Investigating-the-Correlation-Between-Body-Mass-Index-and-Insulin-Resistance-among-Women-Diagnosed-with-Gestational-Diabetes
Investigating-the-Correlation-Between-Body-Mass-Index-and-Insulin-Resistance-among-Women-Diagnosed-with-Gestational-Diabetes
Ahmed J. Jaafer1*, Alaa K. Jassim1, Nidhal A. Hashim2
ABSTRACT
Gestational diabetes mellitus is becoming a more common problem during pregnancy and is on the rise around the world. Screening for and treating gestational diabetes mellitus is a way to stop its consequences. An abnormal body mass index can lead to many problems during pregnancy. It is also one of the main risk factors for pregnancy that can be changed. Knowing and evaluating the relationship of body mass index with insulin resistance in women with gestational diabetes. This case-control study included 50 pregnant women suffering from gestational diabetes who were diagnosed by doctors at Maysan Children’s and Maternity Hospital for the period from 5/11/2023 to 5/20/2024, along with 50 pregnant women who did not have gestational diabetes and 50 non-pregnant women who did not have gestational diabetes as a healthy control group. The study groups were divided according to body mass index into a normal weight group, an overweight group, and an obese group. Ethical approval was taken from all research participants, 5 ml was withdrawn from all participants and placed in a gel tube and left at room temperature for 15 minutes until coagulation, after which it was separated using Centrifuge for 15 minutes, and the serum was stored at a temperature of -20 Celsius until use. Fasting glucose levels were measured using a spectrophotometer, and HBA1c and insulin levels were measured using Cobas e411. Lipid profile, their levels were measured using spectrophotometer. The results showed a significant increase in cholesterol levels in the case group compared to the control group with a normal body mass index. While cholesterol and LDL levels increased in the case group of overweight women. While the results showed a significant increase in cholesterol, HDL and DL levels in the obese case group. While insulin, fasting sugar, and HBA1c levels increased in all condition groups depending on the body mass index. High blood sugar, HBA1c and insulin levels in women with gestational diabetes underscore the importance of insulin resistance, especially with differences in lipid levels according to body mass index. These differences indicate the influence of cellular lipid metabolism on glucose levels and insulin resistance.
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