Effect of False-Positive Syphilis Spirochete-Specific Antigen on Pregnancy
Effect of False-Positive Syphilis Spirochete-Specific Antigen on Pregnancy
Li Wang, Feifei Feng, Kefei Peng, Yan Zhang and Ling Zhou*
ABSTRACT
Chemiluminescent immunoassay (CIA) has been suggested as a screening test for syphilis. The potential clinical value of the false positive result of obstetric CIA screening has not been elucidated. Our study aims to investigate the possible association between CIA false-positivity for syphilis and pregnancy outcome, which may provide information for obstetric clinical management. We retrospectively investigated the singleton pregnant women who had delivered at our center, and screened for syphilis by using CIA during early pregnancy from January 1, 2010 to December 31, 2019. Pregnancy outcomes of syphilis false-positive group were compared with those of syphilis negative group. Total of 16,935 singleton pregnant women were included in present study Compared with negative group, false-positive group shows older delivery age, smaller gestational weeks at delivery, and lower birth weight (P<0.05). Besides, the incidences of gestational hypertension, gestational diabetes, immune system diseases, and preterm delivery were also higher than those of negative group (P<0.05). Our study indicates that the pregnancy outcomes of syphilis false-positive group are poor, suggesting its relevance to obstetric prognostic and may need more attention from early pregnancy period, including antenatal examination and necessary laboratory tests to exclude other systemic diseases.
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