertension in later age due to alteration of different serological parameters. In conclusion weight is associated with biochemical parameters. Any alteration in these parameters may cause health issues. Effective pediatric interventions are essential....
Ahmed M. El-Waziry1,2*, Saeid M. Basmaeil1, Ibrahim A. Alhidary1, Gamaleldin M. Suliman1,3, Mutassim M. Abdelrahman1, Maged A. Al-Garadi1
...d a reduced incidence of diabetes. There have been few studies on the use of ionophores in the diet of goats. Therefore, more research are needed concerning the influence of ionophores on ruminal fermentation, performance and characteristics of carcass of goats.
Keywords | Ionophores, Ruminal Fermentation, Animal Performance, Carcass Characteristics, Meat Quality
...
Owolabi Olutunmise Victoria1*, Saka Olusola Stephen2, Olashinde Oluwaseun Ruth1, Alli Smith Yemisi Rufina3
...abolic disorder known as diabetes mellitus. Researchers are in search for safe drugs that can bring a total recovery from diabetes. Thirty (35) male wistar rats were divided into six (7) groups of five animals each to study the antidiabetic and antioxidative properties of young Cola acuminata leaves aqueous extract. Diabetes was induced using alloxan monohydrate.5 ml of normal saline was g...
