Expression of Serum miRNA-137 in Women with Gestational Diabetes and its Relationship with Neonatal Hyperbilirubinemia
Expression of Serum miRNA-137 in Women with Gestational Diabetes and its Relationship with Neonatal Hyperbilirubinemia
Meixiang Li, Meiyan Liu, Xuehua Sun and Juan Li*
ABSTRACT
Diabetes is the most common endocrine disease in pregnancy, and identifying the risk factors of gestational diabetes mellitus (GDM) helps to discover women who are at risk of neonatal jaundice in the future. The purpose of this study was to investigate the expression level of miR-137 in women with GDM and its relationship with neonatal hyperbilirubinemia. During this cross-sectional descriptive study, the serum of forty patients with GDM (13 pre-diabetic and 27 diabetic) were collected at different gestational ages. Then, the total amount of cellular RNA was extracted and the expraession level of miR-137 was analyzed using real-time polymerase chain reaction (RT-PCR). The results showed that the expression level of miR-137 increased significantly in weeks 25, 26, 27 and 28 of pregnancy. This is despite the fact that the expression of this micro RNA did not show a significant change in the 24th week of pregnancy. The amount of miR-137 expression can be used as a biomarker to predict the stages of GDM. An increase in neonatal hyperbilirubinemia can be considered as an important negative consequence of GDM.
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